Michael R. Moore

Michael R. Moore is the Director of the National Research Centre for Environmental Toxicology (EnTox). He received B.S. degree (with honors) in biochemistry, in 1967; the Ph.D. degree in medicine, in 1971; and the D.S. degree in biochemistry, in 1987, all from University of Glasgow. Michael is a registered toxicologist (Eurotox & Institute of Biology, UK) and Member of the Australasian College of Toxicology and Risk Assessment (ACTRA). He is a Professor in Medicine at the University of Queensland and Adjunct Professor in Griffith University, University of the Sunshine Coast, Queensland University of Technology. He is also a codirector of the Australian Centres for Human Health Risk Assessment. He has trained in Clinical Pharmacology in the Royal Postgraduate Medical School in London. He previously held senior appointments at the University of Glasgow, Glasgow Caledonian University, and Monklands and Bellshill Hospitals NHS Trust. As an international expert in toxicology of water pollutants relevant to public health, his areas of expertise include the toxicology of metals, air toxics, risk assessment, alcoholism, cyanobacterial toxins, and disorders of porphyrin metabolism. He is a Member of wide range of committees and advisory bodies on public health issues including the Australian Drug Evaluation Committee, the Australian Pesticides and Veterinary Medicines Authority and the National Drugs and Poisons Schedules Committee. He chaired the NHMRC Drinking water treatment chemicals working party and the Working Group on Air Quality in Tunnels and was a member in National Cyanobacterial Toxin Guidelines Working Group and the NHMRC Working party on Toxicology and Risk Assessment. He is a Prolific producer of research outputs with over 500 referred publications and numerous books and book chapters to date.

Biography Updated on 14 January 2008

Personal Home Page

http://www.entox.uq.edu.au/index.html?page=62194

Articles in Scholarly Journals [Incomplete List]

  1. Urinary arsenic and porphyrin profile in C57BL/6J mice chronically exposed to monomethylarsonous acid (MMAIII) for two years
    Toxicology and Applied Pharmacology, vol. 224, no. 1, pp. 89–97, 2007
  2. Location and Vitamin D synthesis: Is the hypothesis validated by geophysical data?
    Journal of Photochemistry and Photobiology B: Biology, vol. 86, no. 3, pp. 234–239, 2007
  3. Urinary arsenic methylation and porphyrin profile of C57Bl/6J mice chronically exposed to sodium arsenate
    Science of The Total Environment, vol. 379, no. 2-3, pp. 235–243, 2007
  4. Urinary excretion of cadmium among Torres Strait Islanders (Australia) at risk of elevated dietary exposure through traditional foods
    Journal of Exposure Science and Environmental Epidemiology, vol. 17, no. 4, Article ID 7500520, 5 pages, 2007
  5. Exploring potential dietary contributions including traditional seafood and other determinants of urinary cadmium levels among indigenous women of a Torres Strait Island (Australia)
    Journal of Exposure Science and Environmental Epidemiology, vol. 17, no. 3, Article ID 7500547, 8 pages, 2007
  6. Toxicology in Australia: A Key Component of Environmental Health
    Journal of Toxicology and Environmental Health, Part A, vol. 70, no. 19, pp. 1578–1583, 2007
  7. Public Health Risks from Heavy Metals and Metalloids Present in Traditional Chinese Medicines
    Journal of Toxicology and Environmental Health, Part A, vol. 70, no. 19, pp. 1694–1699, 2007
