Lionel Larue obtained his Ph.D. degree in 1987 from Pierre-et-Marie-Curie University Paris, where he got a training in molecular pharmacology applied in oncology in the Laboratory of Claude Paoletti and Jean-Bernard LePecq at Institut-Gustave-Roussy, Villejuif. As a postodoctoral fellow at Fox Chase Cancer Center in Philadelphia with Beatrice Mintz, he got interested in determination, differentiation, and transformation of melanocytes as well as in the establishment of a melanoma murine system, using transgenesis, from the mice to cell lines. In 1991, Dr. Larue moved to the Department of Rolf Kemler at the Max-Planck Institut für Immunbiologie, Freiburg, Germany, where he got interested in more sophisticated mouse molecular genetics involving embryonic stem cells and conditionnal mutations. From the fourth embryonic layer, neural crest, and its derivatives including melanocytes, Larue focused his interest on preimplantation and gastrulation focusing mainly on the cadherin-catenin complex genes. At the end of the 1990s, Larue came back to France where he started his own laboratory. He is currently a Research Director (INSERM) at Institut Curie, Orsay in the CNRS department “Cellular regulations and oncogenesis.” In order to get a better undestanding in melanoma initiation and progression, our research is based on the normal and pathological development of melanocytes, and it combines molecular, cellular, and physiopathological approaches, using mostly mouse models with ß-catenin as corner stone.
Biography Updated on 22 November 2009