Jim E. Riviere

Jim E. Riviere is the Burroughs Wellcome Fund Distinguished Professor of Pharmacology; and Director of the Center for Chemical Toxicology Research and Pharmacokinetics, College of Veterinary Medicine; North Carolina State University (NCSU) in Raleigh NC. Dr. Riviere received his B.S. (summa cum laude) and M.S. degrees from Boston College, his DVM and Ph.D. degrees in pharmacology as well as a D.S. degree (with honor) from Purdue University. He is an elected member of the Institute of Medicine of the National Academies, serves on its Food and Nutrition Board, and is a Fellow of the Academy of Toxicological Sciences. He has served on the Science Board of the Food and Drug Administration.His honors include the 1999 O. Max Gardner Award from the Consolidated University of North Carolina, the 1991 Ebert Prize from the American Pharmaceutical Association, the Harvey W. Wiley Medal and FDA Commissioner’s Special Citation, and the Lifetime Achievement Award from the European Association of Veterinary Pharmacology and Toxicology. He is the Editor of the Journal of Veterinary Pharmacology and Therapeutics. He has served as an officer in various Specialty Sections of the Society of Toxicology, and has served on the Editorial Boards of various toxicology, pharmacology, and veterinary journals. He has published over 440 full-length research papers and chapters, holds 5 US Patents, has authored/edited 10 books in pharmacokinetics, toxicology and food safety, and received over 17 million dollars as principal investigator on extramural research grants. His current research interests relate to the development of animal models; applying biomathematics to problems in toxicology, including the risk assessment of chemical mixtures, pharmacokinetics, nanomaterials, absorption of drugs, and chemicals across skin; and the food safety and pharmacokinetics of tissue residues in food producing animals.

Biography Updated on 9 February 2008

Personal Home Page

http://cctrp.ncsu.edu/people/jr/

Articles in Scholarly Journals [Incomplete List]

  1. Regression method of the hydrophobicity ruler approach for determining octanol/water partition coefficients of very hydrophobic compounds
    Chemosphere, vol. 66, no. 6, pp. 1086–1093, 2007
  2. Biological stress response terminology: Integrating the concepts of adaptive response and preconditioning stress within a hormetic dose–response framework
    Toxicology and Applied Pharmacology, vol. 222, no. 1, pp. 122–128, 2007
  3. An experimentally based approach for predicting skin permeability of chemicals and drugs using a membrane-coated fiber array
    Toxicology and Applied Pharmacology, vol. 221, no. 3, pp. 320–328, 2007
  4. Variables Influencing Interactions of Untargeted Quantum Dot Nanoparticles with Skin Cells and Identification of Biochemical Modulators
    Nano Letters, vol. 7, no. 5, pp. 1344–1348, 2007
  5. Biodistribution of Quantum Dot Nanoparticles in Perfused Skin: Evidence of Coating Dependency and Periodicity in Arterial Extraction
    Nano Letters, vol. 7, no. 9, pp. 2865–2870, 2007
  6. Surface Coatings Determine Cytotoxicity and Irritation Potential of Quantum Dot Nanoparticles in Epidermal Keratinocytes
    Journal of Investigative Dermatology, vol. 127, no. 1, Article ID 5700508, 10 pages, 2007
  7. Partitioning Behavior of Aromatic Components in Jet Fuel into Diverse Membrane-coated Fibers
    Journal of Toxicology and Environmental Health, Part A, vol. 70, no. 22, pp. 1879–1887, 2007
  8. Membrane-Coated Fiber Array Approach for Predicting Skin Permeability of Chemical Mixtures from Different Vehicles
