John E. Ladbury
John E. Ladbury is a graduate in chemistry and physics from the University of London. He received his Ph.D. degree in inorganic polymer chemistry from the University of Greenwich in 1990. He held postdoctoral appointments at Yale University, Harvard University Medical School, and New York University Medical Center before taking up a Wellcome Trust Career Development Research Fellowship at the University of Oxford in 1994. He received a Wellcome Trust Senior Fellowship after moving to the Department of Biochemistry & Molecular Biology at University College London. His laboratory at UCL adopts a multidisciplinary approach to understanding thermodynamic/structural correlation in interactions of proteins
Biography Updated on 5 November 2007
Personal Home Page
http://www.biochem.ucl.ac.uk/research/ladbury/ladbury.htm
Articles in Scholarly Journals [Incomplete List]
- Survey of the year 2005: literature on applications of isothermal titration calorimetry
Journal of Molecular Recognition, vol. 20, no. 1, pp. 4–14, 2007 - Identification of novel fragment compounds targeted against the pY pocket of v-Src SH2 by computational and NMR screening and thermodynamic evaluation
Proteins: Structure, Function, and Bioinformatics, vol. 67, no. 4, pp. 981–990, 2007 - Editorial
Biophysical Chemistry, vol. 126, no. 1-3, pp. 3–3, 2007 - Partial filling multiple injection affinity capillary electrophoresis (PFMIACE) to estimate binding constants of receptors to ligands
Talanta, vol. 71, no. 1, pp. 192–201, 2007 - Journal of the American Chemical Society, vol. 129, no. 1, pp. 226–233, 2007
- Biochemistry, vol. 45, no. 5, pp. 1421–1434, 2006
- Conformational Diversity in the TPR Domain-Mediated Interaction of Protein Phosphatase 5 with Hsp90
Structure, vol. 14, no. 3, pp. 415–426, 2006 - Conformational changes in the AAA ATPase p97–p47 adaptor complex
The EMBO Journal, vol. 25, no. 9, Article ID 7601055, 9 pages, 2006 - Crystal Structure and Binding Properties of the CD2 and CD244 (2B4)-binding Protein, CD48
Journal of Biological Chemistry, vol. 281, no. 39, pp. 29309–29320, 2006 - Measurement of the formation of complexes in tyrosine kinase-mediated signal transduction
Acta Crystallographica Section D Biological Crystallography, vol. 63, no. 1, pp. 26–31, 2006 - StpA protein from Escherichia coli condenses supercoiled DNA in preference to linear DNA and protects it from digestion by DNase I and EcoKI
Nucleic Acids Research, vol. 33, no. 20, pp. 6540–6546, 2005 - Interaction of Porphyrin with G-Quadruplex Structures
Nucleosides, Nucleotides & Nucleic Acids, vol. 24, no. 5-7, pp. 753–756, 2005 - Molecular Recognition Coupled Folding and Binding in a TPR Domain
Journal of Molecular Biology, vol. 346, no. 3, pp. 717–732, 2005 - Distinct Spatial and Temporal Distribution of ZAP70 and Lck following Stimulation of Interferon and T-cell Receptors
Journal of Molecular Biology, vol. 353, no. 5, pp. 1001–1010, 2005 - NMR Assignment of the Apo and Peptide-bound SH2 Domain from the Rous Sarcoma Viral Protein Src
Journal of Biomolecular NMR, vol. 32, no. 4, pp. 339–339, 2005 - Survey of the year 2004: literature on applications of isothermal titration calorimetry
Journal of Molecular Recognition, vol. 19, no. 1, pp. 79–89, 2005 - Molecular basis for TPR domain-mediated regulation of protein phosphatase 5
The EMBO Journal, vol. 24, no. 1, Article ID 7600496, 9 pages, 2005 - H-NS is a part of a thermally controlled mechanism for bacterial gene regulation
Biochemical Journal, vol. 391, no. 2, p. 203, 2005 - Biochemistry, vol. 43, no. 44, pp. 13910–13925, 2004
- A survey of the year 2003 literature on applications of isothermal titration calorimetry
Journal of Molecular Recognition, vol. 17, no. 6, pp. 513–523, 2004 - Heat Capacity Effects of Water Molecules and Ions at a Protein–DNA Interface
Journal of Molecular Biology, vol. 336, no. 4, pp. 829–842, 2004 - The extended interface: measuring non-local effects in biomolecular interactions
Current Opinion in Structural Biology, vol. 14, no. 5, pp. 562–569, 2004 - Solvation and the hidden thermodynamics of a zinc finger probed by nonstandard repair of a protein crevice
Protein Science, vol. 13, no. 12, pp. 3115–3126, 2004 - Identification of a Novel Proline-Arginine Motif Involved in CIN85-dependent Clustering of Cbl and Down-regulation of Epidermal Growth Factor Receptors
Journal of Biological Chemistry, vol. 278, no. 41, pp. 39735–39746, 2003 - A survey of the year 2002 literature on applications of isothermal titration calorimetry
Journal of Molecular Recognition, vol. 16, no. 6, pp. 383–391, 2003 - Halophilic adaptation of protein?DNA interactions
Biochemical Society Transactions, vol. 31, no. 3, p. 677, 2003 - Accounts of Chemical Research, vol. 36, no. 6, pp. 410–416, 2003
- Reversal of Halophilicity in a Protein-DNA Interaction by Limited Mutation Strategy
Structure, vol. 10, no. 5, pp. 629–637, 2002 - Journal of Biomolecular NMR, vol. 23, no. 4, pp. 327–328, 2002
- The Hidden Thermodynamics of a Zinc Finger???
