Maurizio D'Esposito

Maurizio D’Esposito is born in Naples, Italy. He received his Degree in Biological Sciences, magna cum laude, at University “Federico II” di Napoli under the supervision of prof. Edoardo Boncinelli. From 1990 to 1998 he worked as researcher (tenure track) at International Institute of Genetics and Biophysics (IIGB), CNR, Naples Italy working under the supervision of prof. Michele D’Urso. During this period, he spent two years at Washington University School of Medicine, St. Louis U.S.A, under the supervision of prof. D.Schlessinger. From1998 he’s Group Leader and from 2001 Associate Professor at IGB “A. Buzzati Traverso”, CNR, Naples Italy. He’s currently member of the European Advisory Board on Rett Syndrome. From 2009 he’s Coordinator, UE Initial Training Network “DISCHROM on chromatin diseases (2009-2013). Dr. D’Esposito activity has been focused on the transcriptional regulation of eukaryotic genes. Important milestones reached has been the characterization of the mechanisms of maintenance of X inactivation in man, analyzing as model system the second human pseudoautosomal region and the definition of its regulation by epigenetic mechanisms. Then, he moved to the characterization of human diseases affecting methylation (Rett Syndrome, ICF syndrome and hyperhomocysteinemia) and the analysis of their molecular alterations. He participated to the earlier phases of the RTT gene cloning, by physically mapping MECP2 gene in YAC contigs of human Xq28. Noticeable contributions are also the elucidation of the complex relationships between DNA methylation and histone code and chromosome territory. He published 70 peer reviewed article on international journals. elationships between DNA methylation and histone code and chromosome territory. He published 70 peer reviewed article on international journals.

Biography Updated on 11 July 2011

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