Yang Liu

Yang Liu obtained his Ph.D. degree at the Australian National University and postdoctoral training from Yale University. He has been on faculty in New York University, the Ohio State University, and currently at the University of Michigan at Ann Arbor. His research interest is on pathways and the controls of both cancer and autoimmunity.

Biography Updated on 12 July 2007

Articles in Scholarly Journals [Incomplete List]

  1. Immune competence of cancer-reactive T cells generated de novo in adult tumor-bearing mice
    Blood, vol. 109, no. 1, pp. 253–258, 2007
  2. A Dinucleotide Deletion in CD24 Confers Protection against Autoimmune Diseases
    PLoS Genetics, vol. 3, no. 4, p. e49, 2007
  3. Tumor growth impedes natural-killer-cell maturation in the bone marrow
    Blood, vol. 108, no. 1, pp. 246–252, 2006
  4. Modeling of Charge Trapping Induced Threshold-Voltage Instability in High-$kappa$Gate Dielectric FETs
    IEEE Electron Device Letters, vol. 27, no. 6, pp. 489–491, 2006
  5. Combination Therapy with Anti-CTL Antigen-4 and Anti-4-1BB Antibodies Enhances Cancer Immunity and Reduces Autoimmunity
    Cancer Research, vol. 66, no. 14, pp. 7276–7284, 2006
  6. De novo Induction of a Cancer/Testis Antigen by 5-Aza-2'-Deoxycytidine Augments Adoptive Immunotherapy in a Murine Tumor Model
    Cancer Research, vol. 66, no. 2, pp. 1105–1113, 2006
  7. Different Lineages of P1A-Expressing Cancer Cells Use Divergent Modes of Immune Evasion for T-Cell Adoptive Therapy
    Cancer Research, vol. 66, no. 16, pp. 8241–8249, 2006
  8. Massive and destructive T cell response to homeostatic cue in CD24-deficient lymphopenic hosts
    Journal of Experimental Medicine, vol. 203, no. 7, pp. 1713–1720, 2006
  9. Monte Carlo Pedigree Disequilibrium Test for Markers on the X Chromosome
    The American Journal of Human Genetics, vol. 79, no. 3, pp. 567–573, 2006
  10. Nonlinear Force-Free Modeling of Coronal Magnetic Fields Part I: A Quantitative Comparison of Methods
    Solar Physics, vol. 235, no. 1-2, pp. 161–190, 2006
  11. FoxP3: A genetic link between immunodeficiency and autoimmune diseases
    Autoimmunity Reviews, vol. 5, no. 6, pp. 399–402, 2006
  12. Epm2a suppresses tumor growth in an immunocompromised host by inhibiting Wnt signaling
    Cancer Cell, vol. 10, no. 3, pp. 179–190, 2006
  13. Harnessing the regulatory feedback to T cells to enhance antitumor immune responses
    Drug Discovery Today: Therapeutic Strategies, vol. 3, no. 1, pp. 31–34, 2006
  14. Prediction of protein orientation upon immobilization on biological and nonbiological surfaces
    Proceedings of the National Academy of Sciences, vol. 103, no. 40, pp. 14773–14778, 2006
  15. Dimerization of Laforin Is Required for Its Optimal Phosphatase Activity, Regulation of GSK3beta Phosphorylation, and Wnt Signaling
    Journal of Biological Chemistry, vol. 281, no. 46, pp. 34768–34774, 2006
  16. Coupled optical and electronic simulations of electrically pumped photonic-crystal-based light-emitting diodes
    Journal of Applied Physics, vol. 97, no. 4, p. 044503, 2005
  17. The Scurfy mutation of FoxP3 in the thymus stroma leads to defective thymopoiesis
    Journal of Experimental Medicine, vol. 202, no. 8, pp. 1141–1151, 2005
  18. Innate NKT lymphocytes confer superior adaptive immunity via tumor-capturing dendritic cells
    Journal of Experimental Medicine, vol. 202, no. 11, pp. 1507–1516, 2005
  19. A Rare Transporter Associated with Antigen Processing Polymorphism Overpresented in HLAlow Colon Cancer Reveals the Functional Significance of the Signature Domain in Antigen Processing
    Clinical Cancer Research, vol. 11, no. 10, pp. 3614–3623, 2005
