Jim E. Riviere
Jim E. Riviere is the Burroughs Wellcome Fund Distinguished Professor of Pharmacology; and Director of the Center for Chemical Toxicology Research and Pharmacokinetics, College of Veterinary Medicine; North Carolina State University (NCSU) in Raleigh NC. Dr. Riviere received his B.S. (summa cum laude) and M.S. degrees from Boston College, his DVM and Ph.D. degrees in pharmacology as well as a D.S. degree (with honor) from Purdue University. He is an elected member of the Institute of Medicine of the National Academies, serves on its Food and Nutrition Board, and is a Fellow of the Academy of Toxicological Sciences. He has served on the Science Board of the Food and Drug Administration.His honors include the 1999 O. Max Gardner Award from the Consolidated University of North Carolina, the 1991 Ebert Prize from the American Pharmaceutical Association, the Harvey W. Wiley Medal and FDA Commissioner’s Special Citation, and the Lifetime Achievement Award from the European Association of Veterinary Pharmacology and Toxicology. He is the Editor of the Journal of Veterinary Pharmacology and Therapeutics. He has served as an officer in various Specialty Sections of the Society of Toxicology, and has served on the Editorial Boards of various toxicology, pharmacology, and veterinary journals. He has published over 440 full-length research papers and chapters, holds 5 US Patents, has authored/edited 10 books in pharmacokinetics, toxicology and food safety, and received over 17 million dollars as principal investigator on extramural research grants. His current research interests relate to the development of animal models; applying biomathematics to problems in toxicology, including the risk assessment of chemical mixtures, pharmacokinetics, nanomaterials, absorption of drugs, and chemicals across skin; and the food safety and pharmacokinetics of tissue residues in food producing animals.
Biography Updated on 9 February 2008
Personal Home Page
http://cctrp.ncsu.edu/people/jr/
Articles in Scholarly Journals [Incomplete List]
- Regression method of the hydrophobicity ruler approach for determining octanol/water partition coefficients of very hydrophobic compounds
Chemosphere, vol. 66, no. 6, pp. 1086–1093, 2007 - Biological stress response terminology: Integrating the concepts of adaptive response and preconditioning stress within a hormetic dose–response framework
Toxicology and Applied Pharmacology, vol. 222, no. 1, pp. 122–128, 2007 - An experimentally based approach for predicting skin permeability of chemicals and drugs using a membrane-coated fiber array
Toxicology and Applied Pharmacology, vol. 221, no. 3, pp. 320–328, 2007 - Variables Influencing Interactions of Untargeted Quantum Dot Nanoparticles with Skin Cells and Identification of Biochemical Modulators
Nano Letters, vol. 7, no. 5, pp. 1344–1348, 2007 - Biodistribution of Quantum Dot Nanoparticles in Perfused Skin: Evidence of Coating Dependency and Periodicity in Arterial Extraction
Nano Letters, vol. 7, no. 9, pp. 2865–2870, 2007 - Surface Coatings Determine Cytotoxicity and Irritation Potential of Quantum Dot Nanoparticles in Epidermal Keratinocytes
Journal of Investigative Dermatology, vol. 127, no. 1, Article ID 5700508, 10 pages, 2007 - Partitioning Behavior of Aromatic Components in Jet Fuel into Diverse Membrane-coated Fibers
