David Doolittle

Articles in Scholarly Journals [Incomplete List]

  1. Biological stress response terminology: Integrating the concepts of adaptive response and preconditioning stress within a hormetic dose–response framework
    Toxicology and Applied Pharmacology, vol. 222, no. 1, pp. 122–128, 2007
  2. Comparative 13-Week Inhalation Study of Cigarette Smoke from Cigarettes Containing Cast Sheet Tobacco
    Inhalation Toxicology, vol. 19, no. 8, pp. 701–724, 2007
  3. Altered Methylation in Gene-Specific and GC-Rich Regions of DNA Is Progressive and Nonrandom during Promotion of Skin Tumorigenesis
    Toxicological Sciences, vol. 91, no. 2, pp. 406–418, 2006
  4. Gene Expression in Normal Human Bronchial Epithelial (NHBE) Cells Following In Vitro Exposure to Cigarette Smoke Condensate
    Toxicological Sciences, vol. 86, no. 1, pp. 84–91, 2005
  5. A comparison of in vitro toxicities of cigarette smoke condensate from Eclipse cigarettes and four commercially available ultra low-“tar” cigarettes
    Food and Chemical Toxicology, vol. 42, no. 2, pp. 237–243, 2004
  6. Increased DNA methylation in theHoxA5 promoter region correlates with decreased expression of the gene during tumor promotion
    Molecular Carcinogenesis, vol. 41, no. 1, pp. 54–66, 2004
  7. Differential c-myc expression profiles in normal human bronchial epithelial cells following treatment with benzo[a]pyrene, benzo[a]pyrene-4,5 epoxide, and benzo[a]pyrene-7,8-9,10 diol epoxide
    Molecular Carcinogenesis, vol. 40, no. 2, pp. 79–89, 2004
  8. Progressive Alterations in Global and GC-Rich DNA Methylation during Tumorigenesis
    Toxicological Sciences, vol. 75, no. 2, pp. 289–299, 2003
  9. Evaluation of eight in vitro assays for assessing the cytotoxicity of cigarette smoke condensate
    Toxicology in Vitro, vol. 16, no. 5, pp. 599–607, 2002
  10. Relationship between FTC 'tar' and urine mutagenicity in smokers of tobacco-burning or Eclipse cigarettes
    Mutation Research/Genetic Toxicology and Environmental Mutagenesis, vol. 521, no. 1-2, pp. 137–149, 2002
  11. Gene Expression Profiling of Cultured Human Bronchial Epithelial and Lung Carcinoma Cells
    Toxicological Sciences, vol. 61, no. 1, pp. 154–163, 2001
  12. The effect of a 2-h exposure to cigarette smoke on the metabolic activation of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in A/J mice
    Chemico-Biological Interactions, vol. 138, no. 2, pp. 125–135, 2001
  13. The effect of tobacco smoke, nicotine, and cotinine on the mutagenicity of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL)
    Mutation Research/Genetic Toxicology and Environmental Mutagenesis, vol. 494, no. 1-2, pp. 21–29, 2001
  14. Quantification of Changes in c-myc mRNA Levels in Normal Human Bronchial Epithelial (NHBE) and Lung Adenocarcinoma (A549) Cells following Chemical Treatment
    Toxicological Sciences, vol. 63, no. 1, pp. 107–114, 2001
  15. Cigarette smoke comparative toxicology
    Food and Chemical Toxicology, vol. 39, no. 2, pp. 175–176, 2001
  16. Effect of pyrolysis temperature on the mutagenicity of tobacco smoke condensate
    Food and Chemical Toxicology, vol. 39, no. 5, pp. 499–505, 2001
  17. Erratum to 'IARC Group 2B carcinogens' reported in cigarette mainstream smoke [Food and Chemical Toxicology 38 (2000) 825-848]
    Food and Chemical Toxicology, vol. 39, no. 2, p. 181, 2001
  18. “IARC Group 2B carcinogens” reported in cigarette mainstream smoke
    Food and Chemical Toxicology, vol. 39, no. 2, pp. 183–205, 2001
  19. Urinary Thromboxane, Prostacyclin, Cortisol, and 8-Hydroxy-2'-deoxyguanosine in Nonsmokers Exposed and Not Exposed to Environmental Tobacco Smoke
    Toxicological Sciences, vol. 59, no. 2, pp. 316–323, 2001
  20. The role of glutathione in the toxicity of smoke condensates from cigarettes that burn or heat tobacco
    Free Radical Biology and Medicine, vol. 30, no. 12, pp. 1400–1406, 2001
  21. Pulmonary Function in Nonsmokers Following Exposure to Sidestream Cigarette Smoke
