Robert Pike

Robert Pike received the B.S. degree in agriculture and the Ph.D. degree in biochemistry from the University of Natal, Pietermaritzburg, South Africa, in 1987 and 1991, respectively. From 1992 to 1994, he was a postdoctoral fellow in the Department of Biochemistry and Molecular Biology at the University of Georgia in Athens, Ga, USA, following which he was a Foundation for Research and Development Research Fellow at the University of Natal, Pietermaritzburg, South Africa, from 1994 to 1995. From 1996 to 1997, he was a postdoctoral fellow in the Department of Haematology, University of Cambridge, UK. In 1997 he was appointed to a lectureship in the Department of Biochemistry and Molecular Biology at Monash University in Melbourne, Australia, where he is now an Associate Professor and Head of Department.

Biography Updated on 27 November 2007

Personal Home Page

http://www.med.monash.edu.au/biochem/staff/pike.html

Articles in Scholarly Journals [Incomplete List]

  1. GABA production by glutamic acid decarboxylase is regulated by a dynamic catalytic loop
    Nature Structural & Molecular Biology, vol. 14, no. 4, Article ID nsmb1228, 6 pages, 2007
  2. Molecular characterization of centerin, a germinal centre cell serpin
    Biochemical Journal, vol. 405, no. 3, p. 489, 2007
  3. A Common Fold Mediates Vertebrate Defense and Bacterial Attack
    Science, vol. 317, no. 5844, pp. 1548–1551, 2007
  4. Genome Biology, vol. 7, no. 5, p. 216, 2006
  5. Functional responses of bone cells to thrombin
    Biological Chemistry, vol. 387, no. 8, pp. 1037–1041, 2006
  6. Production and processing of a recombinant Fasciola hepatica cathepsin B-like enzyme (FhcatB1) reveals potential processing mechanisms in the parasite
    Biological Chemistry, vol. 387, no. 8, pp. 1053–1061, 2006
  7. Approaches to Selective Peptidic Inhibitors of Factor Xa
    Chemical Biology Drug Design, vol. 68, no. 1, pp. 11–19, 2006
  8. X-ray crystal structure of MENT: evidence for functional loop–sheet polymers in chromatin condensation
    The EMBO Journal, vol. 25, no. 13, Article ID 7601201, 11 pages, 2006
  9. Studies on the receptors mediating responses of osteoblasts to thrombin
    The International Journal of Biochemistry & Cell Biology, vol. 37, no. 1, pp. 206–213, 2005
  10. Control of the coagulation system by serpins. Getting by with a little help from glycosaminoglycans
    FEBS Journal, vol. 272, no. 19, pp. 4842–4851, 2005
  11. Serpins 2005 - fun between the beta-sheets. Meeting report based upon presentations made at the 4th International Symposium on Serpin Structure, Function and Biology (Cairns, Australia)
    FEBS Journal, vol. 272, no. 19, pp. 4868–4873, 2005
  12. The Murine Orthologue of Human Antichymotrypsin: A STRUCTURAL PARADIGM FOR CLADE A3 SERPINS
    Journal of Biological Chemistry, vol. 280, no. 52, pp. 43168–43178, 2005
  13. Elucidation of the Substrate Specificity of the C1s Protease of the Classical Complement Pathway
    Journal of Biological Chemistry, vol. 280, no. 47, pp. 39510–39514, 2005
  14. Journal of Bioinformatics and Computational Biology, vol. 3, no. 3, p. 551, 2005
  15. Activation of Protease-Activated Receptor-2 Leads to Inhibition of Osteoclast Differentiation
    Journal of Bone and Mineral Research, vol. 19, no. 3, pp. 507–516, 2004
  16. The C-terminal domains of the gingipain K polyprotein are necessary for assembly of the active enzyme and expression of associated activities
    Molecular Microbiology, vol. 54, no. 5, pp. 1393–1408, 2004
  17. Erratum to “Inhibition of osteoblast apoptosis by thrombin” [Bone 33 (2003) 733–743]
    Bone, vol. 35, no. 1, p. 343, 2004
  18. Physical characterization of serpin conformations
    Methods, vol. 32, no. 2, pp. 150–158, 2004
  19. Antithrombin: in control of coagulation
