Helga E. de Vries
Helga E. de Vries has obtained her Ph.D. degree in 1995 on "The cell biology and pharmacology of the blood-brain barrier (BBB)" at Leiden University, The Netherlands. In this period, she established numerous in vitro and in vivo assays to determine BBB alterations under neuroinflammatory conditions. After obtaining her Ph.D. degree, de Vries became interested in the role of monocyte-derived macrophages in cardiovascular diseases. In 1998-1999, she obtained a Marie Curie Fellowship to join the group of Professor John Greenwood (University College London (UCL), London, UK) to investigate signaling events in brain endothelial cells under neuroinflammatory conditions. After that, she moved to the Department of Molecular Cell Biology and Immunology (MCBI) to study processes at the BBB that lead to neuroinflammation, as observed in multiple sclerosis (MS). She now heads her own multidisciplinary research group as an Associate Professor at the MCBI that is part of the MS Center Amsterdam. Key research is dedicated to studying structure and function of the blood-brain barrier and its surrounding cell types during multiple sclerosis. Importantly, neuropathological alterations that follow BBB damage and cellular infiltration such as oxidative stress and astrocyte activation are under investigation. More fundamental research within her group is on the identification of underlying mechanisms of barrier regulation and leukocyte trafficking into the central nervous system.
Biography Updated on 10 January 2010