B. Aggarwal

Bharat B. Aggarwal received his Ph.D. degree in biochemistry from the University of California, Berkeley, he did his postdoctoral fellowship in endocrinology from the University of California Medical Center, San Francisco, and then worked in a Biotechnology company (Genentech Inc.), where he discovered TNF-alfa and TNF-beta, essential components of the Immune System. In 1989, Dr. Aggarwal accepted a position as a Professor and Chief of the Cytokine Research Section at the University of Texas M. D. Anderson Cancer in Houston. He currently holds the Ransom Horne Jr. Endowed Professorship in Cancer Research. He has published almost 450 original peer-reviewed articles and invited reviews; currently, serving on the board of numerous journals, edited 12 books, and been granted almost 35 patents. Since 2001, Dr. Aggarwal has been listed as one of the World’s Most Highly Cited Immunologists by the Institute of Scientific Information. In 2005, Dr. Aggarwal received the Ranbaxy Award for his outstanding contributions to science. In 2006, Dr. Aggarwal, for his outstanding contributions to science, received the similar Award from the American Association of Indian Scientists in Cancer Research. Dr. Aggarwal’s current research is identification of novel inhibitors of NF-kB pathway (from traditional sources) which can suppress pro-inflammatory, anti-apoptotic, cell proliferative, invasive, and angiogenic gene products for the prevention and therapy of cancer and other proinflammatory diseases.

Biography Updated on 12 July 2007

Articles in Scholarly Journals [Incomplete List]

  1. “Spicing Up” of the Immune System by Curcumin
    Journal of Clinical Immunology, vol. 27, no. 1, pp. 19–35, 2007
  2. PTEN down regulates AP-1 and targets c-fos in human glioma cells Via PI3-kinase/Akt pathway
    Molecular and Cellular Biochemistry, vol. 300, no. 1-2, pp. 77–87, 2007
  3. Expression of NF-?B parallels COX-2 expression in oral precancer and cancer: Association with smokeless tobacco
    International Journal of Cancer, vol. 120, no. 12, pp. 2545–2556, 2007
  4. Curcumin induces the degradation of cyclin E expression through ubiquitin-dependent pathway and up-regulates cyclin-dependent kinase inhibitors p21 and p27 in multiple human tumor cell lines
    Biochemical Pharmacology, vol. 73, no. 7, pp. 1024–1032, 2007
  5. Guggulsterone inhibits tumor cell proliferation, induces S-phase arrest, and promotes apoptosis through activation of c-Jun N-terminal kinase, suppression of Akt pathway, and downregulation of antiapoptotic gene products?
    Biochemical Pharmacology, vol. 74, no. 1, pp. 118–130, 2007
  6. Natural products as a gold mine for arthritis treatment
    Current Opinion in Pharmacology, vol. 7, no. 3, pp. 344–351, 2007
  7. Role of pro-oxidants and antioxidants in the anti-inflammatory and apoptotic effects of curcumin (diferuloylmethane)
    Free Radical Biology and Medicine, vol. 43, no. 4, pp. 568–580, 2007
  8. Genetic deletion of PKR abrogates TNF-induced activation of I?Ba kinase, JNK, Akt and cell proliferation but potentiates p44/p42 MAPK and p38 MAPK activation
    Oncogene, vol. 26, no. 8, Article ID 1209906, 11 pages, 2007
  9. Evidence that TNF-TNFR1-TRADD-TRAF2-RIP-TAK1-IKK pathway mediates constitutive NF-?B activation and proliferation in human head and neck squamous cell carcinoma
    Oncogene, vol. 26, no. 10, Article ID 1209945, 12 pages, 2007
  10. Molecular Mechanisms in Barrett’s Metaplasia and Its Progression
    Seminars in Oncology, vol. 34, pp. S2–S6, 2007
  11. Curcumin Potentiates Antitumor Activity of Gemcitabine in an Orthotopic Model of Pancreatic Cancer through Suppression of Proliferation, Angiogenesis, and Inhibition of Nuclear Factor- B-Regulated Gene Products
    Cancer Research, vol. 67, no. 8, pp. 3853–3861, 2007
  12. Fisetin, an Inhibitor of Cyclin-Dependent Kinase 6, Down-Regulates Nuclear Factor- B-Regulated Cell Proliferation, Antiapoptotic and Metastatic Gene Products through the Suppression of TAK-1 and Receptor-Interacting Protein-Regulated I B  Kinase Activation