  8. Regulation of CYP2A5 Gene by the Transcription Factor Nuclear Factor (Erythroid-Derived 2)-Like 2
    Drug Metabolism and Disposition, vol. 35, no. 5, pp. 787–794, 2007
  9. Anxiety, post-traumatic stress disorder and depression in Korean War veterans 50 years after the war
    The British Journal of Psychiatry, vol. 190, no. 6, pp. 475–483, 2007
  10. Kidney Dysfunction and Hypertension: Role for Cadmium, P450 and Heme Oxygenases?
    The Tohoku Journal of Experimental Medicine, vol. 208, no. 3, pp. 179–202, 2006
  11. Endocrine-disrupting compounds: A review of their challenge to sustainable and safe water supply and water reuse
    Environmental Toxicology, vol. 21, no. 2, pp. 181–191, 2006
  12. Urinary porphyrins as biomarkers for arsenic exposure among susceptible populations in Guizhou province, China
    Toxicology and Applied Pharmacology, vol. 206, no. 2, pp. 176–184, 2005
  13. Cadmium-induced nephropathy in the development of high blood pressure
    Toxicology Letters, vol. 157, no. 1, pp. 57–68, 2005
  14. Renal and hepatic accumulation of cadmium and lead in the expression of CYP4F2 and CYP2E1
    Toxicology Letters, vol. 159, no. 2, pp. 182–191, 2005
  15. Evidence for induced microsomal bilirubin degradation by cytochrome P450 2A5
    Biochemical Pharmacology, vol. 70, no. 10, pp. 1527–1535, 2005
  16. Effects of cigarette smoking and exposure to cadmium and lead on phenotypic variability of hepatic CYP2A6 and renal function biomarkers in men
    Toxicology, vol. 204, no. 2-3, pp. 161–173, 2004
  17. Influence of body iron store status and cigarette smoking on cadmium body burden of healthy Thai women and men
    Toxicology Letters, vol. 148, no. 3, pp. 177–185, 2004
  18. A commentary on the impacts of metals and metalloids in the environment upon the metabolism of drugs and chemicals
    Toxicology Letters, vol. 148, no. 3, pp. 153–158, 2004
  19. Effects of chronic exposure to low-level cadmium on renal tubular function and CYP2A6-mediated coumarin metabolism in healthy human subjects
    Toxicology Letters, vol. 148, no. 3, pp. 187–197, 2004
  20. Acute cadmium chloride administration induces hepatic and renal CYP2A5 mRNA, protein and activity in the mouse: involvement of transcription factor NRF2
    Toxicology Letters, vol. 148, no. 3, pp. 199–210, 2004
  21. Evidence for Concurrent Effects of Exposure to Environmental Cadmium and Lead on Hepatic CYP2A6 Phenotype and Renal Function Biomarkers in Non-smokers
    Environmental Health Perspectives, 2004
  22. A global perspective on cadmium pollution and toxicity in non-occupationally exposed population
    Toxicology Letters, vol. 137, no. 1-2, pp. 65–83, 2003
  23. Potential for early involvement of CYP isoforms in aspects of human cadmium toxicity
    Toxicology Letters, vol. 137, no. 1-2, pp. 85–93, 2003
  24. Special issue on environmental toxicology of metals and metalloids
    Toxicology Letters, vol. 137, no. 1-2, p. 1, 2003
  25. Associations between human liver and kidney cadmium content and immunochemically detected CYP4A11 apoprotein
    Biochemical Pharmacology, vol. 63, no. 4, pp. 693–696, 2002
  26. Trace organic compounds in the marine environment
    Marine Pollution Bulletin, vol. 45, no. 1-12, pp. 62–68, 2002
  27. Pharmacogenetics, vol. 12, no. 3, pp. 241–249, 2002
  28. A review of animal models for the study of arsenic carcinogenesis
    Toxicology Letters, vol. 133, no. 1, pp. 17–31, 2002
  29. HPLC measurement of harderoporphyrin in the harderian glands of rodents as a biomarker for sub-lethal or chronic arsenic exposure
