Emil F. Pai

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http://biochemistry.utoronto.ca/pai/bch.html

Articles in Scholarly Journals [Incomplete List]

  1. Enzyme-Driven Speciation: Crystallizing Archaea via Lipid Capture
    Journal of Molecular Evolution, vol. 64, no. 3, pp. 364–374, 2007
  2. A Potent, Covalent Inhibitor of Orotidine 5'-Monophosphate Decarboxylase with Antimalarial Activity
    Journal of Medicinal Chemistry, vol. 50, no. 5, pp. 915–921, 2007
  3. A Potent, Covalent Inhibitor of Orotidine 5'-Monophosphate Decarboxylase with Antimalarial Activity.
    Journal of Medicinal Chemistry, vol. 50, no. 10, pp. 2541–2541, 2007
  4. Transition State Infrared Spectra for the Trans?Cis Isomerization of a Simple Peptide Model
    Journal of Physical Chemistry A, vol. 111, no. 34, pp. 8384–8389, 2007
  5. Journal of Medicinal Chemistry, vol. 49, no. 16, pp. 4937–4945, 2006
  6. Journal of Physical Chemistry A, vol. 110, no. 40, pp. 11527–11536, 2006
  7. A structural basis for Mg2+ homeostasis and the CorA translocation cycle
    The EMBO Journal, vol. 25, no. 16, Article ID 7601269, 11 pages, 2006
  8. Crystallization and preliminary X-ray diffraction analysis of the magnesium transporter CorA
    Acta Crystallographica Section F Structural Biology and Crystallization Communications, vol. 62, no. 2, pp. 148–152, 2006
  9. Atomic model of human Rcd-1 reveals an armadillo-like-repeat protein with in vitro nucleic acid binding properties
    Protein Science, vol. 16, no. 2, pp. 176–188, 2006
  10. Distinct Conformation-mediated Functions of an Active Site Loop in the Catalytic Reactions of NAD-dependent D-Lactate Dehydrogenase and Formate Dehydrogenase
    Journal of Biological Chemistry, vol. 280, no. 17, pp. 17068–17075, 2005
  11. Mechanism of the Conversion of Xanthine Dehydrogenase to Xanthine Oxidase: IDENTIFICATION OF THE TWO CYSTEINE DISULFIDE BONDS AND CRYSTAL STRUCTURE OF A NON-CONVERTIBLE RAT LIVER XANTHINE DEHYDROGENASE MUTANT
    Journal of Biological Chemistry, vol. 280, no. 26, pp. 24888–24894, 2005
  12. The Crystal Structure of (S)-3-O-Geranylgeranylglyceryl Phosphate Synthase Reveals an Ancient Fold for an Ancient Enzyme
    Journal of Biological Chemistry, vol. 281, no. 9, pp. 6070–6078, 2005
  13. The Journal of Physical Chemistry A, vol. 109, no. 11, pp. 2660–2679, 2005
  14. Journal of the American Chemical Society, vol. 127, no. 43, pp. 15048–15050, 2005
  15. A point mutation in the C3 domain of human IgG3 inhibits antibody secretion without affecting antigen specificity
    Molecular Immunology, vol. 42, no. 9, pp. 1111–1119, 2005
  16. Biochemistry, vol. 44, no. 34, pp. 11402–11416, 2005
  17. The crystal structure of xanthine oxidoreductase during catalysis: Implications for reaction mechanism and enzyme inhibition
    Proceedings of the National Academy of Sciences, vol. 101, no. 21, pp. 7931–7936, 2004
  18. Anabaena circadian clock proteins KaiA and KaiB reveal a potential common binding site to their partner KaiC
    The EMBO Journal, vol. 23, no. 8, Article ID 7600190, 10 pages, 2004
  19. Y-700 [1-[3-Cyano-4-(2,2-dimethylpropoxy)phenyl]-1H-pyrazole-4-carboxylic Acid]: A Potent Xanthine Oxidoreductase Inhibitor with Hepatic Excretion
    Journal of Pharmacology and Experimental Therapeutics, vol. 311, no. 2, pp. 519–528, 2004
  20. Structural and functional analysis of a truncated form of Saccharomyces cerevisiae ATP sulfurylase: C-terminal domain essential for oligomer formation but not for activity
