P. Lynne Howell

Personal Home Page

http://biochemistry.utoronto.ca/howell/bch.html

Articles in Scholarly Journals [Incomplete List]

  1. Substrate and Product Complexes of Escherichia coli Adenylosuccinate Lyase Provide New Insights into the Enzymatic Mechanism
    Journal of Molecular Biology, vol. 370, no. 3, pp. 541–554, 2007
  2. Structures of 5-Methylthioribose Kinase Reveal Substrate Specificity and Unusual Mode of Nucleotide Binding
    Journal of Biological Chemistry, vol. 282, no. 30, pp. 22195–22206, 2007
  3. ADP-2Ho as a phasing tool for nucleotide-containing proteins
    Acta Crystallographica Section D Biological Crystallography, vol. 63, no. 4, pp. 493–499, 2007
  4. Expression, purification, crystallization and preliminary X-ray analysis of Pseudomonas fluorescens AlgK
    Acta Crystallographica Section F Structural Biology and Crystallization Communications, vol. 63, no. 5, pp. 415–418, 2007
  5. Structure of Escherichia coli tryptophanase
    Acta Crystallographica Section D Biological Crystallography, vol. 62, no. 7, pp. 814–823, 2006
  6. Journal of Chemical Theory and Computation, vol. 2, no. 3, pp. 725–731, 2006
  7. Absolute free energy calculations by thermodynamic integration in four spatial dimensions
    The Journal of Chemical Physics, vol. 123, no. 3, p. 034104, 2005
  8. Structural Snapshots of MTA/AdoHcy Nucleosidase Along the Reaction Coordinate Provide Insights into Enzyme and Nucleoside Flexibility During Catalysis
    Journal of Molecular Biology, vol. 352, no. 3, pp. 559–574, 2005
  9. Biochemistry, vol. 44, no. 25, pp. 9034–9044, 2005
  10. Biochemistry, vol. 44, no. 33, pp. 11049–11057, 2005
  11. Biochemistry, vol. 44, no. 35, pp. 11647–11659, 2005
  12. Structure of Kre2p/Mnt1p: A YEAST  1,2-MANNOSYLTRANSFERASE INVOLVED IN MANNOPROTEIN BIOSYNTHESIS
    Journal of Biological Chemistry, vol. 279, no. 17, pp. 17921–17931, 2004
  13. Disruption of a Salt Bridge Dramatically Accelerates Subunit Exchange in Duck  2 Crystallin
    Journal of Biological Chemistry, vol. 279, no. 39, pp. 40972–40979, 2004
  14. Structural Rationale for the Affinity of Pico- and Femtomolar Transition State Analogues of Escherichia coli 5'-Methylthioadenosine/S-Adenosylhomocysteine Nucleosidase
    Journal of Biological Chemistry, vol. 280, no. 18, pp. 18274–18282, 2004
  15. Femtomolar Transition State Analogue Inhibitors of 5'-Methylthioadenosine/S-Adenosylhomocysteine Nucleosidase from Escherichia coli
    Journal of Biological Chemistry, vol. 280, no. 18, pp. 18265–18273, 2004
  16. Structural studies of duck d2 crystallin mutants provide insight into the role of Thr161 and the 280s loop in catalysis
    Biochemical Journal, vol. 384, no. 2, p. 437, 2004
  17. Biochemistry, vol. 43, no. 18, pp. 5159–5169, 2004
  18. Biochemistry, vol. 43, no. 37, pp. 11672–11682, 2004
  19. Biochemistry, vol. 42, no. 7, pp. 1900–1909, 2003
  20. Crystallization and preliminary X-ray analysis of 5'-methylthioribose kinase from Bacillus subtilis and Arabidopsis thaliana
    Acta Crystallographica Section D Biological Crystallography, vol. 60, no. 1, pp. 116–119, 2003
  21. Structure of Escherichia coli 5'-Methylthioadenosine/ S-Adenosylhomocysteine Nucleosidase Inhibitor Complexes Provide Insight into the Conformational Changes Required for Substrate Binding and Catalysis
    Journal of Biological Chemistry, vol. 278, no. 10, pp. 8761–8770, 2003
  22. Mutational Analysis of Duck delta 2 Crystallin and the Structure of an Inactive Mutant with Bound Substrate Provide Insight into the Enzymatic Mechanism of Argininosuccinate Lyase
    Journal of Biological Chemistry, vol. 277, no. 6, pp. 4166–4175, 2002
  23. Structure of Penicillium citrinumalpha 1,2-Mannosidase Reveals the Basis for Differences in Specificity of the Endoplasmic Reticulum and Golgi Class I Enzymes
    Journal of Biological Chemistry, vol. 277, no. 7, pp. 5620–5630, 2002
  24. Substrate Induced Conformational Changes in Argininosuccinate Synthetase
    Journal of Biological Chemistry, vol. 277, no. 15, pp. 13074–13081, 2002
  25. S-SAD, Se-SAD and S/Se-SIRAS using Cu Kα radiation: why wait for synchrotron time?
    Acta Crystallographica Section D Biological Crystallography, vol. 58, no. 12, pp. 2096–2101, 2002
  26. Biochemistry, vol. 40, no. 9, pp. 2732–2742, 2001
