Ivan V. Maly0000-0002-3370-2792
Ivan V. Maly is a graduate of Moscow State University, Moscow, Russia, 1999, and holds a Ph.D. degree in life sciences from Northwestern University, Ill, USA, 2002. After a research stint in the Department of Biological Engineering at MIT, in 2004 he joined the faculty of the University of Pittsburgh. He became a Founding Member of the Department of Computational and Systems Biology and remained there till 2012. He now resides in Buffalo, New York. His interests lie in quantitative and systems-level understanding of the cell structure and function. His work on the kinetics of the cytoskeleton assembly and molecular motor-driven transport, which are functionally related and share some mathematical properties as stochastic processes, was summarized a in monograph titled Cytoskeleton and Cell Motility Models: From Kinetics to Structure. Another series of his publications established the theoretical kinetic principles of spatially self-organized autocrine signaling and its function in tissue mechanosensation. Subsequently, he obtained a research grant from the National Institutes of Health to study computationally and experimentally the biophysical mechanism of orientation of immune cells to their targets, which underlies the specificity of the immune response on the cellular level. This work led to generalizations regarding the mechanical instabilities, emergent irreversibility, and dissipative oscillations exhibited by the basic animal cell structure. These observations are the subject of the upcoming (2013) monograph titled Systems Biomechanics of the Cell. Dr. Maly was also the editor of the Systems Biology volume in the Methods in Molecular Biology series (2009).
Biography Updated on 6 January 2013