Olaf-Georg Issinger is a Professor for biomedicine at the Department for Biochemistry and Molecular Biology at the University of Southern Denmark in Odense, Denmark. He received his Ph.D. degree in 1973 in molecular genetics from the University of Freiburg, Germany. He worked as a Postdoctoral Fellow at the Department for Biological Chemistry at the University of California, Davis, USA. In 1996, Dr. Issinger joint the Department of Biochemistry at the Odense University, as a Full Professor for biomedicine and where he was the Head of the Institute from 1998 to 2000. The main research focus of Professor Issinger is the role of protein kinases in signal transduction with focus on cancer, especially, prostate, kidney, and breast cancer. He was the first to show that protein kinase CK2, the first protein kinase to be described, is highly expressed in proliferating cells and tissues, especially in tumors. Moreover, he was also the first to clone and express CK2 from human and plant origin. The human and plant recombinant CK2 products were the basis for the first structures of both the plant and the human CK2 protein kinases which were elucidated together with Dr. Karsten Niefind (University of Cologne). Recent results from Dr. Issinger’s lab include the identification of resorufin as the most selective CK2 inhibitor so far described, opening a new approach for the design of specific and potent inhibitors of CK2, which lately is recognized as a druggable kinase and for which the first clinical trials are ongoing. Professor Issinger is the author of more than 180 peer-reviewed publications and reviews. In addition, Dr. Issinger is the founder of KinaseDetect Aps, a company that provides academia and industry with products for protein kinase research and drug development.
Biography Updated on 23 August 2009