K. Ravi Acharya

Articles in Scholarly Journals [Incomplete List]

  1. Conformational Changes Induced by Binding UDP-2F-galactose to a-1,3 Galactosyltransferase- Implications for Catalysis
    Journal of Molecular Biology, vol. 369, no. 5, pp. 1270–1281, 2007
  2. Enzymatic and Structural Characterisation of Amphinase, a Novel Cytotoxic Ribonuclease from Rana pipiens Oocytes
    Journal of Molecular Biology, vol. 371, no. 1, pp. 93–111, 2007
  3. Biological and Structural Features of Murine Angiogenin-4, an Angiogenic Protein,
    Biochemistry, vol. 46, no. 9, pp. 2431–2443, 2007
  4. The Structure of Testis Angiotensin-Converting Enzyme in Complex with the C Domain-Specific Inhibitor RXPA380,
    Biochemistry, vol. 46, no. 18, pp. 5473–5478, 2007
  5. Identification of the protein receptor binding site of botulinum neurotoxins B and G proves the double-receptor concept
    Proceedings of the National Academy of Sciences, vol. 104, no. 1, pp. 359–364, 2007
  6. Constraining specificity in the N-domain of tissue inhibitor of metalloproteinases-1; gelatinase-selective inhibitors
    Protein Science, vol. 16, no. 9, pp. 1905–1913, 2007
  7. A family of killer toxins.
    FEBS Journal, vol. 273, no. 20, pp. 4579–4593, 2006
  8. Crystal Structure of Protoporphyrinogen Oxidase from Myxococcus xanthus and Its Complex with the Inhibitor Acifluorfen
    Journal of Biological Chemistry, vol. 281, no. 50, pp. 38625–38633, 2006
  9. Crystal Structure of the Catalytic Domain of Matrix Metalloproteinase-1 in Complex with the Inhibitory Domain of Tissue Inhibitor of Metalloproteinase-1
    Journal of Biological Chemistry, vol. 282, no. 1, pp. 364–371, 2006
  10. Biochemistry, vol. 45, no. 15, pp. 5082–5082, 2006
  11. ANG mutations segregate with familial and 'sporadic' amyotrophic lateral sclerosis
    Nature Genetics, vol. 38, no. 4, Article ID ng1742, 2 pages, 2006
  12. Biochemistry, vol. 45, no. 2, pp. 416–426, 2006
  13. Biochemistry, vol. 45, no. 42, pp. 12654–12663, 2006
  14. Human dendritic cells conditioned with Staphylococcus aureus enterotoxin B promote TH2 cell polarization
    Journal of Allergy and Clinical Immunology, vol. 117, no. 5, pp. 1141–1147, 2006
  15. Crystal Structure of the N Domain of Human Somatic Angiotensin I-converting Enzyme Provides a Structural Basis for Domain-specific Inhibitor Design
    Journal of Molecular Biology, vol. 357, no. 3, pp. 964–974, 2006
  16. Crystal Structure of Human Vascular Endothelial Growth Factor-B: Identification of Amino Acids Important for Receptor Binding
    Journal of Molecular Biology, vol. 359, no. 1, pp. 76–85, 2006
  17. Crystal Structure of an Active Form of Human MMP-1
    Journal of Molecular Biology, vol. 362, no. 1, pp. 78–88, 2006
  18. Molecular Recognition of Human Eosinophil-derived Neurotoxin (RNase 2) by Placental Ribonuclease Inhibitor
    Journal of Molecular Biology, vol. 347, no. 3, pp. 637–655, 2005
  19. The advantages and limitations of protein crystal structures
    Trends in Pharmacological Sciences, vol. 26, no. 1, pp. 10–14, 2005
  20. Biochemistry, vol. 44, no. 43, pp. 14152–14158, 2005
  21. Biochemistry, vol. 44, no. 18, pp. 6858–6866, 2005
  22. Journal of Proteome Research, vol. 4, no. 2, pp. 258–267, 2005
  23. Structure of murine angiogenin: features of the substrate- and cell-binding regions and prospects for inhibitor-binding studies
    Acta Crystallographica Section D Biological Crystallography, vol. 61, no. 12, pp. 1568–1578, 2005
