Chikao Morimoto

Chikao Morimoto is a Professor and Chairman of the Division of Clinical Immunology, Advance Clinical Research Center, and Director of the Department of Allergy and Rheumatology, Research Hospital, Institute of Medical Science, The University of Tokyo. He was graduated from School of Medicine, Keio University, in 1973, and received the Ph.D. degree from the Graduate School of Medicine, Keio University, in 1978. He was in Dana-Farber Cancer Institute, Harvard Medical School, from 1979 to 1989; and from 1988 to 1995, he was an Associate Professor of medicine, Harvard Medical School. In 1995, he accepted a position of Professor of Medicine, Institute of Medical Science, The University of Tokyo. He was the first to define in man the functional heterogeneity amongst CD4 cells based on the differential cell surface expression of CD45, CD29, CD26, CD27, and CD70. Not only have his studies contributed to the most basic aspects of human immunobiology but more importantly have led to the application of the new and fundamental knowledge to both the clinical diagnosis and understanding of autoimmune disease. He has been listed as a Highly Cited Researcher (ISI) in the immunology field. His current research focuses on the structure and function of CD26 and beta-1 integrin in immunology and cancer. Moreover, he is a Renowned Translational Research Scientist, and anti-CD26 mAb therapy is soon in the first clinical trial for T-cell lymphoma and CD26 positive cancers.

Biography Updated on 9 May 2007

Articles in Scholarly Journals [Incomplete List]

  1. Stem cell properties and the side population cells as a target for interferon-a in adult T-cell leukemia/lymphoma
    Biochemical and Biophysical Research Communications, 2007
  2. Caveolin-1 Triggers T-cell Activation via CD26 in Association with CARMA1
    Journal of Biological Chemistry, vol. 282, no. 13, pp. 10117–10131, 2007
  3. Transcriptional Up-regulation of Inhibitory PAS Domain Protein Gene Expression by Hypoxia-inducible Factor 1 (HIF-1): A NEGATIVE FEEDBACK REGULATORY CIRCUIT IN HIF-1-MEDIATED SIGNALING IN HYPOXIC CELLS
    Journal of Biological Chemistry, vol. 282, no. 19, pp. 14073–14082, 2007
  4. Knockdown of XAB2 Enhances All-Trans Retinoic Acid-Induced Cellular Differentiation in All-Trans Retinoic Acid-Sensitive and -Resistant Cancer Cells
