Chikao Morimoto
Chikao Morimoto is a Professor and Chairman of the Division of Clinical Immunology, Advance Clinical Research Center, and Director of the Department of Allergy and Rheumatology, Research Hospital, Institute of Medical Science, The University of Tokyo. He was graduated from School of Medicine, Keio University, in 1973, and received the Ph.D. degree from the Graduate School of Medicine, Keio University, in 1978. He was in Dana-Farber Cancer Institute, Harvard Medical School, from 1979 to 1989; and from 1988 to 1995, he was an Associate Professor of medicine, Harvard Medical School. In 1995, he accepted a position of Professor of Medicine, Institute of Medical Science, The University of Tokyo. He was the first to define in man the functional heterogeneity amongst CD4 cells based on the differential cell surface expression of CD45, CD29, CD26, CD27, and CD70. Not only have his studies contributed to the most basic aspects of human immunobiology but more importantly have led to the application of the new and fundamental knowledge to both the clinical diagnosis and understanding of autoimmune disease. He has been listed as a Highly Cited Researcher (ISI) in the immunology field. His current research focuses on the structure and function of CD26 and beta-1 integrin in immunology and cancer. Moreover, he is a Renowned Translational Research Scientist, and anti-CD26 mAb therapy is soon in the first clinical trial for T-cell lymphoma and CD26 positive cancers.
Biography Updated on 9 May 2007
Articles in Scholarly Journals [Incomplete List]
- Stem cell properties and the side population cells as a target for interferon-a in adult T-cell leukemia/lymphoma
Biochemical and Biophysical Research Communications, 2007 - Caveolin-1 Triggers T-cell Activation via CD26 in Association with CARMA1
Journal of Biological Chemistry, vol. 282, no. 13, pp. 10117–10131, 2007 - Transcriptional Up-regulation of Inhibitory PAS Domain Protein Gene Expression by Hypoxia-inducible Factor 1 (HIF-1): A NEGATIVE FEEDBACK REGULATORY CIRCUIT IN HIF-1-MEDIATED SIGNALING IN HYPOXIC CELLS
Journal of Biological Chemistry, vol. 282, no. 19, pp. 14073–14082, 2007 - Knockdown of XAB2 Enhances All-Trans Retinoic Acid-Induced Cellular Differentiation in All-Trans Retinoic Acid-Sensitive and -Resistant Cancer Cells
Cancer Research, vol. 67, no. 3, pp. 1019–1029, 2007 - Humanized Anti-CD26 Monoclonal Antibody as a Treatment for Malignant Mesothelioma Tumors
Clinical Cancer Research, vol. 13, no. 14, pp. 4191–4200, 2007 - Could Serum Antibody to Poly(ADP-Ribose) and/or Histone H1 Be Marker for Senile Dementia of Alzheimer Type?
Annals of the New York Academy of Sciences, vol. 1109, no. 1, pp. 338–344, 2007 - CD26/Dipeptidyl Peptidase IV as a Novel Therapeutic Target for Cancer and Immune Disorders
Mini Reviews in Medicinal Chemistry, vol. 7, no. 3, pp. 253–273, 2007 - Anti-CD26 Monoclonal Antibody-Mediated G1-S Arrest of Human Renal Clear Cell Carcinoma Caki-2 Is Associated with Retinoblastoma Substrate Dephosphorylation, Cyclin-Dependent Kinase 2 Reduction, p27kip1 Enhancement, and Disruption of Binding to the Extracellular Matrix
Clinical Cancer Research, vol. 12, no. 11, pp. 3470–3477, 2006 - Recurrence of ovarian endometrioma after laparoscopic excision
Human Reproduction, vol. 21, no. 8, pp. 2171–2174, 2006 - Crk-associated substrate lymphocyte type regulates transforming growth factor-ß signaling by inhibiting Smad6 and Smad7
Oncogene, vol. 26, no. 6, Article ID 1209848, 11 pages, 2006 - T-cell activation via CD26 and caveolin-1 in rheumatoid synovium
Modern Rheumatology, vol. 16, no. 1, pp. 3–13, 2006 - CD26+ T cells in the pathogenesis of asthma