  24. High-resolution diffraction from crystals of a membrane-protein complex: bacterial outer membrane protein OmpC complexed with the antibacterial eukaryotic protein lactoferrin
    Acta Crystallographica Section F Structural Biology and Crystallization Communications, vol. 61, no. 8, pp. 773–775, 2005
  25. Molecular recognition of an ADP-ribosylating Clostridium botulinum C3 exoenzyme by RalA GTPase
    Proceedings of the National Academy of Sciences, vol. 102, no. 15, pp. 5357–5362, 2005
  26. Crystal structure of human carbonic anhydrase II at 1.95 Å resolution in complex with 667-coumate, a novel anti-cancer agent
    Biochemical Journal, vol. 385, no. 3, p. 715, 2005
  27. Binding of non-natural 3'-nucleotides to ribonuclease A
    FEBS Journal, vol. 272, no. 3, pp. 744–755, 2005
  28. Crystal structure of a dimeric form of streptococcal pyrogenic exotoxin A (SpeA1)
    Protein Science, vol. 13, no. 9, pp. 2285–2290, 2004
  29. Identification of Placenta Growth Factor Determinants for Binding and Activation of Flt-1 Receptor
    Journal of Biological Chemistry, vol. 279, no. 42, pp. 43929–43939, 2004
  30. C3 exoenzyme from Clostridium botulinum: structure of a tetragonal crystal form and a reassessment of NAD-induced flexure
    Acta Crystallographica Section D Biological Crystallography, vol. 60, no. 8, pp. 1502–1505, 2004
  31. Superantigens: Structure-function relationships
    International Journal of Medical Microbiology, vol. 293, no. 7-8, pp. 529–537, 2004
  32. Crystal structures of Erythrina cristagalli lectin with bound N-linked oligosaccharide and lactose
    Glycobiology, vol. 14, no. 10, pp. 923–929, 2004
  33. Roles of active site tryptophans in substrate binding and catalysis by  -1,3 galactosyltransferase
    Glycobiology, vol. 14, no. 12, pp. 1295–1302, 2004
  34. Biochemistry, vol. 43, no. 27, pp. 8718–8724, 2004
  35. What?s new in the renin-angiotensin system?
    Cellular and Molecular Life Sciences, vol. 61, no. 21, pp. 2677–2686, 2004
  36. Crystal Structures of Oligomeric Forms of the IP-10/CXCL10 Chemokine
    Structure, vol. 11, no. 5, pp. 521–532, 2003
  37. The Crystal Structure of Human Angiogenin in Complex with an Antitumor Neutralizing Antibody
    Structure, vol. 11, no. 7, pp. 875–885, 2003
  38. Biochemistry, vol. 42, no. 6, pp. 1451–1459, 2003
  39. Biochemistry, vol. 42, no. 45, pp. 13185–13192, 2003
  40. Biochemistry, vol. 42, no. 46, pp. 13512–13521, 2003
  41. Ace revisited: A new target for structure-based drug design
    Nature Reviews Drug Discovery, vol. 2, no. 11, Article ID nrd1227, 11 pages, 2003
  42. Deglycosylation, processing and crystallization of human testis angiotensin-converting enzyme
    Biochemical Journal, vol. 371, no. 2, p. 437, 2003
  43. High-resolution crystal structures of ribonuclease A complexed with adenylic and uridylic nucleotide inhibitors. Implications for structure-based design of ribonucleolytic inhibitors
    Protein Science, vol. 12, no. 11, pp. 2559–2574, 2003
  44. Crystal structure of the human angiotensin-converting enzyme–lisinopril complex
    Nature, vol. 421, no. 6922, Article ID nature01370, 3 pages, 2003
  45. Identification of a Secondary Zinc-binding Site in Staphylococcal Enterotoxin C2: IMPLICATIONS FOR SUPERANTIGEN RECOGNITION
    Journal of Biological Chemistry, vol. 279, no. 2, pp. 1297–1303, 2003
  46. The Crystal Structure of C3stau2 from Staphylococcus aureus and Its Complex with NAD
    Journal of Biological Chemistry, vol. 278, no. 46, pp. 45924–45930, 2003
  47. Structural and Functional Role of Threonine 112 in a Superantigen Staphylococcus aureus Enterotoxin B
