Jack Leunissen

Jack Leunissen holds a Ph.D. in biochemistry from the University of Nijmegen (the Netherlands). From 1986, he created and managed the Bioinformatics and Genomics Section at the Dutch National Centre for Bioinformatics and Cheminformatics, CAOS/CAMM Center. In 2000, he was appointed a Senior Lecturer in Bioinformatics at the Centre for Molecular and Biomolecular Informatics (CMBI), Nijmegen University. In 2000, he also founded the Dutch bioinformatics company Dalicon B.V. (http://www.dalicon.com/). At the end of 2002, he moved to Wageningen University to be a Full Professor in bioinformatics and the Head of the Laboratory of Bioinformatics.

Biography Updated on 4 November 2008

Personal Home Page

http://www.bioinformatics.nl/~jackl/

Articles in Scholarly Journals [Incomplete List]

  1. Role of the Synthase Domain of Ags1p in Cell Wall  -Glucan Biosynthesis in Fission Yeast
    Journal of Biological Chemistry, vol. 282, no. 26, pp. 18969–18979, 2007
  2. A Protein Classification Benchmark collection for machine learning
    Nucleic Acids Research, vol. 35, no. Database, pp. D232–D236, 2007
  3. Primer3Plus, an enhanced web interface to Primer3
    Nucleic Acids Research, vol. 35, no. Web Server, pp. W71–W74, 2007
  4. BMC Bioinformatics, vol. 7, no. 1, p. 438, 2006
  5. BMC Bioinformatics, vol. 7, no. 1, p. 444, 2006
  6. TreeDomViewer: a tool for the visualization of phylogeny and protein domain structure
    Nucleic Acids Research, vol. 34, no. Web Server, pp. W104–W109, 2006
  7. A text-mining analysis of the human phenome
    European Journal of Human Genetics, vol. 14, no. 5, Article ID 5201585, 7 pages, 2006
  8. Evolution of web services in bioinformatics
    Briefings in Bioinformatics, vol. 6, no. 2, pp. 178–188, 2005
  9. GeneSeeker: extraction and integration of human disease-related information from web-based genetic databases
    Nucleic Acids Research, vol. 33, no. Web Server, pp. W758–W761, 2005
  10. Identification and expression of the first nonmammalian amyloid-beta precursor-like protein APLP2 in the amphibian Xenopus laevis
    European Journal of Biochemistry, vol. 271, no. 10, pp. 1906–1912, 2004
  11. Satellite repeats in the functional centromere and pericentromeric heterochromatin of Medicago truncatula
    Chromosoma, vol. 113, no. 6, pp. 276–283, 2004
  12. A new web-based data mining tool for the identification of candidate genes for human genetic disorders
    European Journal of Human Genetics, vol. 11, no. 1, Article ID 5200918, 6 pages, 2003
  13. The human genome encodes 10 α-crystallin–related small heat shock proteins: HspB1–10
    Cell Stress & Chaperones, vol. 8, no. 1, p. 53, 2003
  14. Chimera: construction of chimeric sequences for phylogenetic analysis
    Bioinformatics, vol. 19, no. 2, pp. 303–304, 2003
  15. EXProt: a database for proteins with an experimentally verified function
    Nucleic Acids Research, vol. 30, no. 1, pp. 50–51, 2002
  16. Hydrogenosomes: convergent adaptations of mitochondria to anaerobic environments
    Zoology, vol. 104, no. 3-4, pp. 290–302, 2001
  17. Oreochromis mossambicus (tilapia) Corticotropin-Releasing Hormone: cDNA Sequence and Bioactivity
    Journal of Neuroendocrinology, vol. 12, no. 2, pp. 177–186, 2000
  18. USAGE: a web-based approach towards the analysis of SAGE data
    Bioinformatics, vol. 16, no. 10, pp. 899–905, 2000
  19. Distinct frequency-distributions of homopolymeric DNA tracts in different genomes
    Nucleic Acids Research, vol. 26, no. 17, pp. 4056–4062, 1998
  20. Cloning and expression of two proopiomelanocortin mRNAs in the common carp (Cyprinus carpio L.)
    Molecular and Cellular Endocrinology, vol. 143, no. 1-2, pp. 23–31, 1998
  21. Genealogy of the a-crystallin—small heat-shock protein superfamily
    International Journal of Biological Macromolecules, vol. 22, no. 3-4, pp. 151–162, 1998
