David Brindley

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http://www.biochem.ualberta.ca/faculty_detail.php?id=3

Articles in Scholarly Journals [Incomplete List]

  1. AKT1 Overexpression in Endothelial Cells Leads to the Development of Cutaneous Vascular Malformations In Vivo
    Archives of Dermatology, vol. 143, no. 4, pp. 504–506, 2007
  2. Intracellular Generation of Sphingosine 1-Phosphate in Human Lung Endothelial Cells: ROLE OF LIPID PHOSPHATE PHOSPHATASE-1 AND SPHINGOSINE KINASE 1
    Journal of Biological Chemistry, vol. 282, no. 19, pp. 14165–14177, 2007
  3. Falsely elevated point-of-care lactate measurement after ingestion of ethylene glycol
    Canadian Medical Association Journal, vol. 176, no. 8, pp. 1097–1099, 2007
  4. Phosphorylation of Heat Shock Protein-90 by TSH in FRTL-5 Thyroid Cells
    Thyroid, vol. 16, no. 8, pp. 737–742, 2006
  5. Lipid Phosphate Phosphatase-1 Regulates Lysophosphatidate-induced Fibroblast Migration by Controlling Phospholipase D2-dependent Phosphatidate Generation
    Journal of Biological Chemistry, vol. 281, no. 50, pp. 38418–38429, 2006
  6. Three Mammalian Lipins Act as Phosphatidate Phosphatases with Distinct Tissue Expression Patterns
    Journal of Biological Chemistry, vol. 282, no. 6, pp. 3450–3457, 2006
  7. Lipid phosphate phosphatase-1 regulates lysophosphatidic acid-induced calcium release, NF-?B activation and interleukin-8 secretion in human bronchial epithelial cells
    Biochemical Journal, vol. 385, no. 2, p. 493, 2005
  8. Lipid Phosphate Phosphatase-2 Activity Regulates S-phase Entry of the Cell Cycle in Rat2 Fibroblasts
    Journal of Biological Chemistry, vol. 281, no. 14, pp. 9297–9306, 2005
  9. Insulin, glucagon and fatty acid treatment of hepatocytes does not result in phosphorylation or changes in activity of triacylglycerol hydrolase
    Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, vol. 1736, no. 3, pp. 189–199, 2005
  10. Mice with transgenic overexpression of lipid phosphate phosphatase-1 display multiple organotypic deficits without alteration in circulating lysophosphatidate level
    Cellular Signalling, vol. 16, no. 3, pp. 385–399, 2004
  11. Molecular mechanisms regulating protein kinase C? turnover and cellular transformation
    Biochemical Journal, vol. 378, no. 1, p. 83, 2004
  12. Lipid phosphate phosphatases and related proteins: Signaling functions in development, cell division, and cancer
    Journal of Cellular Biochemistry, vol. 92, no. 5, pp. 900–912, 2004
  13. Cell-permeable ceramides increase basal glucose incorporation into triacylglycerols but decrease the stimulation by insulin in 3T3-L1 adipocytes
    International Journal of Obesity, vol. 27, no. 1, Article ID 0802183, 8 pages, 2003
  14. Involvement of Phospholipase D2 in Lysophosphatidate-induced Transactivation of Platelet-derived Growth Factor Receptor-  in Human Bronchial Epithelial Cells
    Journal of Biological Chemistry, vol. 278, no. 41, pp. 39931–39940, 2003
  15. Animal models of insulin resistance and cardiovascular disease: some therapeutic approaches using the JCR:LA-cp rat
    Diabetes, Obesity and Metabolism, vol. 4, no. 1, pp. 1–10, 2002
  16. C2-Ceramide Influences the Expression and Insulin-Mediated Regulation of Cyclic Nucleotide Phosphodiesterase 3B and Lipolysis in 3T3-L1 Adipocytes
    Diabetes, vol. 51, no. 3, pp. 631–637, 2002
  17. Cell-permeable ceramides preferentially inhibit coated vesicle formation and exocytosis in Chinese hamster ovary compared with Madin?Darby canine kidney cells by preventing the membrane association of ADP-ribosylation factor
