John E. Ladbury

John E. Ladbury is a graduate in chemistry and physics from the University of London. He received his Ph.D. degree in inorganic polymer chemistry from the University of Greenwich in 1990. He held postdoctoral appointments at Yale University, Harvard University Medical School, and New York University Medical Center before taking up a Wellcome Trust Career Development Research Fellowship at the University of Oxford in 1994. He received a Wellcome Trust Senior Fellowship after moving to the Department of Biochemistry & Molecular Biology at University College London. His laboratory at UCL adopts a multidisciplinary approach to understanding thermodynamic/structural correlation in interactions of proteins

Biography Updated on 5 November 2007

Personal Home Page

http://www.biochem.ucl.ac.uk/research/ladbury/ladbury.htm

Articles in Scholarly Journals [Incomplete List]

  1. Survey of the year 2005: literature on applications of isothermal titration calorimetry
    Journal of Molecular Recognition, vol. 20, no. 1, pp. 4–14, 2007
  2. Identification of novel fragment compounds targeted against the pY pocket of v-Src SH2 by computational and NMR screening and thermodynamic evaluation
    Proteins: Structure, Function, and Bioinformatics, vol. 67, no. 4, pp. 981–990, 2007
  3. Editorial
    Biophysical Chemistry, vol. 126, no. 1-3, pp. 3–3, 2007
  4. Partial filling multiple injection affinity capillary electrophoresis (PFMIACE) to estimate binding constants of receptors to ligands
    Talanta, vol. 71, no. 1, pp. 192–201, 2007
  5. Journal of the American Chemical Society, vol. 129, no. 1, pp. 226–233, 2007
  6. Biochemistry, vol. 45, no. 5, pp. 1421–1434, 2006
  7. Conformational Diversity in the TPR Domain-Mediated Interaction of Protein Phosphatase 5 with Hsp90
    Structure, vol. 14, no. 3, pp. 415–426, 2006
  8. Conformational changes in the AAA ATPase p97–p47 adaptor complex
    The EMBO Journal, vol. 25, no. 9, Article ID 7601055, 9 pages, 2006
  9. Crystal Structure and Binding Properties of the CD2 and CD244 (2B4)-binding Protein, CD48
    Journal of Biological Chemistry, vol. 281, no. 39, pp. 29309–29320, 2006
  10. Measurement of the formation of complexes in tyrosine kinase-mediated signal transduction
    Acta Crystallographica Section D Biological Crystallography, vol. 63, no. 1, pp. 26–31, 2006
  11. StpA protein from Escherichia coli condenses supercoiled DNA in preference to linear DNA and protects it from digestion by DNase I and EcoKI
    Nucleic Acids Research, vol. 33, no. 20, pp. 6540–6546, 2005
  12. Interaction of Porphyrin with G-Quadruplex Structures
    Nucleosides, Nucleotides & Nucleic Acids, vol. 24, no. 5-7, pp. 753–756, 2005
  13. Molecular Recognition Coupled Folding and Binding in a TPR Domain
    Journal of Molecular Biology, vol. 346, no. 3, pp. 717–732, 2005
  14. Distinct Spatial and Temporal Distribution of ZAP70 and Lck following Stimulation of Interferon and T-cell Receptors
    Journal of Molecular Biology, vol. 353, no. 5, pp. 1001–1010, 2005
  15. NMR Assignment of the Apo and Peptide-bound SH2 Domain from the Rous Sarcoma Viral Protein Src
    Journal of Biomolecular NMR, vol. 32, no. 4, pp. 339–339, 2005
  16. Survey of the year 2004: literature on applications of isothermal titration calorimetry
    Journal of Molecular Recognition, vol. 19, no. 1, pp. 79–89, 2005
  17. Molecular basis for TPR domain-mediated regulation of protein phosphatase 5
    The EMBO Journal, vol. 24, no. 1, Article ID 7600496, 9 pages, 2005
  18. H-NS is a part of a thermally controlled mechanism for bacterial gene regulation
    Biochemical Journal, vol. 391, no. 2, p. 203, 2005
  19. Biochemistry, vol. 43, no. 44, pp. 13910–13925, 2004
  20. A survey of the year 2003 literature on applications of isothermal titration calorimetry
    Journal of Molecular Recognition, vol. 17, no. 6, pp. 513–523, 2004
  21. Heat Capacity Effects of Water Molecules and Ions at a Protein–DNA Interface
    Journal of Molecular Biology, vol. 336, no. 4, pp. 829–842, 2004
  22. The extended interface: measuring non-local effects in biomolecular interactions
    Current Opinion in Structural Biology, vol. 14, no. 5, pp. 562–569, 2004
