Alexander Bürkle

Alexander Bürkle was born in Offenburg, Germany, in 1957. He studied medicine at the University of Freiburg, Germany, and received his M.D. degree in 1982. After his military service as a Captain of the Medical Corps (1982–1984), he was a Postdoctoral Fellow (1984–1987) and a Group Leader (1987–2000) at the German Cancer Research Centre, Heidelberg, Germany. From 2000 to 2002, he was a Senior Lecturer at the Department of Gerontology, Institute for Ageing and Health, University of Newcastle upon Tyne, UK. In 2002, he was appointed to his present position of Full Professor and Chair of Molecular Toxicology at the Department of Biology, University of Konstanz, Germany. From 2003 to 2006, he served as Chairman of the University’s Department of Biology. Since 2004, he has been Treasurer and Member of the Executive Committee of the International Union of Toxicology (IUTOX). His research interests are the role of poly(ADP-ribosyl)ation and DNA repair in the ageing and the neurotoxicity of prion protein. He is a Member of the editorial boards of “Biogerontology,” “Cancer Letters,” “Mechanisms of Ageing and Development,” “BiomedCentral,” “Immunity and Ageing,” “Scientific World Journal,” “Eurekah Bioscience,” and “Current Gerontology and Geriatrics Research.”

Biography Updated on 30 April 2007

Articles in Scholarly Journals [Incomplete List]

