Katsuiku Hirokawa

Articles in Scholarly Journals [Incomplete List]

  1. Importance of gastrointestinal ingestion and macromolecular antigens in the vein for oral tolerance induction
    Immunology, vol. 119, no. 2, pp. 167–177, 2006
  2. Immunity & Ageing, vol. 3, no. 1, p. 1, 2006
  3. Dysregulation of T-Cell Function in the Elderly
    Drugs & Aging, vol. 22, no. 7, pp. 589–603, 2005
  4. Expression of IAP-family proteins in adult acute mixed lineage leukemia (AMLL)
    American Journal of Hematology, vol. 78, no. 3, pp. 173–180, 2005
  5. Unexpected clinicopathological phenotype linked to small elongation of CAG repeat in SCA1 gene
    Journal of Neurology, vol. 253, no. 3, pp. 396–398, 2005
  6. Age-related Decline of Brain Monoamines in Mice is Reversed to Young Level by Japanese Herbal Medicine
    Neurochemical Research, vol. 30, no. 1, pp. 75–81, 2005
  7. Basophils Play a Critical Role in the Development of IgE-Mediated Chronic Allergic Inflammation Independently of T Cells and Mast Cells
    Immunity, vol. 23, no. 2, pp. 191–202, 2005
  8. DNA-dependent protein kinase enhances DNA damage-induced apoptosis in association with Friend gp70
    Leukemia Research, vol. 29, no. 3, pp. 307–316, 2005
  9. Resistance against Friend leukemia virus-induced leukemogenesis in DNA-dependent protein kinase (DNA-PK)-deficient mice associated with defective viral integration at the and site
    Leukemia Research, vol. 29, no. 8, pp. 933–942, 2005
  10. Bone marrow cells of myelodysplastic syndromes exhibit significant expression of apollon, livin and ILP-2 with reduction after transformation to overt leukemia
    Leukemia Research, vol. 29, no. 9, pp. 1095–1096, 2005
  11. Expression level of Wnt signaling components possibly influences the biological behavior of colorectal cancer in different age groups
    Experimental and Molecular Pathology, vol. 76, no. 3, pp. 224–233, 2004
  12. Expression of IAP family proteins in esophageal cancer
    Experimental and Molecular Pathology, vol. 76, no. 3, pp. 253–259, 2004
  13. Differential expression of survivin in bone marrow cells from patients with acute lymphocytic leukemia and chronic lymphocytic leukemia
    Leukemia Research, vol. 28, no. 5, pp. 487–494, 2004
  14. Expression of IAP family proteins in myelodysplastic syndromes transforming to overt leukemia
    Leukemia Research, vol. 28, no. 11, pp. 1203–1211, 2004
  15. Regulation of osteoclastogenesis by three human RANKL isoforms expressed in NIH3T3 cells
    Biochemical and Biophysical Research Communications, vol. 314, no. 4, pp. 1021–1027, 2004
  16. Identification of a novel isoform of ZAP-70, truncated ZAP kinase
    Biochemical and Biophysical Research Communications, vol. 315, no. 4, pp. 935–941, 2004
  17. Cancer and aging: symposium of the 27th annual meeting of the Japanese society for biomedical gerontology, Tokyo
    Cancer Immunology, Immunotherapy, vol. 54, no. 7, pp. 623–634, 2004
  18. Lewy bodies in the sinoatrial nodal ganglion: Clinicopathological studies
    Pathology International, vol. 54, no. 9, pp. 682–687, 2004
  19. coq7/clk-1 regulates mitochondrial respiration and the generation of reactive oxygen species via coenzyme Q
    Aging Cell, vol. 3, no. 5, pp. 273–281, 2004
  20. Expression of TNF receptors and related signaling molecules in the bone marrow from patients with myelodysplastic syndromes
    Leukemia Research, vol. 27, no. 7, pp. 583–591, 2003
  21. Hepatocellular carcinoma with osteoclast-like giant cells: Possibility of osteoclastogenesis by hepatocyte-derived cells