Journal of Toxicology and Environmental Health, Part A, vol. 70, no. 22, pp. 1879–1887, 2007 - Membrane-Coated Fiber Array Approach for Predicting Skin Permeability of Chemical Mixtures from Different Vehicles
Toxicological Sciences, vol. 99, no. 1, pp. 153–161, 2007 - Editorial
Journal of Veterinary Pharmacology and Therapeutics, vol. 30, no. s1, pp. iii–iii, 2007 - Na�ve averaged, na�ve pooled, and population pharmacokinetics of orally administered marbofloxacin in juvenile harbor seals
Journal of the American Veterinary Medical Association, vol. 230, no. 3, pp. 390–395, 2007 - Extralabel use of penicillin in food animals
Journal of the American Veterinary Medical Association, vol. 229, no. 9, pp. 1401–1403, 2006 - Use of Probabilistic Modeling within a Physiologically Based Pharmacokinetic Model To Predict Sulfamethazine Residue Withdrawal Times in Edible Tissues in Swine
Antimicrobial Agents and Chemotherapy, vol. 50, no. 7, pp. 2344–2351, 2006 - Cluster Analysis of the Dermal Permeability and Stratum Corneum/Solvent Partitioning of Ten Chemicals in Twenty-Four Chemical Mixtures in Porcine Skin
Skin Pharmacology and Physiology, vol. 19, no. 4, pp. 198–206, 2006 - Application of risk assessment and management principles to the extralabel use of drugs in food-producing animals
Journal of Veterinary Pharmacology and Therapeutics, vol. 29, no. 1, pp. 5–14, 2006 - Pharmacokinetics of flunixin meglumine in swine after intravenous dosing
Journal of Veterinary Pharmacology and Therapeutics, vol. 29, no. 5, pp. 437–440, 2006 - Penetration of Intact Skin by Quantum Dots with Diverse Physicochemical Properties
Toxicological Sciences, vol. 91, no. 1, pp. 159–165, 2006 - Trace analysis of fullerenes in biological samples by simplified liquid–liquid extraction and high-performance liquid chromatography
Journal of Chromatography A, vol. 1129, no. 2, pp. 216–222, 2006 - Toxicity of jet fuel aliphatic and aromatic hydrocarbon mixtures on human epidermal Keratinocytes: evaluation based on in vitro cytotoxicity and interleukin-8 release
Archives of Toxicology, vol. 80, no. 8, pp. 508–523, 2006 - Determination of the partition coefficients and absorption kinetic parameters of chemicals in a lipophilic membrane/water system by using a membrane-coated fiber technique
European Journal of Pharmaceutical Sciences, vol. 24, no. 1, pp. 15–23, 2005 - Comparative studies on the effects of water, ethanol and water/ethanol mixtures on chemical partitioning into porcine stratum corneum and silastic membrane
Toxicology in Vitro, vol. 19, no. 1, pp. 69–77, 2005 - Effect of vehicles and sodium lauryl sulphate on xenobiotic permeability and stratum corneum partitioning in porcine skin
Toxicology, vol. 206, no. 3, pp. 325–335, 2005 - Multi-walled carbon nanotube interactions with human epidermal keratinocytes
Toxicology Letters, vol. 155, no. 3, pp. 377–384, 2005 - Pre-treatment effects of trichloroethylene on the dermal absorption of the biocide, triazine
Toxicology Letters, vol. 159, no. 3, pp. 252–260, 2005 - Effect of JP-8 jet fuel exposure on protein expression in human keratinocyte cells in culture
Toxicology Letters, vol. 160, no. 1, pp. 8–21, 2005 - Predicting skin permeability from complex chemical mixtures
Toxicology and Applied Pharmacology, vol. 208, no. 2, pp. 99–110, 2005 - A Physiologically Based Pharmacokinetic Model of Organophosphate Dermal Absorption
Toxicological Sciences, vol. 89, no. 1, pp. 188–204, 2005 - NDELA and nickel modulation of triazine disposition in skin