  23. Solvation and the hidden thermodynamics of a zinc finger probed by nonstandard repair of a protein crevice
    Protein Science, vol. 13, no. 12, pp. 3115–3126, 2004
  24. Identification of a Novel Proline-Arginine Motif Involved in CIN85-dependent Clustering of Cbl and Down-regulation of Epidermal Growth Factor Receptors
    Journal of Biological Chemistry, vol. 278, no. 41, pp. 39735–39746, 2003
  25. A survey of the year 2002 literature on applications of isothermal titration calorimetry
    Journal of Molecular Recognition, vol. 16, no. 6, pp. 383–391, 2003
  26. Halophilic adaptation of protein?DNA interactions
    Biochemical Society Transactions, vol. 31, no. 3, p. 677, 2003
  27. Accounts of Chemical Research, vol. 36, no. 6, pp. 410–416, 2003
  28. Reversal of Halophilicity in a Protein-DNA Interaction by Limited Mutation Strategy
    Structure, vol. 10, no. 5, pp. 629–637, 2002
  29. Journal of Biomolecular NMR, vol. 23, no. 4, pp. 327–328, 2002
  30. The Hidden Thermodynamics of a Zinc Finger???
    Journal of Molecular Biology, vol. 316, no. 4, pp. 969–989, 2002
  31. Metal-dependent Folding and Stability of Nuclear Hormone Receptor DNA-binding Domains
    Journal of Molecular Biology, vol. 319, no. 1, pp. 87–106, 2002
  32. H-NS Oligomerization Domain Structure Reveals the Mechanism for High Order Self-association of the Intact Protein
    Journal of Molecular Biology, vol. 324, no. 4, pp. 841–850, 2002
  33. Interactions defining the specificity between fungal xylanases and the wheat proteinaceous inhibitor, XIP-I
    Biochemical Journal, 2002
  34. The Role of the Src Homology 3-Src Homology 2 Interface in the Regulation of Src Kinases
    Journal of Biological Chemistry, vol. 276, no. 20, pp. 17199–17205, 2001
  35. Isothermal titration calorimetry: application to structure-based drug design
    Thermochimica Acta, vol. 380, no. 2, pp. 209–215, 2001
  36. Inhibitors to the Src SH2 Domain: A Lesson in Structure–Thermodynamic Correlation in Drug Design
    Archives of Biochemistry and Biophysics, vol. 390, no. 2, pp. 158–168, 2001
  37. Structural characterization of the N-terminal oligomerization domain of the bacterial chromatin-structuring protein, H-NS1
    Journal of Molecular Biology, vol. 306, no. 5, pp. 1127–1137, 2001
  38. Biochemistry, vol. 40, no. 8, pp. 2419–2425, 2001
  39. Biochemistry, vol. 40, no. 16, pp. 4957–4965, 2001
  40. Biochemistry, vol. 40, no. 22, pp. 6580–6588, 2001
  41. Biochemistry, vol. 40, no. 49, pp. 14960–14967, 2001
  42. Biochemistry, vol. 40, no. 28, pp. 8430–8430, 2001
  43. Biochemistry, vol. 39, no. 25, pp. 7570–7579, 2000
  44. Searching for specificity in SH domains
    Chemistry & Biology, vol. 7, no. 1, pp. R3–R8, 2000
  45. Oligomerization of the chromatin-structuring protein H-NS
    Molecular Microbiology, vol. 36, no. 4, pp. 962–972, 2000
  46. Specificity and interactions of the protein OppA: partitioning solvent binding effects using mass spectrometry
    Journal of Molecular Biology, vol. 296, no. 1, pp. 269–279, 2000
  47. Drug-DNA recognition: energetics and implications for design
    Journal of Molecular Recognition, vol. 13, no. 4, pp. 188–197, 2000
  48. Temporally regulated assembly of a dynamic signaling complex associated with the activated TCR
    European Journal of Immunology, vol. 30, no. 9, pp. 2620–2631, 2000
  49. Structural Basis for Recognition of Dipeptides by Peptide Transporters
    Archives of Biochemistry and Biophysics, vol. 384, no. 1, pp. 9–23, 2000
  50. Localization and characterization of the hyaluronan-binding site on the Link module from human TSG-6
    Structure, vol. 8, no. 7, pp. 763–774, 2000
  51. The ATPase cycle of Hsp90 drives a molecular clamp' via transient dimerization of the N-terminal domains
    The EMBO Journal, vol. 19, no. 16, pp. 4383–4392, 2000
  52. Regulation of Hsp90 ATPase activity by tetratricopeptide repeat (TPR)-domain co-chaperones
    The EMBO Journal, vol. 18, no. 3, pp. 754–762, 1999
  53. Oct-1 POU and octamer DNA co-operate to recognise the Bob-1 transcription co-activator via induced folding
    Journal of Molecular Biology, vol. 288, no. 5, pp. 941–952, 1999
