Peter O'Brien

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http://www.pharmacy.utoronto.ca/graduate/faculty/obrien.jsp

Articles in Scholarly Journals [Incomplete List]

  1. Copper-catalyzed ascorbate oxidation results in glyoxal/AGE formation and cytotoxicity
    Molecular Nutrition & Food Research, vol. 51, no. 4, pp. 445–455, 2007
  2. Hepatocyte susceptibility to glyoxal is dependent on cell thiamin content
    Chemico-Biological Interactions, vol. 165, no. 2, pp. 146–154, 2007
  3. Structure–activity relationships for halobenzene induced cytotoxicity in rat and human hepatoctyes
    Chemico-Biological Interactions, vol. 165, no. 3, pp. 165–174, 2007
  4. Molecular cytotoxic mechanisms of catecholic polychlorinated biphenyl metabolites in isolated rat hepatocytes
    Chemico-Biological Interactions, vol. 167, no. 3, pp. 184–192, 2007
  5. A thermolyzed diet increases oxidative stress, plasma a-aldehydes and colonic inflammation in the rat
    Chemico-Biological Interactions, vol. 169, no. 2, pp. 100–109, 2007
  6. CASE REPORT: Plastic Deformation of the Forearm in an Adult
    Clinical Orthopaedics and Related Research, vol. 462, pp. 234–237, 2007
  7. Molecular Mechanisms of Hydrogen Sulfide Toxicity*
    Drug Metabolism Reviews, vol. 38, no. 4, pp. 733–744, 2006
  8. Blood cardiac troponin in toxic myocardial injury: archetype of a translational safety biomarker
    Expert Review of Molecular Diagnostics, vol. 6, no. 5, pp. 685–702, 2006
  9. Mitochondrial function and toxicity: Role of the B vitamin family on mitochondrial energy metabolism
    Chemico-Biological Interactions, vol. 163, no. 1-2, pp. 94–112, 2006
  10. Mitochondrial involvement in genetically determined transition metal toxicityI. Iron toxicity
    Chemico-Biological Interactions, vol. 163, no. 1-2, pp. 68–76, 2006
  11. Mitochondrial function and toxicity: Role of B vitamins on the one-carbon transfer pathways
    Chemico-Biological Interactions, vol. 163, no. 1-2, pp. 113–132, 2006
  12. Mitochondrial involvement in genetically determined transition metal toxicityII. Copper toxicity
    Chemico-Biological Interactions, vol. 163, no. 1-2, pp. 77–85, 2006
  13. Cellular and in vivo hepatotoxicity caused by green tea phenolic acids and catechins
    Free Radical Biology and Medicine, vol. 40, no. 4, pp. 570–580, 2006
  14. Optimization of analytical and pre-analytical variables associated with an ex vivo cytokine secretion assay
    Journal of Pharmaceutical and Biomedical Analysis, vol. 41, no. 1, pp. 189–195, 2006
  15. Herbal monoterpene alcohols inhibit propofol metabolism and prolong anesthesia time
    Life Sciences, vol. 79, no. 1, pp. 21–29, 2006
  16. Fit-for-Purpose Method Development and Validation for Successful Biomarker Measurement
    Pharmaceutical Research, vol. 23, no. 2, pp. 312–328, 2006
  17. Glyoxal markedly compromises hepatocyte resistance to hydrogen peroxide
    Biochemical Pharmacology, vol. 71, no. 11, pp. 1610–1618, 2006
  18. Coenzyme Q1 depletes NAD(P)H and impairs recycling of ascorbate in astrocytes
    Brain Research, vol. 1078, no. 1, pp. 9–18, 2006
  19. Application of quantitative structure?toxicity relationships for acute NSAID cytotoxicity in rat hepatocytes
    Chemico-Biological Interactions, vol. 151, no. 3, pp. 177–191, 2005
  20. Metabolic products and pathways of fluorotelomer alcohols in isolated rat hepatocytes