    Molecular Pharmacology, vol. 71, no. 6, pp. 1703–1714, 2007
  13. Curcumin potentiates the apoptotic effects of chemotherapeutic agents and cytokines through down-regulation of nuclear factor- B and nuclear factor- B-regulated gene products in IFN- -sensitive and IFN- -resistant human bladder cancer cells
    Molecular Cancer Therapeutics, vol. 6, no. 3, pp. 1022–1030, 2007
  14. Butein, a Tetrahydroxychalcone, Inhibits Nuclear Factor (NF)- B and NF- B-regulated Gene Expression through Direct Inhibition of I B  Kinase beta on Cysteine 179 Residue
    Journal of Biological Chemistry, vol. 282, no. 24, pp. 17340–17350, 2007
  15. Morin (3,5,7,2',4'-Pentahydroxyflavone) Abolishes Nuclear Factor- B Activation Induced by Various Carcinogens and Inflammatory Stimuli, Leading to Suppression of Nuclear Factor- B-Regulated Gene Expression and Up-regulation of Apoptosis
    Clinical Cancer Research, vol. 13, no. 7, pp. 2290–2297, 2007
  16. Curcumin Inhibits Tumor Growth and Angiogenesis in Ovarian Carcinoma by Targeting the Nuclear Factor- B Pathway
    Clinical Cancer Research, vol. 13, no. 11, pp. 3423–3430, 2007
  17. Gossypin, a pentahydroxy glucosyl flavone, inhibits the transforming growth factor beta-activated kinase-1-mediated NF- B activation pathway, leading to potentiation of apoptosis, suppression of invasion, and abrogation of osteoclastogenesis
    Blood, vol. 109, no. 12, pp. 5112–5121, 2007
  18. Capsaicin Is a Novel Blocker of Constitutive and Interleukin-6-Inducible STAT3 Activation
    Clinical Cancer Research, vol. 13, no. 10, pp. 3024–3032, 2007
  19. Resveratrol inhibits proliferation, induces apoptosis, and overcomes chemoresistance through down-regulation of STAT3 and nuclear factor- B-regulated antiapoptotic and cell survival gene products in human multiple myeloma cells
    Blood, vol. 109, no. 6, pp. 2293–2302, 2007
  20. Nuclear factor-?B: a transcription factor for all seasons
    Expert Opinion on Therapeutic Targets, vol. 11, no. 2, pp. 109–110, 2007
  21. From Ancient Medicine to Modern Medicine: Ayurvedic Concepts of Health and Their Role in Inflammation and Cancer
    Journal of the Society for Integrative Oncology, vol. 05, no. 01, p. 25, 2007
  22. From traditional Ayurvedic medicine to modern medicine: identification of therapeutic targets for suppression of inflammation and cancer
    Expert Opinion on Therapeutic Targets, vol. 10, no. 1, pp. 87–118, 2006
  23. Role of NF-κB and NF-κB-regulated Gene Products in Chemoresistance and Radioresistance
    Current Cancer Therapy Reviews, vol. 2, no. 2, pp. 115–125, 2006
  24. Targeting Signal-Transducer-and-Activator-of-Transcription-3 for Prevention and Therapy of Cancer: Modern Target but Ancient Solution
    Annals of the New York Academy of Sciences, vol. 1091, no. 1, pp. 151–169, 2006
  25. Honokiol Potentiates Apoptosis, Suppresses Osteoclastogenesis, and Inhibits Invasion through Modulation of Nuclear Factor- B Activation Pathway
    Molecular Cancer Research, vol. 4, no. 9, pp. 621–633, 2006
  26. Association of Activated Transcription Factor Nuclear Factor  B With Chemoradiation Resistance and Poor Outcome in Esophageal Carcinoma
    Journal of Clinical Oncology, vol. 24, no. 5, pp. 748–754, 2006
  27. Isodeoxyelephantopin, a Novel Sesquiterpene Lactone, Potentiates Apoptosis, Inhibits Invasion, and Abolishes Osteoclastogenesis through Suppression of Nuclear Factor- B (NF- B) Activation and NF- B-Regulated Gene Expression
    Clinical Cancer Research, vol. 12, no. 19, pp. 5910–5918, 2006
  28. Celastrol, a novel triterpene, potentiates TNF-induced apoptosis and suppresses invasion of tumor cells by inhibiting NF- B-regulated gene products and TAK1-mediated NF- B activation
    Blood, 2006
  29. Withanolides potentiate apoptosis, inhibit invasion, and abolish osteoclastogenesis through suppression of nuclear factor-?B (NF-?B) activation and NF-?B-regulated gene expression
    Molecular Cancer Therapeutics, vol. 5, no. 6, pp. 1434–1445, 2006