    Toxicological Sciences, vol. 99, no. 1, pp. 153–161, 2007
  9. Editorial
    Journal of Veterinary Pharmacology and Therapeutics, vol. 30, no. s1, pp. iii–iii, 2007
  10. Na�ve averaged, na�ve pooled, and population pharmacokinetics of orally administered marbofloxacin in juvenile harbor seals
    Journal of the American Veterinary Medical Association, vol. 230, no. 3, pp. 390–395, 2007
  11. Extralabel use of penicillin in food animals
    Journal of the American Veterinary Medical Association, vol. 229, no. 9, pp. 1401–1403, 2006
  12. Use of Probabilistic Modeling within a Physiologically Based Pharmacokinetic Model To Predict Sulfamethazine Residue Withdrawal Times in Edible Tissues in Swine
    Antimicrobial Agents and Chemotherapy, vol. 50, no. 7, pp. 2344–2351, 2006
  13. Cluster Analysis of the Dermal Permeability and Stratum Corneum/Solvent Partitioning of Ten Chemicals in Twenty-Four Chemical Mixtures in Porcine Skin
    Skin Pharmacology and Physiology, vol. 19, no. 4, pp. 198–206, 2006
  14. Application of risk assessment and management principles to the extralabel use of drugs in food-producing animals
    Journal of Veterinary Pharmacology and Therapeutics, vol. 29, no. 1, pp. 5–14, 2006
  15. Pharmacokinetics of flunixin meglumine in swine after intravenous dosing
    Journal of Veterinary Pharmacology and Therapeutics, vol. 29, no. 5, pp. 437–440, 2006
  16. Penetration of Intact Skin by Quantum Dots with Diverse Physicochemical Properties
    Toxicological Sciences, vol. 91, no. 1, pp. 159–165, 2006
  17. Trace analysis of fullerenes in biological samples by simplified liquid–liquid extraction and high-performance liquid chromatography
    Journal of Chromatography A, vol. 1129, no. 2, pp. 216–222, 2006
  18. Toxicity of jet fuel aliphatic and aromatic hydrocarbon mixtures on human epidermal Keratinocytes: evaluation based on in vitro cytotoxicity and interleukin-8 release
    Archives of Toxicology, vol. 80, no. 8, pp. 508–523, 2006
  19. Determination of the partition coefficients and absorption kinetic parameters of chemicals in a lipophilic membrane/water system by using a membrane-coated fiber technique
    European Journal of Pharmaceutical Sciences, vol. 24, no. 1, pp. 15–23, 2005
  20. Comparative studies on the effects of water, ethanol and water/ethanol mixtures on chemical partitioning into porcine stratum corneum and silastic membrane
    Toxicology in Vitro, vol. 19, no. 1, pp. 69–77, 2005
  21. Effect of vehicles and sodium lauryl sulphate on xenobiotic permeability and stratum corneum partitioning in porcine skin
    Toxicology, vol. 206, no. 3, pp. 325–335, 2005
  22. Multi-walled carbon nanotube interactions with human epidermal keratinocytes
    Toxicology Letters, vol. 155, no. 3, pp. 377–384, 2005
  23. Pre-treatment effects of trichloroethylene on the dermal absorption of the biocide, triazine
    Toxicology Letters, vol. 159, no. 3, pp. 252–260, 2005
  24. Effect of JP-8 jet fuel exposure on protein expression in human keratinocyte cells in culture
    Toxicology Letters, vol. 160, no. 1, pp. 8–21, 2005
  25. Predicting skin permeability from complex chemical mixtures
    Toxicology and Applied Pharmacology, vol. 208, no. 2, pp. 99–110, 2005
  26. A Physiologically Based Pharmacokinetic Model of Organophosphate Dermal Absorption
    Toxicological Sciences, vol. 89, no. 1, pp. 188–204, 2005
  27. NDELA and nickel modulation of triazine disposition in skin
    Toxicology and Industrial Health , vol. 21, no. 9, pp. 197–205, 2005