    Chemico-Biological Interactions, vol. 155, no. 3, pp. 165–180, 2005
  21. Development of Novel Nonaqueous Ethylcellulose Gel Matrices: Rheological and Mechanical Characterization
    Pharmaceutical Research, vol. 22, no. 4, pp. 676–684, 2005
  22. A comparison of hepatocyte cytotoxic mechanisms for chromate and arsenite
    Toxicology, vol. 206, no. 3, pp. 449–460, 2005
  23. The effects of partial thiamin deficiency and oxidative stress (i.e., glyoxal and methylglyoxal) on the levels of a-oxoaldehyde plasma protein adducts in Fischer 344 rats
    FEBS Letters, 2005
  24. The biosynthesis of ascorbate protects isolated rat hepatocytes from cumene hydroperoxide-mediated oxidative stress
    Free Radical Biology and Medicine, vol. 38, no. 7, pp. 867–873, 2005
  25. Mechanism of Mitochondrial Uncouplers, Inhibitors, and Toxins: Focus on Electron Transfer, Free Radicals, and Structure -Activity Relationships
    Current Medicinal Chemistry, vol. 12, no. 22, pp. 2601–2623, 2005
  26. Accelerated Cytotoxicity Mechanism Screening Using Drug Metabolising Enzyme Modulators
    Current Drug Metabolism, vol. 6, no. 2, pp. 101–109, 2005
  27. An Unusual Fracture of the Talus in a Snowboarder
    Journal of Orthopaedic Trauma, vol. 19, no. 7, pp. 498–500, 2005
  28. Aldehyde Sources, Metabolism, Molecular Toxicity Mechanisms, and Possible Effects on Human Health
    Critical Reviews in Toxicology, vol. 35, no. 7, pp. 609–662, 2005
  29. Oxidative Stress Mediated Idiosyncratic Drug Toxicity
    Drug Metabolism Reviews, vol. 37, no. 2, pp. 311–325, 2005
  30. The Novel Apolipoprotein A5 Is Present in Human Serum, Is Associated with VLDL, HDL, and Chylomicrons, and Circulates at Very Low Concentrations Compared with Other Apolipoproteins
    Clinical Chemistry, vol. 51, no. 2, pp. 351–359, 2005
  31. Drug-induced mitochondrial toxicity
    Expert Opinion on Drug Metabolism Toxicology, vol. 1, no. 4, pp. 655–669, 2005
  32. Sulfation and Glucuronidation of Phenols: Implications in Coenyzme Q Metabolism
    Methods in Enzymology, vol. 400, pp. 342–359, 2005
  33. Peroxidases: a role in the metabolism and side effects of drugs
    Drug Discovery Today, vol. 10, no. 9, pp. 617–625, 2005
  34. Chemical Research in Toxicology, vol. 18, no. 10, pp. 1567–1574, 2005
  35. Chemical Research in Toxicology, vol. 17, no. 10, pp. 1350–1355, 2004
  36. Application of Quantitative Structure-Toxicity Relationships for the Comparison of the Cytotoxicity of 14 p-Benzoquinone Congeners in Primary Cultured Rat Hepatocytes Versus PC12 Cells
    Toxicological Sciences, vol. 81, no. 1, pp. 148–159, 2004
  37. The Escherichia coli 3-Methyladenine DNA Glycosylase AlkA Has a Remarkably Versatile Active Site
    Journal of Biological Chemistry, vol. 279, no. 26, pp. 26876–26884, 2004
  38. Potential toxicity of flavonoids and other dietary phenolics: significance for their chemopreventive and anticancer properties1
    Free Radical Biology and Medicine, vol. 37, no. 3, pp. 287–303, 2004
  39. H2S cytotoxicity mechanism involves reactive oxygen species formation and mitochondrial depolarisation
    Toxicology, vol. 203, no. 1-3, pp. 69–76, 2004
  40. Myocardial concentration of cardiac troponin T as an early discriminator of mechanisms of cardiac hypertrophy
    Comparative Clinical Pathology , vol. 13, no. 2, pp. 59–64, 2004