    Cancer Research, vol. 67, no. 3, pp. 1019–1029, 2007
  5. Humanized Anti-CD26 Monoclonal Antibody as a Treatment for Malignant Mesothelioma Tumors
    Clinical Cancer Research, vol. 13, no. 14, pp. 4191–4200, 2007
  6. Could Serum Antibody to Poly(ADP-Ribose) and/or Histone H1 Be Marker for Senile Dementia of Alzheimer Type?
    Annals of the New York Academy of Sciences, vol. 1109, no. 1, pp. 338–344, 2007
  7. CD26/Dipeptidyl Peptidase IV as a Novel Therapeutic Target for Cancer and Immune Disorders
    Mini Reviews in Medicinal Chemistry, vol. 7, no. 3, pp. 253–273, 2007
  8. Anti-CD26 Monoclonal Antibody-Mediated G1-S Arrest of Human Renal Clear Cell Carcinoma Caki-2 Is Associated with Retinoblastoma Substrate Dephosphorylation, Cyclin-Dependent Kinase 2 Reduction, p27kip1 Enhancement, and Disruption of Binding to the Extracellular Matrix
    Clinical Cancer Research, vol. 12, no. 11, pp. 3470–3477, 2006
  9. Recurrence of ovarian endometrioma after laparoscopic excision
    Human Reproduction, vol. 21, no. 8, pp. 2171–2174, 2006
  10. Crk-associated substrate lymphocyte type regulates transforming growth factor-ß signaling by inhibiting Smad6 and Smad7
    Oncogene, vol. 26, no. 6, Article ID 1209848, 11 pages, 2006
  11. T-cell activation via CD26 and caveolin-1 in rheumatoid synovium
    Modern Rheumatology, vol. 16, no. 1, pp. 3–13, 2006
  12. CD26+ T cells in the pathogenesis of asthma
    Clinical and Experimental Immunology, vol. 139, no. 1, pp. 13–16, 2005
  13. CD26 Mediates Dissociation of Tollip and IRAK-1 from Caveolin-1 and Induces Upregulation of CD86 on Antigen-Presenting Cells
    Molecular and Cellular Biology, vol. 25, no. 17, pp. 7743–7757, 2005
  14. Regulation of p38 Phosphorylation and Topoisomerase II  Expression in the B-Cell Lymphoma Line Jiyoye by CD26/Dipeptidyl Peptidase IV Is Associated with Enhanced In vitro and In vivo Sensitivity to Doxorubicin
    Cancer Research, vol. 65, no. 5, pp. 1973–1983, 2005
  15. CD26 Regulates p38 Mitogen-Activated Protein Kinase-Dependent Phosphorylation of Integrin  1, Adhesion to Extracellular Matrix, and Tumorigenicity of T-Anaplastic Large Cell Lymphoma Karpas 299
    Cancer Research, vol. 65, no. 15, pp. 6950–6956, 2005
  16. Nedd9 Protein, a Cas-L Homologue, Is Upregulated After Transient Global Ischemia in Rats: Possible Involvement of Nedd9 in the Differentiation of Neurons After Ischemia
    Stroke, vol. 36, no. 11, pp. 2457–2462, 2005
  17. The Distinct Agonistic Properties of the Phenylpyrazolosteroid Cortivazol Reveal Interdomain Communication within the Glucocorticoid Receptor
    Molecular Endocrinology, vol. 19, no. 5, pp. 1110–1124, 2005
  18. HEXIM1 forms a transcriptionally abortive complex with glucocorticoid receptor without involving 7SK RNA and positive transcription elongation factor b
    Proceedings of the National Academy of Sciences, vol. 102, no. 24, pp. 8555–8560, 2005
  19. CD26 up-regulates expression of CD86 on antigen-presenting cells by means of caveolin-1
    Proceedings of the National Academy of Sciences, vol. 101, no. 39, pp. 14186–14191, 2004
  20. The tetraspanin CD9 is preferentially expressed on the human CD4+CD45RA+ naive T cell population and is involved in T cell activation
    Clinical and Experimental Immunology, vol. 137, no. 1, pp. 101–108, 2004
  21. Selective modulation of glucocorticoid receptor function toward development of novel antiinflammation: lessons from a phenylpyrazolosteroid cortivazol
    Modern Rheumatology, vol. 14, no. 5, pp. 347–355, 2004
