David Brindley
Personal Home Page
http://www.biochem.ualberta.ca/faculty_detail.php?id=3
Articles in Scholarly Journals [Incomplete List]
- AKT1 Overexpression in Endothelial Cells Leads to the Development of Cutaneous Vascular Malformations In Vivo
Archives of Dermatology, vol. 143, no. 4, pp. 504–506, 2007 - Intracellular Generation of Sphingosine 1-Phosphate in Human Lung Endothelial Cells: ROLE OF LIPID PHOSPHATE PHOSPHATASE-1 AND SPHINGOSINE KINASE 1
Journal of Biological Chemistry, vol. 282, no. 19, pp. 14165–14177, 2007 - Falsely elevated point-of-care lactate measurement after ingestion of ethylene glycol
Canadian Medical Association Journal, vol. 176, no. 8, pp. 1097–1099, 2007 - Phosphorylation of Heat Shock Protein-90 by TSH in FRTL-5 Thyroid Cells
Thyroid, vol. 16, no. 8, pp. 737–742, 2006 - Lipid Phosphate Phosphatase-1 Regulates Lysophosphatidate-induced Fibroblast Migration by Controlling Phospholipase D2-dependent Phosphatidate Generation
Journal of Biological Chemistry, vol. 281, no. 50, pp. 38418–38429, 2006 - Three Mammalian Lipins Act as Phosphatidate Phosphatases with Distinct Tissue Expression Patterns
Journal of Biological Chemistry, vol. 282, no. 6, pp. 3450–3457, 2006 - Lipid phosphate phosphatase-1 regulates lysophosphatidic acid-induced calcium release, NF-?B activation and interleukin-8 secretion in human bronchial epithelial cells
Biochemical Journal, vol. 385, no. 2, p. 493, 2005 - Lipid Phosphate Phosphatase-2 Activity Regulates S-phase Entry of the Cell Cycle in Rat2 Fibroblasts
Journal of Biological Chemistry, vol. 281, no. 14, pp. 9297–9306, 2005 - Insulin, glucagon and fatty acid treatment of hepatocytes does not result in phosphorylation or changes in activity of triacylglycerol hydrolase
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, vol. 1736, no. 3, pp. 189–199, 2005 - Mice with transgenic overexpression of lipid phosphate phosphatase-1 display multiple organotypic deficits without alteration in circulating lysophosphatidate level
Cellular Signalling, vol. 16, no. 3, pp. 385–399, 2004 - Molecular mechanisms regulating protein kinase C? turnover and cellular transformation
Biochemical Journal, vol. 378, no. 1, p. 83, 2004 - Lipid phosphate phosphatases and related proteins: Signaling functions in development, cell division, and cancer
Journal of Cellular Biochemistry, vol. 92, no. 5, pp. 900–912, 2004 - Cell-permeable ceramides increase basal glucose incorporation into triacylglycerols but decrease the stimulation by insulin in 3T3-L1 adipocytes
International Journal of Obesity, vol. 27, no. 1, Article ID 0802183, 8 pages, 2003 - Involvement of Phospholipase D2 in Lysophosphatidate-induced Transactivation of Platelet-derived Growth Factor Receptor- in Human Bronchial Epithelial Cells
Journal of Biological Chemistry, vol. 278, no. 41, pp. 39931–39940, 2003 - Animal models of insulin resistance and cardiovascular disease: some therapeutic approaches using the JCR:LA-cp rat
Diabetes, Obesity and Metabolism, vol. 4, no. 1, pp. 1–10, 2002 - C2-Ceramide Influences the Expression and Insulin-Mediated Regulation of Cyclic Nucleotide Phosphodiesterase 3B and Lipolysis in 3T3-L1 Adipocytes
Diabetes, vol. 51, no. 3, pp. 631–637, 2002 - Cell-permeable ceramides preferentially inhibit coated vesicle formation and exocytosis in Chinese hamster ovary compared with Madin?Darby canine kidney cells by preventing the membrane association of ADP-ribosylation factor
Biochemical Journal, vol. 361, no. 3, p. 653, 2002 - Lipid phosphate phosphatases regulate signal transduction through glycerolipids and sphingolipids
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, vol. 1582, no. 1-3, pp. 33–44, 2002 - Lipid mediators of angiogenesis and the signalling pathways they initiate
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, vol. 1582, no. 1-3, pp. 228–239, 2002 - Lipids and Life
Biochemical and Biophysical Research Communications, vol. 292, no. 5, pp. 1255–1259, 2002 - Migration of Vascular Smooth Muscle Cells Induced by Sphingosine 1-Phosphate and Related Lipids: Potential Role in the Angiogenic Response
Experimental Cell Research, vol. 274, no. 2, pp. 264–274, 2002 - Lipid phosphate phosphatase-1 dephosphorylates exogenous lysophosphatidate and thereby attenuates its effects on cell signalling
