Loredana Frasca was born in Rome (Italy). 1992. Frasca received a degree in biological sciences (University of Rome La Sapienza, IT). From 1994 to 1996, Frasca was a Ph.D. Student at the Department of Immunology, Imperial College of Medicine, London (in the lab of Professors R.I. Lechler and G. Lombardi). From 1997 to 2004, she was a Postdoc at the Department of Cellular and Development Biology, La Sapienza University of Rome and afterwards at the Department of Infectious, parasitic and immune-mediated diseases, Istituto Superiore di Sanità, Rome. From 2005, Frasca held a permanent position as a Researcher in the same institute. From 2007 to 2008, she was a Visiting Senior Scientist in the Laboratory of Dr. KS Schluns, at MD Anderson Cancer Center, Houston, Tex, USA. Her research interest is basic immunology, transplantation, infectious diseases, and autoimmune diseases. She studied the role of indirect allorecognition in chronic allograft rejection in humans and strategies to inhibit rejection by peptide analogues. She addressed the function of anergic T cells as suppressor cells in vitro, their effects on the antigen-presenting cells (APCs), and “infectious tolerance” in transplant rejection. She studied the immune response against hepatitis virus C (HCV). The reactivity of B and T cells to the Hypervariable region 1 (HVR1) of HCV and effects of variants on TCR antagonism has been the object of various publications. Later, she was involved in studies about effects of pathogens and interferons on DC biology and immune regulation. She described a novel role of the receptor CD38 in the effector functions of human DCs. Current research is focused on the role of IFNs, IL-15, and human antimicrobial peptides in activating innate immune cells (DCs and neutrophils) and antigen-specific immune responses in human autoimmune diseases.
Biography Updated on 5 May 2011