Clinical and Experimental Immunology, vol. 139, no. 1, pp. 13–16, 2005 - CD26 Mediates Dissociation of Tollip and IRAK-1 from Caveolin-1 and Induces Upregulation of CD86 on Antigen-Presenting Cells
Molecular and Cellular Biology, vol. 25, no. 17, pp. 7743–7757, 2005 - Regulation of p38 Phosphorylation and Topoisomerase II Expression in the B-Cell Lymphoma Line Jiyoye by CD26/Dipeptidyl Peptidase IV Is Associated with Enhanced In vitro and In vivo Sensitivity to Doxorubicin
Cancer Research, vol. 65, no. 5, pp. 1973–1983, 2005 - CD26 Regulates p38 Mitogen-Activated Protein Kinase-Dependent Phosphorylation of Integrin 1, Adhesion to Extracellular Matrix, and Tumorigenicity of T-Anaplastic Large Cell Lymphoma Karpas 299
Cancer Research, vol. 65, no. 15, pp. 6950–6956, 2005 - Nedd9 Protein, a Cas-L Homologue, Is Upregulated After Transient Global Ischemia in Rats: Possible Involvement of Nedd9 in the Differentiation of Neurons After Ischemia
Stroke, vol. 36, no. 11, pp. 2457–2462, 2005 - The Distinct Agonistic Properties of the Phenylpyrazolosteroid Cortivazol Reveal Interdomain Communication within the Glucocorticoid Receptor
Molecular Endocrinology, vol. 19, no. 5, pp. 1110–1124, 2005 - HEXIM1 forms a transcriptionally abortive complex with glucocorticoid receptor without involving 7SK RNA and positive transcription elongation factor b
Proceedings of the National Academy of Sciences, vol. 102, no. 24, pp. 8555–8560, 2005 - CD26 up-regulates expression of CD86 on antigen-presenting cells by means of caveolin-1
Proceedings of the National Academy of Sciences, vol. 101, no. 39, pp. 14186–14191, 2004 - The tetraspanin CD9 is preferentially expressed on the human CD4+CD45RA+ naive T cell population and is involved in T cell activation
Clinical and Experimental Immunology, vol. 137, no. 1, pp. 101–108, 2004 - Selective modulation of glucocorticoid receptor function toward development of novel antiinflammation: lessons from a phenylpyrazolosteroid cortivazol
Modern Rheumatology, vol. 14, no. 5, pp. 347–355, 2004 - HTLV-I Tax induces and associates with Crk-associated substrate lymphocyte type (Cas-L)
Oncogene, vol. 24, no. 7, Article ID 1208261, 9 pages, 2004 - A novel mechanism for imatinib mesylate (STI571) resistance in CML cell line KT-1: role of TC-PTP in modulating signals downstream from the BCR-ABL fusion protein
Experimental Hematology, vol. 32, no. 11, pp. 1057–1063, 2004 - Effect of CD26/dipeptidyl peptidase IV on Jurkat sensitivity to G2/M arrest induced by topoisomerase II inhibitors
British Journal of Cancer, vol. 88, no. 3, Article ID 6600791, 7 pages, 2003 - CD26/dipeptidyl peptidase IV enhances expression of topoisomerase II alpha and sensitivity to apoptosis induced by topoisomerase II inhibitors
British Journal of Cancer, vol. 89, no. 7, Article ID 6601253, 8 pages, 2003 - CD26: a key molecule in immune regulation and autoimmune diseases
Modern Rheumatology, vol. 13, no. 3, pp. 199–204, 2003 - Role of Crk-associated substrate lymphocyte type in the pathophysiology of rheumatoid arthritis intax transgenic mice and in humans
Arthritis & Rheumatism, vol. 48, no. 7, pp. 1890–1900, 2003 - Association of CD26 with CD45RA outside lipid rafts attenuates cord blood T-cell activation
Blood, vol. 103, no. 3, pp. 1002–1010, 2003 - T-large granular lymphocyte lymphoproliferative disorder: expression of CD26 as a marker of clinically aggressive disease and characterization of marrow inhibition
British Journal of Haematology, vol. 121, no. 6, pp. 857–865, 2003 - Ebastine inhibits T cell migration, production of Th2-type cytokines and proinflammatory cytokines
Clinical Experimental Allergy, vol. 33, no. 11, pp. 1544–1554, 2003 - Suppression of NF-kappaB-dependent gene expression by a hexamethylene bisacetamide-inducible protein HEXIM1 in human vascular smooth muscle cells