Toxicology and Industrial Health , vol. 21, no. 9, pp. 197–205, 2005 - Multivariate meta-analysis of pharmacokinetic studies of ampicillin trihydrate in cattle
American Journal of Veterinary Research, vol. 66, no. 1, pp. 108–112, 2005 - Development of a physiologic-based pharmacokinetic model for estimating sulfamethazine concentrations in swine and application to prediction of violative residues in edible tissues
American Journal of Veterinary Research, vol. 66, no. 10, pp. 1686–1693, 2005 - Membrane Uptake Kinetics of Jet Fuel Aromatic Hydrocarbons from Aqueous Solutions Studied by a Membrane-Coated Fiber Technique
Toxicology Mechanisms and Methods, vol. 15, no. 4, pp. 307–316, 2005 - Effect of In Vivo Jet Fuel Exposure on Subsequent In Vitro Dermal Absorption of Individual Aromatic and Aliphatic Hydrocarbon Fuel Constituents
Journal of Toxicology and Environmental Health, Part A, vol. 68, no. 9, pp. 719–737, 2005 - Comparative In Vivo Toxicity of Topical JP-8 Jet Fuel and Its Individual Hydrocarbon Components: Identification of Tridecane and Tetradecane as Key Constituents Responsible for Dermal Irritation
Toxicologic Pathology, vol. 33, no. 2, pp. 258–266, 2005 - Extralabel intramammary use of drugs in dairy cattle
Journal of the American Veterinary Medical Association, vol. 226, no. 12, pp. 1994–1996, 2005 - Antidotes in food animal practice
Journal of the American Veterinary Medical Association, vol. 226, no. 6, pp. 884–887, 2005 - Effect of formulation and route of administration on tissue residues and withdrawal times
Journal of the American Veterinary Medical Association, vol. 227, no. 10, pp. 1574–1577, 2005 - Aminoglycoside residues in food of animal origin
Journal of the American Veterinary Medical Association, vol. 227, no. 1, pp. 63–66, 2005 - Meta-analysis of pharmacokinetic data of veterinary drugs using the Food Animal Residue Avoidance Databank: oxytetracycline and procaine penicillin G
Journal of Veterinary Pharmacology and Therapeutics, vol. 27, no. 5, pp. 343–353, 2004 - Elimination kinetics of ceftiofur hydrochloride after intramammary administration in lactating dairy cows
Journal of the American Veterinary Medical Association, vol. 224, no. 11, pp. 1827–1830, 2004 - Current approved drugs for aquatic species
Journal of the American Veterinary Medical Association, vol. 224, no. 1, pp. 50–51, 2004 - Drugs approved for small ruminants
Journal of the American Veterinary Medical Association, vol. 224, no. 4, pp. 520–523, 2004 - A Compartment Model for the Membrane-Coated Fiber Technique Used for Determining the Absorption Parameters of Chemicals into Lipophilic Membranes
Pharmaceutical Research, vol. 21, no. 8, pp. 1345–1352, 2004 - Dose Related Absorption of JP-8 Jet Fuel Hydrocarbons Through Porcine Skin with Quantitative Structure Permeability Relationship Analysis
Toxicology Mechanisms and Methods, vol. 14, no. 3, pp. 159–166, 2004 - Analytical Chemistry, vol. 76, no. 14, pp. 4245–4250, 2004
- Mixture additives inhibit the dermal permeation of the fatty acid, ricinoleic acid
Toxicology Letters, vol. 147, no. 1, pp. 15–26, 2004 - Comparative mixture effects of JP-8(100) additives on the dermal absorption and disposition of jet fuel hydrocarbons in different membrane model systems
Toxicology Letters, vol. 150, no. 3, pp. 351–365, 2004 - Skin toxicity of jet fuels: ultrastructural studies and the effects of substance P
Toxicology and Applied Pharmacology, vol. 195, no. 3, pp. 339–347, 2004 - A web-based decision support system to estimate extended withdrawal intervals