    Protein Engineering Design and Selection, vol. 16, no. 12, pp. 1071–1079, 2003
  21. Unique amino acids cluster for switching from the dehydrogenase to oxidase form of xanthine oxidoreductase
    Proceedings of the National Academy of Sciences, vol. 100, no. 14, pp. 8170–8175, 2003
  22. Mutational, Structural, and Kinetic Studies of the ATP-binding Site of Methanobacterium thermoautotrophicum Nicotinamide Mononucleotide Adenylyltransferase
    Journal of Biological Chemistry, vol. 278, no. 36, pp. 34356–34363, 2003
  23. An Extremely Potent Inhibitor of Xanthine Oxidoreductase. CRYSTAL STRUCTURE OF THE ENZYME-INHIBITOR COMPLEX AND MECHANISM OF INHIBITION
    Journal of Biological Chemistry, vol. 278, no. 3, pp. 1848–1855, 2003
  24. An ab initio exploratory study of the full conformational space of MeCO-?-threonine-NH-Me
    Journal of Molecular Structure: THEOCHEM, vol. 666-667, pp. 251–267, 2003
  25. A model study of the IgA hinge region: an exploratory study of selected backbone conformations of MeCO-?-Pro-?-Thr-NH-Me
    Journal of Molecular Structure: THEOCHEM, vol. 666-667, pp. 311–319, 2003
  26. Crystal structure ofMethanobacterium thermoautotrophicum conserved protein MTH1020 reveals an NTN-hydrolase fold
    Proteins: Structure, Function, and Genetics, vol. 48, no. 1, pp. 141–143, 2002
  27. Biochemistry, vol. 41, no. 12, pp. 4002–4011, 2002
  28. Crystal Structures of Inhibitor Complexes Reveal an Alternate Binding Mode in Orotidine-5'-monophosphate Decarboxylase
    Journal of Biological Chemistry, vol. 277, no. 31, pp. 28080–28087, 2002
  29. Cross-Neutralizing Human Monoclonal Anti-HIV-1 Antibody 2F5: Preparation and Crystallographic Analysis of the Free and Epitope-Complexed Forms of its F ab Fragment
    Protein and Peptide Letters, vol. 8, no. 5, pp. 413–418, 2001
  30. Insights into Ligand Binding and Catalysis of a Central Step in NAD+ Synthesis. STRUCTURES OF METHANOBACTERIUM THERMOAUTOTROPHICUM NMN ADENYLYLTRANSFERASE COMPLEXES
    Journal of Biological Chemistry, vol. 276, no. 10, pp. 7225–7232, 2001
  31. The active site architecture of Pisum sativum beta -carbonic anhydrase is a mirror image of that of alpha -carbonic anhydrases
    The EMBO Journal, vol. 19, no. 7, pp. 1407–1418, 2000
  32. Crystal structures of bovine milk xanthine dehydrogenase and xanthine oxidase: Structure-based mechanism of conversion
    Proceedings of the National Academy of Sciences, vol. 97, no. 20, pp. 10723–10728, 2000
  33. Crystal Structure of dTDP-4-keto-6-deoxy-D-hexulose 3,5-Epimerase from Methanobacterium thermoautotrophicum Complexed with dTDP
    Journal of Biological Chemistry, vol. 275, no. 32, pp. 24608–24612, 2000
  34. Electrostatic stress in catalysis: Structure and mechanism of the enzyme orotidine monophosphate decarboxylase
    Proceedings of the National Academy of Sciences, vol. 97, no. 5, pp. 2017–2022, 2000
  35. Nature Structural Biology, vol. 7, no. 10, pp. 903–909, 2000
  36. Structural Basis for Specificity Switching of the Src SH2 Domain
    Molecular Cell, vol. 5, no. 6, pp. 1043–1049, 2000
  37. Purification, crystallization and preliminary X-ray study of orotidine 5'-monophosphate decarboxylase
    Acta Crystallographica Section D Biological Crystallography, vol. 56, no. 7, pp. 912–914, 2000
  38. ß-Carbonic anhydrase from Pisum sativum: crystallization and preliminary X-ray analysis
