Takehiko Uchiyama
Nevada Cancer Institute, Japan

Articles in Scholarly Journals [Incomplete List]

  1. Molecular and supra-molecular structure related differences in toxicity and granulomatogenic activity of mycobacterial cord factor in mice
    Microbial Pathogenesis, vol. 43, no. 1, pp. 10–21, 2007
  2. Crystal Structure of Streptococcus dysgalactiae-Derived Mitogen Reveals a Zinc-Binding Site and Alterations in TcR Binding
    Journal of Molecular Biology, vol. 373, no. 5, pp. 1089–1097, 2007
  3. Long-term exposure to superantigen induces p27Kip1 and Bcl-2 expression in effector memory CD4+ T cells
    Cellular Immunology, vol. 248, no. 2, pp. 77–85, 2007
  4. Cloning, Expression, and Characterization of the Superantigen Streptococcal Pyrogenic Exotoxin G from Streptococcus dysgalactiae
    Infection and Immunity, vol. 75, no. 4, pp. 1721–1729, 2007
  5. Synthesis of Pyrophosphate-Containing Compounds that Stimulate VγVδ2 T Cells: Application to Cancer Immunotherapy
    Medicinal Chemistry, vol. 3, no. 1, pp. 85–99, 2007
  6. A SEVERE CASE OF NEONATAL TOXIC SHOCK SYNDROME-LIKE EXANTHEMATOUS DISEASE WITH SUPERANTIGEN-INDUCED HIGH T CELL RESPONSE
    The Pediatric Infectious Disease Journal, vol. 25, no. 10, pp. 950–952, 2006
  7. Safety profile and anti-tumor effects of adoptive immunotherapy using gamma-delta T cells against advanced renal cell carcinoma: a pilot study
    Cancer Immunology, Immunotherapy, vol. 56, no. 4, pp. 469–476, 2006
  8. Genetic background influences Th cell differentiation by controlling the capacity for IL-2-induced IL-4 production by naive CD4+ T cells
    International Immunology, vol. 18, no. 12, pp. 1681–1690, 2006
  9. Use of DNA Arrays to Identify a Mutation in the Negative Regulator, csrR, Responsible for the High Virulence of a Naturally Occurring Type M3 Group A Streptococcus Clinical Isolate
    The Journal of Infectious Diseases, vol. 193, no. 12, pp. 1677–1684, 2006
  10. Expression, purification and crystallization of Streptococcus dysgalactiae-derived mitogen
    Acta Crystallographica Section F Structural Biology and Crystallization Communications, vol. 62, no. 3, pp. 242–244, 2006
  11. Lipoteichoic acid may affect the pathogenesis of bile duct damage in primary biliary cirrhosis
    Autoimmunity, vol. 39, no. 2, pp. 129–135, 2006
  12. CD28 is required for induction and maintenance of immunological memory in toxin-reactive CD4+ T cells in vivo?
    Cellular Immunology, vol. 238, no. 2, pp. 103–112, 2005
  13. Inhibitory effect of antimicrobial agents and anisodamine on the staphylococcal superantigenic toxin-induced overproduction of proinflammatory cytokines by human peripheral blood mononuclear cells
    Journal of Infection and Chemotherapy, vol. 11, no. 4, pp. 192–195, 2005
  14. Cytocidal Effect of Streptococcus pyogenes on Mouse Neutrophils In Vivo and the Critical Role of Streptolysin S
    The Journal of Infectious Diseases, vol. 192, no. 1, pp. 107–116, 2005
  15. Specific Inhibitory Action of Anisodamine against a Staphylococcal Superantigenic Toxin, Toxic Shock Syndrome Toxin 1 (TSST-1), Leading to Down-Regulation of Cytokine Production and Blocking of TSST-1 Toxicity in Mice
    Clinical and Diagnostic Laboratory Immunology, vol. 12, no. 3, pp. 399–408, 2005
  16. Detection of heat shock proteins but not superantigen by isolated oral bacteria from patients with Behcet's disease
    Oral Microbiology and Immunology, vol. 20, no. 3, pp. 167–171, 2005
  17. Characterization of Novel Staphylococcal Enterotoxin-Like Toxin Type P
    Infection and Immunity, vol. 73, no. 9, pp. 5540–5546, 2005
  18. Biological Properties of Staphylococcal Enterotoxin-Like Toxin Type R
    Infection and Immunity, vol. 72, no. 6, pp. 3664–3667, 2004
  19. Immunologic immaturity, but high IL-4 productivity, of murine neonatal thymic CD4 single-positive T cells in the last stage of maturation
    International Immunology, vol. 16, no. 2, pp. 315–326, 2004
  20. Contrasting contributions of complementarity-determining region 2 and hypervariable region 4 of rat BV8S2+ (V 8.2) TCR to the recognition of myelin basic protein and different types of bacterial superantigens
    International Immunology, vol. 16, no. 5, pp. 655–663, 2004
  21. Akt Is a Neutral Amplifier for Th Cell Differentiation