    Toxicologic Pathology, vol. 29, no. 2, pp. 260–264, 2001
  22. Vanillin (3-methoxy-4-hydroxybenzaldehyde) inhibits mutation induced by hydrogen peroxide, N-methyl-N-nitrosoguanidine and mitomycin C but not 137Cs gamma-radiation at the CD59 locus in human-hamster hybrid AL cells
    Mutagenesis, vol. 15, no. 3, pp. 207–213, 2000
  23. Gap junction intercellular communication and cytotoxicity in normal human cells after exposure to smoke condensates from cigarettes that burn or primarily heat tobacco
    Toxicology in Vitro, vol. 14, no. 1, pp. 41–51, 2000
  24. Urinary mutagenicity in nonsmokers following exposure to fresh diluted sidestream cigarette smoke
    Mutation Research/Genetic Toxicology and Environmental Mutagenesis, vol. 470, no. 1, pp. 53–70, 2000
  25. A comparison of the mainstream smoke chemistry and mutagenicity of a representative sample of the US cigarette market with two Kentucky reference cigarettes (K1R4F and K1R5F)
    Food and Chemical Toxicology, vol. 38, no. 10, pp. 949–962, 2000
  26. “IARC Group 2B Carcinogens” reported in cigarette mainstream smoke
    Food and Chemical Toxicology, vol. 38, no. 9, pp. 825–848, 2000
  27. “IARC Group 2A Carcinogens” reported in cigarette mainstream smoke
    Food and Chemical Toxicology, vol. 38, no. 4, pp. 371–383, 2000
  28. Comparative QSAR evidence for a free-radical mechanism of phenol-induced toxicity
    Chemico-Biological Interactions, vol. 127, no. 1, pp. 61–72, 2000
  29. Mutant yields and mutational spectra of the heterocyclic amines MeIQ and PhIP at the S1 locus of human-hamster AL cells with activation by chick embryo liver (CELC) co-cultures
    Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, vol. 425, no. 1, pp. 29–46, 1999
  30. COMPARISON OF C-MYC EXPRESSION IN NORMAL HUMAN BRONCHIAL EPITHELIAL CELLS AND LUNG CANCER CELL LINES USING A QUANTITATIVE FLUORESCENCE-BASED REVERSE TRANSCRIPTASE-POLYMERASE CHAIN REACTION METHOD
    Toxicology Methods, vol. 9, no. 3, pp. 173–188, 1999
  31. The effect of cotinine or cigarette smoke co-administration on the formation of O6-methylguanine adducts in the lung and liver of A/J mice treated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) [published erratum appears in Toxicol Sci 1999 Jul;50(1):153]
    Toxicological Sciences, vol. 47, no. 1, pp. 33–39, 1999
  32. Correspondence
    Food and Chemical Toxicology, vol. 37, no. 2-3, pp. 265–266, 1999
  33. Comparison of the Cytotoxic and Mutagenic Potential of Liquid Smoke Food Flavourings, Cigarette Smoke Condensate and Wood Smoke Condensate
    Food and Chemical Toxicology, vol. 37, no. 11, pp. 1113–1118, 1999
  34. Chemical and Biological Studies of a New Cigarette that Primarily Heats Tobacco.Part 3. In Vitro Toxicity of Whole Smoke
    Food and Chemical Toxicology, vol. 36, no. 3, pp. 191–197, 1998
  35. Comparative studies of DNA adduct formation in mice following dermal application of smoke condensates from cigarettes that burn or primarily heat tobacco
    Mutation Research/Genetic Toxicology and Environmental Mutagenesis, vol. 414, no. 1-3, pp. 21–30, 1998
  36. URINARY PROSTACYCLIN IN NONSMOKERS LIVING WITH SMOKERS
    Inhalation Toxicology, vol. 10, no. 5, pp. 431–441, 1998
  37. Chemical and biological studies of a newCigarette that primarily heats tobacco. Part 2. In vitro toxicology of mainstreamsmoke condensate
    Food and Chemical Toxicology, vol. 36, no. 3, pp. 183–190, 1998
  38. Comparative studies of the mutagenicity of environmental tobacco smoke from cigarettes that burn or primarily heat tobacco
    Environmental and Molecular Mutagenesis, vol. 31, no. 2, pp. 169–175, 1998
  39. Comparative Cytotoxicity Studies of Smoke Condensates from Different Types of Cigarettes and Tobaccos
    Toxicology in Vitro, vol. 12, no. 3, pp. 241–249, 1998
  40. Comparative study of DNA adduct formation in mice following inhalation of smoke from cigarettes that burn or primarily heat tobacco
    Environmental and Molecular Mutagenesis, vol. 29, no. 3, pp. 303–311, 1997