  28. Multivariate meta-analysis of pharmacokinetic studies of ampicillin trihydrate in cattle
    American Journal of Veterinary Research, vol. 66, no. 1, pp. 108–112, 2005
  29. Development of a physiologic-based pharmacokinetic model for estimating sulfamethazine concentrations in swine and application to prediction of violative residues in edible tissues
    American Journal of Veterinary Research, vol. 66, no. 10, pp. 1686–1693, 2005
  30. Membrane Uptake Kinetics of Jet Fuel Aromatic Hydrocarbons from Aqueous Solutions Studied by a Membrane-Coated Fiber Technique
    Toxicology Mechanisms and Methods, vol. 15, no. 4, pp. 307–316, 2005
  31. Effect of In Vivo Jet Fuel Exposure on Subsequent In Vitro Dermal Absorption of Individual Aromatic and Aliphatic Hydrocarbon Fuel Constituents
    Journal of Toxicology and Environmental Health, Part A, vol. 68, no. 9, pp. 719–737, 2005
  32. Comparative In Vivo Toxicity of Topical JP-8 Jet Fuel and Its Individual Hydrocarbon Components: Identification of Tridecane and Tetradecane as Key Constituents Responsible for Dermal Irritation
    Toxicologic Pathology, vol. 33, no. 2, pp. 258–266, 2005
  33. Extralabel intramammary use of drugs in dairy cattle
    Journal of the American Veterinary Medical Association, vol. 226, no. 12, pp. 1994–1996, 2005
  34. Antidotes in food animal practice
    Journal of the American Veterinary Medical Association, vol. 226, no. 6, pp. 884–887, 2005
  35. Effect of formulation and route of administration on tissue residues and withdrawal times
    Journal of the American Veterinary Medical Association, vol. 227, no. 10, pp. 1574–1577, 2005
  36. Aminoglycoside residues in food of animal origin
    Journal of the American Veterinary Medical Association, vol. 227, no. 1, pp. 63–66, 2005
  37. Meta-analysis of pharmacokinetic data of veterinary drugs using the Food Animal Residue Avoidance Databank: oxytetracycline and procaine penicillin G
    Journal of Veterinary Pharmacology and Therapeutics, vol. 27, no. 5, pp. 343–353, 2004
  38. Elimination kinetics of ceftiofur hydrochloride after intramammary administration in lactating dairy cows
    Journal of the American Veterinary Medical Association, vol. 224, no. 11, pp. 1827–1830, 2004
  39. Current approved drugs for aquatic species
    Journal of the American Veterinary Medical Association, vol. 224, no. 1, pp. 50–51, 2004
  40. Drugs approved for small ruminants
    Journal of the American Veterinary Medical Association, vol. 224, no. 4, pp. 520–523, 2004
  41. A Compartment Model for the Membrane-Coated Fiber Technique Used for Determining the Absorption Parameters of Chemicals into Lipophilic Membranes
    Pharmaceutical Research, vol. 21, no. 8, pp. 1345–1352, 2004
  42. Dose Related Absorption of JP-8 Jet Fuel Hydrocarbons Through Porcine Skin with Quantitative Structure Permeability Relationship Analysis
    Toxicology Mechanisms and Methods, vol. 14, no. 3, pp. 159–166, 2004
  43. Analytical Chemistry, vol. 76, no. 14, pp. 4245–4250, 2004
  44. Mixture additives inhibit the dermal permeation of the fatty acid, ricinoleic acid
    Toxicology Letters, vol. 147, no. 1, pp. 15–26, 2004
  45. Comparative mixture effects of JP-8(100) additives on the dermal absorption and disposition of jet fuel hydrocarbons in different membrane model systems
    Toxicology Letters, vol. 150, no. 3, pp. 351–365, 2004
  46. Skin toxicity of jet fuels: ultrastructural studies and the effects of substance P
    Toxicology and Applied Pharmacology, vol. 195, no. 3, pp. 339–347, 2004
  47. A web-based decision support system to estimate extended withdrawal intervals