    Acta Crystallographica Section D Biological Crystallography, vol. 56, no. 7, pp. 927–929, 2000
  39. Purification, crystallization and preliminary X-ray diffraction studies of xanthine dehydrogenase and xanthine oxidase isolated from bovine milk
    Acta Crystallographica Section D Biological Crystallography, vol. 56, no. 12, pp. 1656–1658, 2000
  40. Catalysis and regulation: There is always another way Editorial overview
    Current Opinion in Structural Biology, vol. 9, no. 6, pp. 661–662, 1999
  41. The alpha and beta of turning on a molecular switch
    Nature Structural Biology, vol. 5, no. 7, Article ID 873, 1 pages, 1998
  42. Biochemistry, vol. 37, no. 2, pp. 451–462, 1998
  43. The alpha and beta of turning on a molecular switch
    Nature Structural Biology, vol. 5, no. 4, Article ID nsb0498-259, 4 pages, 1998
  44. Catalysis and regulation There are always surprises
    Current Opinion in Structural Biology, vol. 7, no. 6, pp. 775–776, 1997
  45. The structure of enzyme IIAlactose from Lactococcus lactis reveals a new fold and points to possible interactions of a multicomponent system
    Structure, vol. 5, no. 6, pp. 775–788, 1997
  46. Biochemistry, vol. 36, no. 21, pp. 6437–6447, 1997
  47. Insights into substrate binding by -2-ketoacid dehydrogenases from the structure of Lactobacillus pentosus -lactate dehydrogenase
    Structure, vol. 4, no. 4, pp. 437–447, 1996
  48. Familiar jaws with new twists
    Nature Structural Biology, vol. 3, no. 4, Article ID nsb0496-307, 2 pages, 1996
  49. Crystallization and preliminary structural studies of lactose-specific enzyme IIA from Lactococcus lactis
    Acta Crystallographica Section D Biological Crystallography, vol. 52, no. 6, pp. 1199–1201, 1996
  50. The structure of OmpF porin in a tetragonal crystal form
    Structure, vol. 3, no. 10, pp. 1041–1050, 1995
  51. X-ray Crystal Structure Analysis of the Catalytic Domain of the Oncogene Product p21H-rasComplexed with Caged GTP and Mant dGppNHp
    Journal of Molecular Biology, vol. 253, no. 1, pp. 132–150, 1995
  52. The Structure ofTrypanosoma cruzitrypanothione Reductase in the Oxidized and NADPH Reduced State
    Proteins: Structure, Function, and Genetics, vol. 18, no. 2, pp. 161–173, 1994
  53. Crystallization and preliminary X-ray diffraction study of the green flavoenzyme 5-Hydroxyvaleryl-CoA dehydratase/dehydrogenase fromClostridium aminovalericum
    Proteins: Structure, Function, and Genetics, vol. 19, no. 3, pp. 269–271, 1994
  54. Crystallization and preliminary X-ray diffraction study of the flavoenzyme 2,4-pentadienoyl-CoA reductase from Clostridium aminovalericum
    Acta Crystallographica Section D Biological Crystallography, vol. 50, no. 6, pp. 913–914, 1994
  55. Crystallization and preliminary crystallographic analysis of trypanothione reductase from Trypanosoma cruzi, the causative agent of Chagas' disease
    FEBS Letters, vol. 317, no. 1-2, pp. 105–108, 1993
  56. Time-resolved macromolecular crystallography
    Current Opinion in Structural Biology, vol. 2, no. 6, pp. 821–827, 1992
  57. Biochemistry, vol. 31, no. 21, pp. 4951–4959, 1992
  58. Studies on the Structure and Mechanism of H-ras p21 [and Discussion]
    Philosophical Transactions of the Royal Society B: Biological Sciences, vol. 336, no. 1276, pp. 3–11, 1992
  59. The structure of Ras protein: a model for a universal molecular switch
