Robert Pike
Robert Pike received the B.S. degree in agriculture and the Ph.D. degree in biochemistry from the University of Natal, Pietermaritzburg, South Africa, in 1987 and 1991, respectively. From 1992 to 1994, he was a postdoctoral fellow in the Department of Biochemistry and Molecular Biology at the University of Georgia in Athens, Ga, USA, following which he was a Foundation for Research and Development Research Fellow at the University of Natal, Pietermaritzburg, South Africa, from 1994 to 1995. From 1996 to 1997, he was a postdoctoral fellow in the Department of Haematology, University of Cambridge, UK. In 1997 he was appointed to a lectureship in the Department of Biochemistry and Molecular Biology at Monash University in Melbourne, Australia, where he is now an Associate Professor and Head of Department.
Biography Updated on 27 November 2007
Personal Home Page
http://www.med.monash.edu.au/biochem/staff/pike.html
Articles in Scholarly Journals [Incomplete List]
- GABA production by glutamic acid decarboxylase is regulated by a dynamic catalytic loop
Nature Structural & Molecular Biology, vol. 14, no. 4, Article ID nsmb1228, 6 pages, 2007 - Molecular characterization of centerin, a germinal centre cell serpin
Biochemical Journal, vol. 405, no. 3, p. 489, 2007 - A Common Fold Mediates Vertebrate Defense and Bacterial Attack
Science, vol. 317, no. 5844, pp. 1548–1551, 2007 - Genome Biology, vol. 7, no. 5, p. 216, 2006
- Functional responses of bone cells to thrombin
Biological Chemistry, vol. 387, no. 8, pp. 1037–1041, 2006 - Production and processing of a recombinant Fasciola hepatica cathepsin B-like enzyme (FhcatB1) reveals potential processing mechanisms in the parasite
Biological Chemistry, vol. 387, no. 8, pp. 1053–1061, 2006 - Approaches to Selective Peptidic Inhibitors of Factor Xa
Chemical Biology Drug Design, vol. 68, no. 1, pp. 11–19, 2006 - X-ray crystal structure of MENT: evidence for functional loop–sheet polymers in chromatin condensation
The EMBO Journal, vol. 25, no. 13, Article ID 7601201, 11 pages, 2006 - Studies on the receptors mediating responses of osteoblasts to thrombin
The International Journal of Biochemistry & Cell Biology, vol. 37, no. 1, pp. 206–213, 2005 - Control of the coagulation system by serpins. Getting by with a little help from glycosaminoglycans
FEBS Journal, vol. 272, no. 19, pp. 4842–4851, 2005 - Serpins 2005 - fun between the beta-sheets. Meeting report based upon presentations made at the 4th International Symposium on Serpin Structure, Function and Biology (Cairns, Australia)
FEBS Journal, vol. 272, no. 19, pp. 4868–4873, 2005 - The Murine Orthologue of Human Antichymotrypsin: A STRUCTURAL PARADIGM FOR CLADE A3 SERPINS
Journal of Biological Chemistry, vol. 280, no. 52, pp. 43168–43178, 2005 - Elucidation of the Substrate Specificity of the C1s Protease of the Classical Complement Pathway
Journal of Biological Chemistry, vol. 280, no. 47, pp. 39510–39514, 2005 - Journal of Bioinformatics and Computational Biology, vol. 3, no. 3, p. 551, 2005
- Activation of Protease-Activated Receptor-2 Leads to Inhibition of Osteoclast Differentiation
Journal of Bone and Mineral Research, vol. 19, no. 3, pp. 507–516, 2004 - The C-terminal domains of the gingipain K polyprotein are necessary for assembly of the active enzyme and expression of associated activities
Molecular Microbiology, vol. 54, no. 5, pp. 1393–1408, 2004 - Erratum to “Inhibition of osteoblast apoptosis by thrombin” [Bone 33 (2003) 733–743]
Bone, vol. 35, no. 1, p. 343, 2004 - Physical characterization of serpin conformations
Methods, vol. 32, no. 2, pp. 150–158, 2004 - Antithrombin: in control of coagulation
The International Journal of Biochemistry & Cell Biology, vol. 36, no. 3, pp. 386–389, 2004 - Inhibition of osteoblast apoptosis by thrombin
Bone, vol. 33, no. 4, pp. 733–743, 2003 - The 1.5 Å Crystal Structure of a Prokaryote SerpinControlling Conformational Change in a Heated Environment
Structure, vol. 11, no. 4, pp. 387–397, 2003 - Determination of the P1', P2' and P3' subsite-specificity of factor Xa
The International Journal of Biochemistry & Cell Biology, vol. 35, no. 2, pp. 221–225, 2003 - Biochemistry, vol. 42, no. 24, pp. 7381–7389, 2003
- Biochemistry, vol. 42, no. 34, pp. 10169–10173, 2003
- Biochemistry, vol. 42, no. 40, pp. 11693–11700, 2003
- Biochemistry, vol. 42, no. 50, pp. 14939–14945, 2003
- The Evolution of Enzyme Specificity in Fasciola spp.