    Journal of Biological Chemistry, vol. 277, no. 4, pp. 2756–2762, 2002
  48. Charcot-Leyden Crystal Protein (Galectin-10) Is Not a Dual Function Galectin with Lysophospholipase Activity but Binds a Lysophospholipase Inhibitor in a Novel Structural Fashion
    Journal of Biological Chemistry, vol. 277, no. 17, pp. 14859–14868, 2002
  49. Structural Basis of Ordered Binding of Donor and Acceptor Substrates to the Retaining Glycosyltransferase, alpha -1,3-Galactosyltransferase
    Journal of Biological Chemistry, vol. 277, no. 31, pp. 28310–28318, 2002
  50. Role of Placenta Growth Factor in Cardiovascular Health
    Trends in Cardiovascular Medicine, vol. 12, no. 3, pp. 128–134, 2002
  51. Biochemistry, vol. 41, no. 8, pp. 2552–2562, 2002
  52. Biochemistry, vol. 41, no. 10, pp. 3341–3352, 2002
  53. Biochemistry, vol. 41, no. 33, pp. 10482–10489, 2002
  54. Biochemistry, vol. 41, no. 40, pp. 12100–12106, 2002
  55. Botulinum and tetanus neurotoxins: structure, function and therapeutic utility
    Trends in Biochemical Sciences, vol. 27, no. 11, pp. 552–558, 2002
  56. High-Level Expression of Three Members of the Murine Angiogenin Family in Escherichia coli and Purification of the Recombinant Proteins
    Protein Expression and Purification, vol. 22, no. 2, pp. 307–317, 2001
  57. Biochemistry, vol. 40, no. 34, pp. 10262–10272, 2001
  58. The Crystal Structure of Human Placenta Growth Factor-1 (PlGF-1), an Angiogenic Protein, at 2.0 A Resolution
    Journal of Biological Chemistry, vol. 276, no. 15, pp. 12153–12161, 2001
  59. Mapping the Ribonucleolytic Active Site of Eosinophil-derived Neurotoxin (EDN). HIGH RESOLUTION CRYSTAL STRUCTURES OF EDN COMPLEXES WITH ADENYLIC NUCLEOTIDE INHIBITORS
    Journal of Biological Chemistry, vol. 276, no. 18, pp. 15009–15017, 2001
  60. Crystal Structure of the Eosinophil Major Basic Protein at 1.8 A. AN ATYPICAL LECTIN WITH A PARADIGM SHIFT IN SPECIFICITY
    Journal of Biological Chemistry, vol. 276, no. 28, pp. 26197–26203, 2001
  61. Crystallization and preliminary investigations on a telomeric repeat sequence C4A2C4A2
    Acta Crystallographica Section D Biological Crystallography, vol. 57, no. 6, pp. 873–875, 2001
  62. Binding of Phosphate and pyrophosphate ions at the active site of human angiogenin as revealed by X-ray crystallography
    Protein Science, vol. 10, no. 8, pp. 1669–1676, 2001
  63. Role of conserved residues in structure and stability: Tryptophans of human serum retinol-binding protein, a model for the lipocalin superfamily
    Protein Science, vol. 10, no. 11, pp. 2301–2316, 2001
  64. Structural features of a zinc binding site in the superantigen strepococcal pyrogenic exotoxin A (SpeA1): Implications for MHC class II recognition
    Protein Science, vol. 10, no. 6, pp. 1268–1273, 2001
  65. Crystal Structures of Apo- and Holo-bovine alpha -Lactalbumin at 2.2-A Resolution Reveal an Effect of Calcium on Inter-lobe Interactions
    Journal of Biological Chemistry, vol. 275, no. 47, pp. 37021–37029, 2000
  66. The crystal structure of the Fab fragment of a rat monoclonal antibody against the main immunogenic region of the human muscle acetylcholine receptor
    European Journal of Biochemistry, vol. 267, no. 8, pp. 2389–2397, 2000
  67. Microbial superantigens: from structure to function
    Trends in Microbiology, vol. 8, no. 8, pp. 369–375, 2000
  68. Refined Crystal Structures of Native Human Angiogenin and Two Active Site Variants: Implications for the Unique Functional Properties of an Enzyme Involved in Neovascularisation During Tumour Growth,