Prostaglandins & Other Lipid Mediators, vol. 64, no. 1-4, pp. 83–92, 2001 - Biochemistry, vol. 40, no. 37, pp. 11227–11233, 2001
- Platelet-released phospholipids link haemostasis and angiogenesis
Cardiovascular Research, vol. 49, no. 3, pp. 588–599, 2001 - Identification of structurally important domains of lipid phosphate phosphatase-1: implications for its sites of action
Biochemical Journal, vol. 345, no. 2, p. 181, 2000 - The characterization of phospholipase D in FRTL-5 thyroid cells
Molecular and Cellular Endocrinology, vol. 167, no. 1-2, pp. 107–115, 2000 - Sphingosine 1-phosphate released from platelets during clotting accounts for the potent endothelial cell chemotactic activity of blood serum and provides a novel link between hemostasis and angiogenesis
The FASEB Journal, vol. 14, no. 14, pp. 2255–2265, 2000 - Induction of Endothelial Cell Chemotaxis by Sphingosine 1-Phosphate and Stabilization of Endothelial Monolayer Barrier Function by Lysophosphatidic Acid, Potential Mediators of Hematopoietic Angiogenesis
Journal of Hematotherapy Stem Cell Research, vol. 8, no. 6, pp. 627–634, 1999 - A Novel Pathway for Tumor Necrosis Factor-alpha and Ceramide Signaling Involving Sequential Activation of Tyrosine Kinase, p21ras, and Phosphatidylinositol 3-Kinase
Journal of Biological Chemistry, vol. 274, no. 18, pp. 12722–12729, 1999 - Structural organization of mammalian lipid phosphate phosphatases: implications for signal transduction
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, vol. 1439, no. 2, pp. 299–316, 1999 - Lipid phosphate phosphohydrolase-1 degrades exogenous glycerolipid and sphingolipid phosphate esters
Biochemical Journal, vol. 340, no. 3, p. 677, 1999 - Tumor necrosis factor-a and ceramides in insulin resistance
Lipids, vol. 34, no. S1, pp. S85–S88, 1999 - Induction of endothelial monolayer permeability by phosphatidate
Journal of Cellular Biochemistry, vol. 75, no. 1, pp. 105–117, 1999 - Epidermal growth factor inhibits ceramide-induced apoptosis and lowers ceramide levels in primary placental trophoblasts
Journal of Cellular Physiology, vol. 180, no. 2, pp. 263–270, 1999 - Improvement of insulin sensitivity and cardiovascular outcomes in the JCR:LA-cp rat by D-fenfluramine
Diabetologia, vol. 41, no. 4, pp. 380–389, 1998 - Exaggerated stress-induced release of nonesterified fatty acids in JCR:LA-corpulent rats*1
Metabolism, vol. 47, no. 11, pp. 1383–1390, 1998 - Mammalian Lipid Phosphate Phosphohydrolases
Journal of Biological Chemistry, vol. 273, no. 38, pp. 24281–24284, 1998 - Mammalian Mg2+-independent Phosphatidate Phosphatase (PAP2) Displays Diacylglycerol Pyrophosphate Phosphatase Activity
Journal of Biological Chemistry, vol. 272, no. 16, pp. 10361–10366, 1997 - Cell-permeable Ceramides Prevent the Activation of Phospholipase D by ADP-ribosylation Factor and RhoA
Journal of Biological Chemistry, vol. 272, no. 2, pp. 1069–1075, 1997 - Activation of Phospholipase D in FRTL-5 Thyroid Cells by Forskolin and Dibutyryl-Cyclic Adenosine Monophosphate
Endocrinology, vol. 138, no. 9, pp. 3645–3651, 1997 - Antiatherogenic effects of long-term benfluorex treatment in male insulin resistant JCR:LA-cp rats
Atherosclerosis, vol. 132, no. 2, pp. 187–197, 1997 - Phosphatidate phosphohydrolase and signal transduction
Chemistry and Physics of Lipids, vol. 80, no. 1-2, pp. 45–57, 1996 - Effects of benfluore× on serum triacylglycerols and insulin sensitivity in the corpulent rat
Canadian Journal of Physiology and Pharmacology, vol. 74, no. 8, pp. 879–886, 1996 - Phosphatidate Phosphohydrolase Catalyzes the Hydrolysis of Ceramide 1-Phosphate, Lysophosphatidate, and Sphingosine 1-Phosphate
Journal of Biological Chemistry, vol. 271, no. 28, pp. 16506–16509, 1996 - Purification and Characterization of a Novel Plasma Membrane Phosphatidate Phosphohydrolase from Rat Liver
Journal of Biological Chemistry, vol. 270, no. 33, pp. 19422–19429, 1995 - Degradation of Apolipoprotein B in Cultured Rat Hepatocytes Occurs in a Post-endoplasmic Reticulum Compartment
Journal of Biological Chemistry, vol. 270, no. 42, pp. 24924–24931, 1995 - Interaction of Ceramides, Sphingosine, and Sphingosine 1-Phosphate in Regulating DNA Synthesis and Phospholipase D Activity
