Florence Janody achieved her Ph.D. degree at Developmental Biology Institute of Marseille (IBDM) in France, where she tried to understand how signaling cascades regulate transcriptional activation of target genes in Drosophila. She moved in 2000 to the Laboratory of Jessica Treisman, at Skirball Institute in New York as a Postdoctoral Fellow, with the goal of characterizing novel genes required for early eye differentiation. Following a mosaic genetic screen in Drosophila, Janody identified mutations for genes that restrict actin filament polymerization, giving her the opportunity to understand how the actin cytoskeleton network promotes differentiation in the context of a whole organism. In August 2004, she moved to the IBDM as an invited researcher, where she has started to understand these processes before establishing her team in Portugal at the Gulbenkian Institute in July 2006. Over the past 5 years, her team has shown that to respond appropriately to signal sent by others cells, the actin cytoskeleton is critical to transduce intracellular signal transduction pathways involved in growth control and cell differentiation. Janody's work suggests that distinct filament actin-based structures prevent conflicts among cells within cellular communities, preventing in this way tumor development. Her present and future goals are to identify these actin filament populations and understand their role in regulating signalling pathway involved in growth control.
Biography Updated on 19 September 2011