  20. Human CTLA4 knock-in mice unravel the quantitative link between tumor immunity and autoimmunity induced by anti-CTLA-4 antibodies
    Blood, vol. 106, no. 9, pp. 3127–3133, 2005
  21. Mode-locking of monolithic laser diodes incorporating coupled-resonator optical waveguides
    Optics Express, vol. 13, no. 12, p. 4539, 2005
  22. Anti-human CTLA-4 monoclonal antibody promotes T-cell expansion and immunity in a hu-PBL-SCID model: a new method for preclinical screening of costimulatory monoclonal antibodies
    Blood, vol. 105, no. 3, pp. 1114–1120, 2004
  23. Failed Adoptive Immunotherapy with Tumor-Specific T Cells: Reversal with Low-Dose Interleukin 15 but not Low-Dose Interleukin 2
    Cancer Research, vol. 64, no. 21, pp. 8062–8067, 2004
  24. A new role for CD28 in the survival of autoreactive T cells in the periphery after chronic exposure to autoantigen
    International Immunology, vol. 16, no. 10, pp. 1403–1409, 2004
  25. Transmembrane protein domains rarely use covalent domain recombination as an evolutionary mechanism
    Proceedings of the National Academy of Sciences, vol. 101, no. 10, pp. 3495–3497, 2004
  26. Expression of tissue-specific autoantigens in the hematopoietic cells leads to activation-induced cell death of autoreactive T cells in the secondary lymphoid organs
    European Journal of Immunology, vol. 34, no. 11, pp. 3126–3134, 2004
  27. Photospheric magnetic field observations during the May 12, 1997 CME and their implications for modeling that event
    Journal of Atmospheric and Solar-Terrestrial Physics, vol. 66, no. 15-16, pp. 1283–1293, 2004
  28. CD24 Controls Expansion and Persistence of Autoreactive T Cells in the Central Nervous System during Experimental Autoimmune Encephalomyelitis
    Journal of Experimental Medicine, vol. 200, no. 4, pp. 447–458, 2004
  29. CD24 Expression on T Cells Is Required for Optimal T Cell Proliferation in Lymphopenic Host
    Journal of Experimental Medicine, vol. 200, no. 8, pp. 1083–1089, 2004
  30. CD24 is a genetic modifier for risk and progression of multiple sclerosis
    Proceedings of the National Academy of Sciences, vol. 100, no. 25, pp. 15041–15046, 2003
  31. A Single-nucleotide Deletion Leads to Rapid Degradation of TAP-1 mRNA in a Melanoma Cell Line
    Journal of Biological Chemistry, vol. 278, no. 17, pp. 15291–15296, 2003
  32. A 'PolyORFomic' Analysis of Prokaryote Genomes Using Disabled-homology Filtering Reveals Conserved But Undiscovered Short ORFs
    Journal of Molecular Biology, vol. 333, no. 5, pp. 885–892, 2003
  33. CIITA-regulated plexin-A1 affects T-cell–dendritic cell interactions
    Nature Immunology, vol. 4, no. 9, Article ID ni960, 7 pages, 2003
  34. Antigenic drift as a mechanism for tumor evasion of destruction by cytolytic T lymphocytes
    Journal of Clinical Investigation, vol. 111, no. 10, pp. 1487–1496, 2003
  35. B7DC/PDL2 Promotes Tumor Immunity by a PD-1-independent Mechanism
    Journal of Experimental Medicine, vol. 197, no. 12, pp. 1721–1730, 2003
  36. Two-signal requirement for activation and effector function of natural killer cell response to allogeneic tumor cells
    Blood, vol. 102, no. 13, pp. 4456–4463, 2003
  37. Molecular Cancer, vol. 2, no. 1, p. 2, 2003
  38. B7-CTLA4 interaction promotes cognate destruction of tumor cells by cytotoxic T lymphocytes in vivo
    Blood, vol. 99, no. 8, pp. 2880–2889, 2002
  39. In vivo evidence for a dependence on interleukin 15 for survival of natural killer cells
    Blood, vol. 100, no. 10, pp. 3633–3638, 2002
  40. Subcellular localization of the yeast proteome
    Genes & Development, vol. 16, no. 6, pp. 707–719, 2002