Journal of Biological Chemistry, vol. 270, no. 44, pp. 26318–26325, 1995 - Thyroid-stimulating hormone activates phospholipase D in FRTL-5 thyroid cells via stimulation of protein kinase C
Endocrinology, vol. 136, no. 9, pp. 3794–3799, 1995 - Metabolic abnormalities linked to obesity: Effects of dexfenfluramine in the corpulent rat*1
Metabolism, vol. 44, pp. 23–27, 1995 - Effect of alcohol on the activity and subcellular distribution of phosphatidate phosphohydrolase in rat liver
Biochimica et Biophysica Acta (BBA) - General Subjects, vol. 1201, no. 3, pp. 411–414, 1994 - Hepatic secretion of lysophosphatidylcholine: A novel transport system for polyunsaturated fatty acids and choline
The Journal of Nutritional Biochemistry, vol. 4, no. 8, pp. 442–449, 1993 - Stress and lipoprotein metabolism: Modulators and mechanisms*1
Metabolism, vol. 42, no. 9, pp. 3–15, 1993 - Cholesterol feeding induces hypertriglyceridaemia in hamsters and increases the activity of the Mg2+-dependent phosphatidate phosphohydrolase in the liver
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, vol. 1166, no. 2-3, pp. 238–243, 1993 - Effects of sphingosine, albumin and unsaturated fatty acids on the activation and translocation of phosphatidate phosphohydrolases in rat hepatocytes
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, vol. 1127, no. 1, pp. 49–56, 1992 - Effects of okadaic acid on the activities of two distinct phosphatidate phosphohydrolases in rat hepatocytes
FEBS Letters, vol. 301, no. 1, pp. 103–106, 1992 - Metabolic approach to atherosclerosis: Effect of gliclazide*1
Metabolism, vol. 41, no. 5, pp. 20–24, 1992 - Effects of the lipase inhibitors, Triton WR-1339 and tetrahydrolipstatin on the synthesis and secretion of lipids by rat hepatocytes
FEBS Letters, vol. 286, no. 1-2, pp. 186–188, 1991 - Hormonal regulation of the hepatic low density of lipoprotein receptor an dthe catabolism of low density lipoproteins: Relationship with the secretion of very low density lipoproteins
Progress in Lipid Research, vol. 30, no. 4, pp. 349–360, 1991 - Sexual dimorphism in the preferential secretion of unsaturated lysophosphatidylcholine by rat hepatocytes but no secretion by sheep hepatocytes
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, vol. 1081, no. 2, pp. 151–158, 1991 - Decreased serum lipids, serum insulin and triacylglycerol synthesis in adipose tissue of JCR:LA-corpulent rats treated with benfluorex
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, vol. 1085, no. 1, pp. 119–125, 1991 - Decreased incorporation of glucose into lipids and increased lactate production by adipose tissue after long-term treatment of rats with ?-fenfluramine
Biochemical Pharmacology, vol. 38, no. 21, pp. 3661–3667, 1989 - Translocation of phosphatidate phosphohydrolase from the cytosol to microsomal membranes in thioacetamide-induced liver tumours in rats
Toxicology Letters, vol. 47, no. 1, pp. 9–16, 1989 - Interactions of triiodothyronine, insulin and dexamethasone on the binding of human LDL to rat hepatocytes in monolayer culture
Atherosclerosis, vol. 71, no. 1, pp. 77–80, 1988 - Effects of chronic administration of benfluorex to rats on the metabolism of corticosterone, glucose, triacylglycerols, glycerol and fatty acid
Biochemical Pharmacology, vol. 37, no. 4, pp. 695–705, 1988 - The biochemistry of lipoproteins
Journal of Inherited Metabolic Disease, vol. 11, no. S1, pp. 4–17, 1988 - Age-related changes in the translocation of phosphatidate phosphohydrolase from the cytosol to microsomal membranes in rat liver
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, vol. 963, no. 2, pp. 384–388, 1988 - Binding of low-density lipoprotein to monolayer cultures of rat hepatocytes is increased by insulin and decreased by dexamethasone
FEBS Letters, vol. 220, no. 1, pp. 159–162, 1987 - Spermine antagonises the effects of dexamethasone, glucagon and cyclic AMP in increasing the activity of phosphatidate phosphohydrolase in isolated rat hepatocytes
FEBS Letters, vol. 207, no. 1, pp. 42–46, 1986 - Insulin antagonises the growth hormone-mediated increase in the activity of phosphatidate phosphohydrolase in isolated rat hepatocytes
FEBS Letters, vol. 202, no. 1, pp. 133–136, 1986 - Relationship between the displacement of phosphatidate phosphohydrolase from the membrane-associated compartment by chlorpromazine and the inhibition of the synthesis of triacylglycerol and phosphatidylcholine in rat hepatocytes
