Xiangming Guan received his B.S. degree in pharmacy from the Zhejiang Medical University in China in 1982. He also earned his M.S. (1988) and Ph.D. (1991) degrees in medicinal chemistry on asymmetric synthesis under the supervision of Professor Gunda I. Georg at the University of Kansas (KU) in Lawrence, Kansas (USA). Guan received one-year postdoctoral training in Professor Ronald T. Borchardt’s group in the Department of Pharmaceutical Chemistry at KU working on the mechanism of autoxidation of the serotonergic neurotoxin 5,7-dihydroxytryptamine. He then moved to Seattle joining Professor Thomas A. Baillie, from 1992 to 1994, and Professor Allan E. Rettie from 1994 to 1995, at the University of Washington (USA) as a Postdoctoral Fellow working on drug metabolism. He took a position as an Assistant Professor in the Department of Pharmaceutical Sciences at South Dakota State University, Brookings, South Dakota (USA) and became an Associate Professor in 2000 and a Professor in 2005. His research interests include thiol oxidative stress, development of anticancer agents with novel mechanism of action (synthesis and evaluation of compounds through assays using enzymes and cells), development of analytical methodologies for biological applications (HPLC, LC/MS), and development of thiol-specific fluorogenic agents for live cell imaging.
Biography Updated on 6 December 2011