Education Undergraduate degree in Chemistry (speciality: Chemistry of Natural Compounds). Graduate project on regulation of enzymatic activity of restriction endonucleases by DNA intercalating compounds (actimomycin and distamycin). PhD project on Immunogenetics (cloning of a mouse plasmacytoma IgG gene fragment). Research Studies on virulence factors of various bacterial pathogens (Yersinia, Aeromonas and Campylobacter). Selected key studies: - genetics and molecular mechanisms of protein secretion in Yersinia pestis (F1 antigen, capsule, usher-chaperone system) - discovery of a polysaccharide capsule in Campylobacter jenuni (genetics and biochemistry) - bacterial genomics (first sequences of genomes of Campylobcter jejuni, the major gastrointestinal pathogen, and Yersinia pestis, a causative agent of plague) - development of an insect model for investigation of human bacterial pathogens - bacterial peptidases (proteases) and their role in pathogenesis/stress response Over 70 publications in high-ranking peer reviewed journals (including Nature) attracting over 300 citations annually. Book chapters and patents.
Biography Updated on 5 August 2012