  41. Quantitative structure toxicity relationships for catechols in isolated rat hepatocytes
    Chemico-Biological Interactions, vol. 147, no. 3, pp. 297–307, 2004
  42. Molecular cytotoxic mechanisms of anticancer hydroxychalcones
    Chemico-Biological Interactions, vol. 148, no. 1-2, pp. 57–67, 2004
  43. Human and animal hepatocytes in vitro with extrapolation in vivo
    Chemico-Biological Interactions, vol. 150, no. 1, pp. 97–114, 2004
  44. Applications of cytotoxicity assays and pre-lethal mechanistic assays for assessment of human hepatotoxicity potential
    Chemico-Biological Interactions, vol. 150, no. 1, pp. 115–128, 2004
  45. Peroxidase catalysed formation of cytotoxic prooxidant phenothiazine free radicals at physiological pH
    Chemico-Biological Interactions, vol. 151, no. 1, pp. 43–51, 2004
  46. Glycogenolysis is directed towards ascorbate synthesis by glutathione conjugation
    Biochemical and Biophysical Research Communications, vol. 317, no. 1, pp. 149–156, 2004
  47. The cytotoxic mechanism of glyoxal involves oxidative stress
    Biochemical Pharmacology, vol. 68, no. 7, pp. 1433–1442, 2004
  48. Marginal dietary thiamin deficiency induces the formation of colonic aberrant crypt foci (ACF) in rats
    Cancer Letters, vol. 202, no. 2, pp. 125–129, 2003
  49. Metabolic activation of 3-hydroxyanisole by isolated rat hepatocytes
    Chemico-Biological Interactions, vol. 142, no. 3, pp. 317–333, 2003
  50. Modulating carbonyl cytotoxicity in intact rat hepatocytes by inhibiting carbonyl-metabolizing enzymes. I. Aliphatic alkenals
    Chemico-Biological Interactions, vol. 143-144, pp. 107–117, 2003
  51. Modulating carbonyl cytotoxicity in intact rat hepatocytes by inhibiting carbonyl metabolizing enzymes. II. Aromatic aldehydes
    Chemico-Biological Interactions, vol. 143-144, pp. 119–128, 2003
  52. Quantitative structure toxicity relationships for phenols in isolated rat hepatocytes
    Chemico-Biological Interactions, vol. 145, no. 2, pp. 213–223, 2003
  53. Differential expression of the lenticular antioxidant system in laboratory animals: A determinant of species predilection to oxidative stress-induced ocular toxicity?
    Current Eye Research, vol. 26, no. 1, pp. 15–23, 2003
  54. Simultaneous Detection of the Antioxidant and Pro-oxidant Activity of Dietary Polyphenolics in a Peroxidase System
    Free Radical Research, vol. 37, no. 7, pp. 787–794, 2003
  55. Carcinogenic metal induced sites of reactive oxygen species formation in hepatocytes
    Toxicology in Vitro, vol. 17, no. 5-6, pp. 803–810, 2003
  56. Dietary flavonoid iron complexes as cytoprotective superoxide radical scavengers
    Free Radical Biology and Medicine, vol. 34, no. 2, pp. 243–253, 2003
  57. Biochemistry, vol. 42, no. 42, pp. 12418–12429, 2003
  58. Molecular and Cellular Biochemistry, vol. 252, no. 1/2, pp. 331–338, 2003
  59. Molecular and Cellular Biochemistry, vol. 252, no. 1/2, pp. 205–211, 2003
  60. Dissecting the Broad Substrate Specificity of Human 3-Methyladenine-DNA Glycosylase
    Journal of Biological Chemistry, vol. 279, no. 11, pp. 9750–9757, 2003
  61. Journal of the American Chemical Society, vol. 124, no. 38, pp. 11295–11306, 2002
  62. Endogenous and endobiotic induced reactive oxygen species formation by isolated hepatocytes
    Free Radical Biology and Medicine, vol. 32, no. 1, pp. 2–10, 2002
  63. Biochemistry, vol. 41, no. 9, pp. 3207–3225, 2002