    The International Journal of Biochemistry & Cell Biology, vol. 36, no. 3, pp. 386–389, 2004
  20. Inhibition of osteoblast apoptosis by thrombin
    Bone, vol. 33, no. 4, pp. 733–743, 2003
  21. The 1.5 Å Crystal Structure of a Prokaryote SerpinControlling Conformational Change in a Heated Environment
    Structure, vol. 11, no. 4, pp. 387–397, 2003
  22. Determination of the P1', P2' and P3' subsite-specificity of factor Xa
    The International Journal of Biochemistry & Cell Biology, vol. 35, no. 2, pp. 221–225, 2003
  23. Biochemistry, vol. 42, no. 24, pp. 7381–7389, 2003
  24. Biochemistry, vol. 42, no. 34, pp. 10169–10173, 2003
  25. Biochemistry, vol. 42, no. 40, pp. 11693–11700, 2003
  26. Biochemistry, vol. 42, no. 50, pp. 14939–14945, 2003
  27. The Evolution of Enzyme Specificity in Fasciola spp.
    Journal of Molecular Evolution, vol. 57, no. 1, pp. 1–15, 2003
  28. Enzymic, Phylogenetic, and Structural Characterization of the Unusual Papain-like Protease Domain of Plasmodium falciparum SERA5
    Journal of Biological Chemistry, vol. 278, no. 48, pp. 48169–48177, 2003
  29. The Elusive Role of the Potential Factor X Cation-binding Exosite-1 in Substrate and Inhibitor Interactions
    Journal of Biological Chemistry, vol. 279, no. 5, pp. 3671–3679, 2003
  30. Cloning and Expression of the Major Secreted Cathepsin B-Like Protein from Juvenile Fasciola hepatica and Analysis of Immunogenicity following Liver Fluke Infection
    Infection and Immunity, vol. 71, no. 12, pp. 6921–6932, 2003
  31. Protease-Activated Receptors: A Means of Converting Extracellular Proteolysis into Intracellular Signals
    IUBMB Life (International Union of Biochemistry and Molecular Biology: Life), vol. 53, no. 6, pp. 277–281, 2002
  32. Serpins: Finely Balanced Conformational Traps
    IUBMB Life (International Union of Biochemistry and Molecular Biology: Life), vol. 54, no. 1, pp. 1–7, 2002
  33. Molecular Determinants of the Mechanism Underlying Acceleration of the Interaction between Antithrombin and Factor Xa by Heparin Pentasaccharide
    Journal of Biological Chemistry, vol. 277, no. 18, pp. 15971–15978, 2002
  34. Inhibitory Activity of a Heterochromatin-associated Serpin (MENT) against Papain-like Cysteine Proteinases Affects Chromatin Structure and Blocks Cell Proliferation
    Journal of Biological Chemistry, vol. 277, no. 15, pp. 13192–13201, 2002
  35. Dissection of Protease-Activated Receptor-1-Dependent and -Independent Responses to Thrombin in Skeletal Myoblasts
    Experimental Cell Research, vol. 274, no. 1, pp. 149–156, 2002
  36. A naturally occurring NAR variable domain binds the Kgp protease from Porphyromonas gingivalis
    FEBS Letters, vol. 516, no. 1-3, pp. 80–86, 2002
  37. Biochemistry, vol. 41, no. 15, pp. 4998–5004, 2002
  38. The role of strand 1 of the C beta-sheet in the structure and function of alpha1-antitrypsin
    Protein Science, vol. 10, no. 12, pp. 2518–2524, 2001
  39. Activation of protease-activated receptors by gingipains from Porphyromonas gingivalis leads to platelet aggregation: a new trait in microbial pathogenicity
    Blood, vol. 97, no. 12, pp. 3790–3797, 2001
  40. Arginine-Specific Protease from Porphyromonas gingivalis Activates Protease-Activated Receptors on Human Oral Epithelial Cells and Induces Interleukin-6 Secretion
    Infection and Immunity, vol. 69, no. 8, pp. 5121–5130, 2001
  41. Prevention of albuminuria by aminoguanidine or ramipril in streptozotocin-induced diabetic rats is associated with the normalization of glomerular protein kinase C
    Diabetes, vol. 49, no. 1, pp. 87–93, 2000
  42. Phylogeny of the Serpin Superfamily: Implications of Patterns of Amino Acid Conservation for Structure and Function
    Genome Research, vol. 10, no. 12, pp. 1845–1864, 2000
  43. Expression of protease-activated receptor-2 by osteoblasts
    Bone, vol. 26, no. 1, pp. 7–14, 2000