    Computers and Electronics in Agriculture, vol. 44, no. 2, pp. 145–151, 2004
  48. Pyridostigmine bromide modulates topical irritant-induced cytokine release from human epidermal keratinocytes and isolated perfused porcine skin
    Toxicology, vol. 183, no. 1-3, pp. 15–28, 2003
  49. Percutaneous absorption of 2,6-di-tert-butyl-4-nitrophenol (DBNP) in isolated perfused porcine skin
    Toxicology in Vitro, 2003
  50. The cytotoxicity of jet fuel aromatic hydrocarbons and dose-related interleukin-8 release from human epidermal keratinocytes
    Archives of Toxicology, vol. 77, no. 7, pp. 384–391, 2003
  51. Toxicokinetics and Physiologically Based Toxicokinetics in Toxicology and Risk Assessment
    Journal of Toxicology and Environmental Health Part B: Critical Reviews, vol. 6, no. 1, pp. 1–40, 2003
  52. Percutaneous Absorption of Topical N , N -Diethyl- m -Toluamide (Deet): Effects of Exposure Variables and Coadministered Toxicants
    Journal of Toxicology and Environmental Health Part A, vol. 66, no. 2, pp. 133–151, 2003
  53. Pharmaceutical Research, vol. 20, no. 2, pp. 275–282, 2003
  54. Update on FARAD food animal drug withholding recommendations
    Journal of the American Veterinary Medical Association, vol. 223, no. 9, pp. 1277–1278, 2003
  55. Evaluation of the advisory services provided by the Food Animal Residue Avoidance Databank
    Journal of the American Veterinary Medical Association, vol. 223, no. 11, pp. 1596–1598, 2003
  56. Physicochemical determinants of linear alkylbenzene sulfonate (LAS) disposition in skin exposed to aqueous cutting fluid mixtures
    Toxicology and Industrial Health, vol. 18, no. 5, pp. 237–248, 2002
  57. Differential Relationship between the Carbon Chain Length of Jet Fuel Aliphatic Hydrocarbons and Their Ability to Induce Cytotoxicity vs. Interleukin-8 Release in Human Epidermal Keratinocytes
    Toxicological Sciences, vol. 69, no. 1, pp. 226–233, 2002
  58. Effect of Chemical Interactions in Pentachlorophenol Mixtures on Skin and Membrane Transport
    Toxicological Sciences, vol. 69, no. 2, pp. 295–305, 2002
  59. Pyridostigmine Bromide Modulates the Dermal Disposition of [14C]Permethrin
    Toxicology and Applied Pharmacology, vol. 181, no. 3, pp. 164–173, 2002
  60. Mixed-effects modeling of the interspecies pharmacokinetic scaling of oxytetracycline
    Journal of Pharmaceutical Sciences, vol. 91, no. 2, pp. 331–341, 2002
  61. Extrapolated Withdrawal-Interval Estimator (EWE) Algorithm: A Quantitative Approach to Establishing Extralabel Withdrawal Times
    Regulatory Toxicology and Pharmacology, vol. 36, no. 1, pp. 131–137, 2002
  62. Analysis of N,N-diethyl-m-toluamide in porcine skin perfusates using solid-phase extraction disks and reversed-phase high-performance liquid chromatography
    Journal of Chromatography B, vol. 780, no. 1, pp. 45–52, 2002
  63. Gulf War related exposure factors influencing topical absorption of 14C-permethrin
    Toxicology Letters, vol. 135, no. 1-2, pp. 61–71, 2002
  64. Applying the biopharmaceutics classification system to veterinary pharmaceutical products Part II. Physiological considerations
    Advanced Drug Delivery Reviews, vol. 54, no. 6, pp. 825–850, 2002
  65. Cytokine induction as a measure of cutaneous toxicity in primary and immortalized porcine keratinocytes exposed to jet fuels, and their relationship to normal human epidermal keratinocytes
    Toxicology Letters, vol. 119, no. 3, pp. 209–217, 2001
  66. Analysis of interleukin-8 release from normal human epidermal keratinocytes exposed to aliphatic hydrocarbons: delivery of hydrocarbons to cell cultures via complexation with a-cyclodextrin