    Toxicology Letters, vol. 133, no. 1, pp. 93–101, 2002
  30. Relationships between non-occupational cadmium exposure and expression of nine cytochrome P450 forms in human liver and kidney cortex samples
    Biochemical Pharmacology, vol. 62, no. 6, pp. 713–721, 2001
  31. A sensitive and specific assay for glutathione with potential application to glutathione disulphide, using high-performance liquid chromatography–tandem mass spectrometry
    Journal of Chromatography B: Biomedical Sciences and Applications, vol. 762, no. 1, pp. 17–23, 2001
  32. Distribution of14C cylindrospermopsinin vivo in the mouse
    Environmental Toxicology, vol. 16, no. 6, pp. 498–505, 2001
  33. Extraction and purification of the zwitterions cylindrospermopsin and deoxycylindrospermopsin fromCylindrospermopsis raciborskii
    Environmental Toxicology, vol. 16, no. 5, pp. 391–396, 2001
  34. Evidence for a Synergistic Interaction between Cadmium and Endotoxin Toxicity and for Nitric Oxide and Cadmium Displacement of Metals in the Kidney
    Nitric Oxide, vol. 4, no. 4, pp. 431–440, 2000
  35. Public health implications of new guidelines for lead in drinking water: a case study in an area with historically high water lead levels
    Food and Chemical Toxicology, vol. 38, pp. S73–S79, 2000
  36. Therapeutic Drug Monitoring, vol. 22, no. 1, pp. 58–60, 2000
  37. Therapeutic Drug Monitoring, vol. 22, no. 1, pp. 89–92, 2000
  38. The oral toxicity for mice of the tropical cyanobacteriumCylindrospermopsis raciborskii (Woloszynska)
    Environmental Toxicology, vol. 14, no. 1, pp. 135–142, 1999
  39. Use of HPLC-MS/MS to monitor cylindrospermopsin, a blue-green algal toxin, for public health purposes
    Environmental Toxicology, vol. 14, no. 1, pp. 151–154, 1999
  40. Stability of cylindrospermopsin, the toxin from the cyanobacterium,Cylindrospermopsis raciborskii: Effect of pH, temperature, and sunlight on decomposition
    Environmental Toxicology, vol. 14, no. 1, pp. 155–161, 1999
  41. Deoxycylindrospermopsin, an analog of cylindrospermopsin fromCylindrospermopsis raciborskii
    Environmental Toxicology, vol. 14, no. 1, pp. 163–165, 1999
  42. Blooms of the cylindrospermopsin containing cyanobacterium,Aphanizomenon ovalisporum (Forti), in newly constructed lakes, Queensland, Australia
    Environmental Toxicology, vol. 14, no. 1, pp. 167–177, 1999
  43. Bracken Fern Carcinogenesis: Multiple Intravenous Doses of Activated Ptaquiloside Induce DNA Adducts, Monocytosis, Increased TNFa Levels, and Mammary Gland Carcinoma in Rats
    Biochemical and Biophysical Research Communications, vol. 244, no. 1, pp. 192–197, 1998
  44. H-rasActivation Is an Early Event in the Ptaquiloside-Induced Carcinogenesis: Comparison of Acute and Chronic Toxicity in Rats
    Biochemical and Biophysical Research Communications, vol. 250, no. 2, pp. 491–497, 1998
  45. H-rasActivation Is an Early Event in the Ptaquiloside-Induced Carcinogenesis: Comparison of Acute and Chronic Toxicity in Rats Volume 250, Number 2 (1998), pages 491–497:
    Biochemical and Biophysical Research Communications, vol. 251, no. 2, p. 668, 1998
  46. Acute intermittent porphyria: alternative splicing of hydroxymethylbilane synthase mRNA excludes exons 3 and 12
    Molecular and Cellular Probes, vol. 12, no. 2, pp. 63–70, 1998
  47. The Biochemistry of Heme Synthesis in Porphyria and in the Porphyrinurias
    Clinics in Dermatology, vol. 16, no. 2, pp. 203–223, 1998
  48. Identification of Two Novel Mutations in the Hydroxymethylbilane Synthase Gene in Three Patients from Two Unrelated Families with Acute Intermittent Porphyria