Computers and Electronics in Agriculture, vol. 44, no. 2, pp. 145–151, 2004 - Pyridostigmine bromide modulates topical irritant-induced cytokine release from human epidermal keratinocytes and isolated perfused porcine skin
Toxicology, vol. 183, no. 1-3, pp. 15–28, 2003 - Percutaneous absorption of 2,6-di-tert-butyl-4-nitrophenol (DBNP) in isolated perfused porcine skin
Toxicology in Vitro, 2003 - The cytotoxicity of jet fuel aromatic hydrocarbons and dose-related interleukin-8 release from human epidermal keratinocytes
Archives of Toxicology, vol. 77, no. 7, pp. 384–391, 2003 - Toxicokinetics and Physiologically Based Toxicokinetics in Toxicology and Risk Assessment
Journal of Toxicology and Environmental Health Part B: Critical Reviews, vol. 6, no. 1, pp. 1–40, 2003 - Percutaneous Absorption of Topical N , N -Diethyl- m -Toluamide (Deet): Effects of Exposure Variables and Coadministered Toxicants
Journal of Toxicology and Environmental Health Part A, vol. 66, no. 2, pp. 133–151, 2003 - Pharmaceutical Research, vol. 20, no. 2, pp. 275–282, 2003
- Update on FARAD food animal drug withholding recommendations
Journal of the American Veterinary Medical Association, vol. 223, no. 9, pp. 1277–1278, 2003 - Evaluation of the advisory services provided by the Food Animal Residue Avoidance Databank
Journal of the American Veterinary Medical Association, vol. 223, no. 11, pp. 1596–1598, 2003 - Physicochemical determinants of linear alkylbenzene sulfonate (LAS) disposition in skin exposed to aqueous cutting fluid mixtures
Toxicology and Industrial Health, vol. 18, no. 5, pp. 237–248, 2002 - Differential Relationship between the Carbon Chain Length of Jet Fuel Aliphatic Hydrocarbons and Their Ability to Induce Cytotoxicity vs. Interleukin-8 Release in Human Epidermal Keratinocytes
Toxicological Sciences, vol. 69, no. 1, pp. 226–233, 2002 - Effect of Chemical Interactions in Pentachlorophenol Mixtures on Skin and Membrane Transport
Toxicological Sciences, vol. 69, no. 2, pp. 295–305, 2002 - Pyridostigmine Bromide Modulates the Dermal Disposition of [14C]Permethrin
Toxicology and Applied Pharmacology, vol. 181, no. 3, pp. 164–173, 2002 - Mixed-effects modeling of the interspecies pharmacokinetic scaling of oxytetracycline
Journal of Pharmaceutical Sciences, vol. 91, no. 2, pp. 331–341, 2002 - Extrapolated Withdrawal-Interval Estimator (EWE) Algorithm: A Quantitative Approach to Establishing Extralabel Withdrawal Times
Regulatory Toxicology and Pharmacology, vol. 36, no. 1, pp. 131–137, 2002 - Analysis of N,N-diethyl-m-toluamide in porcine skin perfusates using solid-phase extraction disks and reversed-phase high-performance liquid chromatography
Journal of Chromatography B, vol. 780, no. 1, pp. 45–52, 2002 - Gulf War related exposure factors influencing topical absorption of 14C-permethrin
Toxicology Letters, vol. 135, no. 1-2, pp. 61–71, 2002 - Applying the biopharmaceutics classification system to veterinary pharmaceutical products Part II. Physiological considerations
Advanced Drug Delivery Reviews, vol. 54, no. 6, pp. 825–850, 2002 - Cytokine induction as a measure of cutaneous toxicity in primary and immortalized porcine keratinocytes exposed to jet fuels, and their relationship to normal human epidermal keratinocytes
Toxicology Letters, vol. 119, no. 3, pp. 209–217, 2001 - Analysis of interleukin-8 release from normal human epidermal keratinocytes exposed to aliphatic hydrocarbons: delivery of hydrocarbons to cell cultures via complexation with a-cyclodextrin
