Changlin Li received his B.S. degree in biochemistry from East China University of Chemical Technology, China in 1991. In 1997, he received his M.S. degree in molecular biology from Shanghai Institute of Cell Biology, Chinese Academy of Sciences, China. In 2002, he received his Ph.D. degree in immunology from Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, China. His Postdoctoral fellowship was supervised by Professor Jack L. Strominger, Department of Molecular and Cellular Biology, Harvard University, Cambridge, Ma, USA. He studied JNK MAPK signal pathway in regulation of NKG2D-mediated NK cell cytotoxicity and is currently studying functionally the interaction of HLA-G dimer with decidual natural killer cells and decidual macrophages that express HLA-G receptors as well as related peripheral leukocytes for comparison. From 1998 till 2002, he completed doctoral studies supervised by Professor Zongliang Chang, in Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, China. He studied MAPK pathways in regulation of MD-2 expression during PMA-induced HL-60 differentiation and studied different expression patterns of CD14, TLR2, and TLR4 during HL-60 differentiation. He demonstrated that NF-kappaB signal pathway was involved in inhibition of IL-12 p40 by heat shock in murine macrophage. During the period from 1994 till 1997, he did his master studies supervised by Professor Qingxiang Shen in Institute of Biochemistry and Cell Biology. He established baculovirus expression system of insect cells for engineering recombinant molecules with biological activities, including murine and human IL-12 expression, beta-subunit of hCG, and lutropin receptor.
Biography Updated on 2 January 2011