    Human Heredity, vol. 48, no. 1, pp. 24–29, 1998
  49. Therapeutic Drug Monitoring, vol. 20, no. 5, pp. 502–509, 1998
  50. Speciation of arsenic metabolites in the urine of occupational workers and experimental rats using an optimised hydride cold-trapping method†
    The Analyst, vol. 123, no. 5, pp. 929–933, 1998
  51. Speciation and absolute bioavailability: risk assessment of arsenic-contaminated sites in a residential suburb in Canberra†
    The Analyst, vol. 123, no. 5, pp. 889–892, 1998
  52. Acute intermittent porphyria: thein vitroexpression of mutant hydroxymethylbilane synthase
    Molecular and Cellular Probes, vol. 11, no. 4, pp. 293–296, 1997
  53. Detection of four mutations in six unrelated South African patients with acute intermittent porphyria
    Molecular and Cellular Probes, vol. 10, no. 1, pp. 57–61, 1996
  54. Regulation of haem biosynthesis in normoblastic erythropoiesis: role of 5-aminolaevulinic acid synthase and ferrochelatase
    Biochimica et Biophysica Acta (BBA) - General Subjects, vol. 1201, no. 1, pp. 85–93, 1994
  55. Acute intermittent porphyria and mental illness ? a family study
    Acta Psychiatrica Scandinavica, vol. 89, no. 4, pp. 262–267, 1994
  56. Drugs and porphyria
    Molecular Aspects of Medicine, vol. 11, no. 1-2, pp. 113–123, 1990
  57. PERIPHERAL BENZODIAZEPINE RECEPTORS AND TREATMENT OF PORPHYRIA
    The Lancet, vol. 333, no. 8649, pp. 1264–1265, 1989
  58. CONTROLLED TRIAL OF HAEM ARGINATE IN ACUTE HEPATIC PORPHYRIA
    The Lancet, vol. 333, no. 8650, pp. 1295–1297, 1989
  59. Haem biosynthesis in the unconjugated hyperbilirubinaemias: Observations in the gunn rat model
    Clinical Biochemistry, vol. 22, no. 3, pp. 177–179, 1989
  60. Therapy of the acute porphyrias
    Clinical Biochemistry, vol. 22, no. 3, pp. 181–188, 1989
  61. The effects of chronic carbamazepine treatment on haem biosynthesis in man and rat
    European Journal of Clinical Pharmacology, vol. 35, no. 3, pp. 241–247, 1988
  62. Lead Effects on the Heme Biosynthetic Pathway Relationship to Toxicity
    Annals of the New York Academy of Sciences, vol. 514, no. 1 Mechanisms of, pp. 191–203, 1987
  63. Lead in water, infant diet and blood: The Glasgow duplicate diet study
    The Science of The Total Environment, vol. 41, no. 3, pp. 235–257, 1985
  64. Successful abatement of lead exposure from water supplies in the West of Scotland
    Environmental Research, vol. 38, no. 1, pp. 67–76, 1985
  65. The acute attack of porphyria
    Clinics in Dermatology, vol. 3, no. 2, pp. 103–111, 1985
  66. Drug therapy in the acute porphyrias
    Clinics in Dermatology, vol. 3, no. 2, pp. 112–124, 1985
  67. Neurotoxic action of lead: Effect on tetrahydrobiopterin metabolism in the rat
    Comparative Biochemistry and Physiology Part C: Comparative Pharmacology, vol. 81, no. 1, pp. 227–231, 1985
  68. CHESTER PORPHYRIA: BIOCHEMICAL STUDIES OF A NEW FORM OF ACUTE PORPHYRIA
    The Lancet, vol. 326, no. 8459, pp. 796–799, 1985
  69. Kinetics of lead following intravenous administration in man
    Toxicology Letters, vol. 21, no. 2, pp. 231–235, 1984
  70. Sex differences in haem biosynthesis and porphyrin content in the harderian gland of the golden hamster
    International Journal of Biochemistry, vol. 16, no. 7, pp. 849–852, 1984
  71. CARBAMAZEPINE AND HAEM BIOSYNTHESIS
    The Lancet, vol. 322, no. 8354, p. 846, 1983
  72. LEAD AND TETRAHYDROBIOPTERIN METABOLISM: POSSIBLE EFFECTS ON IQ
    The Lancet, vol. 319, no. 8278, p. 964, 1982
  73. MATERNAL LEAD LEVELS AFTER ALTERATIONS TO WATER SUPPLY