Journal of Molecular Evolution, vol. 57, no. 1, pp. 1–15, 2003 - Enzymic, Phylogenetic, and Structural Characterization of the Unusual Papain-like Protease Domain of Plasmodium falciparum SERA5
Journal of Biological Chemistry, vol. 278, no. 48, pp. 48169–48177, 2003 - The Elusive Role of the Potential Factor X Cation-binding Exosite-1 in Substrate and Inhibitor Interactions
Journal of Biological Chemistry, vol. 279, no. 5, pp. 3671–3679, 2003 - Cloning and Expression of the Major Secreted Cathepsin B-Like Protein from Juvenile Fasciola hepatica and Analysis of Immunogenicity following Liver Fluke Infection
Infection and Immunity, vol. 71, no. 12, pp. 6921–6932, 2003 - Protease-Activated Receptors: A Means of Converting Extracellular Proteolysis into Intracellular Signals
IUBMB Life (International Union of Biochemistry and Molecular Biology: Life), vol. 53, no. 6, pp. 277–281, 2002 - Serpins: Finely Balanced Conformational Traps
IUBMB Life (International Union of Biochemistry and Molecular Biology: Life), vol. 54, no. 1, pp. 1–7, 2002 - Molecular Determinants of the Mechanism Underlying Acceleration of the Interaction between Antithrombin and Factor Xa by Heparin Pentasaccharide
Journal of Biological Chemistry, vol. 277, no. 18, pp. 15971–15978, 2002 - Inhibitory Activity of a Heterochromatin-associated Serpin (MENT) against Papain-like Cysteine Proteinases Affects Chromatin Structure and Blocks Cell Proliferation
Journal of Biological Chemistry, vol. 277, no. 15, pp. 13192–13201, 2002 - Dissection of Protease-Activated Receptor-1-Dependent and -Independent Responses to Thrombin in Skeletal Myoblasts
Experimental Cell Research, vol. 274, no. 1, pp. 149–156, 2002 - A naturally occurring NAR variable domain binds the Kgp protease from Porphyromonas gingivalis
FEBS Letters, vol. 516, no. 1-3, pp. 80–86, 2002 - Biochemistry, vol. 41, no. 15, pp. 4998–5004, 2002
- The role of strand 1 of the C beta-sheet in the structure and function of alpha1-antitrypsin
Protein Science, vol. 10, no. 12, pp. 2518–2524, 2001 - Activation of protease-activated receptors by gingipains from Porphyromonas gingivalis leads to platelet aggregation: a new trait in microbial pathogenicity
Blood, vol. 97, no. 12, pp. 3790–3797, 2001 - Arginine-Specific Protease from Porphyromonas gingivalis Activates Protease-Activated Receptors on Human Oral Epithelial Cells and Induces Interleukin-6 Secretion
Infection and Immunity, vol. 69, no. 8, pp. 5121–5130, 2001 - Prevention of albuminuria by aminoguanidine or ramipril in streptozotocin-induced diabetic rats is associated with the normalization of glomerular protein kinase C
Diabetes, vol. 49, no. 1, pp. 87–93, 2000 - Phylogeny of the Serpin Superfamily: Implications of Patterns of Amino Acid Conservation for Structure and Function
Genome Research, vol. 10, no. 12, pp. 1845–1864, 2000 - Expression of protease-activated receptor-2 by osteoblasts
Bone, vol. 26, no. 1, pp. 7–14, 2000 - Evidence for the activation of PAR-2 by the sperm protease, acrosin: expression of the receptor on oocytes
FEBS Letters, vol. 484, no. 3, pp. 285–290, 2000 - Conformational changes in serpins: II. the mechanism of activation of antithrombin by heparin ,
Journal of Molecular Biology, vol. 301, no. 5, pp. 1287–1305, 2000 - Cysteine Proteinase Inhibitors Kill Cultured Bloodstream Forms ofTrypanosoma brucei brucei,
