Baklouti graduated from the ຜole Normale Supérieure, Tunis, Tunisia and received his Master'S and Ph.D. degrees in "Cellular and molecular biology" from the Université Lyon 1, France, under the supervision of Dr. Jean Delaunay. His early research was focused on the molecular basis and mRNA metabolism of human globin gene mutations resulting in thalassemia hemoglobinopathies. He further contributed to the characterization of structural and functional abnormalities associated with abnormal red cell morphologies, including protein 4.1R deficiencies in hereditary elliptocytosis. During his post-doc, he joined Dr. Edward Benz's laboratory at the Department of Internal Medicine, School of Medicine, Yale University, New Haven, CT, USA, where he contributed to the cloning of the human 4.1R gene and to functional studies of 4.1R pre-mRNA alternative splicing regulation in the erythroid system. Baklouti is now a Research Director at the Institut National de la Santé et de la Recherche Mຝicale (INSERM) and a Principal Investigator at the Centre de Génétique Molຜulaire et Cellulaire, Université Lyon 1. He is also a Member of the American Society of Hematology and an invited Professor Lecturer at the Université de Sfax, Tunisia. His team has been investigating protein 4.1R pre-mRNA splicing regulation at both the cellular and the molecular levels in normal and leukemic cells. He has also been studying some aspects of mRNA metabolism in erythroid and nonerythroid cells, mostly related to inherited pathologic conditions.
Biography Updated on 31 October 2010