    The Lancet, vol. 318, no. 8239, pp. 203–204, 1981
  74. ALCOHOL AND PORPHYRIA
    The Lancet, vol. 318, no. 8252, p. 925, 1981
  75. The percutaneous absorption of lead-203 in humans from cosmetic preparations containing lead acetate, as assessed by whole-body counting and other techniques
    Food and Cosmetics Toxicology, vol. 18, no. 4, pp. 399–405, 1980
  76. Seasonal variation in (d minolaevulinate synthase and porphyrin content in the harderan gland of the female golden hamster (mesocricetus auratus)
    International Journal of Biochemistry, vol. 12, no. 3, pp. 501–504, 1980
  77. The activities of the enzymes of haem biosynthesis in the porphyrias and during treatment of acute intermittent porphyrias
    International Journal of Biochemistry, vol. 12, no. 5-6, pp. 941–946, 1980
  78. The effects of selected monopyrroles on various aspects of heme biosynthesis and degradation in the rat
    Archives of Biochemistry and Biophysics, vol. 197, no. 1, pp. 132–138, 1979
  79. The contribution of drinking water lead to maternal blood lead concentrations
    Clinica Chimica Acta, vol. 95, no. 1, pp. 129–133, 1979
  80. Changes in serum aluminium, blood zinc, blood lead and erythrocyte d-aminolaevulinic acid dehydratase activity during haemodialysis
    Toxicology Letters, vol. 4, no. 5, pp. 419–424, 1979
  81. HqMATIN THERAPY AND LEUCOCYTE $delta;-AMINOLqVULINIC-ACID-SYNTHASE ACTIVITY IN PROLONGED ATTACK OF ACUTE PORPHYRIA
    The Lancet, vol. 313, no. 8108, pp. 133–134, 1979
  82. Delta-aminolaevulinic acid metabolism in normal and lead-exposed humans
    Toxicology, vol. 9, no. 1-2, pp. 1–9, 1978
  83. The association between lead concentrations in teeth and domestic water lead concentrations
    Clinica Chimica Acta, vol. 87, no. 1, pp. 77–83, 1978
  84. The biosynthesis of haem in congenital (erythropoietic) porphyria
    International Journal of Biochemistry, vol. 9, no. 12, pp. 933–938, 1978
  85. The carcinogenicity of lead
    Archives of Toxicology, vol. 42, no. 2, pp. 87–94, 1978
  86. The effects of industrial lead poisoning on cytochrome P450 mediated phenazone (antipyrine) hydroxylation
    European Journal of Clinical Pharmacology, vol. 12, no. 3, pp. 235–239, 1977
  87. The storage of samples for blood and water lead analysis
    Clinica Chimica Acta, vol. 75, no. 1, pp. 167–170, 1977
  88. Lead in drinking water in soft water areas—health hazards
    The Science of The Total Environment, vol. 7, no. 2, pp. 109–115, 1977
  89. ENZYME ABNORMALITIES IN THE PORPHYRIAS
    The Lancet, vol. 310, no. 8040, pp. 699–701, 1977
  90. A RETROSPECTIVE ANALYSIS OF BLOOD-LEAD IN MENTALLY RETARDED CHILDREN
    The Lancet, vol. 309, no. 8014, pp. 717–719, 1977
  91. CONTRIBUTION OF LEAD IN DRINKING WATER TO BLOOD-LEAD
    The Lancet, vol. 310, no. 8039, pp. 661–662, 1977
  92. Haem biosynthesis in peripheral blood in erythropoietic protoporphyria
    Clinical and Experimental Dermatology, vol. 2, no. 4, pp. 381–388, 1977
  93. BLOOD-LEAD AND DOMESTIC WATER LEAD
    The Lancet, vol. 308, no. 7978, pp. 200–201, 1976
  94. ROLE OF CHRONIC LOW-LEVEL LEAD EXPOSURE IN THE qTIOLOGY OF MENTAL RETARDATION
    The Lancet, vol. 305, no. 7907, pp. 589–592, 1975
  95. Some pharmacological effects of ?-aminolaevulinic acid on blood pressure in the rat and on rabbit isolated ear arteries
    Clinical and Experimental Pharmacology and Physiology, vol. 2, no. 5, pp. 365–371, 1975
  96. The passage of d-aminolaevulinic acid across the blood brain barrier of the rat: Effect of ethanol
    Biochemical Pharmacology, vol. 23, no. 2, pp. 472–474, 1974