R. Loch Macdonald0000-0003-4024-8070
R. Loch Macdonald holds an M.D. degree from the University of British Columbia, Vancouver, BC, Canada and a Ph.D. degree from the University of Alberta. He served as a Scientist at the Keenan Research Centre of the Li Ka Shing Knowledge Institute of St. Michael's Hospital, as a Professor of surgery and neurosurgery at the University of Toronto, as a Division Head of neurosurgery at St. Michael's Hospital, and Keenan Endowed Chair of surgery at St. Michael's Hospital. His clinical specialty is neurosurgery. His research interests are subarachnoid hemorrhage, cerebral vasospasm, cerebral blood flow and metabolism, stroke, cerebral aneurysms, cerebrovascular malformations. His research activities are in the field of aneurismal subarachnoid hemorrhage and cerebral vasospasm. He is investigating the causes of delayed neurological deterioration after subarachnoid hemorrhage using animal models and testing hippocampal electrophysiology and function, animal behavior, learning and memory and changes in gene expression and function. He is also studying mechanisms of large artery vasospasm after aneurismal subarachnoid hemorrhage. He found that endothelin antagonists affect this disease and he uses patch clamp electrophysiology, molecular biology, whole artery isometric tension studies, and in vivo imaging to assess mechanisms of contraction including the role of ion channels and TRP proteins. He served on the Editorial Boards of Neurosurgery, Stroke, Neurocritical Care, and Surgical Neurology and as Ad Hoc Reviewer of multiple medical journals. In addition, he served as a Member of NIH Brain Injury and Neurovascular Pathologies Study Section.
Biography Updated on 1 March 2014