Toxicology in Vitro, vol. 15, no. 6, pp. 663–669, 2001 - Pharmaceutical Research, vol. 18, no. 7, pp. 992–998, 2001
- Potential and problems of developing transdermal patches for veterinary applications
Advanced Drug Delivery Reviews, vol. 50, no. 3, pp. 175–203, 2001 - Use of methyl salicylate as a simulant to predict the percutaneous absorption of sulfur mustard
Journal of Applied Toxicology, vol. 21, no. 2, pp. 91–99, 2001 - Effects of short-term high-dose and low-dose dermal exposure to Jet A, JP-8 and JP-8 + 100 jet fuels
Journal of Applied Toxicology, vol. 21, no. 6, pp. 485–494, 2001 - Mixture Effects of JP-8 Additives on the Dermal Disposition of Jet Fuel Components
Toxicology and Applied Pharmacology, vol. 175, no. 3, pp. 269–281, 2001 - Enhanced Systemic Tissue Distribution after Dermal versus Intravenous 3,3',4,4'-Tetrachlorobiphenyl Exposure: Limited Utility of Radiolabel Blood Area under the Curve and Excretion Data in Dermal Absorption Calculations and Tissue Exposure Assessment
Toxicology and Applied Pharmacology, vol. 177, no. 1, pp. 26–37, 2001 - Mixture component effects on the in vitro dermal absorption of pentachlorophenol
Archives of Toxicology, vol. 75, no. 6, pp. 329–334, 2001 - Identification of early biomarkers of inflammation produced by keratinocytes exposed to jet fuels jet A, JP-8, and JP-8(100)
Journal of Biochemical and Molecular Toxicology, vol. 14, no. 5, pp. 231–237, 2000 - Extralabel use of ivermectin and moxidectin in food animals
Journal of the American Veterinary Medical Association, vol. 217, no. 5, pp. 668–671, 2000 - Membrane transport of naphthalene and dodecane in jet fuel mixtures
Toxicology and Industrial Health, vol. 16, no. 6, pp. 225–238, 2000 - METHODS OF ASSESSING THE PERCUTANEOUS ABSORPTION OF VOLATILE CHEMICALS IN ISOLATED PERFUSED SKIN: STUDIES WITH CHLOROPENT AFLUOROBENZENE AND DICHLOROBENZENE
Toxicology Methods, vol. 10, no. 4, pp. 265–281, 2000 - COMPASS PLOTS: A COMBINATION OF STAR PLOT AND ANALYSIS OF MEANS TO VISUALIZE SIGNIFICANT INTERACTIONS IN COMPLEX TOXICOLOGY STUDIES
Toxicology Methods, vol. 10, no. 4, pp. 313–332, 2000 - Dermatotoxicokinetic Modeling of p-Nitrophenol and Its Conjugation Metabolite in Swine following Topical and Intravenous Administration
Toxicological Sciences, vol. 54, no. 2, pp. 284–294, 2000 - Estimating Provisional Acceptable Residues for Extralabel Drug Use in Livestock
Regulatory Toxicology and Pharmacology, vol. 29, no. 3, pp. 287–299, 1999 - Dermal Absorption and Distribution of Topically Dosed Jet Fuels Jet-A, JP-8, and JP-8(100)
Toxicology and Applied Pharmacology, vol. 160, no. 1, pp. 60–75, 1999 - Percutaneous Absorption of Salicylic Acid, Theophylline, 2,4-Dimethylamine, Diethyl Hexyl Phthalic Acid, andp-Aminobenzoic Acid in the Isolated Perfused Porcine Skin Flap Compared to Manin Vivo
Toxicology and Applied Pharmacology, vol. 151, no. 1, pp. 159–165, 1998 - In VitroPercutaneous Absorption of Benzidine in Complex Mechanistically Defined Chemical Mixtures Volume 141, Number 2 (1996), pages 497–506:
Toxicology and Applied Pharmacology, vol. 144, no. 2, p. 401, 1997 - Pentachlorophenol Dermal Absorption and Disposition from Soil in Swine: Effects of Occlusion and Skin Microorganism Inhibition
Toxicology and Applied Pharmacology, vol. 147, no. 2, pp. 234–246, 1997 - Pharmaceutical Research, vol. 14, no. 6, pp. 687–697, 1997