Genes to Cells, vol. 8, no. 2, pp. 95–107, 2003 - Role of the Glucocorticoid Receptor for Regulation of Hypoxia-dependent Gene Expression
Journal of Biological Chemistry, vol. 278, no. 35, pp. 33384–33391, 2003 - Distinct Interaction of Cortivazol with the Ligand Binding Domain Confers Glucocorticoid Receptor Specificity. CORTIVAZOL IS A SPECIFIC LIGAND FOR THE GLUCOCORTICOID RECEPTOR
Journal of Biological Chemistry, vol. 277, no. 7, pp. 5529–5540, 2002 - Cytokine Receptor Common beta Subunit-mediated STAT5 Activation Confers NF-kappa B Activation in Murine proB Cell Line Ba/F3 Cells
Journal of Biological Chemistry, vol. 277, no. 8, pp. 6254–6265, 2002 - CD27 and CD40 Inhibit p53-independent Mitochondrial Pathways in Apoptosis of B Cells Induced by B Cell Receptor Ligation
Journal of Biological Chemistry, vol. 277, no. 49, pp. 46950–46958, 2002 - G1/S cell cycle arrest provoked in human T cells by antibody to CD26
Immunology, vol. 107, no. 3, pp. 325–333, 2002 - Distinctive signaling pathways through CD82 and ß1 integrins in human T cells
European Journal of Immunology, vol. 32, no. 5, p. 1328, 2002 - Regulation of epithelial and lymphocyte cell adhesion by adenosine deaminase?CD26 interaction
Biochemical Journal, vol. 361, no. 2, p. 203, 2002 - Human GM-CSF induces HIV-1 LTR by multiple signalling pathways
Biochimie, vol. 84, no. 7, pp. 633–642, 2002 - Soluble CD26/dipeptidyl peptidase IV enhances transendothelial migration via its interaction with mannose 6-phosphate/insulin-like growth factor II receptor
Cellular Immunology, vol. 215, no. 1, pp. 106–110, 2002 - Intestinal epithelial cells express and secrete the CD43 glycoform that contains core 2 O-glycans
Microbes and Infection, vol. 3, no. 9, pp. 723–728, 2001 - Recognition of cell surface GD3 by monoclonal antibody anti-6C2 in rheumatoid arthritis synovial fluid: Expression on human T cells with transendothelial migratory activity
Arthritis & Rheumatism, vol. 44, no. 2, pp. 296–306, 2001 - CD26-mediated signaling for T cell activation occurs in lipid rafts through its association with CD45RO
Proceedings of the National Academy of Sciences, vol. 98, no. 21, pp. 12138–12143, 2001 - Comodulation of CXCR4 and CD26 in Human Lymphocytes
Journal of Biological Chemistry, vol. 276, no. 22, pp. 19532–19539, 2001 - Functional Modulation of the Glucocorticoid Receptor and Suppression of NF-kappa B-dependent Transcription by Ursodeoxycholic Acid
Journal of Biological Chemistry, vol. 276, no. 50, pp. 47371–47378, 2001 - Signaling events following chemokine receptor ligation in human dendritic cells at different developmental stages
International Immunology, vol. 13, no. 2, pp. 167–179, 2001 - B cell co-receptors regulating T cell-dependent antibody production in common variable immunodeficiency: CD27 pathway defects identify subsets of severely immuno-compromised patients
International Immunology, vol. 13, no. 7, pp. 871–876, 2001 - Internalization of CD26 by mannose 6-phosphate/insulin-like growth factor II receptor contributes to T cell activation
Proceedings of the National Academy of Sciences, vol. 97, no. 15, pp. 8439–8444, 2000 - Novel in vitro effects of bucillamine: Inhibitory effects on proinflammatory cytokine production and transendothelial migration of T cells
Arthritis & Rheumatism, vol. 43, no. 7, pp. 1616–1623, 2000 - Activation of mitogen-activated protein kinase through a5/ß1 integrin is required for cell cycle progression of B progenitor cell line, Reh, on human marrow stromal cells
Experimental Hematology, vol. 28, no. 10, pp. 1147–1157, 2000 - Good or evil: CD26 and HIV infection