    Toxicology in Vitro, vol. 15, no. 6, pp. 663–669, 2001
  67. Pharmaceutical Research, vol. 18, no. 7, pp. 992–998, 2001
  68. Potential and problems of developing transdermal patches for veterinary applications
    Advanced Drug Delivery Reviews, vol. 50, no. 3, pp. 175–203, 2001
  69. Use of methyl salicylate as a simulant to predict the percutaneous absorption of sulfur mustard
    Journal of Applied Toxicology, vol. 21, no. 2, pp. 91–99, 2001
  70. Effects of short-term high-dose and low-dose dermal exposure to Jet A, JP-8 and JP-8 + 100 jet fuels
    Journal of Applied Toxicology, vol. 21, no. 6, pp. 485–494, 2001
  71. Mixture Effects of JP-8 Additives on the Dermal Disposition of Jet Fuel Components
    Toxicology and Applied Pharmacology, vol. 175, no. 3, pp. 269–281, 2001
  72. Enhanced Systemic Tissue Distribution after Dermal versus Intravenous 3,3',4,4'-Tetrachlorobiphenyl Exposure: Limited Utility of Radiolabel Blood Area under the Curve and Excretion Data in Dermal Absorption Calculations and Tissue Exposure Assessment
    Toxicology and Applied Pharmacology, vol. 177, no. 1, pp. 26–37, 2001
  73. Mixture component effects on the in vitro dermal absorption of pentachlorophenol
    Archives of Toxicology, vol. 75, no. 6, pp. 329–334, 2001
  74. Identification of early biomarkers of inflammation produced by keratinocytes exposed to jet fuels jet A, JP-8, and JP-8(100)
    Journal of Biochemical and Molecular Toxicology, vol. 14, no. 5, pp. 231–237, 2000
  75. Extralabel use of ivermectin and moxidectin in food animals
    Journal of the American Veterinary Medical Association, vol. 217, no. 5, pp. 668–671, 2000
  76. Membrane transport of naphthalene and dodecane in jet fuel mixtures
    Toxicology and Industrial Health, vol. 16, no. 6, pp. 225–238, 2000
  77. METHODS OF ASSESSING THE PERCUTANEOUS ABSORPTION OF VOLATILE CHEMICALS IN ISOLATED PERFUSED SKIN: STUDIES WITH CHLOROPENT AFLUOROBENZENE AND DICHLOROBENZENE
    Toxicology Methods, vol. 10, no. 4, pp. 265–281, 2000
  78. COMPASS PLOTS: A COMBINATION OF STAR PLOT AND ANALYSIS OF MEANS TO VISUALIZE SIGNIFICANT INTERACTIONS IN COMPLEX TOXICOLOGY STUDIES
    Toxicology Methods, vol. 10, no. 4, pp. 313–332, 2000
  79. Dermatotoxicokinetic Modeling of p-Nitrophenol and Its Conjugation Metabolite in Swine following Topical and Intravenous Administration
    Toxicological Sciences, vol. 54, no. 2, pp. 284–294, 2000
  80. Estimating Provisional Acceptable Residues for Extralabel Drug Use in Livestock
    Regulatory Toxicology and Pharmacology, vol. 29, no. 3, pp. 287–299, 1999
  81. Dermal Absorption and Distribution of Topically Dosed Jet Fuels Jet-A, JP-8, and JP-8(100)
    Toxicology and Applied Pharmacology, vol. 160, no. 1, pp. 60–75, 1999
  82. Percutaneous Absorption of Salicylic Acid, Theophylline, 2,4-Dimethylamine, Diethyl Hexyl Phthalic Acid, andp-Aminobenzoic Acid in the Isolated Perfused Porcine Skin Flap Compared to Manin Vivo
    Toxicology and Applied Pharmacology, vol. 151, no. 1, pp. 159–165, 1998
  83. In VitroPercutaneous Absorption of Benzidine in Complex Mechanistically Defined Chemical Mixtures Volume 141, Number 2 (1996), pages 497–506:
    Toxicology and Applied Pharmacology, vol. 144, no. 2, p. 401, 1997
  84. Pentachlorophenol Dermal Absorption and Disposition from Soil in Swine: Effects of Occlusion and Skin Microorganism Inhibition
    Toxicology and Applied Pharmacology, vol. 147, no. 2, pp. 234–246, 1997
  85. Pharmaceutical Research, vol. 14, no. 6, pp. 687–697, 1997
