G. Ian Gallicano0000-0001-8399-1556
G. Ian Gallicano gained a Postdoctoral Fellowship (developmental biology) from the University of Chicago, in 2000, then a Cold Spring Harbor Summer Course in molecular biology, in 1995. He received his Ph.D. degree in developmental biology from Arizona State University (1994), an M.S. degree in developmental biology from Arizona State University (1991), and the B.S. degree in biology from Arizona State University as well (1989). Dr. Gallicano’s laboratory redefined the role of the desmosomal protein desmoplakin through knockout mice, knockdowns using siRNA, and high throughput proteomics. Employing tetraploid aggregation technology, his 2001 Development publication revealed at least four new functions for desmoplakin, the most exciting being its role in endothelial cell adhesion within capillaries. In that paper, it was first shown that without desmoplakin, capillary structure is compromised leading to embryonic lethality. This discovery was followed up with a Journal of Cell Science paper, which revealed the mechanistic nature of desmoplakin function in capillaries using desmoplakin siRNA in endothelial cells. It was found that without desmoplakin endothelial cells fail to elongate into microvascular tubes. Dr. Gallicano’s lab has also been at the forefront of identifying signal transduction events that control embryonic stem cell differentiation into cardiomyocytes and neurons. This work has been published in high impact journals such as Developmental Biology and Stem Cells.
Biography Updated on 15 June 2009