    Pathology International, vol. 53, no. 7, pp. 450–456, 2003
  22. Multimerization of the Receptor Activator of Nuclear Factor- B Ligand (RANKL) Isoforms and Regulation of Osteoclastogenesis
    Journal of Biological Chemistry, vol. 278, no. 47, pp. 47217–47222, 2003
  23. Essential Microenvironment for Thymopoiesis is Preserved in Human Adult and Aged Thymus
    Clinical and Developmental Immunology, vol. 10, no. 1, pp. 53–59, 2003
  24. Glia maturation factor produced by thymic epithelial cells plays a role in T cell differentiation in the thymic microenvironment
    International Immunology, vol. 15, no. 5, pp. 557–564, 2003
  25. Poor Prognosis of Colorectal Cancer in Patients Over 80 Years Old Is Associated With Down-Regulation of Tumor Suppressor Genes
    Journal of Clinical Gastroenterology, vol. 37, no. 1, pp. 48–54, 2003
  26. In vivo distribution of receptor for ecotropic murine leukemia virus and binding of envelope protein of Friend Murine leukemia virus
    Archives of Virology, vol. 148, no. 6, pp. 1175–1184, 2003
  27. Expression ofFoxp2, a gene involved in speech and language, in the developing and adult striatum
    Journal of Neuroscience Research, vol. 73, no. 1, pp. 61–72, 2003
  28. Radiation-induced-thymic lymphoma occurs in young, but not in old mice
    Experimental and Molecular Pathology, vol. 74, no. 3, pp. 319–325, 2003
  29. Animal models and possible human application of immunological restoration in the elderly
    Mechanisms of Ageing and Development, vol. 123, no. 8, pp. 1055–1063, 2002
  30. Age/sex dependent and non-monotonous dose-response effect of diethylstilbestrol on the immune functions in mice
    Toxicology Letters, vol. 135, no. 1-2, pp. 145–153, 2002
  31. Differential expression of various cytokine receptors in the brain after stimulation with LPS in young and old mice
    Experimental Gerontology, vol. 37, no. 2-3, pp. 411–420, 2002
  32. Incidence of apoptosis increases with age in colorectal cancer
    Experimental Gerontology, vol. 37, no. 12, pp. 1469–1479, 2002
  33. Friend Leukemia Virus Infection Enhances DNA Damage-Induced Apoptosis of Hematopoietic Cells, Causing Lethal Anemia in C3H Hosts
    Journal of Virology, vol. 76, no. 15, pp. 7790–7798, 2002
  34. Determination of Three Isoforms of the Receptor Activator of Nuclear Factor- B Ligand and Their Differential Expression in Bone and Thymus
    Endocrinology, vol. 142, no. 4, pp. 1419–1426, 2001
  35. Expression Profiles of Receptor Activator of Nuclear Factor kappaB Ligand, Receptor Activator of Nuclear Factor kappaB, and Osteoprotegerin Messenger RNA in Aged and Ovariectomized Rat Bones
    Journal of Bone and Mineral Research, vol. 16, no. 8, pp. 1416–1425, 2001
  36. Research on biomedical gerontology in Japan
    Experimental Gerontology, vol. 36, no. 10, pp. 1581–1597, 2001
  37. Immune responses and protection in different strains of aged mice immunized intranasally with an adjuvant-combined influenza vaccine
    Vaccine, vol. 19, no. 28-29, pp. 3981–3989, 2001
  38. Immunological restoration and anti-tumor effect by Japanese herbal medicine in aged mice
    Mechanisms of Ageing and Development, vol. 122, no. 3, pp. 341–352, 2001
  39. Effect of maternal age on incidences of apoptotic and proliferative cells in trophoblasts of full-term human placenta
    Molecular Human Reproduction, vol. 7, no. 12, pp. 1179–1185, 2001
  40. Immunohistological Analysis of Thymoma by Molecules Differentially Expressed in the Thymic Cortex and Medulla, and Its Application inthe Differential Diagnosis of Thymoma from Esophageal and Lung Cancer
