Toshio Yanagida
Toshio Yanagida received the Ph.D. degree from Osaka University, Japan, in 1976. He was an Associate Researcher, an Assistant Professor, and a Professor in the faculty of engineering science at the Osaka university, Japan, in 1974, 1987, and 1988, respectively. He led Biomotron Project, ERATO, JST, in 1992, Single molecule processes Project, ICORP, JST, in 1998 and Creation and Application of Soft Nano-Machine, the Hyperfunctional Molecular Machine Project, CREST, JST, in 2002. He was a Professor at the Osaka University Graduate School of Medicine in 1996. From 2002 to 2004, he was a Dean and Professor at the Osaka University Graduate School of Frontier Biosciences. Currently, he is a Professor at the Osaka University Graduate School of Frontier Biosciences. Professor Yanagida received 7th Osaka science award in 1989, 4th Tsukahara memotial award in 1992, 25th Naito memorial science promotion award in 1994, the Japan academy award and the imperial award in 1998, and 1998 Asahi award in 1999 for his outstanding achievement in the field of molecular motors and single molecule detection. Professor Yanagida is a Member of Japan biophysical society and USA biophysical society. He served as a President of Japan Biophysical Society and a Member of editorial board of Biophysical journal. He is a Counselor in USA Biophysical Society.
Biography Updated on 25 January 2008
Personal Home Page
http://www.jst.go.jp/erato/project/ysu_P/ysu_P.html
Articles in Scholarly Journals [Incomplete List]
- The diffusive search mechanism of processive myosin class-V motor involves directional steps along actin subunits
Biochemical and Biophysical Research Communications, vol. 354, no. 2, pp. 379–384, 2007 - Cooperative actions between myosin heads bring effective functions
Biosystems, vol. 88, no. 3, pp. 293–300, 2007 - Input–output relationship in galvanotactic response of Dictyostelium cells
Biosystems, vol. 88, no. 3, pp. 261–272, 2007 - Stochastic signal inputs for chemotactic response in Dictyostelium cells revealed by single molecule imaging techniques
Biosystems, vol. 88, no. 3, pp. 251–260, 2007 - Dynamic polymorphism of actin as activation mechanism for cell motility
Biosystems, vol. 88, no. 3, pp. 273–282, 2007 - Brownian motion, fluctuation and life
Biosystems, vol. 88, no. 3, pp. 228–242, 2007 - Single molecule thermodynamics in biological motors
Biosystems, vol. 88, no. 3, pp. 283–292, 2007 - Single molecule FRET for the study on structural dynamics of biomolecules
Biosystems, vol. 88, no. 3, pp. 243–250, 2007 - Role of Multiple Bonds Between the Single Cell Adhesion Molecules, Nectin and Cadherin, Revealed by High Sensitive Force Measurements
Journal of Molecular Biology, vol. 367, no. 4, pp. 996–1006, 2007 - VEPs elicited by local correlations and global symmetry: Characteristics and interactions
Vision Research, vol. 47, no. 16, pp. 2212–2222, 2007 - Myosin-V makes two brownian 90° rotations per 36-nm step
Nature Structural & Molecular Biology, vol. 14, no. 10, Article ID nsmb1298, 5 pages, 2007 - Ischemic Vasoconstriction And Tissue Energy Metabolism during Global Cerebral Ischemia in Gerbils
Journal of Neurotrauma, vol. 24, no. 3, pp. 547–558, 2007 - Immobilizing BK-channels in artificial lipid bilayers using annexin V
e-Journal of Surface Science and Nanotechnology, vol. 5, pp. 1–5, 2007 - Telencephalin Slows Spine Maturation
Journal of Neuroscience, vol. 26, no. 6, pp. 1776–1786, 2006 - Single-molecule analysis of chemoattractant-stimulated membrane recruitment of a PH-domain-containing protein
Journal of Cell Science, vol. 119, no. 6, pp. 1071–1079, 2006 - Synthesis of Long-template DNA Using Enzymatic Reaction for Regular Alignment of Au-nanoparticles
Chemistry Letters, vol. 35, no. 11, pp. 1290–1291, 2006 - Noncontact backscatter-mode near-infrared time-resolved imaging system: preliminary study for functional brain mapping
