Ivonne P. Ronchetti

Ivonne P. Ronchetti, a holder of a Ph.D. degree, is a Full Professor of general pathology (University of Modena and Reggio Emilia) and is the Rector’s Delegate for Student’s Affairs and Member of the Regional Conference for Student’s Rights and for the Instruction System. She gave courses of general pathology, molecular immunology, physiopathology, genetic and environmental pathology (Faculties of Medicine and Surgery, of Sciences, of Biosciences-Biotechnology). Her scientific interests are oxidative metabolism of cultured myoblasts, fibroblasts, and isolated mitochondria; structure, macromolecular organization, and composition of soft connective tissues and elastic fibers in physiology and pathology. She studied experimental lathyrism, human disorders of connective tissues (systemic sclerosis and osteoarthritis), and human genetic disorders (O.I., Menkes, cutis laxa, PXE). She was in the team who identified the gene causing PXE (ABCC6); she works on (i) correlation between mutations and phenotypic expression in PXE, (ii) other genes and environmental factors involved in the occurrence and severity of clinical manifestations, and (iii) molecular events leading to elastic fiber calcification aiming to prevent/reverse ectopic calcification. The PXE lab. of the Department of Biomedical Sciences of the University of Modena and Reggio Emilia is the reference centre in Italy for structural, molecular biology, and research on PXE and has a bank of DNA and fibroblasts of patients from Italy and European countries. Her Methodologies are structural, ultrastructural, immunocytochemical, biochemical, and biophysical approaches on isolated molecules, cell culture, cellular and molecular biology, and gene expression at mRNA and protein levels. With her excellent collaborators, she is author of more than 160 publication on peer-reviewed international journals. She is in the referee’s board of several international journals and of NIH.

Biography Updated on 11 October 2011

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