    Pathology - Research and Practice, vol. 197, no. 9, pp. 611–619, 2001
  41. Age-related hypermethylation of thehMLH1 promoter in gastric cancers
    International Journal of Cancer, vol. 94, no. 2, pp. 208–211, 2001
  42. Mouse Homologue of coq7/clk-1, Longevity Gene in Caenorhabditis elegans, Is Essential for Coenzyme Q Synthesis, Maintenance of Mitochondrial Integrity, and Neurogenesis
    Biochemical and Biophysical Research Communications, vol. 289, no. 2, pp. 463–471, 2001
  43. Cell Dynamics and Expression of Tumor Necrosis Factor (TNF)-a, Interleukin-6, and TNF Receptors in Angioimmunoblastic Lymphadenopathy-Type T Cell Lymphoma
    Experimental and Molecular Pathology, vol. 68, no. 2, pp. 85–94, 2000
  44. Expression of Protein Tyrosine Phosphatases and Its Significance in Esophageal Cancer
    Experimental and Molecular Pathology, vol. 68, no. 3, pp. 187–195, 2000
  45. Age-related changes of human bone marrow: a histometric estimation of proliferative cells, apoptotic cells, T cells, B cells and macrophages
    Mechanisms of Ageing and Development, vol. 117, no. 1-3, pp. 57–68, 2000
  46. Diversity of T cell repertoire shaped by a single peptide ligand is critically affected by its amino acid residue at a T cell receptor contact
    Proceedings of the National Academy of Sciences, vol. 97, no. 25, pp. 13760–13765, 2000
  47. Impaired delayed-type hypersensitivity response in mutant mice secreting soluble CD4 without expression of membrane-bound CD4
    Immunology, vol. 100, no. 3, pp. 309–316, 2000
  48. Fulminant hepatic failure in the elderly: A clinicopathological study of autopsy cases aged over 65 years
    Pathology International, vol. 50, no. 2, pp. 98–105, 2000
  49. Molecular mechanism of the impairment in activation signal transduction in CD4+ T cells from old mice
    International Immunology, vol. 12, no. 8, pp. 1205–1215, 2000
  50. Nature Medicine, vol. 5, no. 7, pp. 760–767, 1999
  51. Differential age effect of oral administration of an antigen on antibody response: an induction of tolerance in young mice but enhancement of immune response in old mice
    Mechanisms of Ageing and Development, vol. 109, no. 3, pp. 191–201, 1999
  52. Immunological enhancement with a low dose of cyclophosphamide in aged mice
    Mechanisms of Ageing and Development, vol. 111, no. 1, pp. 1–12, 1999
  53. Protection of retrovirus-induced disease by transplantation of bone marrow cells transduced with MuLV env gene via retrovirus vector
    Experimental Hematology, vol. 27, no. 2, pp. 234–241, 1999
  54. Age-related alteration of cytokine production profile by T cell subsets in mice: a flow cytometric study
    Experimental Gerontology, vol. 34, no. 2, pp. 231–242, 1999
  55. Age-related changes of signal transduction in T cells
    Experimental Gerontology, vol. 34, no. 1, pp. 7–18, 1999
  56. Vitamin E enhances the immune functions of young but not old mice under restraint stress
    Experimental Gerontology, vol. 34, no. 7, pp. 853–862, 1999
  57. Signal Pathway of Mitogen- induced Ca2+-activated K+ Currents in Young and Aged T-cell Clones of C57BL/6 Mice
    Cellular Signalling, vol. 11, no. 6, pp. 391–398, 1999
  58. Abstract
    Mechanisms of Ageing and Development, vol. 102, no. 2-3, p. 309, 1998
  59. Hypothalamic control of development and aging of the thymus
    Mechanisms of Ageing and Development, vol. 100, no. 2, pp. 177–185, 1998
  60. Localization of Fas and Fas ligand in bone marrow cells demonstrating myelodysplasia
    Leukemia, vol. 12, no. 4, Article ID 2400980, 6 pages, 1998
  61. Pathological Characteristics of Gastric Carcinomas in the Very Old