Journal of Biomedical Optics, vol. 11, no. 5, p. 054006, 2006 - Single Supramolecule Spectroscopy of Natural and Alkaline-Treated Chlorosomes from Green Sulfur Photosynthetic Bacteria
Journal of Nanoscience and Nanotechnology, vol. 6, no. 6, pp. 1750–1757, 2006 - Cargo-Binding Makes a Wild-Type Single-Headed Myosin-VI Move Processively
Biophysical Journal, vol. 90, no. 10, pp. 3643–3652, 2006 - Single-molecule analysis of epidermal growth factor binding on the surface of living cells
The EMBO Journal, vol. 25, no. 18, Article ID 7601308, 7 pages, 2006 - Epidermal growth factor-regulated activation of Rac GTPase enhances CD44 cleavage by metalloproteinase disintegrin ADAM10
Biochemical Journal, vol. 395, no. 1, p. 65, 2006 - Dynamic polymorphism of single actin molecules in the actin filament
Nature Chemical Biology, vol. 2, no. 2, Article ID nchembio763, 3 pages, 2006 - Tumor suppressor PTEN acts through dynamic interaction with the plasma membrane
Proceedings of the National Academy of Sciences, vol. 103, no. 10, pp. 3633–3638, 2006 - Optical coherence tomography reveals in vivo cortical plasticity of adult mice in response to peripheral neuropathic pain
Neuroscience Letters, vol. 397, no. 1-2, pp. 35–39, 2006 - Langmuir, vol. 22, no. 14, pp. 6302–6307, 2006
- Covalent immobilization of epidermal growth factor molecules for single-molecule imaging analysis of intracellular signaling
Biomaterials, vol. 27, no. 18, pp. 3343–3350, 2006 - Formation of signal transduction complexes during immobile phase of NGFR movements
Biochemical and Biophysical Research Communications, vol. 342, no. 1, pp. 316–322, 2006 - Dynamic polymorphism of Ras observed by single molecule FRET is the basis for molecular recognition
Biochemical and Biophysical Research Communications, 2006 - A unique mechanism for the processive movement of single-headed myosin-IX
Biochemical and Biophysical Research Communications, vol. 343, no. 4, pp. 1159–1164, 2006 - Lysenin forms a voltage-dependent channel in artificial lipid bilayer membranes
Biochemical and Biophysical Research Communications, vol. 346, no. 1, pp. 288–292, 2006 - On Myosin II dynamics in the presence of external loads
Biosystems, vol. 81, no. 2, pp. 163–175, 2005 - The sensorimotor transformation of cross-modal spatial information in the anterior intraparietal sulcus as revealed by functional MRI
Cognitive Brain Research, vol. 22, no. 3, pp. 385–396, 2005 - The Neck Domain of Myosin II Primarily Regulates the Actomyosin Kinetics, not the Stepsize
Journal of Molecular Biology, vol. 353, no. 2, pp. 213–221, 2005 - Entropy rectifies the Brownian steps of kinesin
Nature Chemical Biology, vol. 1, no. 6, Article ID nchembio741, 5 pages, 2005 - Transcranial Ultrasonography System for Visualizing Skull and Brain Surface Aided by Fuzzy Expert System
IEEE Transactions on Systems, Man and Cybernetics, Part B (Cybernetics), vol. 35, no. 6, pp. 1360–1373, 2005 - Dynamic Medicine, vol. 4, no. 1, p. 5, 2005
- Non-contact surface force microscopy for molecular interaction study
e-Journal of Surface Science and Nanotechnology, vol. 3, pp. 46–50, 2005 - Single-Molecule Analysis of Epidermal Growth Factor Signaling that Leads to Ultrasensitive Calcium Response
Biophysical Journal, vol. 88, no. 5, pp. 3720–3730, 2005 - Trafficking of a Ligand-Receptor Complex on the Growth Cones as an Essential Step for the Uptake of Nerve Growth Factor at the Distal End of the Axon: A Single-Molecule Analysis
Journal of Neuroscience, vol. 25, no. 9, pp. 2181–2191, 2005 - Unconstrained Steps of Myosin VI Appear Longest among Known Molecular Motors
Biophysical Journal, vol. 86, no. 6, pp. 3804–3810, 2004 - Single-Molecule Imaging of the Dynamic Interactions between Macromolecules