    Biochemical Journal, vol. 361, no. 3, p. 653, 2002
  18. Lipid phosphate phosphatases regulate signal transduction through glycerolipids and sphingolipids
    Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, vol. 1582, no. 1-3, pp. 33–44, 2002
  19. Lipid mediators of angiogenesis and the signalling pathways they initiate
    Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, vol. 1582, no. 1-3, pp. 228–239, 2002
  20. Lipids and Life
    Biochemical and Biophysical Research Communications, vol. 292, no. 5, pp. 1255–1259, 2002
  21. Migration of Vascular Smooth Muscle Cells Induced by Sphingosine 1-Phosphate and Related Lipids: Potential Role in the Angiogenic Response
    Experimental Cell Research, vol. 274, no. 2, pp. 264–274, 2002
  22. Lipid phosphate phosphatase-1 dephosphorylates exogenous lysophosphatidate and thereby attenuates its effects on cell signalling
    Prostaglandins & Other Lipid Mediators, vol. 64, no. 1-4, pp. 83–92, 2001
  23. Biochemistry, vol. 40, no. 37, pp. 11227–11233, 2001
  24. Platelet-released phospholipids link haemostasis and angiogenesis
    Cardiovascular Research, vol. 49, no. 3, pp. 588–599, 2001
  25. Identification of structurally important domains of lipid phosphate phosphatase-1: implications for its sites of action
    Biochemical Journal, vol. 345, no. 2, p. 181, 2000
  26. The characterization of phospholipase D in FRTL-5 thyroid cells
    Molecular and Cellular Endocrinology, vol. 167, no. 1-2, pp. 107–115, 2000
  27. Sphingosine 1-phosphate released from platelets during clotting accounts for the potent endothelial cell chemotactic activity of blood serum and provides a novel link between hemostasis and angiogenesis
    The FASEB Journal, vol. 14, no. 14, pp. 2255–2265, 2000
  28. Induction of Endothelial Cell Chemotaxis by Sphingosine 1-Phosphate and Stabilization of Endothelial Monolayer Barrier Function by Lysophosphatidic Acid, Potential Mediators of Hematopoietic Angiogenesis
    Journal of Hematotherapy Stem Cell Research, vol. 8, no. 6, pp. 627–634, 1999
  29. A Novel Pathway for Tumor Necrosis Factor-alpha and Ceramide Signaling Involving Sequential Activation of Tyrosine Kinase, p21ras, and Phosphatidylinositol 3-Kinase
    Journal of Biological Chemistry, vol. 274, no. 18, pp. 12722–12729, 1999
  30. Structural organization of mammalian lipid phosphate phosphatases: implications for signal transduction
    Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, vol. 1439, no. 2, pp. 299–316, 1999
  31. Lipid phosphate phosphohydrolase-1 degrades exogenous glycerolipid and sphingolipid phosphate esters
    Biochemical Journal, vol. 340, no. 3, p. 677, 1999
  32. Tumor necrosis factor-a and ceramides in insulin resistance
    Lipids, vol. 34, no. S1, pp. S85–S88, 1999
  33. Induction of endothelial monolayer permeability by phosphatidate
    Journal of Cellular Biochemistry, vol. 75, no. 1, pp. 105–117, 1999
  34. Epidermal growth factor inhibits ceramide-induced apoptosis and lowers ceramide levels in primary placental trophoblasts
    Journal of Cellular Physiology, vol. 180, no. 2, pp. 263–270, 1999
  35. Improvement of insulin sensitivity and cardiovascular outcomes in the JCR:LA-cp rat by D-fenfluramine
    Diabetologia, vol. 41, no. 4, pp. 380–389, 1998
  36. Exaggerated stress-induced release of nonesterified fatty acids in JCR:LA-corpulent rats*1
    Metabolism, vol. 47, no. 11, pp. 1383–1390, 1998
  37. Mammalian Lipid Phosphate Phosphohydrolases
    Journal of Biological Chemistry, vol. 273, no. 38, pp. 24281–24284, 1998