    Cancer Science, vol. 89, no. 10, pp. 1087–1092, 1998
  62. Expression of VCAM-1 in Lymphocytes during the Process of Apoptosis
    Pathobiology, vol. 66, no. 6, pp. 274–283, 1998
  63. Aging of the recipients but not of the bone marrow donors enhances autoimmunity in syngeneic radiation chimeras
    Mechanisms of Ageing and Development, vol. 95, no. 1-2, pp. 131–142, 1997
  64. Altered expression of various receptors on T cells in young and old mice after mitogenic stimulation: a flow cytometric analysis
    Mechanisms of Ageing and Development, vol. 94, no. 1-3, pp. 113–122, 1997
  65. Induction of thymic hyperplasia and suppression of splenic T cells by lesioning of the anterior hypothalamus in aging Wistar rats
    Journal of Neuroimmunology, vol. 77, no. 2, pp. 174–180, 1997
  66. Positive and Negative CD4+ Thymocyte Selection by a Single MHC Class II/Peptide Ligand Affected by Its Expression Level in the Thymus
    Immunity, vol. 6, no. 4, pp. 401–410, 1997
  67. Effect of restraint stress on immune system and experimental B16 melanoma metastasis in aged mice
    Mechanisms of Ageing and Development, vol. 93, no. 1-3, pp. 107–117, 1997
  68. Reversing and restoring immune functions
    Mechanisms of Ageing and Development, vol. 93, no. 1-3, pp. 119–124, 1997
  69. Impairment of signal transduction in T cells from old mice
    Mechanisms of Ageing and Development, vol. 93, no. 1-3, pp. 131–144, 1997
  70. Expression of the cyclin dependent kinase inhibitor p21 WAF1/CIP1 in oesophageal squamous cell carcinomas
    Virchows Archiv, vol. 430, no. 5, pp. 389–395, 1997
  71. Proliferative activity and p53 protein accumulation correlate with early invasive trend, and apoptosis correlates with differentiation grade in oesophageal squamous cell carcinomas
    Virchows Archiv, vol. 430, no. 2, pp. 107–115, 1997
  72. Difference in antigen presentation pathways between cortical and medullary thymic epithelial cells
    European Journal of Immunology, vol. 26, no. 9, pp. 2101–2107, 1996
  73. Retardation of the age-associated decline of immune functions in aging rats under dietary restriction and daily physical exercise
    Mechanisms of Ageing and Development, vol. 91, no. 3, pp. 219–228, 1996
  74. Antibodies to amyloid ? protein (A?) crossreact with glyceraldehyde-3-phosphate dehydrogenase (GAPDH)
    Neurobiology of Aging, vol. 17, no. 3, pp. 405–414, 1996
  75. Critical proline residues of the cytoplasmic domain of the IL-5 receptor a chain and its function in IL-5-mediated activation of JAK kinase and STAT5
    International Immunology, vol. 8, no. 2, pp. 237–245, 1996
  76. Demonstration of a cross-talk between IL-2 and IL-5 in Phosphorylation of IL-2 and IL-5 receptor ß chains
    International Immunology, vol. 8, no. 6, pp. 951–960, 1996
  77. A novel type of cell death of lymphocytes induced by a monoclonal antibody without participation of complement
    Journal of Experimental Medicine, vol. 181, no. 6, pp. 2007–2015, 1995
  78. Differential effects of gonadectomy on thymic stromal cells in promoting T cell differentiation in mice
    Mechanisms of Ageing and Development, vol. 81, no. 2-3, pp. 107–117, 1995
  79. Differential Expression of Protein Tyrosine Kinases in the Cortical and Medullary Thymic Epithelial Cell Lines
    Biochemical and Biophysical Research Communications, vol. 213, no. 3, pp. 768–773, 1995
  80. Cholinergic Stimulation Modulates Apoptosis and Differentiation of Murine Thymocytes via a Nicotinic Effect on Thymic Epithelium
    Biochemical and Biophysical Research Communications, vol. 203, no. 2, pp. 1057–1062, 1994