  22. HTLV-I Tax induces and associates with Crk-associated substrate lymphocyte type (Cas-L)
    Oncogene, vol. 24, no. 7, Article ID 1208261, 9 pages, 2004
  23. A novel mechanism for imatinib mesylate (STI571) resistance in CML cell line KT-1: role of TC-PTP in modulating signals downstream from the BCR-ABL fusion protein
    Experimental Hematology, vol. 32, no. 11, pp. 1057–1063, 2004
  24. Effect of CD26/dipeptidyl peptidase IV on Jurkat sensitivity to G2/M arrest induced by topoisomerase II inhibitors
    British Journal of Cancer, vol. 88, no. 3, Article ID 6600791, 7 pages, 2003
  25. CD26/dipeptidyl peptidase IV enhances expression of topoisomerase II alpha and sensitivity to apoptosis induced by topoisomerase II inhibitors
    British Journal of Cancer, vol. 89, no. 7, Article ID 6601253, 8 pages, 2003
  26. CD26: a key molecule in immune regulation and autoimmune diseases
    Modern Rheumatology, vol. 13, no. 3, pp. 199–204, 2003
  27. Role of Crk-associated substrate lymphocyte type in the pathophysiology of rheumatoid arthritis intax transgenic mice and in humans
    Arthritis & Rheumatism, vol. 48, no. 7, pp. 1890–1900, 2003
  28. Association of CD26 with CD45RA outside lipid rafts attenuates cord blood T-cell activation
    Blood, vol. 103, no. 3, pp. 1002–1010, 2003
  29. T-large granular lymphocyte lymphoproliferative disorder: expression of CD26 as a marker of clinically aggressive disease and characterization of marrow inhibition
    British Journal of Haematology, vol. 121, no. 6, pp. 857–865, 2003
  30. Ebastine inhibits T cell migration, production of Th2-type cytokines and proinflammatory cytokines
    Clinical Experimental Allergy, vol. 33, no. 11, pp. 1544–1554, 2003
  31. Suppression of NF-kappaB-dependent gene expression by a hexamethylene bisacetamide-inducible protein HEXIM1 in human vascular smooth muscle cells
    Genes to Cells, vol. 8, no. 2, pp. 95–107, 2003
  32. Role of the Glucocorticoid Receptor for Regulation of Hypoxia-dependent Gene Expression
    Journal of Biological Chemistry, vol. 278, no. 35, pp. 33384–33391, 2003
  33. Distinct Interaction of Cortivazol with the Ligand Binding Domain Confers Glucocorticoid Receptor Specificity. CORTIVAZOL IS A SPECIFIC LIGAND FOR THE GLUCOCORTICOID RECEPTOR
    Journal of Biological Chemistry, vol. 277, no. 7, pp. 5529–5540, 2002
  34. Cytokine Receptor Common beta Subunit-mediated STAT5 Activation Confers NF-kappa B Activation in Murine proB Cell Line Ba/F3 Cells
    Journal of Biological Chemistry, vol. 277, no. 8, pp. 6254–6265, 2002
  35. CD27 and CD40 Inhibit p53-independent Mitochondrial Pathways in Apoptosis of B Cells Induced by B Cell Receptor Ligation
    Journal of Biological Chemistry, vol. 277, no. 49, pp. 46950–46958, 2002
  36. G1/S cell cycle arrest provoked in human T cells by antibody to CD26
    Immunology, vol. 107, no. 3, pp. 325–333, 2002
  37. Distinctive signaling pathways through CD82 and ß1 integrins in human T cells
    European Journal of Immunology, vol. 32, no. 5, p. 1328, 2002
  38. Regulation of epithelial and lymphocyte cell adhesion by adenosine deaminase?CD26 interaction
    Biochemical Journal, vol. 361, no. 2, p. 203, 2002
  39. Human GM-CSF induces HIV-1 LTR by multiple signalling pathways
    Biochimie, vol. 84, no. 7, pp. 633–642, 2002
  40. Soluble CD26/dipeptidyl peptidase IV enhances transendothelial migration via its interaction with mannose 6-phosphate/insulin-like growth factor II receptor
    Cellular Immunology, vol. 215, no. 1, pp. 106–110, 2002