Experimental Parasitology, vol. 91, no. 4, pp. 349–355, 1999 - Serpins in theCaenorhabditis elegans genome
Proteins: Structure, Function, and Genetics, vol. 36, no. 1, pp. 31–41, 1999 - A trypanosome oligopeptidase as a target for the trypanocidal agents pentamidine, diminazene and suramin
FEBS Letters, vol. 433, no. 3, pp. 251–256, 1998 - Cleavage and activation of proteinase-activated receptor-2 on human neutrophils by gingipain-R from Porphyromonas gingivalis
FEBS Letters, vol. 435, no. 1, pp. 45–48, 1998 - Angiotensinogen cleavage by renin: importance of a structurally constrained N-terminus
FEBS Letters, vol. 436, no. 2, pp. 267–270, 1998 - Production of anti-peptide antibodies against trypanopain-Tb from Trypanosoma brucei brucei: effects of antibodies on enzyme activity against Z-Phe-Arg-AMC
Immunopharmacology, vol. 36, no. 2-3, pp. 295–303, 1997 - The anticoagulant activation of antithrombin by heparin
Proceedings of the National Academy of Sciences, vol. 94, no. 26, pp. 14683–14688, 1997 - Molecular Cloning and Characterization of Porphyromonas gingivalis Lysine-specific Gingipain. A NEW MEMBER OF AN EMERGING FAMILY OF PATHOGENIC BACTERIAL CYSTEINE PROTEINASES
Journal of Biological Chemistry, vol. 272, no. 3, pp. 1595–1600, 1997 - The potential role of alpha2-macroglobulin in the control of cysteine proteinases (gingipains) from Porphyromonas gingivalis
Journal of Periodontal Research, vol. 32, no. 1, pp. 61–68, 1997 - Porphyromonas gingivalis proteinases as virulence factors in the development of periodontitis
Journal of Periodontal Research, vol. 32, no. 1, pp. 120–125, 1997 - Purification and Characterization of a Novel Endopeptidase in Ragweed (Ambrosia artemisiifolia) Pollen
Journal of Biological Chemistry, vol. 271, no. 42, pp. 26227–26232, 1996 - The amino acid sequences, structure comparisons and inhibition kinetics of sheep cathepsin L and sheep stefin B
Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology, vol. 114, no. 2, pp. 193–198, 1996 - Mature Cathepsin L Is Substantially Active in the Ionic Milieu of the Extracellular Medium
Archives of Biochemistry and Biophysics, vol. 324, no. 1, pp. 93–98, 1995 - Host andPorphyromonas gingivalis proteinases in periodontitis: A biochemical model of infection and tissue destruction
Perspectives in Drug Discovery and Design, vol. 2, no. 3, pp. 445–458, 1995 - Molecular Cloning and Structural Characterization of the Arg-gingipain Proteinase of Porphyromonas gingivalis
Journal of Biological Chemistry, vol. 270, no. 3, pp. 1007–1010, 1995 - Proteolytically active complexes of cathepsin L and a cysteine proteinase inhibitor; purification and demonstration of their formation in vitro
Archives of Biochemistry and Biophysics, vol. 294, no. 2, pp. 623–629, 1992 - Anti-peptide antibodies to cathepsins B, L and D and type IV collagenase Specific recognition and inhibition of the enzymes
Journal of Immunological Methods, vol. 136, no. 2, pp. 199–210, 1991 - Isolation of cathepsin D using three-phase partitioning in t-butanol/water/ammonium sulfate
Analytical Biochemistry, vol. 180, no. 1, pp. 169–171, 1989 - Protein fractionation by three phase partitioning (TPP) in aqueous/t-butanol mixtures
Biotechnology and Bioengineering, vol. 33, no. 2, pp. 221–228, 1989