  54. Crystallographic and Calorimetric Analysis of Peptide Binding to OppA Protein
    Journal of Molecular Biology, vol. 291, no. 2, pp. 393–415, 1999
  55. Journal of Medicinal Chemistry, vol. 42, no. 2, pp. 260–266, 1999
  56. Structure of the PH domain from Bruton's tyrosine kinase in complex with inositol 1,3,4,5-tetrakisphosphate
    Structure, vol. 7, no. 4, pp. 449–460, 1999
  57. TCR Binding to Peptide-MHC Stabilizes a Flexible Recognition Interface
    Immunity, vol. 10, no. 3, pp. 357–365, 1999
  58. Mass spectrometric and thermodynamic studies reveal the role of water molecules in complexes formed between SH2 domains and tyrosyl phosphopeptides
    Structure, vol. 6, no. 9, pp. 1141–1151, 1998
  59. Biochemistry, vol. 37, no. 25, pp. 9083–9090, 1998
  60. Biochemistry, vol. 37, no. 42, pp. 14683–14691, 1998
  61. The effects of salt on the TATA binding protein-DNA interaction from a hyperthermophilic archaeon
    Journal of Molecular Biology, vol. 279, no. 1, pp. 117–125, 1998
  62. Molecular design using electrostatic interactions. 1. Synthesis and properties of flexible tripodand tri- and hexa-cations with restricted conformations. Molecular selection of ferricyanide from ferrocyanide
    Tetrahedron, vol. 54, no. 5-6, pp. 949–968, 1998
  63. ATP binding and hydrolysis are essential to the function of the Hsp90 molecular chaperone invivo
    The EMBO Journal, vol. 17, no. 16, pp. 4829–4836, 1998
  64. Two EGF molecules contribute additively to stabilization of the EGFR dimer
    The EMBO Journal, vol. 16, no. 2, pp. 281–294, 1997
  65. Identification and Structural Characterization of the ATP/ADP-Binding Site in the Hsp90 Molecular Chaperone
    Cell, vol. 90, no. 1, pp. 65–75, 1997
  66. Specific binding of hoechst 33258 to the d(CGCAAATTTGCG)2 duplex: calorimetric and spectroscopic studies
    Journal of Molecular Biology, vol. 271, no. 2, pp. 244–257, 1997
  67. The high-resolution crystal structure of a 24-kDa gyrase B fragment fromE. coli complexed with one of the most potent coumarin inhibitors, clorobiocin
    Proteins: Structure, Function, and Genetics, vol. 28, no. 1, pp. 41–52, 1997
  68. Biochemistry, vol. 35, no. 34, pp. 11062–11069, 1996
  69. Biochemistry, vol. 35, no. 49, pp. 15646–15653, 1996
  70. Molecular Anchoring of Duplex and Triplex DNA by Disubstituted Anthracene-9,10-diones: Calorimetric, UV Melting, and Competition Dialysis Studies
    Journal of the American Chemical Society, vol. 118, no. 44, pp. 10693–10701, 1996
  71. The role of water in sequence-independent ligand binding by an oligopeptide transporter protein
    Nature Structural Biology, vol. 3, no. 12, Article ID nsb1296-998, 3 pages, 1996
  72. Sensing the heat: the application of isothermal titration calorimetry to thermodynamic studies of biomolecular interactions
    Chemistry & Biology, vol. 3, no. 10, pp. 791–801, 1996
  73. Just add water! The effect of water on the specificity of protein-ligand binding sites and its potential application to drug design
    Chemistry & Biology, vol. 3, no. 12, pp. 973–980, 1996
  74. Biochemistry, vol. 34, no. 7, pp. 2148–2152, 1995
  75. Measurement of the Binding of Tyrosyl Phosphopeptides to SH2 Domains: A Reappraisal
    Proceedings of the National Academy of Sciences, vol. 92, no. 8, pp. 3199–3203, 1995
  76. Counting the calories to stay in the groove
    Structure, vol. 3, no. 7, pp. 635–639, 1995
  77. Heparin-induced oligomerization of FGF molecules is responsible for FGF receptor dimerization, activation, and cell proliferation
    Cell, vol. 79, no. 6, pp. 1015–1024, 1994
  78. A Thermodynamic Study of the trp Repressor—Operator Interaction
    Journal of Molecular Biology, vol. 238, no. 5, pp. 669–681, 1994
  79. Turning Up the Heat On Rational Drug Design
    Bio/Technology, vol. 12, no. 11, Article ID nbt1194-1083, 2 pages, 1994
  80. Biochemistry, vol. 33, no. 17, pp. 5070–5076, 1994
  81. Biochemistry, vol. 33, no. 22, pp. 6828–6833, 1994
  82. A ribonuclease S-peptide antagonist discovered with a bacteriophage display library
    Gene, vol. 128, no. 1, pp. 37–42, 1993
  83. Biochemistry, vol. 31, no. 44, pp. 10699–10702, 1992