I obtained my Ph.D. in Immunology in 2002 at the ‘Pierre and Marie Curie’ University and the Institut Pasteur (Paris, France), for my work focusing on the development and function of mouse T cells. After moving in 2003 to the Academic Medical Center (Amsterdam, The Netherlands), I focused my work on human immunology and developed new pre-clinical mouse models of the human immune system, with support from the ‘Grand Challenges in Global Health’ (Bill & Melinda Gates Foundation) funding program. In 2010, I joined AIMM Therapeutics (Amsterdam, The Netherlands), where I stared focusing my interest on industrial use and applications of such models for the generation of new therapeutic approaches, in particular human monoclonal antibodies. I am mostly interested in processes driving hematopoiesis, lymphocyte development and generation of antigen-specific immune responses in humans, with a particular interest towards humanized mouse systems. With the help of these new experimental models, we aim at modeling the behavior of human leukocytes in vivo, to address topics such as lymphocyte development, vaccination strategies and screening of novel therapeutic interventions in a pre-clinical setting. Humanized mice are also attractive platforms to study host-pathogen and host-tumor interactions in the presence of human immune cells in vivo.
Biography Updated on 16 April 2013