  44. Evidence for the activation of PAR-2 by the sperm protease, acrosin: expression of the receptor on oocytes
    FEBS Letters, vol. 484, no. 3, pp. 285–290, 2000
  45. Conformational changes in serpins: II. the mechanism of activation of antithrombin by heparin ,
    Journal of Molecular Biology, vol. 301, no. 5, pp. 1287–1305, 2000
  46. Cysteine Proteinase Inhibitors Kill Cultured Bloodstream Forms ofTrypanosoma brucei brucei,
    Experimental Parasitology, vol. 91, no. 4, pp. 349–355, 1999
  47. Serpins in theCaenorhabditis elegans genome
    Proteins: Structure, Function, and Genetics, vol. 36, no. 1, pp. 31–41, 1999
  48. A trypanosome oligopeptidase as a target for the trypanocidal agents pentamidine, diminazene and suramin
    FEBS Letters, vol. 433, no. 3, pp. 251–256, 1998
  49. Cleavage and activation of proteinase-activated receptor-2 on human neutrophils by gingipain-R from Porphyromonas gingivalis
    FEBS Letters, vol. 435, no. 1, pp. 45–48, 1998
  50. Angiotensinogen cleavage by renin: importance of a structurally constrained N-terminus
    FEBS Letters, vol. 436, no. 2, pp. 267–270, 1998
  51. Production of anti-peptide antibodies against trypanopain-Tb from Trypanosoma brucei brucei: effects of antibodies on enzyme activity against Z-Phe-Arg-AMC
    Immunopharmacology, vol. 36, no. 2-3, pp. 295–303, 1997
  52. The anticoagulant activation of antithrombin by heparin
    Proceedings of the National Academy of Sciences, vol. 94, no. 26, pp. 14683–14688, 1997
  53. Molecular Cloning and Characterization of Porphyromonas gingivalis Lysine-specific Gingipain. A NEW MEMBER OF AN EMERGING FAMILY OF PATHOGENIC BACTERIAL CYSTEINE PROTEINASES
    Journal of Biological Chemistry, vol. 272, no. 3, pp. 1595–1600, 1997
  54. The potential role of alpha2-macroglobulin in the control of cysteine proteinases (gingipains) from Porphyromonas gingivalis
    Journal of Periodontal Research, vol. 32, no. 1, pp. 61–68, 1997
  55. Porphyromonas gingivalis proteinases as virulence factors in the development of periodontitis
    Journal of Periodontal Research, vol. 32, no. 1, pp. 120–125, 1997
  56. Purification and Characterization of a Novel Endopeptidase in Ragweed (Ambrosia artemisiifolia) Pollen
    Journal of Biological Chemistry, vol. 271, no. 42, pp. 26227–26232, 1996
  57. The amino acid sequences, structure comparisons and inhibition kinetics of sheep cathepsin L and sheep stefin B
    Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology, vol. 114, no. 2, pp. 193–198, 1996
  58. Mature Cathepsin L Is Substantially Active in the Ionic Milieu of the Extracellular Medium
    Archives of Biochemistry and Biophysics, vol. 324, no. 1, pp. 93–98, 1995
  59. Host andPorphyromonas gingivalis proteinases in periodontitis: A biochemical model of infection and tissue destruction
    Perspectives in Drug Discovery and Design, vol. 2, no. 3, pp. 445–458, 1995
  60. Molecular Cloning and Structural Characterization of the Arg-gingipain Proteinase of Porphyromonas gingivalis
    Journal of Biological Chemistry, vol. 270, no. 3, pp. 1007–1010, 1995
  61. Proteolytically active complexes of cathepsin L and a cysteine proteinase inhibitor; purification and demonstration of their formation in vitro
    Archives of Biochemistry and Biophysics, vol. 294, no. 2, pp. 623–629, 1992
  62. Anti-peptide antibodies to cathepsins B, L and D and type IV collagenase Specific recognition and inhibition of the enzymes
    Journal of Immunological Methods, vol. 136, no. 2, pp. 199–210, 1991
  63. Isolation of cathepsin D using three-phase partitioning in t-butanol/water/ammonium sulfate
    Analytical Biochemistry, vol. 180, no. 1, pp. 169–171, 1989
  64. Protein fractionation by three phase partitioning (TPP) in aqueous/t-butanol mixtures
    Biotechnology and Bioengineering, vol. 33, no. 2, pp. 221–228, 1989