  86. Cutaneous toxicity of the benzidine dye direct red 28 applied as mechanistically-defined chemical mixtures (MDCM) in perfused porcine skin
    Toxicology Letters, vol. 93, no. 2-3, pp. 159–169, 1997
  87. Pharmacokinetics and ovarian-stimulatory effects of equine and human chorionic gonadotropins administered singly and in combination in the domestic cat
    Biology of Reproduction, vol. 57, no. 2, pp. 295–302, 1997
  88. Quantitative Percutaneous Absorption and Cutaneous Distribution of Binary Mixtures of Phenol and para-Nitrophenol in Isolated Perfused Porcine Skin
    Toxicological Sciences, vol. 32, no. 2, pp. 233–243, 1996
  89. Cutaneous metabolism of isosorbide dinitrate after transdermal administration in isolated perfused porcine skin
    International Journal of Pharmaceutics, vol. 127, no. 2, pp. 213–217, 1996
  90. An in vitro-in vivo validation of the isolated perfused tumor and skin flap preparation as a model of cisplatin delivery to tumors
    Journal of Pharmacological and Toxicological Methods, vol. 35, no. 3, pp. 173–177, 1996
  91. Pharmacokinetics and toxicity of oral and intravenous lonidamine in dogs
    Cancer Chemotherapy and Pharmacology, vol. 38, no. 2, pp. 129–135, 1996
  92. Quantitative Percutaneous Absorption and Cutaneous Distribution of Binary Mixtures of Phenol andpara-Nitrophenol in Isolated Perfused Porcine Skin
    Fundamental and Applied Toxicology, vol. 32, no. 2, pp. 233–243, 1996
  93. The Use of Mechanistically Defined Chemical Mixtures (MDCM) to Assess Component Effects on the Percutaneous Absorption and Cutaneous Disposition of Topically Exposed Chemicals. I. Studies with Parathion Mixtures in Isolated Perfused Porcine Skin
    Toxicology and Applied Pharmacology, vol. 141, no. 2, pp. 473–486, 1996
  94. The Use of Mechanistically Defined Chemical Mixtures (MDCM) to Assess Mixture Component Effects on the Percutaneous Absorption and Cutaneous Disposition of Topically Exposed Chemicals II. Development of a General Dermatopharmacokinetic Model for Use in Risk Assessment
    Toxicology and Applied Pharmacology, vol. 141, no. 2, pp. 487–496, 1996
  95. A biophysically based dermatopharmacokinetic compartment model for quantifying percutaneous penetration and absorption of topically applied agents. I. Theory
    Journal of Pharmaceutical Sciences, vol. 84, no. 5, pp. 599–608, 1995
  96. Evaluation of protective effects of sodium thiosulfate, cysteine, niacinamide and indomethacin on sulfur mustard-treated isolated perfused porcine skin
    Chemico-Biological Interactions, vol. 96, no. 3, pp. 249–262, 1995
  97. Detection of sulfur mustard bis (2-chloroethyl) sulfide and metabolites after topical application in the isolated perfused porcine skin flap
    Life Sciences, vol. 56, no. 17, pp. 1385–1394, 1995
  98. Pulsatile transdermal delivery of LHRH using electroporation: Drug delivery and skin toxicology
    Journal of Controlled Release, vol. 36, no. 3, pp. 229–233, 1995
  99. Toxicokinetics of Topical Sulfur Mustard Penetration, Disposition, and Vascular Toxicity in Isolated Perfused Porcine Skin
    Toxicology and Applied Pharmacology, vol. 135, no. 1, pp. 25–34, 1995
  100. Absence of whole body hyperthermia effect on cisplatin distribution in spontaneous canine tumors
    International Journal of Radiation Oncology*Biology*Physics, vol. 32, no. 4, pp. 1097–1102, 1995
  101. Effect of whole-body hyperthermia on the pharmacokinetics and toxicity of lonidamine in dogs
    International Journal of Hyperthermia, vol. 11, no. 4, pp. 531–544, 1995