Journal of Nanoscience and Nanotechnology, vol. 4, no. 6, pp. 616–621, 2004 - Changes in regional cerebral blood volume in frontal cortex during mental work with and without caffeine intake: functional monitoring using near-infrared spectroscopy
Journal of Biomedical Optics, vol. 9, no. 4, p. 788, 2004 - Absorber's Effect Projected Directly Above Improves Spatial Resolution in Near Infrared Backscattered Imaging
The Japanese Journal of Physiology, vol. 54, no. 1, pp. 79–86, 2004 - Mechano-chemical Coupling of Molecular Motors Revealed by Single Molecule Measurements
Current Protein and Peptide Science, vol. 5, no. 2, pp. 81–87, 2004 - A one-headed class V myosin molecule develops multiple large ( 32-nm) steps successively
Proceedings of the National Academy of Sciences, vol. 101, no. 26, pp. 9630–9635, 2004 - Circulatory basis of fMRI signals: relationship between changes in the hemodynamic parameters and BOLD signal intensity
NeuroImage, vol. 21, no. 4, pp. 1204–1214, 2004 - EGF signalling amplification induced by dynamic clustering of EGFR
Biochemical and Biophysical Research Communications, vol. 324, no. 3, pp. 1143–1149, 2004 - Monitoring Molecular Beacon DNA Probe Hybridization at the Single-Molecule Level
Chemistry - A European Journal, vol. 9, no. 22, pp. 5686–5692, 2003 - Single- and Multiple-Molecule Dynamics of the Signaling from H-Ras to cRaf-1 Visualized on the Plasma Membrane of Living Cells
ChemPhysChem, vol. 4, no. 7, pp. 748–753, 2003 - Noncontact Surface Force Microscopy of Protein Molecules
ChemPhysChem, vol. 4, no. 12, pp. 1361–1364, 2003 - Stochastic properties of actomyosin motor
Biosystems, vol. 71, no. 1-2, pp. 101–110, 2003 - Stochastic processes in nano-biomachines revealed by single molecule detection
Biosystems, vol. 71, no. 1-2, pp. 233–244, 2003 - Single molecule processes on the stepwise movement of ATP-driven molecular motors
Biosystems, vol. 71, no. 1-2, pp. 145–156, 2003 - Attentional set for external information activates the right intraparietal area
Cognitive Brain Research, vol. 16, no. 2, pp. 199–209, 2003 - Discrete stochastic process underlying perceptual rivalry
NeuroReport, vol. 14, no. 10, pp. 1347–1352, 2003 - Engagement of CD44 Promotes Rac Activation and CD44 Cleavage during Tumor Cell Migration
Journal of Biological Chemistry, vol. 279, no. 6, pp. 4541–4550, 2003 - Model describing the biased Brownian movement of myosin.
Proceedings of the Japan Academy, Series B, vol. 79B, no. 1, pp. 9–14, 2003 - Spectral Heterogeneity in Single Light-harvesting Chlorosomes from Green Sulfur Photosynthetic Bacterium Chlorobium tepidum¶
Photochemistry and Photobiology, vol. 75, no. 4, p. 433, 2002 - Simultaneous Optical and Electrical Recording of a Single Ion-Channel.
The Japanese Journal of Physiology, vol. 52, no. 5, pp. 429–434, 2002 - The motor domain determines the large step of myosin-V
Nature, vol. 415, no. 6868, pp. 192–195, 2002 - Chemomechanical coupling of the forward and backward steps of single kinesin molecules
Nature Cell Biology, vol. 4, no. 10, Article ID ncb857, 7 pages, 2002 - The Journal of Physical Chemistry B, vol. 106, no. 6, pp. 1430–1433, 2002
- Development of an Experimental Apparatus for Simultaneous Observation of Optical and Electrical Signals from Single Ion Channels
Single Molecules, vol. 3, no. 1, pp. 33–42, 2002 - Detection of Thermal Processes of Protein Function
Single Molecules, vol. 3, no. 2-3, pp. 149–153, 2002 - Class VI Myosin Moves Processively along Actin Filaments Backward with Large Steps
Biochemical and Biophysical Research Communications, vol. 290, no. 1, pp. 311–317, 2002 - A new view concerning an actomyosin motor
Cellular and Molecular Life Sciences, vol. 59, no. 11, pp. 1767–1770, 2002 - Cortical Mapping of Gait in Humans: A Near-Infrared Spectroscopic Topography Study
