Gianni Sava
Gianni Sava was born at Gemona del Friuli, Udine, Italy, on September 9th, 1952. He received the Diploma of Scientific Liceum, in 1971, Udine, Italy; and the degree in biological sciences, in 1975, University of Trieste, Italy. He is a Full Professor of pharmacology in the Faculty of Pharmacy, University of Trieste, since 2002. Since 1992, he is a Scientific Director of Callerio Foundation Onlus, since 2003, he is Head of the Department of Biomedical Sciences, and since 2006, he is the President of the Council of the Scientific Structures, University of Trieste. His scientific expertises are in the in vivo and in vitro pharmacology of compounds active on metastases of solid tumours, metal-based drugs for cancer chemotherapy. He is a Coordinator of the Working Group on “Intracellular and Extracellular Targets for Antitumour and Toxicicity of Ruthenium Complexes”, COST D20, 2001–2006; and a Coordinator of the Working Group on “New Targets for Metal-based Drugs: Behyond DNA”, COST D39, since 2007. He has 230 full-lenght papers (95%) in international peer-reviewed journals; over 300 presentations (posters and oral) at conferences, and a member in the Editorial Board of In Vivo, Pathology and Oncology Research, and Editor-in-chief of Metal-Based Drugs.
Biography Updated on 1 November 2007
Articles in Scholarly Journals [Incomplete List]
- Development of Ruthenium Antitumor Drugs that Overcome Multidrug Resistance Mechanisms
Journal of Medicinal Chemistry, vol. 50, no. 9, pp. 2166–2175, 2007 - Ruthenium complexes can target determinants of tumour malignancy
Dalton Transactions, no. 13, p. 1267, 2007 - Metal-based antitumour drugs in the post genomic era
Dalton Transactions, no. 16, p. 1929, 2006 - Organometallics, vol. 25, no. 3, pp. 756–765, 2006
- A novel retinoic/butyric hyaluronan ester for the treatment of acute promyelocytic leukemia: preliminary preclinical results
Leukemia, vol. 20, no. 5, Article ID 2404179, 7 pages, 2006 - Journal of Medicinal Chemistry, vol. 49, no. 18, pp. 5552–5561, 2006
- Journal of Medicinal Chemistry, vol. 48, no. 12, pp. 4161–4171, 2005
- Inhibition of B16 Melanoma Metastases with the Ruthenium Complex Imidazolium trans-Imidazoledimethylsulfoxide-tetrachlororuthenate and Down-Regulation of Tumor Cell Invasion
Journal of Pharmacology and Experimental Therapeutics, vol. 317, no. 1, pp. 284–291, 2005 - Intratumoral NAMI-A Treatment Triggers Metastasis Reduction, Which Correlates to CD44 Regulation and Tumor Infiltrating Lymphocyte Recruitment
Journal of Pharmacology and Experimental Therapeutics, vol. 310, no. 2, pp. 737–744, 2004 - Free Exchange across Cells, and Echistatin-Sensitive Membrane Target for the Metastasis Inhibitor NAMI-A (Imidazolium trans-Imidazole Dimethyl Sulfoxide Tetrachlororuthenate) on KB Tumor Cells
Journal of Pharmacology and Experimental Therapeutics, vol. 313, no. 1, pp. 227–233, 2004 - Inhibition of Hepatocellular Carcinomas in vitro and Hepatic Metastases in vivo in Mice by the Histone Deacetylase Inhibitor HA-But
Clinical Cancer Research, vol. 10, no. 14, pp. 4822–4830, 2004 - Stability and compatibility of the investigational antimetastatic ruthenium complex NAMI-A in infusion systems and its hemolytic potential
Journal of Oncology Pharmacy Practice, vol. 10, no. 1, pp. 7–15, 2004 - Ruthenium Antimetastatic Agents