  38. Mammalian Mg2+-independent Phosphatidate Phosphatase (PAP2) Displays Diacylglycerol Pyrophosphate Phosphatase Activity
    Journal of Biological Chemistry, vol. 272, no. 16, pp. 10361–10366, 1997
  39. Cell-permeable Ceramides Prevent the Activation of Phospholipase D by ADP-ribosylation Factor and RhoA
    Journal of Biological Chemistry, vol. 272, no. 2, pp. 1069–1075, 1997
  40. Activation of Phospholipase D in FRTL-5 Thyroid Cells by Forskolin and Dibutyryl-Cyclic Adenosine Monophosphate
    Endocrinology, vol. 138, no. 9, pp. 3645–3651, 1997
  41. Antiatherogenic effects of long-term benfluorex treatment in male insulin resistant JCR:LA-cp rats
    Atherosclerosis, vol. 132, no. 2, pp. 187–197, 1997
  42. Phosphatidate phosphohydrolase and signal transduction
    Chemistry and Physics of Lipids, vol. 80, no. 1-2, pp. 45–57, 1996
  43. Effects of benfluore× on serum triacylglycerols and insulin sensitivity in the corpulent rat
    Canadian Journal of Physiology and Pharmacology, vol. 74, no. 8, pp. 879–886, 1996
  44. Phosphatidate Phosphohydrolase Catalyzes the Hydrolysis of Ceramide 1-Phosphate, Lysophosphatidate, and Sphingosine 1-Phosphate
    Journal of Biological Chemistry, vol. 271, no. 28, pp. 16506–16509, 1996
  45. Purification and Characterization of a Novel Plasma Membrane Phosphatidate Phosphohydrolase from Rat Liver
    Journal of Biological Chemistry, vol. 270, no. 33, pp. 19422–19429, 1995
  46. Degradation of Apolipoprotein B in Cultured Rat Hepatocytes Occurs in a Post-endoplasmic Reticulum Compartment
    Journal of Biological Chemistry, vol. 270, no. 42, pp. 24924–24931, 1995
  47. Interaction of Ceramides, Sphingosine, and Sphingosine 1-Phosphate in Regulating DNA Synthesis and Phospholipase D Activity
    Journal of Biological Chemistry, vol. 270, no. 44, pp. 26318–26325, 1995
  48. Thyroid-stimulating hormone activates phospholipase D in FRTL-5 thyroid cells via stimulation of protein kinase C
    Endocrinology, vol. 136, no. 9, pp. 3794–3799, 1995
  49. Metabolic abnormalities linked to obesity: Effects of dexfenfluramine in the corpulent rat*1
    Metabolism, vol. 44, pp. 23–27, 1995
  50. Effect of alcohol on the activity and subcellular distribution of phosphatidate phosphohydrolase in rat liver
    Biochimica et Biophysica Acta (BBA) - General Subjects, vol. 1201, no. 3, pp. 411–414, 1994
  51. Hepatic secretion of lysophosphatidylcholine: A novel transport system for polyunsaturated fatty acids and choline
    The Journal of Nutritional Biochemistry, vol. 4, no. 8, pp. 442–449, 1993
  52. Stress and lipoprotein metabolism: Modulators and mechanisms*1
    Metabolism, vol. 42, no. 9, pp. 3–15, 1993
  53. Cholesterol feeding induces hypertriglyceridaemia in hamsters and increases the activity of the Mg2+-dependent phosphatidate phosphohydrolase in the liver
    Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, vol. 1166, no. 2-3, pp. 238–243, 1993
  54. Effects of sphingosine, albumin and unsaturated fatty acids on the activation and translocation of phosphatidate phosphohydrolases in rat hepatocytes
    Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, vol. 1127, no. 1, pp. 49–56, 1992
  55. Effects of okadaic acid on the activities of two distinct phosphatidate phosphohydrolases in rat hepatocytes
    FEBS Letters, vol. 301, no. 1, pp. 103–106, 1992
  56. Metabolic approach to atherosclerosis: Effect of gliclazide*1
    Metabolism, vol. 41, no. 5, pp. 20–24, 1992
  57. Effects of the lipase inhibitors, Triton WR-1339 and tetrahydrolipstatin on the synthesis and secretion of lipids by rat hepatocytes