  41. Intestinal epithelial cells express and secrete the CD43 glycoform that contains core 2 O-glycans
    Microbes and Infection, vol. 3, no. 9, pp. 723–728, 2001
  42. Recognition of cell surface GD3 by monoclonal antibody anti-6C2 in rheumatoid arthritis synovial fluid: Expression on human T cells with transendothelial migratory activity
    Arthritis & Rheumatism, vol. 44, no. 2, pp. 296–306, 2001
  43. CD26-mediated signaling for T cell activation occurs in lipid rafts through its association with CD45RO
    Proceedings of the National Academy of Sciences, vol. 98, no. 21, pp. 12138–12143, 2001
  44. Comodulation of CXCR4 and CD26 in Human Lymphocytes
    Journal of Biological Chemistry, vol. 276, no. 22, pp. 19532–19539, 2001
  45. Functional Modulation of the Glucocorticoid Receptor and Suppression of NF-kappa B-dependent Transcription by Ursodeoxycholic Acid
    Journal of Biological Chemistry, vol. 276, no. 50, pp. 47371–47378, 2001
  46. Signaling events following chemokine receptor ligation in human dendritic cells at different developmental stages
    International Immunology, vol. 13, no. 2, pp. 167–179, 2001
  47. B cell co-receptors regulating T cell-dependent antibody production in common variable immunodeficiency: CD27 pathway defects identify subsets of severely immuno-compromised patients
    International Immunology, vol. 13, no. 7, pp. 871–876, 2001
  48. Internalization of CD26 by mannose 6-phosphate/insulin-like growth factor II receptor contributes to T cell activation
    Proceedings of the National Academy of Sciences, vol. 97, no. 15, pp. 8439–8444, 2000
  49. Novel in vitro effects of bucillamine: Inhibitory effects on proinflammatory cytokine production and transendothelial migration of T cells
    Arthritis & Rheumatism, vol. 43, no. 7, pp. 1616–1623, 2000
  50. Activation of mitogen-activated protein kinase through a5/ß1 integrin is required for cell cycle progression of B progenitor cell line, Reh, on human marrow stromal cells
    Experimental Hematology, vol. 28, no. 10, pp. 1147–1157, 2000
  51. Good or evil: CD26 and HIV infection
    Journal of Dermatological Science, vol. 22, no. 3, pp. 152–160, 2000
  52. Beta 1-integrin-mediated cell signaling in T lymphocytes
    Journal of Dermatological Science, vol. 23, no. 2, pp. 75–86, 2000
  53. Human T lymphocyte populations which bind to P- or E-selectin are enriched with cells expressing core 2 O-glycans
    Immunology Letters, vol. 67, no. 2, pp. 117–124, 1999
  54. Decreased Dipeptidyl Peptidase IV Enzyme Activity of Plasma Soluble CD26 and Its Inverse Correlation with HIV-1 RNA in HIV-1 Infected Individuals
    Clinical Immunology, vol. 91, no. 3, pp. 283–295, 1999
  55. Specific inhibition of TH2-type cytokine production from human peripheral T cells by terfenadine in vitro
    Clinical Experimental Allergy, vol. 29, no. 9, pp. 1281–1286, 1999
  56. CD26/Dipeptidyl Peptidase IV in Context: the Different Roles of a Multifunctional Ectoenzyme in Malignant Transformation
    Journal of Experimental Medicine, vol. 190, no. 3, pp. 301–306, 1999
  57. Core 2-containing O-glycans on CD43 are preferentially expressed in the memory subset of human CD4 T cells
    International Immunology, vol. 11, no. 2, pp. 259–268, 1999
  58. CD26/dipeptidyl peptidase IV differentially regulates the chemotaxis of T cells and monocytes toward RANTES: possible mechanism for the switch from innate to acquired immune response
    International Immunology, vol. 11, no. 3, pp. 417–426, 1999
  59. The structure and function of CD26 in the T-cell immune response
