Zhanju Liu began his studies in 1983 at the Henan Medical University in Zhengzhou, China, where he graduated with an M.D. degree. He then started working as a Resident in Department of Medicine, the Second Affiliated Hospital of Henan Medical University. He completed his academic studies with a Ph.D. degree in mucosal immunopathology of inflammatory bowel disease (IBD) from the University of Leuven, Leuven, Belgium. He then joined Beth Israel Deaconess Medical Center in Harvard and University of Connecticut Health Center as a Research Fellow. It was there that he investigated intestinal mucosal immune responses and inflammatory injury. Dr. Liu now serves as the Chairman of the Department of Gastroenterology, Shanghai Tenth People’s Hospital of Tongji University in Shanghai, China. While completing his Ph.D. training, Dr. Liu became interested in intestinal mucosal immunology, with specific opportunities in IBD. He received several grants from Crohn’s and Colitis Foundation of America (CCFA) and National Nature Scientific Foundation of China. In the past ten years, he has found that profound proinflammatory cytokines (e.g., IL-15, IL-21, and IL-23) as well as costimulatory molecules (eg., CD40 and CD80) are present in inflamed intestinal mucosa of IBD patients. Targeted therapy directed against either CD40 ligand or IL-12 or TNF could effectively prevent experimental colitis in murine colitis models. Importantly, Dr. Liu observed that IL-21 and IL-23 strongly promote IBD NK cell activation and cytolytic activities and induce mucosal CD4 T cell differentiation. All of data prove that abnormal immune response plays a critical role in the development of IBD. The importance of his research work will not only allow physicians and scientists to perform basic research in the field of IBD but can also develop clinical trials to test new therapies. Dr. Liu serves as an Ad Hoc Reviewer for Journal of Immunology, Inflammatory Bowel Disease, Clinical & Experimental Immunology, Clinical Immunology, and Journal of Leukocyte Biology.
Biography Updated on 27 January 2011