Howard Beverley Osborne
Howard Beverley Osborne, after obtaining a B.S. degree in physics from the University of London in 1971, started his research work at the CNRS Centre for Molecular Genetics at Gif-sur-Yvette near Paris and subsequently moved to the Biology Laboratories of Atomic Energy Commission in Grenoble. This period of research was devoted to the biochemical and structural characterization of the light-sensitive protein in retinal rods and rhodopsin, an integral membrane protein. He obtained his Ph.D. degree in 1978, and then moved to more cellular research, initially at the Research Institute of the Scripps Clinic at La Jolla (Calif, USA) and then in Grenoble. During this time, he was concerned with identifying molecular changes associated with induced erythroleukemic cell differentiation leading to the characterization of changes in intracellular polyamine concentrations. One of the possible readouts of such polyamine changes could be the post-transcriptional control of gene expression. To develop this line of research, he moved to the University of Rennes in 1986, where his major research interests have been to describe at a molecular level the elements that post-transcriptionally control the expression of maternal mRNA in early Xenopus embryos, and to evaluate the biological importance of the characterized regulatory pathways. The biological importance of these proteins in Xenopus somitogenesis and mouse spermatogenesis has been demonstrated by the group in Rennes.
Biography Updated on 29 June 2008