Journal of Dermatological Science, vol. 22, no. 3, pp. 152–160, 2000 - Beta 1-integrin-mediated cell signaling in T lymphocytes
Journal of Dermatological Science, vol. 23, no. 2, pp. 75–86, 2000 - Human T lymphocyte populations which bind to P- or E-selectin are enriched with cells expressing core 2 O-glycans
Immunology Letters, vol. 67, no. 2, pp. 117–124, 1999 - Decreased Dipeptidyl Peptidase IV Enzyme Activity of Plasma Soluble CD26 and Its Inverse Correlation with HIV-1 RNA in HIV-1 Infected Individuals
Clinical Immunology, vol. 91, no. 3, pp. 283–295, 1999 - Specific inhibition of TH2-type cytokine production from human peripheral T cells by terfenadine in vitro
Clinical Experimental Allergy, vol. 29, no. 9, pp. 1281–1286, 1999 - CD26/Dipeptidyl Peptidase IV in Context: the Different Roles of a Multifunctional Ectoenzyme in Malignant Transformation
Journal of Experimental Medicine, vol. 190, no. 3, pp. 301–306, 1999 - Core 2-containing O-glycans on CD43 are preferentially expressed in the memory subset of human CD4 T cells
International Immunology, vol. 11, no. 2, pp. 259–268, 1999 - CD26/dipeptidyl peptidase IV differentially regulates the chemotaxis of T cells and monocytes toward RANTES: possible mechanism for the switch from innate to acquired immune response
International Immunology, vol. 11, no. 3, pp. 417–426, 1999 - The structure and function of CD26 in the T-cell immune response
Immunological Reviews, vol. 161, no. 1, pp. 55–70, 1998 - Anti-HIV-1 and chemotactic activities of human stromal cell-derived factor 1alpha (SDF-1alpha ) and SDF-1beta are abolished by CD26/dipeptidyl peptidase IV-mediated cleavage
Proceedings of the National Academy of Sciences, vol. 95, no. 11, pp. 6331–6336, 1998 - T Cell Receptor-mediated Tyrosine Phosphorylation of Cas-L, a 105-kDa Crk-associated Substrate-related Protein, and Its Association of Crk and C3G
Journal of Biological Chemistry, vol. 273, no. 11, pp. 6446–6451, 1998 - CD27, a Member of the Tumor Necrosis Factor Receptor Superfamily, Activates NF-kappa B and Stress-activated Protein Kinase/c-Jun N-terminal Kinase via TRAF2, TRAF5, and NF-kappa B-inducing Kinase
Journal of Biological Chemistry, vol. 273, no. 21, pp. 13353–13358, 1998 - Interaction of Hic-5, A Senescence-related Protein, with Focal Adhesion Kinase
Journal of Biological Chemistry, vol. 273, no. 41, pp. 26516–26521, 1998 - Interleukin-12 Induces Tyrosine Phosphorylation of an 85-kDa Protein Associated with the Interleukin-12 Receptor ß1 Subunit
Cellular Immunology, vol. 186, no. 1, pp. 39–44, 1998 - Negative regulation of the anti-human immunodeficiency virus and chemotactic activity of human stromal cell-derived factor 1a by CD26/dipeptidyl peptidase IV
FEBS Letters, vol. 431, no. 2, pp. 236–240, 1998 - Correlation of the epitopes defined by anti-CD26 mAbs and CD26 function
Molecular Immunology, vol. 35, no. 1, pp. 13–21, 1998 - Surrogate thrombopoietin
Immunology Letters, vol. 61, no. 2-3, pp. 73–78, 1998 - Journal of Clinical Immunology, vol. 17, no. 3, pp. 247–252, 1997
- Journal of Clinical Immunology, vol. 17, no. 1, pp. 53–62, 1997
- CD27/CD70 Interaction Contributes to the Activation and the Function of Human Autoreactive CD27+Regulatory T Cells, ,
Cellular Immunology, vol. 179, no. 1, pp. 48–54, 1997 - B cell subpopulations separated by CD27 and crucial collaboration of CD27+ B cells and helper T cells in immunoglobulin production
European Journal of Immunology, vol. 27, no. 8, pp. 2073–2079, 1997 - Ligation of the T cell antigen receptor induces tyrosine phosphorylation of p105CasL, a member of the p130Cas-related docking protein family, and its subsequent binding to the Src homology 2 domain of c-Crk