    FEBS Letters, vol. 286, no. 1-2, pp. 186–188, 1991
  58. Hormonal regulation of the hepatic low density of lipoprotein receptor an dthe catabolism of low density lipoproteins: Relationship with the secretion of very low density lipoproteins
    Progress in Lipid Research, vol. 30, no. 4, pp. 349–360, 1991
  59. Sexual dimorphism in the preferential secretion of unsaturated lysophosphatidylcholine by rat hepatocytes but no secretion by sheep hepatocytes
    Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, vol. 1081, no. 2, pp. 151–158, 1991
  60. Decreased serum lipids, serum insulin and triacylglycerol synthesis in adipose tissue of JCR:LA-corpulent rats treated with benfluorex
    Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, vol. 1085, no. 1, pp. 119–125, 1991
  61. Decreased incorporation of glucose into lipids and increased lactate production by adipose tissue after long-term treatment of rats with ?-fenfluramine
    Biochemical Pharmacology, vol. 38, no. 21, pp. 3661–3667, 1989
  62. Translocation of phosphatidate phosphohydrolase from the cytosol to microsomal membranes in thioacetamide-induced liver tumours in rats
    Toxicology Letters, vol. 47, no. 1, pp. 9–16, 1989
  63. Interactions of triiodothyronine, insulin and dexamethasone on the binding of human LDL to rat hepatocytes in monolayer culture
    Atherosclerosis, vol. 71, no. 1, pp. 77–80, 1988
  64. Effects of chronic administration of benfluorex to rats on the metabolism of corticosterone, glucose, triacylglycerols, glycerol and fatty acid
    Biochemical Pharmacology, vol. 37, no. 4, pp. 695–705, 1988
  65. The biochemistry of lipoproteins
    Journal of Inherited Metabolic Disease, vol. 11, no. S1, pp. 4–17, 1988
  66. Age-related changes in the translocation of phosphatidate phosphohydrolase from the cytosol to microsomal membranes in rat liver
    Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, vol. 963, no. 2, pp. 384–388, 1988
  67. Binding of low-density lipoprotein to monolayer cultures of rat hepatocytes is increased by insulin and decreased by dexamethasone
    FEBS Letters, vol. 220, no. 1, pp. 159–162, 1987
  68. Spermine antagonises the effects of dexamethasone, glucagon and cyclic AMP in increasing the activity of phosphatidate phosphohydrolase in isolated rat hepatocytes
    FEBS Letters, vol. 207, no. 1, pp. 42–46, 1986
  69. Insulin antagonises the growth hormone-mediated increase in the activity of phosphatidate phosphohydrolase in isolated rat hepatocytes
    FEBS Letters, vol. 202, no. 1, pp. 133–136, 1986
  70. Relationship between the displacement of phosphatidate phosphohydrolase from the membrane-associated compartment by chlorpromazine and the inhibition of the synthesis of triacylglycerol and phosphatidylcholine in rat hepatocytes
    Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, vol. 876, no. 3, pp. 581–591, 1986
  71. Possible relationships between changes in body weight set-point and stress metabolism after treating rats chronically with ?-fenfluramine Effects of feeding rats acutely with fructose on the metabolism of corticosterone, glucose, fatty acids, glycerol and triacylglycerol
    Biochemical Pharmacology, vol. 34, no. 8, pp. 1265–1271, 1985
  72. Stimulation of specific GTPase activity by vasopressin in isolated membranes from cultured rat hepatocytes
    FEBS Letters, vol. 192, no. 2, pp. 251–254, 1985
  73. Spermine promotes the translocation of phosphatidate phosphohydrolase from the cytosol to the microsomal fraction of rat liver and it enhances the effects of oleate in this respect