Current Topics in Medicinal Chemistry, vol. 4, no. 15, pp. 1525–1535, 2004 - Journal of Medicinal Chemistry, vol. 47, no. 5, pp. 1110–1121, 2004
- Hyaluronic-acid butyric esters as promising antineoplastic agents in human lung carcinoma: A preclinical study
Investigational New Drugs, vol. 22, no. 3, pp. 207–217, 2004 - Actin-dependent tumour cell adhesion after short-term exposure to the antimetastasis ruthenium complex NAMI-A
European Journal of Cancer, vol. 40, no. 9, pp. 1383–1396, 2004 - Synthesis, characterization and biological activity of copper complexes with pyridoxal thiosemicarbazone derivatives. X-ray crystal structure of three dimeric complexes
Journal of Inorganic Biochemistry, vol. 98, no. 2, pp. 301–312, 2004 - Solution, solid state and biological characterization of ruthenium(III)-DMSO complexes with purine base derivatives
Journal of Inorganic Biochemistry, vol. 98, no. 2, pp. 393–401, 2004 - The hydrolysis of the anti-cancer ruthenium complex NAMI-A affects its DNA binding and antimetastatic activity: an NMR evaluation
Journal of Inorganic Biochemistry, vol. 98, no. 2, pp. 402–412, 2004 - Electrochemical measurements confirm the preferential bonding of the antimetastatic complex 6ImH96RuCl4(DMSO)(Im)9 (NAMI-A) with proteins and the weak interaction with nucleobases*1
Journal of Inorganic Biochemistry, vol. 98, no. 6, pp. 984–990, 2004 - TGF?1 regulation and collagen-release-independent connective tissue re-modelling by the ruthenium complex NAMI-A in solid tumours
Journal of Inorganic Biochemistry, vol. 98, no. 10, pp. 1648–1654, 2004 - Antiviral properties and cytotoxic activity of platinum(II) complexes with 1,10-phenanthrolines and acyclovir or penciclovir
Journal of Inorganic Biochemistry, vol. 98, no. 8, pp. 1385–1390, 2004 - Cocultures of metastatic and host immune cells: selective effects of NAMI-A for tumor cells
Cancer Immunology, Immunotherapy, vol. 53, no. 12, pp. 1101–1110, 2004 - Structure-dependent in vitro cytotoxicity of the isomeric complexes [Ru(L) 2 Cl 2 ] (L= o- tolylazopyridine and 4-methyl-2-phenylazopyridine) in comparison to [Ru(azpy) 2 Cl 2 ]
Journal of Biological Inorganic Chemistry, vol. 9, no. 3, pp. 354–364, 2004 - Investigational New Drugs, vol. 21, no. 1, pp. 55–62, 2003
- Investigational New Drugs, vol. 21, no. 4, pp. 401–411, 2003
- Molecular structure, solution chemistry and biological properties of the novel [ImH][trans-IrCl4(Im)(DMSO)], (I) and of the orange form of [(DMSO)2H][trans-IrCl4(DMSO)2], (II), complexes
Journal of Inorganic Biochemistry, vol. 95, no. 1, pp. 37–46, 2003 - Development of a LC method for pharmaceutical quality control of the antimetastatic ruthenium complex NAMI-A
Journal of Pharmaceutical and Biomedical Analysis, vol. 31, no. 2, pp. 215–228, 2003 - Antiangiogenic properties of selected ruthenium(III) complexes that are nitric oxide scavengers
British Journal of Cancer, vol. 88, no. 9, Article ID 6600906, 7 pages, 2003 - Distinct Effects of Dinuclear Ruthenium(III) Complexes on Cell Proliferation and on Cell Cycle Regulation in Human and Murine Tumor Cell Lines
Journal of Pharmacology and Experimental Therapeutics, vol. 305, no. 2, pp. 725–732, 2003 - Analysis of the cytotoxicity of synthetic antimicrobial peptides on mouse leucocytes: implications for systemic use