    Immunological Reviews, vol. 161, no. 1, pp. 55–70, 1998
  60. Anti-HIV-1 and chemotactic activities of human stromal cell-derived factor 1alpha (SDF-1alpha ) and SDF-1beta are abolished by CD26/dipeptidyl peptidase IV-mediated cleavage
    Proceedings of the National Academy of Sciences, vol. 95, no. 11, pp. 6331–6336, 1998
  61. T Cell Receptor-mediated Tyrosine Phosphorylation of Cas-L, a 105-kDa Crk-associated Substrate-related Protein, and Its Association of Crk and C3G
    Journal of Biological Chemistry, vol. 273, no. 11, pp. 6446–6451, 1998
  62. CD27, a Member of the Tumor Necrosis Factor Receptor Superfamily, Activates NF-kappa B and Stress-activated Protein Kinase/c-Jun N-terminal Kinase via TRAF2, TRAF5, and NF-kappa B-inducing Kinase
    Journal of Biological Chemistry, vol. 273, no. 21, pp. 13353–13358, 1998
  63. Interaction of Hic-5, A Senescence-related Protein, with Focal Adhesion Kinase
    Journal of Biological Chemistry, vol. 273, no. 41, pp. 26516–26521, 1998
  64. Interleukin-12 Induces Tyrosine Phosphorylation of an 85-kDa Protein Associated with the Interleukin-12 Receptor ß1 Subunit
    Cellular Immunology, vol. 186, no. 1, pp. 39–44, 1998
  65. Negative regulation of the anti-human immunodeficiency virus and chemotactic activity of human stromal cell-derived factor 1a by CD26/dipeptidyl peptidase IV
    FEBS Letters, vol. 431, no. 2, pp. 236–240, 1998
  66. Correlation of the epitopes defined by anti-CD26 mAbs and CD26 function
    Molecular Immunology, vol. 35, no. 1, pp. 13–21, 1998
  67. Surrogate thrombopoietin
    Immunology Letters, vol. 61, no. 2-3, pp. 73–78, 1998
  68. Journal of Clinical Immunology, vol. 17, no. 3, pp. 247–252, 1997
  69. Journal of Clinical Immunology, vol. 17, no. 1, pp. 53–62, 1997
  70. CD27/CD70 Interaction Contributes to the Activation and the Function of Human Autoreactive CD27+Regulatory T Cells, ,
    Cellular Immunology, vol. 179, no. 1, pp. 48–54, 1997
  71. B cell subpopulations separated by CD27 and crucial collaboration of CD27+ B cells and helper T cells in immunoglobulin production
    European Journal of Immunology, vol. 27, no. 8, pp. 2073–2079, 1997
  72. Ligation of the T cell antigen receptor induces tyrosine phosphorylation of p105CasL, a member of the p130Cas-related docking protein family, and its subsequent binding to the Src homology 2 domain of c-Crk
    European Journal of Immunology, vol. 27, no. 8, pp. 2113–2117, 1997
  73. Tyrosine Phosphorylation of Crk-associated Substrates by Focal Adhesion Kinase. A PUTATIVE MECHANISM FOR THE INTEGRIN-MEDIATED TYROSINE PHOSPHORYLATION OF Crk-ASSOCIATED SUBSTRATES
    Journal of Biological Chemistry, vol. 272, no. 46, pp. 29083–29090, 1997
  74. Aids, vol. 11, no. 14, pp. 1719–1724, 1997
  75. Structure and function of Cas-L, a 105-kD Crk-associated substrate- related protein that is involved in beta 1 integrin-mediated signaling in lymphocytes
    Journal of Experimental Medicine, vol. 184, no. 4, pp. 1365–1375, 1996
  76. Src Kinase Plays an Essential Role in Integrin-Mediated Tyrosine Phosphorylation of Crk-Associated Substrate p130Cas
    Biochemical and Biophysical Research Communications, vol. 222, no. 2, pp. 338–343, 1996
  77. Influence of CD26 and integrins on the antigen sensitivity of human memory T cells
    Human Immunology, vol. 50, no. 2, pp. 79–90, 1996
  78. Focal Adhesion Kinase (pp125FAK) Is Tyrosine Phosphorylated after Engagement of a4ß1 and a5ß1 Integrins on Human T-Lymphoblastic Cells
    Cellular Immunology, vol. 161, no. 1, pp. 8–13, 1995