  41. An international literature survey of ?IARC group I carcinogens? reported in mainstream cigarette smoke
    Food and Chemical Toxicology, vol. 35, no. 10-11, pp. 1107–1130, 1997
  42. Correlation between Hydrophobicity of Short-Chain Aliphatic Alcohols and Their Ability to Alter Plasma Membrane Integrity
    Fundamental and Applied Toxicology, vol. 36, no. 1, pp. 62–70, 1997
  43. Evaluation of the Genotoxic and Cytotoxic Potential of Mainstream Whole Smoke and Smoke Condensate from a Cigarette Containing a Novel Carbon Filter
    Fundamental and Applied Toxicology, vol. 39, no. 1, pp. 11–17, 1997
  44. CYTOTOXICITY ASSESSMENT OF WHOLE SMOKE AND VAPOR PHASE OF MAINSTREAM AND SIDESTREAM CIGARETTE SMOKE FROM THREE KENTUCKY REFERENCE CIGARETTES
    Toxicology Methods, vol. 7, no. 3, pp. 177–190, 1997
  45. Correlation between Hydrophobicity of Short-Chain Aliphatic Alcohols and Their Ability to Alter Plasma Membrane Integrity
    Toxicological Sciences, vol. 36, no. 1, pp. 62–70, 1997
  46. Human urine mutagenicity study comparing cigarettes which burn or primarily heat tobacco
    Mutation Research/Environmental Mutagenesis and Related Subjects, vol. 361, no. 1, pp. 1–9, 1996
  47. Urinary mutagenicity and thioethers in nonsmokers: Role of environmental tobacco smoke (ETS) and diet
    Mutation Research/Genetic Toxicology, vol. 368, no. 3-4, pp. 195–204, 1996
  48. Tyrosinase enhances the covalent modification of DNA by dopamine
    Molecular Brain Research, vol. 42, no. 1, pp. 167–170, 1996
  49. Autocrine regulation of cell cycle progression in normal human keratinocytes
    In Vitro Cellular & Developmental Biology - Animal, vol. 32, no. 10, pp. 640–655, 1996
  50. Inhibition of mutagenicity of -nitrosamines by tobacco smoke and its constituents
    Mutation Research/Genetic Toxicology, vol. 367, no. 2, pp. 83–92, 1996
  51. A comparison of the mutagenicity of mainstream cigarette smoke condensates from a representative sample of the U.S. cigarette market with a Kentucky reference cigarette (K1R4F)
    Mutation Research/Genetic Toxicology, vol. 342, no. 3-4, pp. 179–190, 1995
  52. Effect of pH of the T4 Polynucleotide Kinase Reaction on the 32P-Postlabeling Assay of DNA Adducts
    Analytical Biochemistry, vol. 227, no. 1, pp. 156–161, 1995
  53. The genotoxic potential of nicotine and its major metabolites
    Mutation Research/Genetic Toxicology, vol. 344, no. 3-4, pp. 95–102, 1995
  54. Inhibitory activity of cigarette-smoke condensate on the mutagenicity of heterocyclic amines
    Mutation Research/Genetic Toxicology, vol. 322, no. 1, pp. 21–32, 1994
  55. Recommendations for the performance of UDS tests in vitro and in vivo
    Mutation Research/Environmental Mutagenesis and Related Subjects, vol. 312, no. 3, pp. 263–285, 1994
  56. Ninety-Day Inhalation Study in Rats, Using Aged and Diluted Sidestream Smoke from a Reference Cigarette: DNA Adducts and Alveolar Macrophage Cytogenetics
    Fundamental and Applied Toxicology, vol. 20, no. 4, pp. 393–401, 1993
  57. JAMA: The Journal of the American Medical Association, vol. 270, no. 14, pp. 1689–1690, 1993
  58. Fourteen-day inhalation study in rats, using aged and diluted sidestream smoke from a reference cigarette II. DNA adducts and alveolar macrophage cytogenetics
    Fundamental and Applied Toxicology, vol. 19, no. 1, pp. 141–146, 1992
  59. Limitations of the scrape-loading/dye transfer technique to quantify inhibition of gap junctional intercellular communication
    Cell Biology and Toxicology, vol. 8, no. 1, pp. 89–103, 1992
  60. Mutagenic activity of a series of synthetic and naturally occurring heterocyclic amines in Salmonella
    Mutation Research/Genetic Toxicology, vol. 279, no. 1, pp. 61–73, 1992
  61. DNA adduct formation in mice following dermal application of smoke condensates from cigarettes that burn or heat tobacco
    Environmental and Molecular Mutagenesis, vol. 20, no. 4, pp. 313–319, 1992