  30. Pretherapy nuclear factor- B status, chemoradiation resistance, and metastatic progression in esophageal carcinoma
    Molecular Cancer Therapeutics, vol. 5, no. 11, pp. 2844–2850, 2006
  31. 1'-Acetoxychavicol Acetate Inhibits RANKL-Induced Osteoclastic Differentiation of RAW 264.7 Monocytic Cells by Suppressing Nuclear Factor-?B Activation
    Molecular Cancer Research, vol. 4, no. 4, pp. 275–281, 2006
  32. Progress in Chemoprevention Drug Development: The Promise of Molecular Biomarkers for Prevention of Intraepithelial Neoplasia and Cancer--A Plan to Move Forward
    Clinical Cancer Research, vol. 12, no. 12, pp. 3661–3697, 2006
  33. Guggulsterone Inhibits Osteoclastogenesis Induced by Receptor Activator of Nuclear Factor-?B Ligand and by Tumor Cells by Suppressing Nuclear Factor-?B Activation
    Clinical Cancer Research, vol. 12, no. 2, pp. 662–668, 2006
  34. Mitogen-activated Protein Kinase Kinase-4 Promotes Cell Survival by Decreasing PTEN Expression through an NF B-dependent Pathway
    Journal of Biological Chemistry, vol. 282, no. 6, pp. 3507–3519, 2006
  35. Overexpression of Tissue Transglutaminase Leads to Constitutive Activation of Nuclear Factor- B in Cancer Cells: Delineation of a Novel Pathway
    Cancer Research, vol. 66, no. 17, pp. 8788–8795, 2006
  36. Embelin, an Inhibitor of X Chromosome-Linked Inhibitor-of-Apoptosis Protein, Blocks Nuclear Factor- B (NF- B) Signaling Pathway Leading to Suppression of NF- B-Regulated Antiapoptotic and Metastatic Gene Products
    Molecular Pharmacology, vol. 71, no. 1, pp. 209–219, 2006
  37. A Synthetic Triterpenoid, CDDO-Me, Inhibits I B  Kinase and Enhances Apoptosis Induced by TNF and Chemotherapeutic Agents through Down-Regulation of Expression of Nuclear Factor  B-Regulated Gene Products in Human Leukemic Cells
    Clinical Cancer Research, vol. 12, no. 6, pp. 1828–1838, 2006
  38. Plumbagin (5-Hydroxy-2-methyl-1,4-naphthoquinone) Suppresses NF-?B Activation and NF-?B-regulated Gene Products Through Modulation of p65 and I?B? Kinase Activation, Leading to Potentiation of Apoptosis Induced by Cytokine and Chemotherapeutic Agents
    Journal of Biological Chemistry, vol. 281, no. 25, pp. 17023–17033, 2006
  39. Indirubin Enhances Tumor Necrosis Factor-induced Apoptosis through Modulation of Nuclear Factor- B Signaling Pathway
    Journal of Biological Chemistry, vol. 281, no. 33, pp. 23425–23435, 2006
  40. Genetic Deletion of NAD(P)H:Quinone Oxidoreductase 1 Abrogates Activation of Nuclear Factor-?B, I?B? Kinase, c-Jun N-terminal Kinase, Akt, p38, and p44/42 Mitogen-activated Protein Kinases and Potentiates Apoptosis
    Journal of Biological Chemistry, vol. 281, no. 29, pp. 19798–19808, 2006
  41.  -Tocotrienol Inhibits Nuclear Factor- B Signaling Pathway through Inhibition of Receptor-interacting Protein and TAK1 Leading to Suppression of Antiapoptotic Gene Products and Potentiation of Apoptosis
    Journal of Biological Chemistry, vol. 282, no. 1, pp. 809–820, 2006
  42. All pathways to cancer apoptosis meeting in Thiruvananthapuram (India)
    Cell Death and Differentiation, vol. 13, no. 12, Article ID 4401981, 1 pages, 2006
  43. Diosgenin inhibits osteoclastogenesis, invasion, and proliferation through the downregulation of Akt, I?B kinase activation and NF-?B-regulated gene expression
    Oncogene, vol. 25, no. 10, Article ID 1209194, 10 pages, 2006
  44. Journal of Agricultural and Food Chemistry, vol. 54, no. 3, pp. 980–985, 2006
  45. Curcumin down regulates smokeless tobacco-induced NF-?B activation and COX-2 expression in human oral premalignant and cancer cells
    Toxicology, vol. 228, no. 1, pp. 1–15, 2006
  46. Novel curcumin analogs targeting TNF-induced NF-?B activation and proliferation in human leukemic KBM-5 cells
    Bioorganic & Medicinal Chemistry, vol. 14, no. 21, pp. 7196–7204, 2006
  47. Targeting constitutive and interleukin-6-inducible signal transducers and activators of transcription 3 pathway in head and neck squamous cell carcinoma cells by curcumin (diferuloylmethane)
