Bronwen Martin serves as the Head of the Metabolism Unit at the National Institute on Aging, National Institutes of Health, Baltimore, MD, USA. His group uses an integrative systems biology approach to understand the multitude of factors that control metabolic function and energy homeostasis. Metabolism and aging are highly complex biological traits that involve entire networks of changes at both a molecular and systemic level, and they require a broad systems approach to understanding how these networks change with age or are disrupted during disease. His group focuses on the development of novel therapeutic strategies that enhance metabolic function during the aging process and aims to uncover effective treatment avenues for complex aging-related disorders that have underlying endocrine pathophysiologies. Additionally, the Metabolism Unit is investigating how cognitive ability or susceptibility to neurodegenerative disorders is affected by general systemic metabolic function, and how cognitive decline during aging could potentially be reduced by enhancing general metabolic health. The Metabolism Unit uses genetic, proteomic, bioinformatic, metabolomic, NMR, in vitro, and animal behavioral approaches to investigate alterations in metabolic function during aging and aging-related disorders, and to screen potential drug targets that can maintain or enhance metabolic function. http://www.grc.nia.nih.gov/branches/lci/mu.htm.
Biography Updated on 3 April 2012