NeuroImage, vol. 14, no. 5, pp. 1186–1192, 2001 - Non-Contact Electrostatic Surface Force Imaging of Single Protein Filaments using Intermolecular Force Microscopy
Single Molecules, vol. 2, no. 3, pp. 183–190, 2001 - Substeps within the 8-nm step of the ATPase cycle of single kinesin molecules
Nature Cell Biology, vol. 3, no. 4, Article ID 35070116, 3 pages, 2001 - Single molecule nanobioscience
Trends in Biochemical Sciences, vol. 26, no. 7, pp. 438–444, 2001 - Single molecule nanomanipulation of biomolecules
Trends in Biotechnology, vol. 19, no. 6, pp. 211–216, 2001 - Single-Molecule Analysis of Chemotactic Signaling in Dictyostelium Cells
Science, vol. 294, no. 5543, pp. 864–867, 2001 - Single-Molecule Imaging of Interaction between Dextran and Glucosyltransferase from Streptococcus sobrinus
Journal of Bacteriology, vol. 182, no. 4, pp. 1162–1166, 2000 - A large step for myosin
Proceedings of the National Academy of Sciences, vol. 97, no. 17, pp. 9357–9359, 2000 - Electrophysiological Study of a Novel Large Pore Formed by Bax and the Voltage-dependent Anion Channel That Is Permeable to Cytochrome c
Journal of Biological Chemistry, vol. 275, no. 16, pp. 12321–12325, 2000 - Single-motor mechanics and models of the myosin motor
Philosophical Transactions of the Royal Society B: Biological Sciences, vol. 355, no. 1396, pp. 441–447, 2000 - Nature Cell Biology, vol. 2, no. 3, pp. 168–172, 2000
- Imaging And Nano-Manipulation Of Single Actomyosin Motors At Work
Clinical and Experimental Pharmacology and Physiology, vol. 27, no. 3, pp. 229–237, 2000 - Single molecule analysis of the actomyosin motor
Current Opinion in Cell Biology, vol. 12, no. 1, pp. 20–25, 2000 - Single-Molecule Imaging of Signaling Molecules in Living Cells
Single Molecules, vol. 1, no. 2, pp. 159–163, 2000 - Single molecular observation of the interaction of GroEL with substrate proteins
Journal of Molecular Biology, vol. 292, no. 5, pp. 965–972, 1999 - An Artificial Lipid Bilayer Formed on an Agarose-Coated Glass for Simultaneous Electrical and Optical Measurement of Single Ion Channels
Biochemical and Biophysical Research Communications, vol. 265, no. 2, pp. 595–599, 1999 - Simultaneous Measurement of Individual ATPase and Mechanical Reactions by a Single Myosin Molecule at Work
Optical Review, vol. 6, no. 1, pp. 16–23, 1999 - Biochemistry, vol. 38, no. 32, pp. 10318–10323, 1999
- Nature, vol. 397, no. 6715, pp. 129–134, 1999
- Fluorescence resonance energy transfer between single fluorophores attached to a coiled-coil protein in aqueous solution
Chemical Physics, vol. 247, no. 1, pp. 163–173, 1999 - The gamma -subunit rotation and torque generation in F1-ATPase from wild-type or uncoupled mutant Escherichia coli
Proceedings of the National Academy of Sciences, vol. 96, no. 14, pp. 7780–7784, 1999 - Single Molecule Imaging of Fluorescently Labeled Proteins on Metal by Surface Plasmons in Aqueous Solution
Physical Review Letters, vol. 80, no. 20, pp. 4606–4609, 1998 - Filament structure as an essential factor for regulation of Dictyostelium myosin by regulatory light chain phosphorylation
Proceedings of the National Academy of Sciences, vol. 95, no. 24, pp. 14124–14129, 1998 - Simultaneous Observation of Individual ATPase and Mechanical Events by a Single Myosin Molecule during Interaction with Actin
Cell, vol. 92, no. 2, pp. 161–171, 1998 - Imaging and nano-manipulation of single biomolecules
Biophysical Chemistry, vol. 68, no. 1-3, pp. 63–72, 1997 - Single molecular assay of individual ATP turnover by a myosin-GFP fusion protein expressed in vitro
FEBS Letters, vol. 407, no. 2, pp. 235–238, 1997 - Non-contact scanning probe microscopy with sub-piconewton force sensitivity
Ultramicroscopy, vol. 70, no. 1-2, pp. 45–55, 1997 - Myosin Subfragment-1 Is Fully Equipped with Factors Essential for Motor Function?