  79. Comparison of lymphokine secretion and mRNA expression in the CD45RA+ and CD45RO+ subsets of human peripheral blood CD4+ and CD8+ lymphocytes
    European Journal of Immunology, vol. 25, no. 3, pp. 644–648, 1995
  80. CD27/CD70 interaction directly drives B cell IgG and IgM synthesis
    European Journal of Immunology, vol. 25, no. 10, pp. 2825–2829, 1995
  81. A Novel Form of Dipeptidylpeptidase IV Found in Human Serum
    Journal of Biological Chemistry, vol. 270, no. 23, pp. 14107–14114, 1995
  82. Integrin-mediated Cell Adhesion Promotes Tyrosine Phosphorylation of p130[IMAGE], a Src Homology 3-containing Molecule Having Multiple Src Homology 2-binding Motifs
    Journal of Biological Chemistry, vol. 270, no. 25, pp. 15398–15402, 1995
  83. CD27-CD70 Interactions Regulate B-Cell Activation by T Cells
    Proceedings of the National Academy of Sciences, vol. 92, no. 24, pp. 11249–11253, 1995
  84. Role of CD26/Dipeptidyl Peptidase IV in Human Immunodeficiency Virus Type 1 Infection and Apoptosis
    Proceedings of the National Academy of Sciences, vol. 91, no. 21, pp. 9960–9964, 1994
  85. Enhancement of Antigen-Induced T-Cell Proliferation by Soluble CD26/ Dipeptidyl Peptidase IV
    Proceedings of the National Academy of Sciences, vol. 91, no. 8, pp. 3082–3086, 1994
  86. CD Antigens 1993
    Leukemia and Lymphoma, vol. 13, pp. 59–60, 1994
  87. Differential Regulation of CD27 Expression on Subsets of CD4 T Cells
    Cellular Immunology, vol. 158, no. 2, pp. 365–375, 1994
  88. CD antigens 1993
    Immunology Today, vol. 15, no. 3, pp. 98–99, 1994
  89. The 4F9 Antigen Is a Member of the Tetra Spans Transmembrane Protein Family and Functions as an Accessory Molecule in T Cell Activation and Adhesion
    Cellular Immunology, vol. 152, no. 1, pp. 249–260, 1993
  90. Direct Demonstration of the CD27 Molecule Involved in the Negative Regulatory Effect on T Cell Activation
    Cellular Immunology, vol. 152, no. 1, pp. 279–285, 1993
  91. The Costimulatory Activity of the CD26 Antigen Requires Dipeptidyl Peptidase IV Enzymatic Activity
    Proceedings of the National Academy of Sciences, vol. 90, no. 10, pp. 4586–4590, 1993
  92. Ligation of VLA-4 on T cells stimulates tyrosine phosphorylation of a 105-kD protein
    Journal of Experimental Medicine, vol. 175, no. 4, pp. 1045–1053, 1992
  93. The cellular basis for lack of antibody response to hepatitis B vaccine in humans
    Journal of Experimental Medicine, vol. 173, no. 3, pp. 531–538, 1991
  94. VLA-4 mediates CD3-dependent CD4+ T cell activation via the CS1 alternatively spliced domain of fibronectin
    Journal of Experimental Medicine, vol. 172, no. 4, pp. 1185–1192, 1990
  95. A cytotoxic T lymphocyte inhibits acquired immunodeficiency syndrome virus replication in peripheral blood lymphocytes
    Journal of Experimental Medicine, vol. 169, no. 4, pp. 1421–1434, 1989
  96. Activation of CD4 cells by fibronectin and anti-CD3 antibody. A synergistic effect mediated by the VLA-5 fibronectin receptor complex
    Journal of Experimental Medicine, vol. 170, no. 4, pp. 1133–1148, 1989
  97. Molecular Interactions, T-Cell Subsets and a Role of the CD4/CD8:p56lck Complex in Human T-Cell Activation
    Immunological Reviews, vol. 111, no. 1, pp. 225–266, 1989
  98. Decrease of suppressor inducer (cd4+ 2h4+) t cells in multiple sclerosis cerebrospinal fluid
    Annals of Neurology, vol. 25, no. 5, pp. 494–499, 1989
  99. Antilymphocyte antibodies against CD4+2H4+ cell populations in patients with systemic lupus erythematosus