  81. Understanding the mechanism of the age-change of thymic function to promote T cell differentiation
    Immunology Letters, vol. 40, no. 3, pp. 269–277, 1994
  82. Immunological alterations with aging—laying a stress on recent progress in Japan
    Archives of Gerontology and Geriatrics, vol. 19, no. 2, pp. 171–183, 1994
  83. Differential effect of host microenvironment and systemic humoral factors on the implantation and the growth rate of metastatic tumor in parabiotic mice constructed between young and old mice
    Mechanisms of Ageing and Development, vol. 71, no. 3, pp. 213–221, 1993
  84. Effects of a protein-free diet or food restriction on the immune system of Wistar and Buffalo rats at different ages
    Mechanisms of Ageing and Development, vol. 72, no. 3, pp. 183–197, 1993
  85. Proenzyme Form of Cathepsin L Produced by Thymic Epithelial Cells Promotes Proliferation of Immature Thymocytes in the Presence of IL-1, IL-7, and Anti-CD3 Antibody
    Cellular Immunology, vol. 150, no. 1, pp. 124–136, 1993
  86. Restricted expression of transgenic HLA-DRA gene in thymic epithelial cells and its role in acquisition of T cell tolerance to self-superantigens and processed DRa-derived peptide
    European Journal of Immunology, vol. 23, no. 7, pp. 1678–1686, 1993
  87. Gene expression of CD24 core peptide molecule in developing brain and developing non-neural tissues
    American Journal of Anatomy, vol. 198, no. 1, pp. 1–13, 1993
  88. An immunohistologic study of the epithelial components of 81 cases of thymoma
    Cancer, vol. 69, no. 10, pp. 2463–2468, 1992
  89. Immunohistological study on brains of Alzheimer's disease using antibodies to fetal antigens, C-series gangliosides and microtubule-associated protein 5
    Acta Neuropathologica, vol. 81, no. 6, pp. 626–631, 1991
  90. A novel cofactor produced by a thymic epithelial cell line: Promotion of proliferation of immature thymic lymphocytes by the presence of interleukin-1 and various mitogens
    Cellular Immunology, vol. 132, no. 2, pp. 377–390, 1991
  91. Production of a monoclonal antibody strongly reacting with immature thymic T lymphocytes and its immunohistological application
    Cellular Immunology, vol. 137, no. 1, pp. 175–188, 1991
  92. Age influence on the thymic capacity to promote differentiation of T cells: Induction of different composition of T cell subsets by aging thymus
    Mechanisms of Ageing and Development, vol. 58, no. 2-3, pp. 267–277, 1991
  93. Immunohistological study on the distribution of a1-antichymotrypsin in Alzheimer's brain, compared to ß-amyloid precursor protein and ß-amyloid protein
    Journal of the Neurological Sciences, vol. 99, no. 2-3, pp. 301–310, 1990
  94. A comparison of patterns of metastasis in gastric cancer by histologic type and age
    Cancer, vol. 65, no. 9, pp. 2086–2090, 1990
  95. Distribution of immunoglobulins and secretory component in gastric cancer of the aged
    Cancer, vol. 66, no. 10, pp. 2168–2173, 1990
  96. Immunohistological study of senile brains by using a monoclonal antibody recognizing ? amyloid precursor protein: significance of granular deposits in relation with senile plaques
    Acta Neuropathologica, vol. 80, no. 3, pp. 260–265, 1990
  97. Changes in serum levels of forssman-like antibody in patients with gastric cancer
    Cancer, vol. 63, no. 8, pp. 1528–1533, 1989
  98. Establishment of a monoclonal antibody against senile plaques and its application for immunohistological and immunoelectron microscopical studies in the brain of the elderly