Journal of Antimicrobial Chemotherapy, vol. 50, no. 3, pp. 339–348, 2002 - Inhibition of the MEK/ERK signaling pathway by the novel antimetastatic agent NAMI-A down regulates c-myc gene expression and endothelial cell proliferation
European Journal of Biochemistry, vol. 269, no. 23, pp. 5861–5870, 2002 - Inhibition of endothelial cell functions and of angiogenesis by the metastasis inhibitor NAMI-A
British Journal of Cancer, vol. 86, no. 6, Article ID 6600176, 5 pages, 2002 - Synthesis, catalytic properties and biological activity of new water soluble ruthenium cyclopentadienyl PTA complexes [(C5R5)RuCl(PTA)2] (R = H, Me; PTA = 1,3,5-triaza-7-phosphaadamantane)Electronic supplementary information (ESI) available: synthesis, 31P{1H}, 1H, 13C NMR characterisation and elemental analysis of 1 and 2. See http://www.rsc.org/suppdata/cc/b2/b210102e/
Chemical Communications, no. 2, pp. 264–265, 2002 - The anti-metastatic agent imidazolium trans-imidazoledimethylsulfoxide-tetrachlororuthenate induces endothelial cell apoptosis by inhibiting the mitogen-activated protein kinase/extracellular signal-regulated kinase signaling pathway
Archives of Biochemistry and Biophysics, vol. 403, no. 2, pp. 209–218, 2002 - Tumour cell uptake of the metastasis inhibitor ruthenium complex NAMI-A and its in vitro effects on KB cells
Cancer Chemotherapy and Pharmacology, vol. 50, no. 5, pp. 405–411, 2002 - Validated method for the determination of the novel organo-ruthenium anticancer drug NAMI-A in human biological fluids by Zeeman atomic absorption spectrometry
Fresenius' Journal of Analytical Chemistry, vol. 369, no. 5, pp. 442–445, 2001 - Pharmacological Effects of the Ruthenium Complex NAMI-A Given Orally to CBA Mice With MCa Mammary Carcinoma
Metal-Based Drugs, vol. 8, no. 1, pp. 1–7, 2001 - Anti-Cancer Drugs, vol. 11, no. 8, pp. 665–672, 2000
- Antimetastatic properties and DNA interactions of the novel class of dimeric Ru(III) compounds Na2[?trans-RuCl4(Me2SO)?2(µ-L)] (L=ditopic, non-chelating aromatic N-ligand). A preliminary investigation
Journal of Inorganic Biochemistry, vol. 79, no. 1-4, pp. 173–177, 2000 - Paracrine Effects of IL-4 Transfection on TS/A Adenocarcinoma Cells Mediate Reduced In Vivo Growth
Pathology and Oncology Research, vol. 5, no. 2, pp. 110–116, 1999 - Modification of cell cycle and viability of TLX5 lymphoma in vitro by sulfoxide-ruthenium compounds and cisplatin detected by flow cytometry
Chemico-Biological Interactions, vol. 113, no. 1, pp. 51–64, 1998 - Rhodium(III) analogues of antitumour-active ruthenium(III) compounds: The crystal structure of [ImH][-RhCl(Im)] (Im=imidazole)
Inorganica Chimica Acta, vol. 273, no. 1-2, pp. 62–71, 1998 - Clinical and Experimental Metastasis, vol. 16, no. 4, pp. 371–379, 1997
- Down-regulation of tumour gelatinase/inhibitor balance and preservation of tumour endothelium by an anti-metastatic ruthenium complex
International Journal of Cancer, vol. 68, no. 1, pp. 60–66, 1996 - Treatment of residual metastases with Na[trans-RuCl4(DMSO)lm] and ruthenium uptake by tumor cells
Anti-Cancer Drugs, vol. 7, no. 6, pp. 697–702, 1996 - Reduction of Lung Metastases by Na[trans-RuCl4(DMSO)Im] is not
Coupled With the Induction of Chemical Xenogenization