  41. Cis elements for transporter associated with antigen-processing-2 transcription: two new promoters and an essential role of the IFN response factor binding element in IFN-gamma-mediated activation of the transcription initiator
    International Immunology, vol. 14, no. 2, pp. 189–200, 2002
  42. Thermostability of membrane protein helix–helix interaction elucidated by statistical analysis
    FEBS Letters, vol. 532, no. 1-2, pp. 231–236, 2002
  43. Perinatal Blockade of B7-1 and B7-2 Inhibits Clonal Deletion of Highly Pathogenic Autoreactive T Cells
    Journal of Experimental Medicine, vol. 195, no. 8, pp. 959–971, 2002
  44. B7H Costimulates Clonal Expansion of, and Cognate Destruction of Tumor Cells by, CD8+ T Lymphocytes In Vivo
    Journal of Experimental Medicine, vol. 194, no. 9, pp. 1339–1348, 2001
  45. Solar Physics, vol. 201, no. 2, pp. 337–355, 2001
  46. Cytotoxic T Lymphocytes to An Unmutated Tumor Rejection Antigen P1A: Normal Development but Restrained Effector Function In Vivo
    Journal of Experimental Medicine, vol. 189, no. 5, pp. 811–820, 1999
  47. CD28-independent Induction of T Helper Cells and Immunoglobulin Class Switches Requires Costimulation by the Heat-stable Antigen
    Journal of Experimental Medicine, vol. 187, no. 7, pp. 1151–1156, 1998
  48. B7-CTLA4 interaction enhances both production of antitumor cytotoxic T lymphocytes and resistance to tumor challenge
    Proceedings of the National Academy of Sciences, vol. 95, no. 11, pp. 6284–6289, 1998
  49. Nature, vol. 396, no. 6709, pp. 373–376, 1998
  50. Identification of conserved amino acids in murine B7-1IgV domain critical for CTLA4/CD28:B7 interaction by site-directed mutagenesis: a novel structural model of the binding site
    Molecular Immunology, vol. 35, no. 4, pp. 215–225, 1998
  51. Solar Physics, vol. 177, no. 1/2, pp. 395–410, 1998
  52. Solar Physics, vol. 180, no. 1/2, pp. 377–392, 1998
  53. Distinct Costimulatory Molecules Are Required for the Induction of Effector and Memory Cytotoxic T Lymphocytes
    Journal of Experimental Medicine, vol. 185, no. 2, pp. 251–262, 1997
  54. CTLA-4-B7 Interaction Is Sufficient to Costimulate T Cell Clonal Expansion
    Journal of Experimental Medicine, vol. 185, no. 7, pp. 1327–1336, 1997
  55. Costimulation by B7 Modulates Specificity of Cytotoxic T Lymphocytes: A Missing Link That Explains Some Bystander T Cell Activation
    Journal of Experimental Medicine, vol. 186, no. 10, pp. 1787–1791, 1997
  56. Identification of a costimulatory molecule rapidly induced by CD40L as CD44H
    Journal of Experimental Medicine, vol. 184, no. 3, pp. 955–961, 1996
  57. Gradients of the line-of-sight magnetic fields in active region NOAA 6659
    Solar Physics, vol. 169, no. 1, pp. 79–89, 1996
  58. Signaling by a New Anti-Thy 1 Monoclonal Antibody Inhibits T Cell Proliferation and Interferes with T-Cell-Mediated Induction of Costimulatory Molecule B7-2
    Cellular Immunology, vol. 165, no. 2, pp. 266–277, 1995
  59. Mutational analysis and an alternatively spliced product of B7 defines its CD28/CTLA4-binding site on immunoglobulin C-like domain
    Journal of Experimental Medicine, vol. 181, no. 4, pp. 1345–1355, 1995
  60. T cell costimulation by B7/BB1 induces CD8 T cell-dependent tumor rejection: an important role of B7/BB1 in the induction, recruitment, and effector function of antitumor T cells
    Journal of Experimental Medicine, vol. 179, no. 4, pp. 1205–1214, 1994
  61. Evolution of Vector Magnetic Field and White-Light Flares in a Solar Active Region (NOAA 6659) in 1991 June
    The Astrophysical Journal, vol. 423, p. 828, 1994
  62. Heat-stable antigen is a costimulatory molecule for CD4 T cell growth
    Journal of Experimental Medicine, vol. 175, no. 2, pp. 437–445, 1992