  102. Effect of whole-body hyperthermia on lonidamine and doxorubicin pharmacokinetics and toxicity in dogs
    International Journal of Hyperthermia, vol. 11, no. 4, pp. 545–559, 1995
  103. Effect of hyperthermia on cisplatin and carboplatin disposition in the isolated, perfused tumour and skin flap
    International Journal of Hyperthermia, vol. 10, no. 4, pp. 563–572, 1994
  104. Effect of whole body hyperthermia on carboplatin disposition and toxicity in dogs
    International Journal of Hyperthermia, vol. 10, no. 6, pp. 807–816, 1994
  105. Pharmaceutical Research, vol. 11, no. 7, pp. 1000–1003, 1994
  106. Pharmaceutical Research, vol. 11, no. 2, pp. 251–256, 1994
  107. A “full-space” method for predictingin vivo transdermal plasma drug profiles reflecting both cutaneous and systemic variability
    Journal of Pharmaceutical Sciences, vol. 83, no. 7, pp. 1062–1064, 1994
  108. Effects of Anatomical Site and Occlusion on the Percutaneous Absorption and Residue Pattern of 2,6-(ring-14C)Parathion in Vivo in Pigs
    Toxicology and Applied Pharmacology, vol. 122, no. 1, pp. 131–138, 1993
  109. Effect of tumor presence on cisplatin and carboplatin: disposition in the isolated, perfused tumor and skin flap
    Cancer Chemotherapy and Pharmacology, vol. 32, no. 1, pp. 31–38, 1993
  110. Pharmaceutical Research, vol. 10, no. 9, pp. 1326–1331, 1993
  111. Pharmaceutical Research, vol. 10, no. 1, pp. 152–155, 1993
  112. Kidney trace metal response to combined cisplatin (CDDP) and hyperthermia
    International Journal of Hyperthermia, vol. 9, no. 4, pp. 529–537, 1993
  113. Pharmaceutical Research, vol. 09, no. 2, pp. 211–214, 1992
  114. Effects of vasoactive drugs on transdermal lidocaine iontophoresis
    Journal of Pharmaceutical Sciences, vol. 80, no. 7, pp. 615–620, 1991
  115. Determination of doxycycline in bovine tissues and body fluids by high-performance liquid chromatography using photodiode array ultraviolet-visible detection
    Journal of Pharmaceutical Sciences, vol. 78, no. 1, pp. 44–47, 1989
  116. Definition of a physiologic pharmacokinetic model of cutaneous drug distribution using the isolated perfused porcine skin flap
    Journal of Pharmaceutical Sciences, vol. 78, no. 7, pp. 550–555, 1989
  117. The isolated perfused porcine skin flap III. Percutaneous absorption pharmacokinetics of organophosphates, steroids, benzoic acid, and caffeine
    Toxicology and Applied Pharmacology, vol. 97, no. 2, pp. 324–337, 1989
  118. On the definition of viability in isolated perfused skin preparations
    British Journal of Dermatology, vol. 116, no. 5, pp. 739–741, 1987
  119. Effect of hypertherrnia on cisplatin pharrnacokinetics in normal dogs
    International Journal of Hyperthermia, vol. 2, no. 4, pp. 351–358, 1986
  120. Exponential intravenous infusions in toxicological studies: Achieving identical serum drug concentration profiles in individuals with altered pharmacokinetic states
    Journal of Pharmaceutical Sciences, vol. 75, no. 5, pp. 448–451, 1986
  121. The isolated perfused porcine skin flap (IPPSF) I. A novel in vitro model for percutaneous absorption and cutaneous toxicology studies
    Fundamental and Applied Toxicology, vol. 7, no. 3, pp. 444–453, 1986
  122. Identification of a subgroup of Dprague-Dawley rats highly sensitive to drug-induced renal toxicity
    Fundamental and Applied Toxicology, vol. 7, no. 1, pp. 126–131, 1986
  123. Dose-response studies of gentamicin nephrotoxicity in rats with experimental renal dysfunction II. Polyvinyl alcohol glomerulopathy
    Toxicology and Applied Pharmacology, vol. 80, no. 2, pp. 264–273, 1985