Journal of Molecular Biology, vol. 316, no. 4, pp. 969–989, 2002 - Metal-dependent Folding and Stability of Nuclear Hormone Receptor DNA-binding Domains
Journal of Molecular Biology, vol. 319, no. 1, pp. 87–106, 2002 - H-NS Oligomerization Domain Structure Reveals the Mechanism for High Order Self-association of the Intact Protein
Journal of Molecular Biology, vol. 324, no. 4, pp. 841–850, 2002 - Interactions defining the specificity between fungal xylanases and the wheat proteinaceous inhibitor, XIP-I
Biochemical Journal, 2002 - The Role of the Src Homology 3-Src Homology 2 Interface in the Regulation of Src Kinases
Journal of Biological Chemistry, vol. 276, no. 20, pp. 17199–17205, 2001 - Isothermal titration calorimetry: application to structure-based drug design
Thermochimica Acta, vol. 380, no. 2, pp. 209–215, 2001 - Inhibitors to the Src SH2 Domain: A Lesson in Structure–Thermodynamic Correlation in Drug Design
Archives of Biochemistry and Biophysics, vol. 390, no. 2, pp. 158–168, 2001 - Structural characterization of the N-terminal oligomerization domain of the bacterial chromatin-structuring protein, H-NS1
Journal of Molecular Biology, vol. 306, no. 5, pp. 1127–1137, 2001 - Biochemistry, vol. 40, no. 8, pp. 2419–2425, 2001
- Biochemistry, vol. 40, no. 16, pp. 4957–4965, 2001
- Biochemistry, vol. 40, no. 22, pp. 6580–6588, 2001
- Biochemistry, vol. 40, no. 49, pp. 14960–14967, 2001
- Biochemistry, vol. 40, no. 28, pp. 8430–8430, 2001
- Biochemistry, vol. 39, no. 25, pp. 7570–7579, 2000
- Searching for specificity in SH domains
Chemistry & Biology, vol. 7, no. 1, pp. R3–R8, 2000 - Oligomerization of the chromatin-structuring protein H-NS
Molecular Microbiology, vol. 36, no. 4, pp. 962–972, 2000 - Specificity and interactions of the protein OppA: partitioning solvent binding effects using mass spectrometry
Journal of Molecular Biology, vol. 296, no. 1, pp. 269–279, 2000 - Drug-DNA recognition: energetics and implications for design
Journal of Molecular Recognition, vol. 13, no. 4, pp. 188–197, 2000 - Temporally regulated assembly of a dynamic signaling complex associated with the activated TCR
European Journal of Immunology, vol. 30, no. 9, pp. 2620–2631, 2000 - Structural Basis for Recognition of Dipeptides by Peptide Transporters
Archives of Biochemistry and Biophysics, vol. 384, no. 1, pp. 9–23, 2000 - Localization and characterization of the hyaluronan-binding site on the Link module from human TSG-6
Structure, vol. 8, no. 7, pp. 763–774, 2000 - The ATPase cycle of Hsp90 drives a molecular clamp' via transient dimerization of the N-terminal domains
The EMBO Journal, vol. 19, no. 16, pp. 4383–4392, 2000 - Regulation of Hsp90 ATPase activity by tetratricopeptide repeat (TPR)-domain co-chaperones
The EMBO Journal, vol. 18, no. 3, pp. 754–762, 1999 - Oct-1 POU and octamer DNA co-operate to recognise the Bob-1 transcription co-activator via induced folding
Journal of Molecular Biology, vol. 288, no. 5, pp. 941–952, 1999 - Crystallographic and Calorimetric Analysis of Peptide Binding to OppA Protein
Journal of Molecular Biology, vol. 291, no. 2, pp. 393–415, 1999 - Journal of Medicinal Chemistry, vol. 42, no. 2, pp. 260–266, 1999
- Structure of the PH domain from Bruton's tyrosine kinase in complex with inositol 1,3,4,5-tetrakisphosphate
Structure, vol. 7, no. 4, pp. 449–460, 1999 - TCR Binding to Peptide-MHC Stabilizes a Flexible Recognition Interface