    Journal of Molecular Biology, vol. 285, no. 3, pp. 1209–1233, 1999
  69. Biochemistry, vol. 38, no. 42, pp. 13837–13843, 1999
  70. Biochemistry, vol. 38, no. 32, pp. 10287–10297, 1999
  71. Biochemistry, vol. 38, no. 51, pp. 16794–16801, 1999
  72. Biochemistry, vol. 38, no. 46, pp. 15406–15406, 1999
  73. Crystal structure of a hybrid between ribonuclease A and bovine seminal ribonuclease - the basic surface, at 2.0 A resolution
    European Journal of Biochemistry, vol. 260, no. 1, pp. 176–182, 1999
  74. Structural basis for the recognition of superantigen streptococcal pyrogenic exotoxin A (SpeA1) by MHC class II molecules and T-cell receptors
    The EMBO Journal, vol. 18, no. 1, pp. 9–21, 1999
  75. Stability, activity and flexibility in  -lactalbumin
    Protein Engineering Design and Selection, vol. 12, no. 7, pp. 581–587, 1999
  76. Biochemistry, vol. 37, no. 14, pp. 4767–4772, 1998
  77. Biochemistry, vol. 37, no. 40, pp. 13930–13940, 1998
  78. Crystal structure of microbial superantigen staphylococcal enterotoxin B at 1.5 Å resolution: implications for superantigen recognition by MHC class II molecules and T-cell receptors
    Journal of Molecular Biology, vol. 277, no. 1, pp. 61–79, 1998
  79. A structural and functional comparison of staphylococcal enterotoxins A and C2 reveals remarkable similarity and dissimilarity
    Journal of Molecular Biology, vol. 269, no. 2, pp. 270–280, 1997
  80. Biochemistry, vol. 36, no. 18, pp. 5578–5588, 1997
  81. Superantigens as immunomodulators: recent structural insights
    Structure, vol. 5, no. 8, pp. 991–996, 1997
  82. Molecular recognition of human angiogenin by placental ribonuclease inhibitor_an X-ray crystallographic study at 2.0Aresolution
    The EMBO Journal, vol. 16, no. 17, pp. 5162–5177, 1997
  83. Investigation of spectral content from discrete plantar areas during adult gait: an expansion of rehabilitation technology
    IEEE Transactions on Rehabilitation Engineering, vol. 4, no. 4, pp. 360–374, 1996
  84. A combined kinetic and modeling study of the catalytic center subsites of human angiogenin
    Proceedings of the National Academy of Sciences, vol. 93, no. 2, pp. 804–808, 1996
  85. The Refined Crystal Structure of Toxic Shock Syndrome Toxin-1 at 2.07 Å Resolution
    Journal of Molecular Biology, vol. 260, no. 4, pp. 553–569, 1996
  86. Characterisation, crystallisation and preliminary X-ray diffraction analysis of a Fab fragment of a rat monoclonal antibody with very high affinity for the human muscle acetylcholine receptor
    FEBS Letters, vol. 389, no. 2, pp. 195–198, 1996
  87. Amino acid sequence and crystal structure of buffalo a-lactalbumin
    FEBS Letters, vol. 394, no. 1, pp. 91–95, 1996
  88. Crystal structures of guinea-pig, goat and bovine ?-lactalbumin highlight the enhanced conformational flexibility of regions that are significant for its action in lactose synthase
    Structure, vol. 4, no. 6, pp. 691–703, 1996
  89. Crystal structure of the superantigen enterotoxin C2 from Staphylococcus aureus reveals a zinc-binding site
    Structure, vol. 3, no. 8, pp. 769–779, 1995
  90. Crystal structure of human Charcot?Leyden crystal protein, an eosinophil lysophospholipase, identifies it as a new member of the carbohydrate-binding family of galectins
    Structure, vol. 3, no. 12, pp. 1379–1393, 1995
  91. The Binding of 2-Deoxy-?-glucose 6-Phosphate to Glycogen Phosphorylaseb: Kinetic and Crystallographic Studies
    Journal of Molecular Biology, vol. 254, no. 5, pp. 900–917, 1995