    FEBS Letters, vol. 179, no. 2, pp. 262–266, 1985
  74. Long-chain fatty acids and their acyl-CoA esters cause the translocation of phosphatidate phosphohydrolase from the cytosolic to the microsomal fraction of rat liver
    FEBS Letters, vol. 175, no. 2, pp. 284–288, 1984
  75. Intracellular translocation of phosphatidate phosphohydrolase and its possible role in the control of glycerolipid synthesis
    Progress in Lipid Research, vol. 23, no. 3, pp. 115–133, 1984
  76. The metabolism of CDP-diacylglycerol and phosphatidylinositol in the microsomal fraction of rat liver effects of chlorpromazine, magnesium and manganese
    Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, vol. 751, no. 1, pp. 81–89, 1983
  77. Antagonistic effects of insulin on the corticosterone-induced increase of phosphatidate phosphohydrolase activity in isolated rat hepatocytes
    FEBS Letters, vol. 143, no. 1, pp. 9–12, 1982
  78. Effects of corticosterone and insulin on enzymes of triacylglycerol synthesis in isolated rat hepatocytes
    FEBS Letters, vol. 146, no. 1, pp. 204–208, 1982
  79. Effect of chronic clofibrate feeding on the activities of enzymes involved in glycerolipid synthesis and in peroxisomal metabolism in rat liver
    Biochemical Pharmacology, vol. 31, no. 8, pp. 1650–1652, 1982
  80. Effects of starvation, corticotropin injection and ethanol feeding on the activity and amount of phosphatidate phosphohydrolase in rat liver
    FEBS Letters, vol. 126, no. 2, pp. 297–300, 1981
  81. Stimulation of the activities of phosphatidate phosphohydrolase and tyrosine aminotransferase in rat hepatocytes by glucocorticoids
    FEBS Letters, vol. 133, no. 1, pp. 119–122, 1981
  82. Factors controlling the metabolism of phosphatidate by phosphohydrolase and phospholipase A-type activities Effects of magnesium, calcium and amphiphilic cationic drugs
    Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, vol. 619, no. 3, pp. 494–505, 1980
  83. Selective inhibition by clofenapate of glycerolipid synthesis via the esterification of dihydroxyacetone phosphate in rat liver slices
    International Journal of Biochemistry, vol. 7, no. 3-4, pp. 141–147, 1976
  84. Propertis of Phosphatidate Phosphohydrolase
    European Journal of Biochemistry, vol. 18, no. 2, pp. 214–220, 1971
  85. Acyl carrier protein from
    Biochemical and Biophysical Research Communications, vol. 38, no. 3, pp. 369–377, 1970
  86. The effect of unsaturated fatty acids and the particle-free supernatant on the incorporation of palmitate into glycerides
    Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, vol. 144, no. 2, pp. 285–295, 1967
  87. Stimulation of Biosynthesis of Glyceride
    Nature, vol. 216, no. 5114, Article ID 216449a0, 4 pages, 1967
  88. The Role of Phosphatidate Phosphohydrolase in Glyceride Biosynthesis
    European Journal of Biochemistry, vol. 3, no. 1, pp. 70–77, 1967
  89. The effect of chain length on the activation and subsequent incorporation of fatty acids into glycerides by the small intestinal mucosa
    Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, vol. 125, no. 1, pp. 92–105, 1966
  90. The intracellular distribution of the enzymes catalysing the biosynthesis of glycerides in the intestinal mucosa
    Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, vol. 106, no. 3, pp. 495–509, 1965
  91. Metabolism of phospholipids VIII. Biosynthesis of phosphatidylcholine in the intestinal mucosa
    Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, vol. 98, no. 3, pp. 486–501, 1965