- Cutaneous toxicity of the benzidine dye direct red 28 applied as mechanistically-defined chemical mixtures (MDCM) in perfused porcine skin
Toxicology Letters, vol. 93, no. 2-3, pp. 159–169, 1997 - Pharmacokinetics and ovarian-stimulatory effects of equine and human chorionic gonadotropins administered singly and in combination in the domestic cat
Biology of Reproduction, vol. 57, no. 2, pp. 295–302, 1997 - Quantitative Percutaneous Absorption and Cutaneous Distribution of Binary Mixtures of Phenol and para-Nitrophenol in Isolated Perfused Porcine Skin
Toxicological Sciences, vol. 32, no. 2, pp. 233–243, 1996 - Cutaneous metabolism of isosorbide dinitrate after transdermal administration in isolated perfused porcine skin
International Journal of Pharmaceutics, vol. 127, no. 2, pp. 213–217, 1996 - An in vitro-in vivo validation of the isolated perfused tumor and skin flap preparation as a model of cisplatin delivery to tumors
Journal of Pharmacological and Toxicological Methods, vol. 35, no. 3, pp. 173–177, 1996 - Pharmacokinetics and toxicity of oral and intravenous lonidamine in dogs
Cancer Chemotherapy and Pharmacology, vol. 38, no. 2, pp. 129–135, 1996 - Quantitative Percutaneous Absorption and Cutaneous Distribution of Binary Mixtures of Phenol andpara-Nitrophenol in Isolated Perfused Porcine Skin
Fundamental and Applied Toxicology, vol. 32, no. 2, pp. 233–243, 1996 - The Use of Mechanistically Defined Chemical Mixtures (MDCM) to Assess Component Effects on the Percutaneous Absorption and Cutaneous Disposition of Topically Exposed Chemicals. I. Studies with Parathion Mixtures in Isolated Perfused Porcine Skin
Toxicology and Applied Pharmacology, vol. 141, no. 2, pp. 473–486, 1996 - The Use of Mechanistically Defined Chemical Mixtures (MDCM) to Assess Mixture Component Effects on the Percutaneous Absorption and Cutaneous Disposition of Topically Exposed Chemicals II. Development of a General Dermatopharmacokinetic Model for Use in Risk Assessment
Toxicology and Applied Pharmacology, vol. 141, no. 2, pp. 487–496, 1996 - A biophysically based dermatopharmacokinetic compartment model for quantifying percutaneous penetration and absorption of topically applied agents. I. Theory
Journal of Pharmaceutical Sciences, vol. 84, no. 5, pp. 599–608, 1995 - Evaluation of protective effects of sodium thiosulfate, cysteine, niacinamide and indomethacin on sulfur mustard-treated isolated perfused porcine skin
Chemico-Biological Interactions, vol. 96, no. 3, pp. 249–262, 1995 - Detection of sulfur mustard bis (2-chloroethyl) sulfide and metabolites after topical application in the isolated perfused porcine skin flap
Life Sciences, vol. 56, no. 17, pp. 1385–1394, 1995 - Pulsatile transdermal delivery of LHRH using electroporation: Drug delivery and skin toxicology
Journal of Controlled Release, vol. 36, no. 3, pp. 229–233, 1995 - Toxicokinetics of Topical Sulfur Mustard Penetration, Disposition, and Vascular Toxicity in Isolated Perfused Porcine Skin
Toxicology and Applied Pharmacology, vol. 135, no. 1, pp. 25–34, 1995 - Absence of whole body hyperthermia effect on cisplatin distribution in spontaneous canine tumors
International Journal of Radiation Oncology*Biology*Physics, vol. 32, no. 4, pp. 1097–1102, 1995 - Effect of whole-body hyperthermia on the pharmacokinetics and toxicity of lonidamine in dogs