    Arthritis & Rheumatism, vol. 32, no. 4, pp. 398–405, 1989
  100. Functional characterization of the CD45R (2H4) molecule on CD8 (T8) cells in the autologous mixed lymphocyte reaction system
    European Journal of Immunology, vol. 19, no. 4, pp. 747–755, 1989
  101. Amplification of suppressor inducer pathway with monoclonal antibody, anti-2H4, identifying a novel epitope of the common leukocyte antigen/T200 antigen
    Cellular Immunology, vol. 118, no. 1, pp. 68–84, 1989
  102. Generation of CD8 (T8) cytotoxic cells has a preferential requirement for CD4+2H4? inducer cells*1
    Cellular Immunology, vol. 111, no. 2, pp. 379–389, 1988
  103. CD11 molecule defines two types of suppressor cells within the T8+ population*1
    Cellular Immunology, vol. 111, no. 2, pp. 398–409, 1988
  104. Crosslinking CD3 with CD2 using Sepharose-immobilized antibodies enhances T lymphocyte proliferation
    Cellular Immunology, vol. 115, no. 2, pp. 246–256, 1988
  105. Monoclonal antibody 4B4 blocks suppression of the immune response to Cryptomeria japonica pollen antigen
    Human Immunology, vol. 22, no. 1, pp. 1–7, 1988
  106. Regulatory interactions between members of the immunoglobulin superfamily
    Immunology Today, vol. 9, no. 7-8, pp. 199–203, 1988
  107. Abnormalities in CD4+ T-lymphocyte subsets in inflammatory rheumatic diseases*1
    The American Journal of Medicine, vol. 84, no. 5, pp. 817–825, 1988
  108. Loss of functional suppression is linked to decreases in circulating suppressor inducer (CD4 + 2H4 +) T Cells in multiple sclerosis
    Annals of Neurology, vol. 24, no. 2, pp. 185–191, 1988
  109. Dual-label immunocytochemistry of the active multiple sclerosis lesion: Major histocompatibility complex and activation antigens
    Annals of Neurology, vol. 24, no. 4, pp. 523–531, 1988
  110. Role of the 2H4 molecule in the activation of suppressor inducer function
    European Journal of Immunology, vol. 18, no. 5, pp. 731–737, 1988
  111. CD4CD45R cells are preferentially activated through the CD2 pathway
    European Journal of Immunology, vol. 18, no. 9, pp. 1473–1476, 1988
  112. Lymphocyte Activation: Modulatory Effects Mediated by Interactions between Cell Adhesion Molecules
    Annals of the New York Academy of Sciences, vol. 551, no. 1 Membrane in C, pp. 347–353, 1988
  113. Immunohistochemical Analysis of Suppressor-Inducer and Helper-Inducer T Cells in Multiple Sclerosis Brain Tissue
    Annals of the New York Academy of Sciences, vol. 540, no. 1 Advances in N, pp. 306–308, 1988
  114. Identification of the sequence required for expression of the 2H4 epitope on the human leukocyte common antigens
    Journal of Experimental Medicine, vol. 166, no. 5, pp. 1567–1572, 1987
  115. The subdivision of the T4 (CD4) subset on the basis of the differential expression of L-C/T200 antigens
    Journal of Experimental Medicine, vol. 166, no. 6, pp. 1758–1773, 1987
  116. Induction of suppression following autologous mixed lymphocyte reaction; role of a novel 2H4 antigen
    European Journal of Immunology, vol. 17, no. 1, pp. 97–103, 1987
  117. Antilymphocyte antibodies and systemic lupus erythematosus
    Arthritis & Rheumatism, vol. 30, no. 2, pp. 225–228, 1987
  118. The 2H4 molecule but not the T3-receptor complex is involved in suppressor inducer signals in the AMLR system
    Cellular Immunology, vol. 107, no. 1, pp. 107–114, 1987
  119. A novel epitope of the LFA-1 antigen which can distinguish killer effector and suppressor cells in human CD8 cells