Immunity, vol. 10, no. 3, pp. 357–365, 1999 - Mass spectrometric and thermodynamic studies reveal the role of water molecules in complexes formed between SH2 domains and tyrosyl phosphopeptides
Structure, vol. 6, no. 9, pp. 1141–1151, 1998 - Biochemistry, vol. 37, no. 25, pp. 9083–9090, 1998
- Biochemistry, vol. 37, no. 42, pp. 14683–14691, 1998
- The effects of salt on the TATA binding protein-DNA interaction from a hyperthermophilic archaeon
Journal of Molecular Biology, vol. 279, no. 1, pp. 117–125, 1998 - Molecular design using electrostatic interactions. 1. Synthesis and properties of flexible tripodand tri- and hexa-cations with restricted conformations. Molecular selection of ferricyanide from ferrocyanide
Tetrahedron, vol. 54, no. 5-6, pp. 949–968, 1998 - ATP binding and hydrolysis are essential to the function of the Hsp90 molecular chaperone invivo
The EMBO Journal, vol. 17, no. 16, pp. 4829–4836, 1998 - Two EGF molecules contribute additively to stabilization of the EGFR dimer
The EMBO Journal, vol. 16, no. 2, pp. 281–294, 1997 - Identification and Structural Characterization of the ATP/ADP-Binding Site in the Hsp90 Molecular Chaperone
Cell, vol. 90, no. 1, pp. 65–75, 1997 - Specific binding of hoechst 33258 to the d(CGCAAATTTGCG)2 duplex: calorimetric and spectroscopic studies
Journal of Molecular Biology, vol. 271, no. 2, pp. 244–257, 1997 - The high-resolution crystal structure of a 24-kDa gyrase B fragment fromE. coli complexed with one of the most potent coumarin inhibitors, clorobiocin
Proteins: Structure, Function, and Genetics, vol. 28, no. 1, pp. 41–52, 1997 - Biochemistry, vol. 35, no. 34, pp. 11062–11069, 1996
- Biochemistry, vol. 35, no. 49, pp. 15646–15653, 1996
- Molecular Anchoring of Duplex and Triplex DNA by Disubstituted Anthracene-9,10-diones: Calorimetric, UV Melting, and Competition Dialysis Studies
Journal of the American Chemical Society, vol. 118, no. 44, pp. 10693–10701, 1996 - The role of water in sequence-independent ligand binding by an oligopeptide transporter protein
Nature Structural Biology, vol. 3, no. 12, Article ID nsb1296-998, 3 pages, 1996 - Sensing the heat: the application of isothermal titration calorimetry to thermodynamic studies of biomolecular interactions
Chemistry & Biology, vol. 3, no. 10, pp. 791–801, 1996 - Just add water! The effect of water on the specificity of protein-ligand binding sites and its potential application to drug design
Chemistry & Biology, vol. 3, no. 12, pp. 973–980, 1996 - Biochemistry, vol. 34, no. 7, pp. 2148–2152, 1995
- Measurement of the Binding of Tyrosyl Phosphopeptides to SH2 Domains: A Reappraisal
Proceedings of the National Academy of Sciences, vol. 92, no. 8, pp. 3199–3203, 1995 - Counting the calories to stay in the groove
Structure, vol. 3, no. 7, pp. 635–639, 1995 - Heparin-induced oligomerization of FGF molecules is responsible for FGF receptor dimerization, activation, and cell proliferation
Cell, vol. 79, no. 6, pp. 1015–1024, 1994 - A Thermodynamic Study of the trp Repressor—Operator Interaction
Journal of Molecular Biology, vol. 238, no. 5, pp. 669–681, 1994 - Turning Up the Heat On Rational Drug Design
Bio/Technology, vol. 12, no. 11, Article ID nbt1194-1083, 2 pages, 1994 - Biochemistry, vol. 33, no. 17, pp. 5070–5076, 1994
- Biochemistry, vol. 33, no. 22, pp. 6828–6833, 1994
- A ribonuclease S-peptide antagonist discovered with a bacteriophage display library
Gene, vol. 128, no. 1, pp. 37–42, 1993 - Biochemistry, vol. 31, no. 44, pp. 10699–10702, 1992