International Journal of Hyperthermia, vol. 11, no. 4, pp. 531–544, 1995 - Effect of whole-body hyperthermia on lonidamine and doxorubicin pharmacokinetics and toxicity in dogs
International Journal of Hyperthermia, vol. 11, no. 4, pp. 545–559, 1995 - Effect of hyperthermia on cisplatin and carboplatin disposition in the isolated, perfused tumour and skin flap
International Journal of Hyperthermia, vol. 10, no. 4, pp. 563–572, 1994 - Effect of whole body hyperthermia on carboplatin disposition and toxicity in dogs
International Journal of Hyperthermia, vol. 10, no. 6, pp. 807–816, 1994 - Pharmaceutical Research, vol. 11, no. 7, pp. 1000–1003, 1994
- Pharmaceutical Research, vol. 11, no. 2, pp. 251–256, 1994
- A “full-space” method for predictingin vivo transdermal plasma drug profiles reflecting both cutaneous and systemic variability
Journal of Pharmaceutical Sciences, vol. 83, no. 7, pp. 1062–1064, 1994 - Effects of Anatomical Site and Occlusion on the Percutaneous Absorption and Residue Pattern of 2,6-(ring-14C)Parathion in Vivo in Pigs
Toxicology and Applied Pharmacology, vol. 122, no. 1, pp. 131–138, 1993 - Effect of tumor presence on cisplatin and carboplatin: disposition in the isolated, perfused tumor and skin flap
Cancer Chemotherapy and Pharmacology, vol. 32, no. 1, pp. 31–38, 1993 - Pharmaceutical Research, vol. 10, no. 9, pp. 1326–1331, 1993
- Pharmaceutical Research, vol. 10, no. 1, pp. 152–155, 1993
- Kidney trace metal response to combined cisplatin (CDDP) and hyperthermia
International Journal of Hyperthermia, vol. 9, no. 4, pp. 529–537, 1993 - Pharmaceutical Research, vol. 09, no. 2, pp. 211–214, 1992
- Effects of vasoactive drugs on transdermal lidocaine iontophoresis
Journal of Pharmaceutical Sciences, vol. 80, no. 7, pp. 615–620, 1991 - Determination of doxycycline in bovine tissues and body fluids by high-performance liquid chromatography using photodiode array ultraviolet-visible detection
Journal of Pharmaceutical Sciences, vol. 78, no. 1, pp. 44–47, 1989 - Definition of a physiologic pharmacokinetic model of cutaneous drug distribution using the isolated perfused porcine skin flap
Journal of Pharmaceutical Sciences, vol. 78, no. 7, pp. 550–555, 1989 - The isolated perfused porcine skin flap III. Percutaneous absorption pharmacokinetics of organophosphates, steroids, benzoic acid, and caffeine
Toxicology and Applied Pharmacology, vol. 97, no. 2, pp. 324–337, 1989 - On the definition of viability in isolated perfused skin preparations
British Journal of Dermatology, vol. 116, no. 5, pp. 739–741, 1987 - Effect of hypertherrnia on cisplatin pharrnacokinetics in normal dogs
International Journal of Hyperthermia, vol. 2, no. 4, pp. 351–358, 1986 - Exponential intravenous infusions in toxicological studies: Achieving identical serum drug concentration profiles in individuals with altered pharmacokinetic states
Journal of Pharmaceutical Sciences, vol. 75, no. 5, pp. 448–451, 1986 - The isolated perfused porcine skin flap (IPPSF) I. A novel in vitro model for percutaneous absorption and cutaneous toxicology studies
Fundamental and Applied Toxicology, vol. 7, no. 3, pp. 444–453, 1986 - Identification of a subgroup of Dprague-Dawley rats highly sensitive to drug-induced renal toxicity
Fundamental and Applied Toxicology, vol. 7, no. 1, pp. 126–131, 1986 - Dose-response studies of gentamicin nephrotoxicity in rats with experimental renal dysfunction II. Polyvinyl alcohol glomerulopathy
Toxicology and Applied Pharmacology, vol. 80, no. 2, pp. 264–273, 1985