  64. Metabolism of caffeic acid by isolated rat hepatocytes and subcellular fractions
    Toxicology Letters, vol. 133, no. 2-3, pp. 141–151, 2002
  65. Prooxidant activity of free radicals derived from phenol-containing neurotransmitters
    Toxicology, vol. 177, no. 1, pp. 81–90, 2002
  66. Prooxidant activity and cellular effects of the phenoxyl radicals of dietary flavonoids and other polyphenolics
    Toxicology, vol. 177, no. 1, pp. 91–104, 2002
  67. N-OXIDATION OF AROMATIC AMINES BY INTRACELLULAR OXIDASES
    Drug Metabolism Reviews, vol. 34, no. 3, pp. 549–564, 2002
  68. Coenzyme Q Cytoprotective Mechanisms for Mitochondrial Complex I Cytopathies Involves NAD(P)H: Quinone Oxidoreductase 1(NQO1)
    Free Radical Research, vol. 36, no. 4, pp. 421–427, 2002
  69. Journal of Orthopaedic Trauma, vol. 16, no. 7, pp. 498–502, 2002
  70. Comparative quantitative structure toxicity relationships for flavonoids evaluated in isolated rat hepatocytes and HeLa tumor cells
    Chemico-Biological Interactions, vol. 139, no. 3, pp. 251–264, 2002
  71. Idiosyncratic NSAID drug induced oxidative stress
    Chemico-Biological Interactions, vol. 142, no. 1-2, pp. 25–41, 2002
  72. Effect of Diquat on the Antioxidant System and Cell Growth in Human Neuroblastoma Cells
    Toxicology and Applied Pharmacology, vol. 178, no. 2, pp. 63–70, 2002
  73. Flavonoid B-Ring Chemistry and Antioxidant Activity: Fast Reaction Kinetics
    Biochemical and Biophysical Research Communications, vol. 282, no. 5, pp. 1161–1168, 2001
  74. Cytochrome P450 2E1 metabolically activates propargyl alcohol: propiolaldehyde-induced hepatocyte cytotoxicity
    Chemico-Biological Interactions, vol. 130-132, no. 1-3, pp. 931–942, 2001
  75. The formaldehyde metabolic detoxification enzyme systems and molecular cytotoxic mechanism in isolated rat hepatocytes
    Chemico-Biological Interactions, vol. 130-132, no. 1-3, pp. 285–296, 2001
  76. Iron complexes of deferiprone and dietary plant catechols as cytoprotective superoxide radical scavengers
    Biochemical Pharmacology, vol. 62, no. 12, pp. 1579–1585, 2001
  77. Gene induction by coagulation factor Xa is mediated by activation of protease-activated receptor 1
    Blood, vol. 97, no. 10, pp. 3109–3116, 2001
  78. Biochemistry, vol. 40, no. 19, pp. 5691–5699, 2001
  79. Lysosomal involvement in hepatocyte cytotoxicity induced by Cu2+ but not Cd2+
    Free Radical Biology and Medicine, vol. 30, no. 1, pp. 89–97, 2001
  80. Peroxidative metabolism of apigenin and naringenin versus luteolin and quercetin: glutathione oxidation and conjugation
    Free Radical Biology and Medicine, vol. 30, no. 4, pp. 370–382, 2001
  81. Chemical Research in Toxicology, vol. 14, no. 7, pp. 841–848, 2001
  82. Evaluation of the Substrate Specificity of Human Mast Cell Tryptase beta I and Demonstration of Its Importance in Bacterial Infections of the Lung
    Journal of Biological Chemistry, vol. 276, no. 28, pp. 26276–26284, 2001
  83. Nature Medicine, vol. 7, no. 7, pp. 814–820, 2001
  84. Protease activated receptors: theme and variations
    Oncogene, vol. 20, no. 13, Article ID 1204194, 11 pages, 2001
  85. Loss of signaling through the G protein, Gz, results in abnormal platelet activation and altered responses to psychoactive drugs
    Proceedings of the National Academy of Sciences, vol. 97, no. 18, pp. 9984–9989, 2000