  62. Correlations between urinary nicotine or cotinine and urinary mutagenicity in smokers on controlled diets
    Environmental and Molecular Mutagenesis, vol. 17, no. 4, pp. 244–252, 1991
  63. Assessment of mitochondrial membrane potential as an indicator of cytotoxicity
    Fundamental and Applied Toxicology, vol. 16, no. 3, pp. 435–448, 1991
  64. Fundamental and Applied Toxicology, vol. 16, no. 4, pp. 841–842, 1991
  65. A quantitative approach to assessing intercellular communication: Studies on cigarette smoke condensates
    Toxicology and Applied Pharmacology, vol. 111, no. 1, pp. 58–68, 1991
  66. The effect of exposure to nicotine, carbon monoxide, cigarette smoke or cigarette smoke condensate on the mutagenicity of rat urine
    Mutation Research/Genetic Toxicology, vol. 260, no. 1, pp. 9–18, 1991
  67. Comparative genotoxicity testing of mainstream whole smoke from cigarettes which burn or heat tobacco
    Mutation Research/Genetic Toxicology, vol. 242, no. 1, pp. 37–45, 1990
  68. Analysis of cytogenetic effects in bone-marrow cells of rats subchronically exposed to smoke from cigarettes which burn or only heat tobacco
    Mutation Research/Genetic Toxicology, vol. 240, no. 4, pp. 251–257, 1990
  69. Genetic toxicology studies comparing the activity of sidestream smoke from cigarettes which burn or only heat tobacco
    Mutation Research/Genetic Toxicology, vol. 240, no. 2, pp. 59–72, 1990
  70. Comparative studies on the genotoxic activity of mainstream smoke condensate from cigarettes which burn or only heat tobacco
    Environmental and Molecular Mutagenesis, vol. 15, no. 2, pp. 93–105, 1990
  71. Effect of cooking methods on the mutagenicity of food and on urinary mutagenicity of human consumers By D. J. Doolittle, C. A. Rahn, G. T. Burger, C. K. Lee, B. Reed, E. Riccio, G. Howard, G. T. Passananti, E. S. Vesell and A. W. Hayes (Vol. 27, No. 10, pp. 657–666)
    Food and Chemical Toxicology, vol. 28, no. 2, p. 140, 1990
  72. Comparative studies of the mutagenicity of urine from smokers and non-smokers on a controlled non-mutagenic diet
    Food and Chemical Toxicology, vol. 28, no. 9, pp. 639–646, 1990
  73. Effect of cooking methods on the mutagenicity of food and on urinary mutagenicity of human consumers
    Food and Chemical Toxicology, vol. 27, no. 10, pp. 657–666, 1989
  74. Human urine mutagenicity study comparing cigarettes which burn or only heat tobacco
    Mutation Research/Genetic Toxicology, vol. 223, no. 2, pp. 221–232, 1989
  75. Role of oxygen free radicals in the induction of sister chromatid exchanges by cigarette smoke
    Environmental and Molecular Mutagenesis, vol. 13, no. 1, pp. 54–59, 1989
  76. The genotoxic activity of glycerol in an in vitro test battery
    Food and Chemical Toxicology, vol. 26, no. 7, pp. 631–635, 1988
  77. The in vivo-in vitro hepatocyte assay for assessing DNA repair and DNA replication: Studies in the CD-1 mouse
    Food and Chemical Toxicology, vol. 25, no. 5, pp. 399–405, 1987
  78. A comparative study of hepatic DNA repair, DNA replication and hepatotoxicity in the CD-1 mouse following multiple administrations of dimethylnitrosamine
    Mutation Research/Genetic Toxicology, vol. 188, no. 2, pp. 141–147, 1987
  79. Unscheduled DNA synthesis in rat tracheal epithelial cells, hepatocytes and spermatocytes following exposure to methyl chloride in vitro and in vivo
    Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, vol. 162, no. 2, pp. 219–224, 1986
  80. Assessment of chemically induced DNA repair in primary cultures of human bronchial epithelial cells
    Toxicology and Applied Pharmacology, vol. 79, no. 1, pp. 28–38, 1985
  81. Measurement of genotoxic activity in multiple tissues following inhalation exposure to dimethylnitrosamine
    Mutation Research Letters, vol. 141, no. 2, pp. 123–127, 1984
  82. Quantitative studies on metabolic activation in vitro employing benzo[a]pyrene as the test compound
    Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, vol. 108, no. 1-3, pp. 29–44, 1983