European Journal of Immunology, vol. 27, no. 8, pp. 2113–2117, 1997 - Tyrosine Phosphorylation of Crk-associated Substrates by Focal Adhesion Kinase. A PUTATIVE MECHANISM FOR THE INTEGRIN-MEDIATED TYROSINE PHOSPHORYLATION OF Crk-ASSOCIATED SUBSTRATES
Journal of Biological Chemistry, vol. 272, no. 46, pp. 29083–29090, 1997 - Aids, vol. 11, no. 14, pp. 1719–1724, 1997
- Structure and function of Cas-L, a 105-kD Crk-associated substrate- related protein that is involved in beta 1 integrin-mediated signaling in lymphocytes
Journal of Experimental Medicine, vol. 184, no. 4, pp. 1365–1375, 1996 - Src Kinase Plays an Essential Role in Integrin-Mediated Tyrosine Phosphorylation of Crk-Associated Substrate p130Cas
Biochemical and Biophysical Research Communications, vol. 222, no. 2, pp. 338–343, 1996 - Influence of CD26 and integrins on the antigen sensitivity of human memory T cells
Human Immunology, vol. 50, no. 2, pp. 79–90, 1996 - Focal Adhesion Kinase (pp125FAK) Is Tyrosine Phosphorylated after Engagement of a4ß1 and a5ß1 Integrins on Human T-Lymphoblastic Cells
Cellular Immunology, vol. 161, no. 1, pp. 8–13, 1995 - Comparison of lymphokine secretion and mRNA expression in the CD45RA+ and CD45RO+ subsets of human peripheral blood CD4+ and CD8+ lymphocytes
European Journal of Immunology, vol. 25, no. 3, pp. 644–648, 1995 - CD27/CD70 interaction directly drives B cell IgG and IgM synthesis
European Journal of Immunology, vol. 25, no. 10, pp. 2825–2829, 1995 - A Novel Form of Dipeptidylpeptidase IV Found in Human Serum
Journal of Biological Chemistry, vol. 270, no. 23, pp. 14107–14114, 1995 - Integrin-mediated Cell Adhesion Promotes Tyrosine Phosphorylation of p130[IMAGE], a Src Homology 3-containing Molecule Having Multiple Src Homology 2-binding Motifs
Journal of Biological Chemistry, vol. 270, no. 25, pp. 15398–15402, 1995 - CD27-CD70 Interactions Regulate B-Cell Activation by T Cells
Proceedings of the National Academy of Sciences, vol. 92, no. 24, pp. 11249–11253, 1995 - Role of CD26/Dipeptidyl Peptidase IV in Human Immunodeficiency Virus Type 1 Infection and Apoptosis
Proceedings of the National Academy of Sciences, vol. 91, no. 21, pp. 9960–9964, 1994 - Enhancement of Antigen-Induced T-Cell Proliferation by Soluble CD26/ Dipeptidyl Peptidase IV
Proceedings of the National Academy of Sciences, vol. 91, no. 8, pp. 3082–3086, 1994 - CD Antigens 1993
Leukemia and Lymphoma, vol. 13, pp. 59–60, 1994 - Differential Regulation of CD27 Expression on Subsets of CD4 T Cells
Cellular Immunology, vol. 158, no. 2, pp. 365–375, 1994 - CD antigens 1993
Immunology Today, vol. 15, no. 3, pp. 98–99, 1994 - The 4F9 Antigen Is a Member of the Tetra Spans Transmembrane Protein Family and Functions as an Accessory Molecule in T Cell Activation and Adhesion
Cellular Immunology, vol. 152, no. 1, pp. 249–260, 1993 - Direct Demonstration of the CD27 Molecule Involved in the Negative Regulatory Effect on T Cell Activation
Cellular Immunology, vol. 152, no. 1, pp. 279–285, 1993 - The Costimulatory Activity of the CD26 Antigen Requires Dipeptidyl Peptidase IV Enzymatic Activity
Proceedings of the National Academy of Sciences, vol. 90, no. 10, pp. 4586–4590, 1993 - Ligation of VLA-4 on T cells stimulates tyrosine phosphorylation of a 105-kD protein
Journal of Experimental Medicine, vol. 175, no. 4, pp. 1045–1053, 1992 - The cellular basis for lack of antibody response to hepatitis B vaccine in humans
Journal of Experimental Medicine, vol. 173, no. 3, pp. 531–538, 1991 - VLA-4 mediates CD3-dependent CD4+ T cell activation via the CS1 alternatively spliced domain of fibronectin
Journal of Experimental Medicine, vol. 172, no. 4, pp. 1185–1192, 1990 - A cytotoxic T lymphocyte inhibits acquired immunodeficiency syndrome virus replication in peripheral blood lymphocytes