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, vol. 876, no. 3, pp. 581–591, 1986 - Possible relationships between changes in body weight set-point and stress metabolism after treating rats chronically with ?-fenfluramine Effects of feeding rats acutely with fructose on the metabolism of corticosterone, glucose, fatty acids, glycerol and triacylglycerol
Biochemical Pharmacology, vol. 34, no. 8, pp. 1265–1271, 1985 - Stimulation of specific GTPase activity by vasopressin in isolated membranes from cultured rat hepatocytes
FEBS Letters, vol. 192, no. 2, pp. 251–254, 1985 - Spermine promotes the translocation of phosphatidate phosphohydrolase from the cytosol to the microsomal fraction of rat liver and it enhances the effects of oleate in this respect
FEBS Letters, vol. 179, no. 2, pp. 262–266, 1985 - Long-chain fatty acids and their acyl-CoA esters cause the translocation of phosphatidate phosphohydrolase from the cytosolic to the microsomal fraction of rat liver
FEBS Letters, vol. 175, no. 2, pp. 284–288, 1984 - Intracellular translocation of phosphatidate phosphohydrolase and its possible role in the control of glycerolipid synthesis
Progress in Lipid Research, vol. 23, no. 3, pp. 115–133, 1984 - The metabolism of CDP-diacylglycerol and phosphatidylinositol in the microsomal fraction of rat liver effects of chlorpromazine, magnesium and manganese
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, vol. 751, no. 1, pp. 81–89, 1983 - Antagonistic effects of insulin on the corticosterone-induced increase of phosphatidate phosphohydrolase activity in isolated rat hepatocytes
FEBS Letters, vol. 143, no. 1, pp. 9–12, 1982 - Effects of corticosterone and insulin on enzymes of triacylglycerol synthesis in isolated rat hepatocytes
FEBS Letters, vol. 146, no. 1, pp. 204–208, 1982 - Effect of chronic clofibrate feeding on the activities of enzymes involved in glycerolipid synthesis and in peroxisomal metabolism in rat liver
Biochemical Pharmacology, vol. 31, no. 8, pp. 1650–1652, 1982 - Effects of starvation, corticotropin injection and ethanol feeding on the activity and amount of phosphatidate phosphohydrolase in rat liver
FEBS Letters, vol. 126, no. 2, pp. 297–300, 1981 - Stimulation of the activities of phosphatidate phosphohydrolase and tyrosine aminotransferase in rat hepatocytes by glucocorticoids
FEBS Letters, vol. 133, no. 1, pp. 119–122, 1981 - Factors controlling the metabolism of phosphatidate by phosphohydrolase and phospholipase A-type activities Effects of magnesium, calcium and amphiphilic cationic drugs
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, vol. 619, no. 3, pp. 494–505, 1980 - Selective inhibition by clofenapate of glycerolipid synthesis via the esterification of dihydroxyacetone phosphate in rat liver slices
International Journal of Biochemistry, vol. 7, no. 3-4, pp. 141–147, 1976 - Propertis of Phosphatidate Phosphohydrolase
European Journal of Biochemistry, vol. 18, no. 2, pp. 214–220, 1971 - Acyl carrier protein from
Biochemical and Biophysical Research Communications, vol. 38, no. 3, pp. 369–377, 1970 - The effect of unsaturated fatty acids and the particle-free supernatant on the incorporation of palmitate into glycerides
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, vol. 144, no. 2, pp. 285–295, 1967 - Stimulation of Biosynthesis of Glyceride
Nature, vol. 216, no. 5114, Article ID 216449a0, 4 pages, 1967 - The Role of Phosphatidate Phosphohydrolase in Glyceride Biosynthesis
European Journal of Biochemistry, vol. 3, no. 1, pp. 70–77, 1967 - The effect of chain length on the activation and subsequent incorporation of fatty acids into glycerides by the small intestinal mucosa
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, vol. 125, no. 1, pp. 92–105, 1966 - The intracellular distribution of the enzymes catalysing the biosynthesis of glycerides in the intestinal mucosa
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, vol. 106, no. 3, pp. 495–509, 1965 - Metabolism of phospholipids VIII. Biosynthesis of phosphatidylcholine in the intestinal mucosa
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, vol. 98, no. 3, pp. 486–501, 1965