  22. Cloning and sequence analysis of a hypothalamic cDNA encoding a D1c dopamine receptor in tilapia
    Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, vol. 1308, no. 1, pp. 17–22, 1996
  23. Protein sequences indicate that turtles branched off from the amniote tree after mammals
    Journal of Molecular Evolution, vol. 42, no. 5, pp. 580–586, 1996
  24. Molecular characterization of the human peroxisomal branchedchain acyl-CoA oxidase: cDNA cloning, chromosomal assignment, tissue distribution, and evidence for the absence of the protein in Zellweger syndrome
    Proceedings of the National Academy of Sciences, vol. 93, no. 24, pp. 13748–13753, 1996
  25. The expanding small heat-shock protein family, and structure predictions of the conserved ??-crystallin domain?
    Journal of Molecular Evolution, vol. 40, no. 3, pp. 238–248, 1995
  26. Molecular evolution of interleukin-3
    Journal of Molecular Evolution, vol. 39, no. 3, pp. 255–267, 1994
  27. A molecular dynamics approach for the generation of complete protein structures from limited coordinate data
    Proteins: Structure, Function, and Genetics, vol. 18, no. 2, pp. 174–185, 1994
  28. Journal of Chemical Information and Computer Sciences, vol. 33, no. 6, pp. 858–862, 1993
  29. Sequence analysis of the first intron of the bovine ?s-crystallin gene
    Molecular Biology Reports, vol. 15, no. 2, pp. 93–94, 1991
  30. Light microscopical detection of leukocyte cell surface antigens with a one-nanometer gold probe
    Histochemistry, vol. 95, no. 5, pp. 483–490, 1991
  31. Extreme differences in charge changes during protein evolution
    Journal of Molecular Evolution, vol. 31, no. 1, pp. 33–39, 1990
  32. The ?-crystallin gene families: Sequence and evolutionary patterns
    Journal of Molecular Evolution, vol. 27, no. 2, pp. 163–172, 1988
  33. Biogenesis of F71 and F72 fimbriae of uropathogenic Escherichia coli: influence of the FsoF and FstFG proteins and localization of the Fso/FstE protein
    Molecular Microbiology, vol. 2, no. 1, pp. 73–80, 1988
  34. Analysis of a cDNA Clone Expressing a Human Autoimmune Antigen: Full-Length Sequence of the U2 Small Nuclear RNA-Associated B' '} Antigen
    Proceedings of the National Academy of Sciences, vol. 84, no. 8, pp. 2421–2425, 1987
  35. The Lens Protein alpha A-crystallin of the Blind Mole Rat, Spalax ehrenbergi: Evolutionary Change and Functional Constraints
    Proceedings of the National Academy of Sciences, vol. 84, no. 15, pp. 5320–5324, 1987
  36. Copper/Zinc superoxide dismutase: How likely is gene transfer from ponyfish toPhotobacterium leiognathi?
    Journal of Molecular Evolution, vol. 23, no. 3, pp. 250–258, 1986
  37. Phylogenetic trees constructed from hydrophobicity values of protein sequences
    Journal of Theoretical Biology, vol. 119, no. 2, pp. 189–196, 1986
  38. Periplasmic accumulation of truncated forms of outer-membrane PhoE protein of Escherichia coli K-12
    Journal of Molecular Biology, vol. 189, no. 3, pp. 449–455, 1986
  39. Ultrastructural localization of a peroxisomal protein in rat liver using the specific antibody against the non-specific lipid transfer protein (sterol carrier protein 2)
    Biochimica et Biophysica Acta (BBA) - Biomembranes, vol. 812, no. 2, pp. 387–392, 1985
  40. Interaction of alpha-crystallin with lens plasma membranes. Affinity for MP26
    European Journal of Biochemistry, vol. 152, no. 3, pp. 721–728, 1985
  41. The localisation of phoE and ?-galactosidase antigens in wild type and phoE/lacZ hybrid
    Cell Biology International Reports, vol. 8, no. 3, p. 187, 1984
  42. Ratites as oldest offshoot of avian stem—evidence from a-crystallin A sequences
    Nature, vol. 311, no. 5983, Article ID 311257a0, 2 pages, 1984
  43. Internally elongated rodent ?-crystallin A chain: Resulting from incomplete RNA splicing?
    Biochemical and Biophysical Research Communications, vol. 96, no. 2, pp. 648–655, 1980