    International Journal of Cancer, vol. 119, no. 6, pp. 1268–1275, 2006
  48. Molecular targets of dietary agents for prevention and therapy of cancer?
    Biochemical Pharmacology, vol. 71, no. 10, pp. 1397–1421, 2006
  49. Inflammation and cancer: How hot is the link?
    Biochemical Pharmacology, vol. 72, no. 11, pp. 1605–1621, 2006
  50. PTEN enhances TNF-induced apoptosis through modulation of nuclear factor-?B signaling pathway in human glioma cells
    Biochemical and Biophysical Research Communications, vol. 350, no. 2, pp. 463–471, 2006
  51. Nuclear factor-?B (nf-?B) is frequently expressed in lung cancer and preneoplastic lesions
    Cancer, vol. 107, no. 11, pp. 2637–2646, 2006
  52. Mutant human tumor suppressor p53 modulates the activation of mitogen-activated protein kinase and nuclear factor-κB, but not c-Jun N-terminal kinase and activated protein-1
    Molecular Carcinogenesis, vol. 45, no. 1, pp. 26–37, 2005
  53. Curcumin-induced antiproliferative and proapoptotic effects in melanoma cells are associated with suppression of I?B kinase and nuclear factor ?B activity and are independent of the B-Raf/mitogen-activated/extracellular signal-regulated protein kinase pathway and the Akt pathway
    Cancer, vol. 104, no. 4, pp. 879–890, 2005
  54. Curcumin (diferuloylmethane) inhibits constitutive NF-?B activation, induces G1/S arrest, suppresses proliferation, and induces apoptosis in mantle cell lymphoma
    Biochemical Pharmacology, vol. 70, no. 5, pp. 700–713, 2005
  55. Atiprimod blocks STAT3 phosphorylation and induces apoptosis in multiple myeloma cells
    British Journal of Cancer, vol. 93, no. 1, Article ID 6602637, 10 pages, 2005
  56. Zerumbone abolishes NF-?B and I?Ba kinase activation leading to suppression of antiapoptotic and metastatic gene expression, upregulation of apoptosis, and downregulation of invasion
    Oncogene, vol. 24, no. 46, Article ID 1208845, 12 pages, 2005
  57. Chemosensitization and Radiosensitization of Tumors by Plant Polyphenols
    Antioxidants Redox Signaling, vol. 7, no. 11-12, pp. 1630–1647, 2005
  58. Synthetic Vpr Protein Activates Activator Protein-1, c-Jun N-terminal Kinase, and NF- B and Stimulates HIV-1 Transcription in Promonocytic Cells and Primary Macrophages
    Journal of Biological Chemistry, vol. 280, no. 52, pp. 42557–42567, 2005
  59. Redox Regulation of Apoptosis by Members of the TNF Superfamily
    Antioxidants Redox Signaling, vol. 7, no. 3-4, pp. 482–496, 2005
  60. Evodiamine Abolishes Constitutive and Inducible NF-?B Activation by Inhibiting I?B? Kinase Activation, Thereby Suppressing NF-?B-regulated Antiapoptotic and Metastatic Gene Expression, Up-regulating Apoptosis, and Inhibiting Invasion
    Journal of Biological Chemistry, vol. 280, no. 17, pp. 17203–17212, 2005
  61. N-(4-Hydroxyphenyl)Retinamide Inhibits Invasion, Suppresses Osteoclastogenesis, and Potentiates Apoptosis through Down-regulation of I?B? Kinase and Nuclear Factor-?B-Regulated Gene Products
    Cancer Research, vol. 65, no. 20, pp. 9555–9565, 2005
  62. Curcumin (Diferuloylmethane) Downregulates Expression of Cell Proliferation, Antiapoptotic and Metastatic Gene Products Through Suppression of I?B? Kinase and AKT Activation
    Molecular Pharmacology, 2005
  63. Suberoylanilide Hydroxamic Acid Potentiates Apoptosis, Inhibits Invasion, and Abolishes Osteoclastogenesis by Suppressing Nuclear Factor-?B Activation
    Journal of Biological Chemistry, vol. 281, no. 9, pp. 5612–5622, 2005