Biochemical and Biophysical Research Communications, vol. 230, no. 1, pp. 76–80, 1997 - Subpiconewton Intermolecular Force Microscopy
Biochemical and Biophysical Research Communications, vol. 231, no. 3, pp. 566–569, 1997 - Single Molecule Imaging of Fluorophores and Enzymatic Reactions Achieved by Objective-Type Total Internal Reflection Fluorescence Microscopy
Biochemical and Biophysical Research Communications, vol. 235, no. 1, pp. 47–53, 1997 - Movements of truncated kinesin fragments with a short or an artificial flexible neck
Proceedings of the National Academy of Sciences, vol. 94, no. 14, pp. 7275–7280, 1997 - Kinetics of force generation by single kinesin molecules activated by laser photolysis of caged ATP
Proceedings of the National Academy of Sciences, vol. 94, no. 9, pp. 4395–4400, 1997 - Direct observation of single kinesin molecules moving along microtubules
Nature, vol. 380, no. 6573, Article ID 380451a0, 2 pages, 1996 - Modification of the bi-directional sliding movement of actin filaments along native thick filaments isolated from a clam
Journal of Muscle Research and Cell Motility, vol. 17, no. 6, pp. 637–646, 1996 - Imaging of single fluorescent molecules and individual ATP turnovers by
single myosin molecules in aqueous solution
Nature, vol. 374, no. 6522, Article ID 374555a0, 4 pages, 1995 - Single-Molecule Analysis of the Actomyosin Motor Using Nano-Manipulation
Biochemical and Biophysical Research Communications, vol. 199, no. 2, pp. 1057–1063, 1994 - Force-Generating Domain of Myosin Motor
Biochemical and Biophysical Research Communications, vol. 196, no. 3, pp. 1504–1510, 1993 - Nano-manipulation of actomyosin molecular motors in vitro: a new working principle
Trends in Biochemical Sciences, vol. 18, no. 9, pp. 319–324, 1993 - Charge-Reversion Mutagenesis of Dictyostelium Actin to Map the Surface Recognized by Myosin During ATP-Driven Sliding Motion
Proceedings of the National Academy of Sciences, vol. 90, no. 6, pp. 2127–2131, 1993 - Loose coupling between chemical and mechanical reactions in actomyosin energy transduction
Advances in Biophysics, vol. 26, pp. 75–95, 1990 - Direct observation of molecular motility by light microscopy
Cell Motility and the Cytoskeleton, vol. 10, no. 1-2, pp. 71–76, 1988 - Force measurements by micromanipulation of a single actin filament by glass needles
Nature, vol. 334, no. 6177, Article ID 334074a0, 2 pages, 1988 - Sliding movement of single actin filaments on one-headed myosin filaments
Nature, vol. 326, no. 6115, Article ID 326805a0, 3 pages, 1987 - Sliding distance of actin filament induced by a myosin crossbridge during one ATP hydrolysis cycle
Nature, vol. 316, no. 6026, Article ID 316366a0, 3 pages, 1985 - Angle of active site of myosin heads in contracting muscle during sudden length changes
Journal of Muscle Research and Cell Motility, vol. 6, no. 1, pp. 43–52, 1985 - Predominant attached state of myosin cross-bridges during contraction and relaxation at low ionic strength
Journal of Molecular Biology, vol. 177, no. 4, pp. 769–785, 1984 - Direct observation of motion of single F-actin filaments in the presence of myosin
Nature, vol. 307, no. 5946, Article ID 307058a0, 2 pages, 1984 - Studies on conformation of F-actin in muscle fibers in the relaxed state, rigor, and during contraction using fluorescent phalloidin
The Journal of Cell Biology, vol. 97, no. 6, pp. 1663–1667, 1983 - Angles of nucleotides bound to cross-bridges in glycerinated muscle fiber at various concentrations of ?-ATP, ?-ADP and ?-AMPPNP detected by polarized fluorescence
Journal of Molecular Biology, vol. 146, no. 4, pp. 539–560, 1981 - Conformational changes of F-actin-?-ADP in thin filaments in myosin-free muscle fibers induced by Ca2+
Journal of Molecular Biology, vol. 140, no. 2, pp. 313–320, 1980 - Polarized fluorescence from ?-ADP incorporated into F-actin in a myosin-free single fiber: Conformation of F-actin and hanges induced in it by heavy meromyosin
Journal of Molecular Biology, vol. 126, no. 3, pp. 507–524, 1978 - Effect of Myosin on Conformational Changes of F-Actin in Thin Filament in vivo Induced by Calcium Ions
European Journal of Biochemistry, vol. 56, no. 2, pp. 547–556, 1975 - Conformational changes of F-actin in the thin filaments of muscle induced in Vivo and in Vitro by calcium ions
Journal of Molecular Biology, vol. 90, no. 3, pp. 509–522, 1974