  27. Biochemistry, vol. 40, no. 51, pp. 15570–15580, 2001
  28. Biochemistry, vol. 40, no. 51, pp. 15581–15590, 2001
  29. Structure of E. coli 5'-methylthioadenosine/S-adenosylhomocysteine Nucleosidase Reveals Similarity to the Purine Nucleoside Phosphorylases
    Structure, vol. 9, no. 10, pp. 941–953, 2001
  30. The 1.6 Å Crystal Structure of E. coli Argininosuccinate Synthetase Suggests a Conformational Change during Catalysis
    Structure, vol. 9, no. 12, pp. 1153–1164, 2001
  31. Intragenic complementation and the structure and function of argininosuccinate lyase
    Cellular and Molecular Life Sciences, vol. 57, no. 11, pp. 1637–1651, 2000
  32. Mutation of Arg273 to Leu Alters the Specificity of the Yeast N-Glycan Processing Class I alpha 1,2-Mannosidase
    Journal of Biological Chemistry, vol. 275, no. 15, pp. 11071–11074, 2000
  33. Structural Basis for Catalysis and Inhibition of N-Glycan Processing Class I alpha 1,2-Mannosidases
    Journal of Biological Chemistry, vol. 275, no. 52, pp. 41287–41298, 2000
  34. Optimizing DREAR and SnB parameters for determining Se-atom substructures
    Acta Crystallographica Section D Biological Crystallography, vol. 56, no. 5, pp. 604–617, 2000
  35. Crystal structure of a class I a1,2-mannosidase involved in N-glycan processing and endoplasmic reticulum quality control
    The EMBO Journal, vol. 19, no. 4, Article ID 7592169, 7 pages, 2000
  36. Structure and Function of S-Adenosylhomocysteine Hydrolase
    Cell Biochemistry and Biophysics, vol. 33, no. 2, pp. 101–125, 2000
  37. Purification, crystallization and preliminary X-ray crystallographic analysis of recombinant murine Golgi mannosidase IA, a class I a-mannosidase involved in Asn-linked oligosaccharide maturation
    Acta Crystallographica Section D Biological Crystallography, vol. 55, no. 2, pp. 571–573, 1999
  38. Expression, purification, crystallization and preliminary X-ray analysis of Escherichia coli argininosuccinate synthetase
    Acta Crystallographica Section D Biological Crystallography, vol. 55, no. 12, pp. 2028–2030, 1999
  39. Biochemistry, vol. 38, no. 8, pp. 2425–2434, 1999
  40. Biochemistry, vol. 38, no. 8, pp. 2435–2443, 1999
  41. Journal of Inherited Metabolic Disease, vol. 21, no. 1+, pp. 72–85, 1998
  42. Structure determination of selenomethionyl S-adenosylhomocysteine hydrolase using data at a single wavelength
    Nature Structural Biology, vol. 5, no. 5, Article ID nsb0598-369, 7 pages, 1998
  43. Human argininosuccinate lyase: A structural basis for intragenic complementation
    Proceedings of the National Academy of Sciences, vol. 94, no. 17, pp. 9063–9068, 1997
  44. Intragenic Complementation at the Human Argininosuccinate Lyase Locus. IDENTIFICATION OF THE MAJOR COMPLEMENTING ALLELES
    Journal of Biological Chemistry, vol. 272, no. 10, pp. 6777–6783, 1997
  45. Biochemistry, vol. 36, no. 46, pp. 14012–14022, 1997
  46. Crystallization and Preliminary X-Ray Analysis of the Class 1 a1,2-Mannosidase fromSaccharomyces cerevisiae
    Journal of Structural Biology, vol. 120, no. 1, pp. 69–72, 1997
  47. Crystallization and preliminary X-ray analysis of human placental S-adenosylhomocysteine hydrolase
    Acta Crystallographica Section D Biological Crystallography, vol. 53, no. 3, pp. 339–341, 1997
  48. Structure of hexagonal turkey egg-white lysozyme at 1.65Å resolution
    Acta Crystallographica Section D Biological Crystallography, vol. 51, no. 5, pp. 654–662, 1995
  49. Expression, Purification, Crystallization and Preliminary X-ray Analysis of Human Argininosuccinic Acid Lyase
    Journal of Molecular Biology, vol. 239, no. 2, pp. 336–338, 1994
  50. Crystallization and Preliminary X-ray Analysis of a Mutant Duck d II Crystallin
    Journal of Molecular Biology, vol. 243, no. 5, pp. 944–946, 1994
  51. Activity of crystalline turkey egg white lysozyme
    Proteins: Structure, Function, and Genetics, vol. 12, no. 1, pp. 91–99, 1992
  52. Identification of heavy-atom derivatives by normal probability methods
    Journal of Applied Crystallography, vol. 25, no. 1, pp. 81–86, 1992
  53. Structure determination of turkey egg-white lysozyme using Laue diffraction data
    Acta Crystallographica Section B Structural Science, vol. 48, no. 2, pp. 200–207, 1992
  54. Biochemistry, vol. 30, no. 38, pp. 9264–9273, 1991