Francisco Garcia-Sierra

Francisco GarcÍa-Sierra received the Ph.D. degree in cell biology and neuroscience from the Center for Research and Advanced Studies of the National polytechnic Institute, Mexico City, Mexico, in 1999. GarcÍa-Sierra serves as the Head and the Main Researcher at the Laboratory of neurodegeneration at the Department of Cell Biology , Center for Research and Advanced Studies of the National polytechnic Institute, Mexico City, Mexico from 2002 to date. GarcÍa-Sierra’s areas of expertise include molecular mechanisms involved in neurodegeneration in Alzheimer´s disease, morphological and neuropathological analysis of human brain tissue, immunohistochemistry, immunofluorescence, confocal, and electron microscopy of human brain tissue, Isolation and biochemical characterization of abnormally aggregated tau and amyloid proteins from the brain of Alzheimer´s disease patients, in vitro assays to characterize the mechanisms involved in the abnormal proteolysis of tau protein, and in vitro paradigms of tau polymerization: mechanisms and regulation, cell culture, and evaluation of the pathological effects produced by the overexpression of modified-tau protein in neurons.

Biography Updated on 17 April 2012

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