    Trends in Biochemical Sciences, vol. 16, pp. 382–387, 1991
  60. p21 and other guanine-nucleotide-interacting proteins
    Current Opinion in Structural Biology, vol. 1, no. 6, pp. 941–945, 1991
  61. Variations on a theme: the family of FAD-dependent NAD(P)H-(disulphide)-oxidoreductases
    Current Opinion in Structural Biology, vol. 1, no. 5, pp. 796–803, 1991
  62. Structure of the detoxification catalyst mercuric ion reductase from Bacillus sp. strain RC607
    Nature, vol. 352, no. 6331, Article ID 352168a0, 4 pages, 1991
  63. GTPase Domains of Ras p21 Oncogene Protein and Elongation Factor Tu: Analysis of Three-Dimensional Structures, Sequence Families, and Functional Sites
    Proceedings of the National Academy of Sciences, vol. 88, no. 12, pp. 5443–5447, 1991
  64. Time-resolved X-ray crystallographic study of the conformational change in Ha-Ras p21 protein on GTP hydrolysis
    Nature, vol. 345, no. 6273, Article ID 345309a0, 6 pages, 1990
  65. Atomic structure of the actin: DNase I complex
    Nature, vol. 347, no. 6288, Article ID 347037a0, 7 pages, 1990
  66. Three-dimensional structures of H-ras p21 mutants: Molecular basis for their inability to function as signal switch molecules
    Cell, vol. 62, no. 3, pp. 539–548, 1990
  67. Adenylate kinases from thermosensitive Escherichia coli strains*1
    Journal of Molecular Biology, vol. 207, no. 1, pp. 151–162, 1989
  68. Crystallization and preliminary X-ray analysis of the human c-H--oncogene product p21 complexed with GTP analogues
    Journal of Molecular Biology, vol. 206, no. 1, pp. 257–259, 1989
  69. Structure of the guanine-nucleotide-binding domain of the Ha-ras oncogene product p21 in the triphosphate conformation
    Nature, vol. 341, no. 6239, Article ID 341209a0, 5 pages, 1989
  70. Biochemical and Crystallographic Characterization of a Complex of c-Ha-ras p21 and Caged GTP with Flash Photolysis
    Proceedings of the National Academy of Sciences, vol. 86, no. 20, pp. 7687–7690, 1989
  71. A crystallographic study of the glutathione binding site of glutathione reductase at 0.3-nm resolution
    European Journal of Biochemistry, vol. 178, no. 3, pp. 693–703, 1989
  72. Biochemistry, vol. 27, no. 7, pp. 2300–2305, 1988
  73. Biochemistry, vol. 27, no. 12, pp. 4465–4474, 1988
  74. Biochemistry, vol. 25, no. 22, pp. 6807–6816, 1986
  75. Preliminary X-ray studies on an unspecific NAD(P)H dehydrogenase from human erythrocytes
    Journal of Molecular Biology, vol. 174, no. 4, pp. 727–728, 1984
  76. Journal of the American Chemical Society, vol. 106, no. 11, pp. 3277–3285, 1984
  77. Preliminary X-ray studies on the GTP: AMP phosphotransferase from beef heart mitochondria
    Journal of Molecular Biology, vol. 164, no. 2, pp. 347–350, 1983
  78. FAD-binding site of glutathione reductase
    Journal of Molecular Biology, vol. 160, no. 2, pp. 287–308, 1982
  79. Three-dimensional structure of glutathione reductase at 2 p resolution
    Journal of Molecular Biology, vol. 152, no. 4, pp. 763–782, 1981
  80. The structure of the flavoenzyme glutathione reductase
    Nature, vol. 273, no. 5658, Article ID 273120a0, 4 pages, 1978
  81. Substrate positions and induced-fit in crystalline adenylate kinase
    Journal of Molecular Biology, vol. 114, no. 1, pp. 37–45, 1977
  82. Halothane binds in the adenine-specific niche of crystalline adenylate kinase
    FEBS Letters, vol. 79, no. 2, pp. 310–312, 1977