Yin Tintutt completed the B.S. degree (summa cum laude) in chemistry at the California State University, Los Angeles, CA, USA, and the Ph.D. degree in biochemistry at the University of California, Los Angeles, in 1990 and 1995, respectively. Dr. Tintut joined UCLA Department of Medicine/Cardiology as a Researcher in 1995. Presently, Dr. Tintut is an Adjunct Professor of medicine. Her research interests focus on regulatory mechanisms of inflammatory agents, such as oxidized lipids and inflammatory cytokines, and on mineralization in the artery wall and bone. Her findings suggest that inflammatory agents promote vascular calcification by inducing osteoblastic differentiation and mineralization of artery wall cells. Interestingly, the same agents promote osteoporosis by inhibiting osteoblastic differentiation of bone-derived preosteoblasts and potentiating osteoclastic differentiation of bone marrow macrophages. Her recent findings now suggest that oxidized lipids mediate adverse effects of hyperlipidemia on bone anabolic effects of intermittent parathyroid hormone therapy, an FDA-approved postmenopausal osteoporosis treatment.
Biography Updated on 28 August 2012