Ji-jing Pang currently is a Research Associate Professor in ophthalmology, University of Florida. Dr. Pang received his M.D. degree in 1988 from China Medical University. He became an Attending Doctor in ophthalmology, 2nd Affiliated Hospital of CMU in 1993. Dr. Pang got his Ph.D. degree in 1999 from Tokyo Medical and Dental University. During his Ph.D. course, Dr. Pang found a new type of Retinitis Pigmentosa due to vitamin E. This experience prompted him to a postdoctoral position in Dr. Blanks’ lab at Oakland University in 1999. He tested adenoviral and lentiviral vectors via subretinal injections to rescue the photoreceptor degeneration seen in rd mice. It is this gene replacement technique that captured his interest and remained the focus of his research program since then. Dr. Pang moved to UF in 2002. With rd12 mice, a model of LCA with Rpe65 mutation, he showed that AAV-mediated RPE65 expression led to biochemical, structural, physioelectrical, and behavioral rescues. After this concept-proving program, Dr. Pang has expanded his retinal rescue program to many other mouse models of human retinal disease, for example, (1) the Cpfl5 mouse, a model of human achromatopsia with cnga3 mutations, (2) the cngb3 KO mouse, a model of human achromatopsia 1 with a Cngb3 mutations, and (3) the rd10 mouse, a model of human retinitis pigmentosa with PDEb mutations. Dr. Pang also collaborated with other researchers to rescue many other mouse models of human retinal degenerations, such as rd6, rd17, GC-1-/-, LART-/-, and Ccl2/Cx3cr1 deficient mice and RCS rat. Dr. Pang has published more than 30 refereed journal articles. Dr. Pang has been a 2005-2006 Burns Visiting Professorship at University of Missouri-Columbia. He received H. Talmage Dobbs Ophthalmic Research Award from Emory Eye Center in 2003.
Biography Updated on 14 November 2013