Metal-Based Drugs, vol. 3, no. 2, pp. 67–73, 1996 - Effects of ruthenium complexes on experimental tumors: irrelevance of cytotoxicity for metastasis inhibition
Chemico-Biological Interactions, vol. 95, no. 1-2, pp. 109–126, 1995 - Antimetastatic action and toxicity on healthy tissues of Na[trans-RuCl4(DMSO)Im] in the mouse
Clinical & Experimental Metastasis, vol. 12, no. 2, pp. 93–100, 1994 - Anti-leukaemic action of RuCl2(DMSO)4 isomers and prevention of brain involvement on P388 leukaemia and on P388/DDP subline
European Journal of Cancer, vol. 29, no. 13, pp. 1873–1879, 1993 - Antineoplastic action ofp-(3-methyl-1-triazeno)benzoic acid potassium salt, a monomethyl derivative of the antimetastatic compound DM-COOK
Cancer Chemotherapy and Pharmacology, vol. 27, no. 6, pp. 423–428, 1991 - Antineoplastic effects of mer-trichlorobisdimethylsulphoxideaminorutheniumIII against murine tumors: Comparison with cisplatin and with ImH[RuIm2Cl4]
Chemico-Biological Interactions, vol. 78, no. 2, pp. 223–234, 1991 - Effects of gamma interferon on mice bearing P388 or friend leukemias as sensitive or doxorubicin-resistant variants
European Journal of Pharmacology, vol. 183, no. 2, pp. 195–196, 1990 - The effects of tocainide and its chiral analogs on sodium channels of human muscle
Pharmacological Research, vol. 22, pp. 95–96, 1990 - trans-Ru(II)dimethylsulphoxides: antineoplastic action on mouse tumours
Pharmacological Research, vol. 21, no. 4, pp. 453–454, 1989 - Tumour metastatic potential after treatment with selective antimetastatic drugs
Pharmacological Research, vol. 21, no. 4, pp. 457–459, 1989 - Antitumour properties of dimethylsulphoxide ruthenium(II) complexes in the Lewis lung carcinoma system
Pharmacological Research, vol. 21, no. 5, pp. 617–628, 1989 - Reduction of B16 melanoma metastases by oral administration of egg-white lysozyme
Cancer Chemotherapy and Pharmacology, vol. 25, no. 3, pp. 221–222, 1989 - Antimetastatic action of the prostacyclin analog Iloprost in the mouse
Clinical & Experimental Metastasis, vol. 7, no. 6, pp. 671–678, 1989 - Effects of two pyridinalalkyliminerhodium(I) complexes in mice bearing MCa mammary carcinoma
Cancer Chemotherapy and Pharmacology, vol. 24, no. 5, pp. 302–306, 1989 - Antimetastatic action of orally administered lysozyme in mice bearing Lewis lung carcinoma
Clinical & Experimental Metastasis, vol. 6, no. 3, pp. 245–253, 1988 - Evidence for host-mediated antitumor effects of lysozyme in mice bearing the MCa mammary carcinoma
European Journal of Cancer and Clinical Oncology, vol. 24, no. 11, pp. 1737–1743, 1988 - Inorganic Chemistry, vol. 27, no. 23, pp. 4099–4106, 1988
- Effects of lysozyme on spleen and lungs in mice with lewis lung carcinoma
Pharmacological Research Communications, vol. 20, no. 7, pp. 615–616, 1988 - Effects of antimetastatic, antiinvasive and cytotoxic agents on the growth and spread of transplantable leukemias in mice
Clinical & Experimental Metastasis, vol. 5, no. 1, pp. 27–34, 1987 - Mutagenic activity of the dacarbazine analog p-(3,3-dimethyl-l-triazeno)benzoic acid potassium salt in bacterial cells
Pharmacological Research Communications, vol. 18, no. 5, pp. 491–501, 1986 - Antiinflammatory action of hydrosoluble dimethyl-triazenes on the carrageenin-induced edema in guinea pigs
