Rakesh Mishra received his Ph.D. degree in organic chemistry in 1986 from the University of Allahabad, Allahabad, India. He started his carrier in biology by studying non-B DNA conformations and DNA topology at Molecular Biophysics Unit of the Indian Institute of Science, Bangalore, India, and by initiation of transcription at the Centre for Cellular and Molecular Biology, Hyderabad, India. He used this expertise to extend application of oligonucleotides against protozoan parasites and for knockout of small nucleolar RNAs in Xenopus oocytes to study the role of such RNAs. He then became interested in chromatin organization and decided to take a genetic approach using homeotic gene complex of Drosophila melanogaster at the University of Geneva, Geneva, Switzerland. He joined CCMB as senior Scientist in March 2001. At CCMB, his lab has studied the role of chromatin organization in regulation of genes and the epigenetic mechanisms involved in this process. Taking biochemical, genetic, and comparative genomics approaches, they revealed the chromatin-mediated establishment and maintenance of epigenetic mechanisms. In particular, his work has contributed to an understanding how specific Polycomb group proteins are recruited to established epigenetic cellular memory. In order to look for the packaging code in the genome leading to cell-type-specific epigenome and finding novel functional elements, he has analysed noncoding regions of the human genome. In vivo assays have recently shown that several repeats are involved in chromatin-mediated higher-order regulatory mechanisms and organization of the genome.
Biography Updated on 12 August 2013