Journal of Experimental Medicine, vol. 169, no. 4, pp. 1421–1434, 1989 - Activation of CD4 cells by fibronectin and anti-CD3 antibody. A synergistic effect mediated by the VLA-5 fibronectin receptor complex
Journal of Experimental Medicine, vol. 170, no. 4, pp. 1133–1148, 1989 - Molecular Interactions, T-Cell Subsets and a Role of the CD4/CD8:p56lck Complex in Human T-Cell Activation
Immunological Reviews, vol. 111, no. 1, pp. 225–266, 1989 - Decrease of suppressor inducer (cd4+ 2h4+) t cells in multiple sclerosis cerebrospinal fluid
Annals of Neurology, vol. 25, no. 5, pp. 494–499, 1989 - Antilymphocyte antibodies against CD4+2H4+ cell populations in patients with systemic lupus erythematosus
Arthritis & Rheumatism, vol. 32, no. 4, pp. 398–405, 1989 - Functional characterization of the CD45R (2H4) molecule on CD8 (T8) cells in the autologous mixed lymphocyte reaction system
European Journal of Immunology, vol. 19, no. 4, pp. 747–755, 1989 - Amplification of suppressor inducer pathway with monoclonal antibody, anti-2H4, identifying a novel epitope of the common leukocyte antigen/T200 antigen
Cellular Immunology, vol. 118, no. 1, pp. 68–84, 1989 - Generation of CD8 (T8) cytotoxic cells has a preferential requirement for CD4+2H4? inducer cells*1
Cellular Immunology, vol. 111, no. 2, pp. 379–389, 1988 - CD11 molecule defines two types of suppressor cells within the T8+ population*1
Cellular Immunology, vol. 111, no. 2, pp. 398–409, 1988 - Crosslinking CD3 with CD2 using Sepharose-immobilized antibodies enhances T lymphocyte proliferation
Cellular Immunology, vol. 115, no. 2, pp. 246–256, 1988 - Monoclonal antibody 4B4 blocks suppression of the immune response to Cryptomeria japonica pollen antigen
Human Immunology, vol. 22, no. 1, pp. 1–7, 1988 - Regulatory interactions between members of the immunoglobulin superfamily
Immunology Today, vol. 9, no. 7-8, pp. 199–203, 1988 - Abnormalities in CD4+ T-lymphocyte subsets in inflammatory rheumatic diseases*1
The American Journal of Medicine, vol. 84, no. 5, pp. 817–825, 1988 - Loss of functional suppression is linked to decreases in circulating suppressor inducer (CD4 + 2H4 +) T Cells in multiple sclerosis
Annals of Neurology, vol. 24, no. 2, pp. 185–191, 1988 - Dual-label immunocytochemistry of the active multiple sclerosis lesion: Major histocompatibility complex and activation antigens
Annals of Neurology, vol. 24, no. 4, pp. 523–531, 1988 - Role of the 2H4 molecule in the activation of suppressor inducer function
European Journal of Immunology, vol. 18, no. 5, pp. 731–737, 1988 - CD4CD45R cells are preferentially activated through the CD2 pathway
European Journal of Immunology, vol. 18, no. 9, pp. 1473–1476, 1988 - Lymphocyte Activation: Modulatory Effects Mediated by Interactions between Cell Adhesion Molecules
Annals of the New York Academy of Sciences, vol. 551, no. 1 Membrane in C, pp. 347–353, 1988 - Immunohistochemical Analysis of Suppressor-Inducer and Helper-Inducer T Cells in Multiple Sclerosis Brain Tissue
Annals of the New York Academy of Sciences, vol. 540, no. 1 Advances in N, pp. 306–308, 1988 - Identification of the sequence required for expression of the 2H4 epitope on the human leukocyte common antigens
Journal of Experimental Medicine, vol. 166, no. 5, pp. 1567–1572, 1987 - The subdivision of the T4 (CD4) subset on the basis of the differential expression of L-C/T200 antigens
Journal of Experimental Medicine, vol. 166, no. 6, pp. 1758–1773, 1987 - Induction of suppression following autologous mixed lymphocyte reaction; role of a novel 2H4 antigen
European Journal of Immunology, vol. 17, no. 1, pp. 97–103, 1987 - Antilymphocyte antibodies and systemic lupus erythematosus
