Kenjiro Ono serves as an Associate Professor at the Department of Neurology and Neurobiology of Aging, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan. He received an M.D. degree (1997) from Showa University School of Medicine, Tokyo, Japan, a Ph.D. in neurology (2002) from Kanazawa University Graduate School of Medical Science, Kanazawa, Japan. He was born in Buffalo, NY. Beginning in 2000, he engaged to biophysical research on amyloid ß-protein (Aß) aggregation under the supervision of Professors Masahito Yamada (Kanazawa University) and Hironobu Naiki (Fukui University). From 2007–2009, he worked under the supervision of Professor David B. Teplow (UCLA) to delve more deeply into the conformational dynamics of Aß assembly and its inhibition. His team previously reported that the phenolic compounds such as myricetin (Myr) and rosmarinic acid (RA) inhibited Aß aggregation in vitro and in vivo. To elucidate a mechanistic basis for these results, they recently showed that the phenolic compounds blocked Aß oligomerization, and myricetin promoted significant NMR chemical shift changes of monomeric Aß. Both Myr and RA reduced cellular toxicity and synaptic dysfunction of the Aß oligomers. They also found that some organic compounds with antioxidative motifs, including wine-related polyphenols and melatonin inhibited alpha-synuclein aggregation including oligomerization. Moreover, the cerebrospinal fluid (CSF) from non-Alzheimer disease (AD) patients inhibited Aß oligomerization more strongly than that of AD patients, although the CSF obtained from both groups inhibited Aß oligomerization.
Biography Updated on 29 May 2012