Chrisostomos Prodromou is a Senior Research Fellow at the University of Sussex, from 2010 till present and was a Senior Staff Scientist at the Institute of Cancer Research, London, from 1999 to 2010, a Research Fellow at the University College of London, from 1991 to 1999, and a Research Assistant at the University College of London, from 1988 to 1991. In 1988, Prodromou got the Ph.D. degree in molecular genetics from Queen Mary College, University of London. In 1984, Prodromou got the B.S. degree 1st class (honors) in applied biology from Chelsea College, University of London. Prodromou's research interests have been directed towards understanding molecular chaperones and how they achieve folding and maturation of proteins. He has particularly concentrated on the Hsp90 chaperone complex. his aims are to understand the molecular details by which Hsp90 and its cochaperones bring about the maturation of proteins (known as client proteins). Prodromou has used biochemical, genetic, and structural approaches to gain an insight into Hsp90 mechanistic action and regulation of its chaperone cycle. The activation of client proteins by Hsp90 is also dependent on a number of cochaperones that aid/regulate Hsp90 and its chaperone cycle. These include Cdc37, Hop/Sti1, Sba1/p23, Aha1, PP5, Xap2, Unc-45, Cyp40, Rar1, Sgt1, FKBP51, and FKBP52 amongst others. As Hsp90 is essential for the maturation of a variety of oncogenes, his research has been directed towards structure-based drug design against the N-terminal ATP-binding domain of Hsp90. Prodromou is also currently collaborating in the development of C-terminal-binding inhibitors of Hsp90. Another aspect of his research involves determining the resistance mechanisms of Hsp90-targeted drugs. Prodromou has determined the natural resistance mechanism for radicicol and geldanamycin, which target the N-terminal ATP-binding site of Hsp90.
Biography Updated on 9 January 2012