Bart Staels

Bart Staels received his Ph.D. degree. He is a Professor and the Director of the Inserm Unit U1011, Institut Pasteur de Lille and the University of Lille 2, Lille, France. Staels is a member of several learned societies and the Ex-President of the French Atherosclerosis Society (NSFA). His research focuses on molecular pharmacology of cardiovascular and metabolic diseases, including dyslipidemia and type 2 diabetes. Staels particularly studies the role of nuclear receptors (such as the PPARs, FXR, Rev-erba, and RORa) in the control of inflammation and lipid and glucose homeostasis as well as the transcriptional mechanisms involved. He contributed to our current understanding on the role of the nuclear receptor PPARa in the control of lipid and glucose metabolism as well as cardiovascular function in humans. He studied the action mechanism of the hypolipidemic fibrate class of drugs and worked also on the action mechanism of the glitazones, clinically used antidiabetic drugs. His work has contributed to the identification of the PPAR transcription factors as drug targets for the treatment of diabetes, dyslipidemia, and cardiovascular disease, which contributed to pharmacological applications. To date, Staels has published more than 300 original papers, authored on 115 review articles, and contributed several book chapters.

Biography Updated on 26 July 2011

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