    Nature, vol. 330, no. 6147, Article ID 330479a0, 3 pages, 1987
  120. The cellular basis for the induction of antigen-specific T8 suppressor cells
    European Journal of Immunology, vol. 16, no. 2, pp. 198–204, 1986
  121. Definition of the T-lymphocyte inducer of suppression in primates using a monoclonal antibody
    Cellular Immunology, vol. 94, no. 2, pp. 360–368, 1985
  122. Cellular interaction between subsets of T8 population for maximal suppression of antigen-specific antibody response
    Cellular Immunology, vol. 88, no. 1, pp. 75–84, 1984
  123. Reactivity of inducer cell subsets and T8-cell activation during the human autologous mixed lymphocyte reaction
    Clinical Immunology and Immunopathology, vol. 30, no. 1, pp. 117–128, 1984
  124. Hapten-specific carrier-dependent tolerance induction in man in vitro*1
    Cellular Immunology, vol. 82, no. 2, pp. 415–421, 1983
  125. Functional Differences of Anti-T-Cell Antibody in Patients with Systemic Lupus Erythematosus and Ulcerative Colitis
    Scandinavian Journal of Immunology, vol. 18, no. 6, pp. 521–530, 1983
  126. Direct demonstration of the function of T cell subsets reactive with anti-T cell antibodies from SLE sera
    Rheumatology International, vol. 1, no. 4, pp. 157–163, 1982
  127. Comparison in T- and B-cell markers in patients with Sjögren's syndrome and systemic lupus erythematosus
    Clinical Immunology and Immunopathology, vol. 22, no. 2, pp. 270–278, 1982
  128. Evidence of Aberration of T-cell Subsets in Aged Individuals
    Scandinavian Journal of Immunology, vol. 13, no. 2, pp. 151–157, 1981
  129. Studies of Anti-Lymphocyte Antibody in Patients with Active SLE.
    Scandinavian Journal of Immunology, vol. 11, no. 5, pp. 479–488, 1980
  130. Cell-mediated immunity to platelets in SLE patients with thrombocytopenia: Two different types of lymphocyte stimulation
    Clinical Immunology and Immunopathology, vol. 15, no. 1, pp. 1–10, 1980
  131. Characteristics of anti-T-cell antibodies in systemic lupus erythematosus: Evidence for selective reactivity with normal suppressor cells defined by monoclonal antibodies
    Clinical Immunology and Immunopathology, vol. 16, no. 4, pp. 474–484, 1980
  132. Enhancement of lymphocyte response to PHA by lysosomal enzymes from polymorphonuclear leukocytes of RA joint fluid
    Inflammation, vol. 4, no. 2, pp. 169–180, 1980
  133. Regulation of B cell immunoglobulin secretion by functional subsets of T lymphocytes in man
    European Journal of Immunology, vol. 10, no. 7, pp. 570–572, 1980
  134. Restoration of T-cell function in aged mice with long-term administration of levamisole
    Clinical Immunology and Immunopathology, vol. 12, no. 3, pp. 316–322, 1979
  135. Altered function of suppressor T lymphocytes in patients with active systemic lupus erythematosus—In vitro immune response to autoantigen
    Clinical Immunology and Immunopathology, vol. 13, no. 2, pp. 161–170, 1979
  136. Studies of Anti-lymphocyte Antibody of Patients with Active SLE.
    Scandinavian Journal of Immunology, vol. 10, no. 3, pp. 213–221, 1979
  137. In Vitro TNP-Specific Antibody Formation by Peripheral Lymphocytes from Patients with Systemic Lupus Erythematosus
    Scandinavian Journal of Immunology, vol. 6, no. 6-7, pp. 575–579, 1977
  138. Cell-mediated immune response in idiopathic thrombocytopenic purpura In vitro cellular response to autologous and homologous platelet and platelet membrane by macrophage inhibitory test
    Clinical Immunology and Immunopathology, vol. 8, no. 2, pp. 181–189, 1977