Arthritis & Rheumatism, vol. 30, no. 2, pp. 225–228, 1987 - The 2H4 molecule but not the T3-receptor complex is involved in suppressor inducer signals in the AMLR system
Cellular Immunology, vol. 107, no. 1, pp. 107–114, 1987 - A novel epitope of the LFA-1 antigen which can distinguish killer effector and suppressor cells in human CD8 cells
Nature, vol. 330, no. 6147, Article ID 330479a0, 3 pages, 1987 - The cellular basis for the induction of antigen-specific T8 suppressor cells
European Journal of Immunology, vol. 16, no. 2, pp. 198–204, 1986 - Definition of the T-lymphocyte inducer of suppression in primates using a monoclonal antibody
Cellular Immunology, vol. 94, no. 2, pp. 360–368, 1985 - Cellular interaction between subsets of T8 population for maximal suppression of antigen-specific antibody response
Cellular Immunology, vol. 88, no. 1, pp. 75–84, 1984 - Reactivity of inducer cell subsets and T8-cell activation during the human autologous mixed lymphocyte reaction
Clinical Immunology and Immunopathology, vol. 30, no. 1, pp. 117–128, 1984 - Hapten-specific carrier-dependent tolerance induction in man in vitro*1
Cellular Immunology, vol. 82, no. 2, pp. 415–421, 1983 - Functional Differences of Anti-T-Cell Antibody in Patients with Systemic Lupus Erythematosus and Ulcerative Colitis
Scandinavian Journal of Immunology, vol. 18, no. 6, pp. 521–530, 1983 - Direct demonstration of the function of T cell subsets reactive with anti-T cell antibodies from SLE sera
Rheumatology International, vol. 1, no. 4, pp. 157–163, 1982 - Comparison in T- and B-cell markers in patients with Sjögren's syndrome and systemic lupus erythematosus
Clinical Immunology and Immunopathology, vol. 22, no. 2, pp. 270–278, 1982 - Evidence of Aberration of T-cell Subsets in Aged Individuals
Scandinavian Journal of Immunology, vol. 13, no. 2, pp. 151–157, 1981 - Studies of Anti-Lymphocyte Antibody in Patients with Active SLE.
Scandinavian Journal of Immunology, vol. 11, no. 5, pp. 479–488, 1980 - Cell-mediated immunity to platelets in SLE patients with thrombocytopenia: Two different types of lymphocyte stimulation
Clinical Immunology and Immunopathology, vol. 15, no. 1, pp. 1–10, 1980 - Characteristics of anti-T-cell antibodies in systemic lupus erythematosus: Evidence for selective reactivity with normal suppressor cells defined by monoclonal antibodies
Clinical Immunology and Immunopathology, vol. 16, no. 4, pp. 474–484, 1980 - Enhancement of lymphocyte response to PHA by lysosomal enzymes from polymorphonuclear leukocytes of RA joint fluid
Inflammation, vol. 4, no. 2, pp. 169–180, 1980 - Regulation of B cell immunoglobulin secretion by functional subsets of T lymphocytes in man
European Journal of Immunology, vol. 10, no. 7, pp. 570–572, 1980 - Restoration of T-cell function in aged mice with long-term administration of levamisole
Clinical Immunology and Immunopathology, vol. 12, no. 3, pp. 316–322, 1979 - Altered function of suppressor T lymphocytes in patients with active systemic lupus erythematosus—In vitro immune response to autoantigen
Clinical Immunology and Immunopathology, vol. 13, no. 2, pp. 161–170, 1979 - Studies of Anti-lymphocyte Antibody of Patients with Active SLE.
Scandinavian Journal of Immunology, vol. 10, no. 3, pp. 213–221, 1979 - In Vitro TNP-Specific Antibody Formation by Peripheral Lymphocytes from Patients with Systemic Lupus Erythematosus
Scandinavian Journal of Immunology, vol. 6, no. 6-7, pp. 575–579, 1977 - Cell-mediated immune response in idiopathic thrombocytopenic purpura In vitro cellular response to autologous and homologous platelet and platelet membrane by macrophage inhibitory test
Clinical Immunology and Immunopathology, vol. 8, no. 2, pp. 181–189, 1977