  92. Crystal Structure of Bovine Angiogenin at 1.5-A Resolution
    Proceedings of the National Academy of Sciences, vol. 92, no. 7, pp. 2949–2953, 1995
  93. Crystal Structure of Human Angiogenin Reveals the Structural Basis for Its Functional Divergence from Ribonuclease
    Proceedings of the National Academy of Sciences, vol. 91, no. 8, pp. 2915–2919, 1994
  94. Role of Glutamine-117 in the Ribonucleolytic Activity of Human Angiogenin
    Proceedings of the National Academy of Sciences, vol. 91, no. 8, pp. 2920–2924, 1994
  95. A comparison of the predicted and X-ray structures of angiogenin. Implications for further studies of model building of homologous proteins
    Journal of Protein Chemistry, vol. 13, no. 7, pp. 649–658, 1994
  96. Models of the three-dimensional structures of echidna, horse, and pigeon lysozymes: Calcium-binding lysozymes and their relationship with a-lactalbumins
    Journal of Protein Chemistry, vol. 13, no. 6, pp. 569–584, 1994
  97. Structural basis of superantigen action inferred from crystal structure of toxic-shock syndrome toxin-1
    Nature, vol. 367, no. 6458, Article ID 367094a0, 3 pages, 1994
  98. Crystallographic Binding Studies on the Allosteric Inhibitor Glucose-6-Phosphate to T State Glycogen Phosphorylase b
    Journal of Molecular Biology, vol. 232, no. 1, pp. 253–267, 1993
  99. Crystallization and Preliminary X-ray Analysis of a Microbial Superantigen Staphylococcal Enterotoxin C2
    Journal of Molecular Biology, vol. 233, no. 1, pp. 170–172, 1993
  100. Molecular Modelling of Malaria Calmodulin Suggests that it is not a Suitable Target for Novel Antimalarials
    Philosophical Transactions of the Royal Society B: Biological Sciences, vol. 340, no. 1291, pp. 39–53, 1993
  101. Purification, crystallization and preliminary X-ray analysis of toxic shock syndrome toxin-1 from Staphylococcus aureus
    Journal of Molecular Biology, vol. 228, no. 3, pp. 983–986, 1992
  102. Crystal structure of human a-lactalbumin at 1·7 Å resolution
    Journal of Molecular Biology, vol. 221, no. 2, pp. 571–581, 1991
  103. Refined crystal structure of the phosphorylase-heptulose 2-phosphate-oligosaccharide-AMP complex
    Journal of Molecular Biology, vol. 211, no. 3, pp. 645–661, 1990
  104. A critical evaluation of the predicted and X-ray structures of ?-Lactalbumin
    Journal of Protein Chemistry, vol. 9, no. 5, pp. 549–563, 1990
  105. The binding of ?-glycerophosphate to glycogen phosphorylase b in the crystal
    Archives of Biochemistry and Biophysics, vol. 270, no. 1, pp. 62–68, 1989
  106. Refined structure of baboon ?-lactalbumin at 1.7 p resolution Comparison with C-type lysozyme
    Journal of Molecular Biology, vol. 208, no. 1, pp. 99–127, 1989
  107. Catalysis in enzyme crystals
    Trends in Biochemical Sciences, vol. 13, no. 3, pp. 104–109, 1988
  108. Structural changes in glycogen phosphorylase induced by phosphorylation
    Nature, vol. 336, no. 6196, Article ID 336215a0, 6 pages, 1988
  109. Biochemistry, vol. 27, no. 18, pp. 6733–6741, 1988
  110. Uridine(5')diphospho(1)-alpha-d-glucose. A binding study to glycogen phosphorylase b in the crystal
    European Journal of Biochemistry, vol. 173, no. 3, pp. 569–578, 1988
  111. Biochemistry, vol. 26, no. 25, pp. 8381–8389, 1987
  112. Crystallization and preliminary X-ray diffraction analysis of foot-and-mouth disease virus
    Journal of Molecular Biology, vol. 196, no. 3, pp. 591–597, 1987
  113. a-Lactalbumin possesses a novel calcium binding loop
    Nature, vol. 324, no. 6092, Article ID 324084a0, 3 pages, 1986