Alessio Lodola was born in 1976 and received his Pharm.D. degree in the academic year 2000-2001 from the Faculty of Pharmacy at the University of Parma. In November 2005, he obtained his Ph.D. degree in medicinal chemistry after working for three years with the Computational Medicinal Chemistry Group led by Professor Marco Mor. In the same year, he became a Lecturer in medicinal chemistry at the Faculty of Pharmacy of the University of Parma. In 2003, 2006, and 2007, he served as a Visiting Researcher at the University of Bristol (UK), in the Group of Professor Adrian Mulholland, working in the field of enzymatic reaction simulations applying hybrid quantum mechanics/molecular mechanics (QM/MM) approaches. In 2008, he spent a year in the Drug Discovery and Development Unit led by Professor Daniele Piomelli at the IIT, in Genova as a Visiting Scientist. Recently, his scientific interests have been directed to rational drug design and to the study of structure-activity relationships (SARs) of biologically active compounds. In his research, he applies a variety of chemometric and molecular modelling techniques including QSAR, docking, molecular dynamics simulations (using classical and hybrid QM/MM potential). The research activities of Dr. Lodola, which have led to nearly 40 papers in peer-reviewed international journals and to two patent applications, are focused on the following research fields: (i) the endocannabinoid system, with particular emphasis on the characterization of the catalytic mechanism and inhibition of the enzyme fatty acid amide hydrolase (FAAH) and the design of FAAH inhibitors based on a carbamic structure; (ii) antiproliferative agents with particular emphasis on the design and SAR investigations of inhibitors of the epidermal growth factor receptor (EGFR) kinase activity; (iii) the design and SAR investigation of nonpeptide antagonists of the Eph-ephrin system.
Biography Updated on 8 March 2012