  86. Thrombin Responses in Human Endothelial Cells. CONTRIBUTIONS FROM RECEPTORS OTHER THAN PAR1 INCLUDE THE TRANSACTIVATION OF PAR2 BY THROMBIN-CLEAVED PAR1
    Journal of Biological Chemistry, vol. 275, no. 18, pp. 13502–13509, 2000
  87. A comparison of hepatocyte cytotoxic mechanisms for Cu2+ and Cd2+
    Toxicology, vol. 143, no. 3, pp. 263–273, 2000
  88. Superoxide radical scavenging and attenuation of hypoxia-reoxygenation injury by neurotransmitter ferric complexes in isolated rat hepatocytes
    Neuroscience Letters, vol. 296, no. 1, pp. 37–40, 2000
  89. Reamed nailing of Gustilo grade-IIIB tibial fractures
    The Journal of Bone and Joint Surgery, vol. 82, no. 8, pp. 1113–1116, 2000
  90. Contrasting role of Na+ ions in modulating Cu+2 or Cd+2 induced hepatocyte toxicity
    Chemico-Biological Interactions, vol. 126, no. 2, pp. 159–169, 2000
  91. Peroxidases
    Chemico-Biological Interactions, vol. 129, no. 1-2, pp. 113–139, 2000
  92. Fully-automated spectrophotometric method for measurement of antioxidant activity of catalase
    Clinical Biochemistry, vol. 33, no. 7, pp. 525–534, 2000
  93. Role of the cellular redox state in modulating acute ethanol toxicity in isolated hepatocytes
    Clinical Biochemistry, vol. 32, no. 7, pp. 585–589, 1999
  94. Oxygen activation during peroxidase catalysed metabolism of flavones or flavanones
    Chemico-Biological Interactions, vol. 122, no. 1, pp. 15–25, 1999
  95. Evaluation of Alamar Blue Reduction for the In Vitro Assay of Hepatocyte Toxicity
    Toxicology in Vitro, vol. 13, no. 4-5, pp. 567–569, 1999
  96. The effects of heme-binding proteins on the peroxidative and catalatic activities of hemin
    Free Radical Biology and Medicine, vol. 27, no. 1-2, pp. 214–219, 1999
  97. Chemical Research in Toxicology, vol. 12, no. 6, pp. 521–525, 1999
  98. Journal of the American Chemical Society, vol. 121, no. 47, pp. 11022–11023, 1999
  99. Journal of the American Chemical Society, vol. 120, no. 47, pp. 12369–12370, 1998
  100. Differential reactivity of cardiac and skeletal muscle from various species in two generations of cardiac troponin-T immunoassays
    Research in Veterinary Science, vol. 65, no. 2, pp. 135–137, 1998
  101. The glutathione dependence of inorganic sulfate formation from ?- or ?-cysteine in isolated rat hepatocytes
    Chemico-Biological Interactions, vol. 110, no. 3, pp. 189–202, 1998
  102. Erratum
    Chemico-Biological Interactions, vol. 114, no. 1-2, p. 141, 1998
  103. Hepatocyte-Catalysed Detoxification of Cyanide by ?- and ?-Cysteine
    Biochemical Pharmacology, vol. 55, no. 12, pp. 1983–1990, 1998
  104. Catecholic iron complexes as cytoprotective superoxide scavengers against hypoxia:reoxygenation injury in isolated hepatocytes
    Biochemical Pharmacology, vol. 56, no. 7, pp. 825–830, 1998
  105. The prevention of ferric nitrilotriacetate-induced nephro- and hepatotoxicity by methylenedioxybenzene antioxidants
    Chemico-Biological Interactions, vol. 108, no. 1-2, pp. 107–118, 1997
  106. Rapid and Specific Efflux of Glutathione before Hepatocyte Injury Induced by Hypoxia
    Biochemical and Biophysical Research Communications, vol. 238, no. 2, pp. 320–322, 1997
  107. Chemical Research in Toxicology, vol. 10, no. 5, pp. 582–588, 1997
  108. Phenylenediamine induced hepatocyte cytotoxicity redox Cycling mediated oxidative stress without oxygen activation