  1. Lethal recessive myelin toxicity of prion protein lacking its central domain
    The EMBO Journal, vol. 26, no. 2, Article ID 7601510, 9 pages, 2007
  2. DNA repair and PARP in agingâ? 
    Free Radical Research, vol. 40, no. 12, pp. 1295–1302, 2006
  3. Poly(ADP-RIBOSE) polymerase-1 (Parp-1) antagonizes topoisomerase I-dependent recombination stimulation by P53
    Nucleic Acids Research, vol. 34, no. 3, pp. 1036–1049, 2006
  4. Immunity & Ageing, vol. 3, no. 1, p. 8, 2006
  5. Neuroprotective Therapies for Alzheimer's Disease
    Current Pharmaceutical Design, vol. 12, no. 6, pp. 705–717, 2006
  6. Poly(ADP-ribose). The most elaborate metabolite of NAD+
    FEBS Journal, vol. 272, no. 18, pp. 4576–4589, 2005
  7. Ageing and PARP
    Pharmacological Research, vol. 52, no. 1, pp. 93–99, 2005
  8. Poly-ADP-ribosylation in health and disease
    CMLS Cellular and Molecular Life Sciences, vol. 62, no. 7-8, pp. 721–730, 2005
  9. Poly(ADP-ribosyl)ation during chromatin remodeling steps in rat spermiogenesis
    Chromosoma, vol. 114, no. 1, pp. 67–74, 2005
  10. The emerging role of poly(ADP-ribose) polymerase-1 in longevity
    The International Journal of Biochemistry & Cell Biology, vol. 37, no. 5, pp. 1043–1053, 2005
  11. Poly(ADP-ribose) glycohydrolase as a target for neuroprotective intervention: assessment of currently available pharmacological tools
    European Journal of Pharmacology, vol. 497, no. 1, pp. 7–16, 2004
  12. Poly(ADP-ribosyl)ation and aging
    Experimental Gerontology, vol. 39, no. 11-12, pp. 1599–1601, 2004
  13. Poly(ADP-ribosyl)ation inhibitors: Promising drug candidates for a wide variety of pathophysiologic conditions
    International Journal of Cancer, vol. 111, no. 6, pp. 813–818, 2004
  14. Poly(ADP-ribose) polymerase (PARP-1) and p53 independently function in regulating double-strand break repair in primate cells
    Nucleic Acids Research, vol. 32, no. 2, pp. 669–680, 2004
  15. L-Selegiline Potentiates the Cellular Poly(ADP-Ribosyl)ation Response to Ionizing Radiation
    Journal of Pharmacology and Experimental Therapeutics, vol. 306, no. 3, pp. 973–979, 2003
  16. Up-regulation of cathepsin B and cathepsin L activities in scrapie-infected mouse Neuro2a cells
    Journal of General Virology, vol. 84, no. 8, pp. 2279–2283, 2003
  17. Poly(ADP-ribose) polymerase-1 is a survival factor for radiation-exposed intestinal epithelial stem cells in vivo
    Nucleic Acids Research, vol. 31, no. 21, pp. 6198–6205, 2003
  18. Very low concentrations of arsenite suppress poly(ADP-ribosyl)ation in mammalian cells
    International Journal of Cancer, vol. 104, no. 1, pp. 1–6, 2003
  19. Induction of poly(ADP-ribosyl)ation and DNA damage in human peripheral lymphocytes after treatment with (-)-epigallocatechin-gallate
    Mutation Research/Genetic Toxicology and Environmental Mutagenesis, vol. 534, no. 1-2, pp. 77–84, 2003
  20. The Histochemical Journal, vol. 34, no. 6/7, pp. 357–363, 2002
  21. Increase in de novo HBV DNA integrations in response to oxidative DNA damage or inhibition of poly(ADP-ribosyl)ation
    Hepatology, vol. 35, no. 1, pp. 217–223, 2002
  22. In memoriam Bernard Strehler—genomic instability in ageing: a persistent challenge
    Mechanisms of Ageing and Development, vol. 123, no. 8, pp. 899–906, 2002
  23. Poly(ADP-ribose) polymerase-1, DNA repair and mammalian longevity
    Experimental Gerontology, vol. 37, no. 10-11, pp. 1203–1205, 2002
  24. Reduced poly(ADP-ribosyl)ation in lymphocytes of laryngeal cancer patients: Results of a case-control study
    International Journal of Cancer, vol. 98, no. 5, pp. 780–784, 2002
  25. Genomic structure, conservation and FISH mapping of the Rattus norvegicus Adprt gene
    Cytogenetic and Genome Research, vol. 98, no. 4, pp. 298–301, 2002
  26. Physiology and pathophysiology of poly(ADP-ribosyl)ation
    BioEssays, vol. 23, no. 9, pp. 795–806, 2001
  27. Poly(APD-ribosyl)ation, a DNA damage-driven protein modification and regulator of genomic instability
    Cancer Letters, vol. 163, no. 1, pp. 1–5, 2001
  28. Stress, DNA damage and ageing — an integrative approach
    Experimental Gerontology, vol. 36, no. 7, pp. 1049–1062, 2001
  29. Quantitative assessment of bleomycin-induced poly(ADP-ribosyl)ation in human lymphocytes by immunofluorescence and image analysis
    Journal of Immunological Methods, vol. 244, no. 1-2, pp. 145–151, 2000
  30. British Journal of Cancer, vol. 82, no. 3, pp. 629–634, 2000
  31. Negative regulation of alkylation-induced sister-chromatid exchange by poly(ADP-ribose) polymerase-1 activity
    International Journal of Cancer, vol. 88, no. 3, pp. 351–355, 2000
  32. New polymorphisms in the human poly(ADP-ribose) polymerase-1 coding sequence: lack of association with longevity or with increased cellular poly(ADP-ribosyl)ation capacity
    Journal of Molecular Medicine, vol. 78, no. 8, pp. 431–440, 2000
  33. Detection of poly(ADP-ribose) synthesis in Drosophila testes upon γ-irradiation
    Chromosoma, vol. 108, no. 1, pp. 44–51, 1999
  34. Quantitative Nonisotopic Immuno-Dot-Blot Method for the Assessment of Cellular Poly(ADP-ribosyl)ation Capacity
    Analytical Biochemistry, vol. 275, no. 1, pp. 118–122, 1999
  35. Tumorigenic conversion of immortal human skin keratinocytes (HaCaT) by elevated temperature
    Oncogene, vol. 18, no. 41, pp. 5638–5645, 1999
  36. Overexpression of dominant negative PARP interferes with tumor formation of HeLa cells in nude mice: Evidence for increased tumor cell apoptosis in vivo
    Oncogene, vol. 18, no. 50, pp. 7010–7015, 1999
  37. Histochemical Journal, vol. 31, no. 11, pp. 711–716, 1999
  38. Molecular and Cellular Biochemistry, vol. 193, no. 1/2, pp. 31–35, 1999
  39. Reactive oxygen species participate in mdr1b mRNA and P-glycoprotein overexpression in primary rat hepatocyte cultures
    Carcinogenesis, vol. 20, no. 3, pp. 407–414, 1999
  40. Selective Loss of Poly(ADP-ribose) and the 85-kDa Fragment of Poly(ADP-ribose) Polymerase in Nucleoli during Alkylation-induced Apoptosis of HeLa Cells
    Journal of Biological Chemistry, vol. 274, no. 45, pp. 32122–32126, 1999
  41. Poly(ADP-ribose) polymerase and aging
    Experimental Gerontology, vol. 33, no. 6, pp. 519–523, 1998
  42. Immunodot Blot Method for the Detection of Poly(ADP-ribose) Synthesizedin Vitroandin Vivo
    Analytical Biochemistry, vol. 259, no. 2, pp. 280–283, 1998
  43. Increased poly(ADP-ribose) polymerase activity in lymphoblastoid cell lines from centenarians
    Journal of Molecular Medicine, vol. 76, no. 5, pp. 346–354, 1998
  44. Multiparametric Staining to Identify Apoptotic Human Cells
    Experimental Cell Research, vol. 234, no. 1, pp. 174–177, 1997
  45. NAD+ loading of mammalian cells by electrotransfection leads to increased poly(ADP-ribosyl)ation capacity
    Biochimie, vol. 79, no. 4, pp. 175–178, 1997
  46. The Histochemical Journal, vol. 29, no. 11, pp. 831–837, 1997
  47. Isolation of cDNA encoding full-length rat (Rattus norvegicus) poly(ADP-ribose) polymerase
    IUBMB Life, vol. 43, no. 4, pp. 755–761, 1997
  48. Functional overexpression of human poly(ADP-ribose) polymerase in transfected rat tumor cells
    Carcinogenesis, vol. 18, no. 4, pp. 663–668, 1997
  49. Introduction
    Biochimie, vol. 77, no. 5, p. 311, 1995
  50. Inactivation of the poly(ADP-ribose) polymerase gene affects oxygen radical and nitric oxide toxicity in islet cells
    Journal of Biological Chemistry, vol. 270, no. 19, pp. 11176–11180, 1995
  51. Nitric Oxide Toxicity in Islet Cells Involves Poly(ADP-Ribose) Polymerase Activation and Concomitant NAD+ Depletion
    Biochemical and Biophysical Research Communications, vol. 199, no. 3, pp. 1270–1277, 1994
  52. Erratum
    Analytical Biochemistry, vol. 195, no. 2, p. 378, 1991