Chemico-Biological Interactions, vol. 53, pp. 37–43, 1985 - Hemostasis and mechanism of action of selective antimetastatic drugs in mice bearing Lewis lung carcinoma
European Journal of Cancer and Clinical Oncology, vol. 20, no. 7, pp. 961–966, 1984 - Effects of p-(3,3-dimethyl-1-triazeno)benzoic acid potassium salt on leukemic infiltration of brain and liver in mice bearing P388 leukemia*1
European Journal of Cancer and Clinical Oncology, vol. 20, no. 2, pp. 287–289, 1984 - Antineoplastic activity and toxicity of an organometallic complex of ruthenium(II) in comparison with cis-PDD in mice bearing solid malignant neoplasms
European Journal of Cancer and Clinical Oncology, vol. 20, no. 6, pp. 841–847, 1984 - Effects of DTIC, DM-COOK and ICRF-159 on the number of circulating Lewis lung carcinoma cells detected by flow cytometry
Clinical & Experimental Metastasis, vol. 2, no. 2, pp. 151–159, 1984 - Antitumor and antimetastatic activity of the immunoadjuvant peptidoglycan monomer PGM in mice bearing MCa mammary carcinoma
Cancer Immunology Immunotherapy, vol. 18, no. 1, pp. 49–53, 1984 - Immunotherapy of lewis lung carcinoma with hydrosoluble peptidoglycan monomer (PGM)
Cancer Immunology Immunotherapy, vol. 15, no. 2, pp. 84–86, 1983 - Effects of isomeric aryldimethyltriazenes on lewis lung carcinoma growth and metastases in mice
Chemico-Biological Interactions, vol. 46, no. 1, pp. 131–136, 1983 - Antitumor effects of rhodium(I), iridium(I) and ruthenium(II) complexes in comparison with cis-dichlorodiammino platinum(II) in mice bearing Lewis lung carcinoma
Chemico-Biological Interactions, vol. 45, no. 1, pp. 1–6, 1983 - Mechanism of the antileukemic effects of 1-p-carboxamidophenyl3,3-dimethyltriazene and its in vitro metabolites
Biochemical Pharmacology, vol. 31, no. 22, pp. 3629–3634, 1982 - Antimetastatic effects and tumor proteinase inhibition by spleen intracellular inhibitors of neutral proteinases
European Journal of Cancer and Clinical Oncology, vol. 17, no. 12, pp. 1301–1306, 1981 - Mechanism of the antimetastatic action of N-diazoacetylglycinamide in mice bearing lewis lung carcinoma
European Journal of Cancer (1965), vol. 16, no. 1, pp. 87–92, 1980 - Neutral proteinase inhibitors and antimetastatic effects in mice
European Journal of Cancer (1965), vol. 16, no. 4, pp. 449–454, 1980 - Antitumor and antimetastatic effects of benzenoid triazenes in mice bearing lewis lung carcinoma1
Pharmacological Research Communications, vol. 12, no. 1, pp. 1–11, 1980 - Antitumour action of rhodium (I) and iridium (I) complexes
Chemico-Biological Interactions, vol. 22, no. 2-3, pp. 231–238, 1978 - Lysosomal enzyme inhibitors and antimetastatic activity in the mouse
European Journal of Cancer (1965), vol. 13, no. 11, pp. 1321–1323, 1977 - Observations on the ?in vitro? oxidative N-demethylation of 4-(3,3-dimetryl-1-triazeno)-imidazole-5-carboxamide (DIC, NSC 45388)
Pharmacological Research Communications, vol. 8, no. 1, pp. 25–29, 1976 - Effects of N-diazoacetyl-glycine amide on the pool of 5-phosphoribosyl 1-pyrophosphate in Ehrlich ascites tumour cells
Biochemical Pharmacology, vol. 25, no. 6, p. 725, 1976 - Investigation on the oxidative N-demethylation of aryl triazenes In vitro
Biochemical Pharmacology, vol. 24, no. 19, pp. 1793–1797, 1975