    Biochimica et Biophysica Acta (BBA) - General Subjects, vol. 1335, no. 3, pp. 343–352, 1997
  109. Knee Pain After Tibial Nailing
    Journal of Orthopaedic Trauma, vol. 11, no. 1, pp. 10–13, 1997
  110. Targeting of HIV- and SIV-Infected Cells by CD4-Chemokine Receptor Pseudotypes
    Science, vol. 278, no. 5342, pp. 1462–1464, 1997
  111. Journal of Orthopaedic Trauma, vol. 10, no. 5, pp. 298–303, 1996
  112. Chemical Research in Toxicology, vol. 9, no. 6, pp. 924–931, 1996
  113. Antidotal Effect of Dihydroxyacetone against Cyanide Toxicityin Vivo
    Toxicology and Applied Pharmacology, vol. 138, no. 1, pp. 186–191, 1996
  114. The Prevention of CCl4-Induced Liver Necrosis in Mice by Naturally Occurring Methylenedioxybenzenes
    Toxicology and Applied Pharmacology, vol. 140, no. 2, pp. 411–421, 1996
  115. Involvement of nitric oxide in nitroprusside-induced hepatocyte cytotoxicity
    Biochemical Pharmacology, vol. 51, no. 8, pp. 1031–1039, 1996
  116. Effect of a high omega-3 fatty acid diet on cardiac contractile performance in Oncorhynchus mykiss
    Cardiovascular Research, vol. 31, no. 2, pp. 249–262, 1996
  117. Hepatocyte injury resulting from the inhibition of mitochondrial respiration at low oxygen concentrations involves reductive stress and oxygen activation
    Chemico-Biological Interactions, vol. 98, no. 1, pp. 27–44, 1995
  118. Modulating hypoxia-induced hepatocyte injury by affecting intracellular redox state
    Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, vol. 1269, no. 2, pp. 153–161, 1995
  119. Oxygen dependence of hepatocyte susceptibility to mitochondrial respiratory inhibitors
    Biochemical Pharmacology, vol. 50, no. 11, pp. 1859–1865, 1995
  120. Chemical Research in Toxicology, vol. 8, no. 8, pp. 997–1004, 1995
  121. Chloroacetaldehyde-induced hepatocyte cytotoxicity Mechanisms for cytoprotection
    Biochemical Pharmacology, vol. 48, no. 5, pp. 1025–1032, 1994
  122. Prevention of Cyanide-Induced Cytotoxicity by Nutrients in Isolated Rat Hepatocytes
    Toxicology and Applied Pharmacology, vol. 128, no. 2, pp. 271–279, 1994
  123. Molecular Mechanisms of Nitrofurantoin-Induced Hepatocyte Toxicity in Aerobic versus Hypoxic Conditions
    Archives of Biochemistry and Biophysics, vol. 305, no. 2, pp. 362–369, 1993
  124. Molecular mechanisms of dibromoalkane cytotoxicity in isolated rat hepatocytes
    Biochemical Pharmacology, vol. 45, no. 2, pp. 439–447, 1993
  125. Contrasting molecular cytotoxic mechanisms of mitomycin C and its two analogs, BMY 25282 and BMY 25067, in isolated rat hepatocytes
    Biochemical Pharmacology, vol. 45, no. 11, pp. 2303–2309, 1993
  126. Molecular mechanisms of chloroacetaldehyde-induced cytotoxicity in isolated rat hepatocytes
    Biochemical Pharmacology, vol. 46, no. 9, pp. 1621–1626, 1993
  127. Comparative mammal model of chronic rate overload: Relationship of myocardial Ca-cycling to heart, metabolic and lipoperoxidation rates
    Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology, vol. 106, no. 2, pp. 453–461, 1993
  128. Intra-articular fracture of the calcaneus associated with rupture of the peroneus longus tendon
    Injury, vol. 24, no. 4, pp. 269–271, 1993
  129. Role of sulfhydryl groups in benzoquinone-induced Ca2+ release by rat liver mitochondria
    Archives of Biochemistry and Biophysics, vol. 267, no. 2, pp. 539–550, 1988