    Acta Neuropathologica, vol. 79, no. 1, pp. 44–47, 1989
  99. Hypertrophy of the thymus and restoration of immune functions in mice and rats by gonadectomy
    Mechanisms of Ageing and Development, vol. 47, no. 3, pp. 175–185, 1989
  100. Combined grafting of bone marrow and thymus, and sequential multiple thymus graftings in various strains of mice. The effect on immune functions and life span
    Mechanisms of Ageing and Development, vol. 49, no. 1, pp. 49–60, 1989
  101. Age-associated changes in renal glomeruli of mice
    Experimental Gerontology, vol. 24, no. 3, pp. 237–249, 1989
  102. Decline in the production of interleukin-3 with age in mice
    Cellular Immunology, vol. 115, no. 1, pp. 1–12, 1988
  103. Age-related changes of splenic T cells in mice — a flow cytometric analysis
    Mechanisms of Ageing and Development, vol. 40, no. 1, pp. 89–102, 1987
  104. Multiple gastric cancers in the aged with special reference to intramucosal cancers
    Cancer, vol. 59, no. 3, pp. 560–565, 1987
  105. Age-related change in the potential of bone marrow cells to repopulate the thymus and splenic T cells in mice
    Cellular Immunology, vol. 100, no. 2, pp. 443–451, 1986
  106. Contrasting feature in the repopulation of host-type T cells in the spleens of F ? P and P ? F radiation bone marrow chimeras
    Cellular Immunology, vol. 103, no. 1, pp. 174–182, 1986
  107. Age-related increase of focal lymphocytic infiltration in the human submandibular glands
    Journal of Oral Pathology and Medicine, vol. 15, no. 3, pp. 172–178, 1986
  108. The effect of sequential multiple grafting of syngeneic newborn thymus on the immune functions and life expectancy of aging mice
    Mechanisms of Ageing and Development, vol. 28, no. 1, pp. 111–121, 1984
  109. Immunohistochemical study on the liver in autopsy cases with disseminated intravascular coagulation (DIC) with reference to clinicopathological analysis
    Virchows Archiv A Pathological Anatomy and Histopathology, vol. 404, no. 3, pp. 229–241, 1984
  110. Age-related change of distribution of immunoglobulin containing cells in human bone marrow
    Virchows Archiv A Pathological Anatomy and Histopathology, vol. 404, no. 3, pp. 243–251, 1984
  111. Radiation effects on regeneration and T-cell-inducing function of the thymus
    Cellular Immunology, vol. 84, no. 2, pp. 372–379, 1984
  112. Long-lasting impairment of immune and endocrine systems of offspring induced by injection of dexamethasone into pregnant mice
    Clinical Immunology and Immunopathology, vol. 26, no. 3, pp. 335–349, 1983
  113. Restoration of impaired immune functions in aging animals V. Long-term immunopotentiating effects of combined young bone marrow and newborn thymus grafts
    Clinical Immunology and Immunopathology, vol. 22, no. 3, pp. 297–304, 1982
  114. Influence of age of thymic grafts on the differentiation of T cells in nude mice
    Clinical Immunology and Immunopathology, vol. 24, no. 2, pp. 251–262, 1982
  115. Experimental allergic orchitis in mice
    Virchows Archiv A Pathological Anatomy and Histology, vol. 392, no. 2, pp. 147–158, 1981
  116. Early decline of thymic effect on T cell differentiation
    Mechanisms of Ageing and Development, vol. 7, pp. 89–95, 1978
  117. Restoration of impaired immune functions in aging animals I. Effect of syngeneic thymus and bone marrow grafts
    Clinical Immunology and Immunopathology, vol. 5, no. 3, pp. 371–376, 1976
  118. Characterization of age-associated kidney disease in Wistar rats
    Mechanisms of Ageing and Development, vol. 4, pp. 301–316, 1975