    Journal of Biological Chemistry, vol. 279, no. 12, pp. 11408–11416, 2004
  22. Streptococcus dysgalactiae-derived mitogen (SDM), a novel bacterial superantigen: characterization of its biological activity and predicted tertiary structure
    Molecular Microbiology, vol. 47, no. 6, pp. 1589–1599, 2003
  23. Preparation of a superantigen-adsorbing device and its superantigen removal efficacies in vitro and in vivo
    International Journal of Infectious Diseases, vol. 7, no. 1, pp. 21–28, 2003
  24. Quantitative and Qualitative Comparison of Virulence Traits, Including Murine Lethality, among Different M Types of Group A Streptococci
    The Journal of Infectious Diseases, vol. 187, no. 12, pp. 1876–1887, 2003
  25. Maturation of adult peripheral blood CD38+CD4+ T cells demonstrated by cytokine production in response to a superantigen, TSST-1
    Cellular Immunology, vol. 222, no. 2, pp. 89–96, 2003
  26. Molecular Epidemiology of Methicillin-Resistant Staphylococcus aureus Strains Causing Neonatal Toxic Shock Syndrome-Like Exanthematous Disease in Neonatal and Perinatal Wards
    Journal of Clinical Microbiology, vol. 41, no. 7, pp. 3001–3006, 2003
  27. Evaluation of a new serotyping kit for Streptococcus pneumoniae
    Journal of Medical Microbiology, vol. 52, no. 11, pp. 975–980, 2003
  28. A co-stimulatory molecule on activated T cells, H4/ICOS, delivers specific signals in Th cells and regulates their responses
    International Immunology, vol. 14, no. 6, pp. 555–566, 2002
  29. Gamma /delta T cells provide innate immunity against renal cell carcinoma
    Cancer Immunology, Immunotherapy, vol. 50, no. 3, pp. 115–124, 2001
  30. Functional Uncoupling of T-cell Receptor Engagement and Lck Activation in Anergic Human Thymic CD4+ T Cells
    Journal of Biological Chemistry, vol. 276, no. 20, pp. 17455–17460, 2001
  31. Recurrent Septicemia Caused by Streptococcus canis after a Dog Bite
    Scandinavian Journal of Infectious Diseases, vol. 33, no. 12, pp. 927–928, 2001
  32. Comparison of pathogenic factors expressed by group A Streptococci isolated from patients with streptococcal toxic shock syndrome and scarlet fever
    Microbial Pathogenesis, vol. 27, no. 4, pp. 243–252, 1999
  33. Exanthematous disease induced by toxic shock syndrome toxin 1 in the early neonatal period
    The Lancet, vol. 351, no. 9116, pp. 1614–1619, 1998
  34. Influence of Retinoic Acid on the Differentiation Pathway of T Cells in the Thymus
    Cellular Immunology, vol. 181, no. 2, pp. 153–162, 1997
  35. In vitro combined effects of fosfomycin and ß-lactam antibiotics against penicillin-resistantStreptococcus pneumoniae
    Journal of Infection and Chemotherapy, vol. 3, no. 1, pp. 49–54, 1997
  36. Tumor necrosis factor production by human T-cells stimulated with bacterial superantigens
    International Journal of Immunopharmacology, vol. 17, no. 10, pp. 841–848, 1995
  37. Inhibin .ALPHA., .BETA.A Subunit and Activin Type II Receptor mRNAs Are Expressed in Human Brain Tumors.
    Endocrine Journal, vol. 42, no. 3, pp. 307–313, 1995
  38. Expression of Inhibin .ALPHA., and .BETA.A Subunit and Activin Type II Receptor mRNAs in Various Human Pituitary Adenomas.
    Endocrine Journal, vol. 42, no. 1, pp. 95–100, 1995
  39. Toxicological and immunological evaluation of the immunosuppressant 15-deoxyspergualin in BALB/c mice: an in vivo and in vitro study
    Immunopharmacology, vol. 21, no. 2, pp. 99–107, 1991
  40. Activation of murine T cells by staphylococcal enterotoxin E: Requirement of MHC class II molecules expressed on accessory cells and identification of V? sequence of T cell receptors in T cells reactive to the toxin
    Cellular Immunology, vol. 133, no. 2, pp. 446–455, 1991
  41. Activation of human t cells by toxic shock syndrome toxin-1: the toxin-binding structures expressed on human lymphoid cells acting as accessory cells are hla class ii molecules
    European Journal of Immunology, vol. 19, no. 10, pp. 1803–1809, 1989
  42. Lupus nephropathy in New Zealand F1 hybrid mice treated by (-)15-deoxyspergualin
    Kidney International, vol. 34, no. 4, Article ID ki1988204, 6 pages, 1988
  43. A low level of macrophages enhances anti-TNP plaque-forming cell generation by human lymphocytes against TNP-Brucella abortus, a T-independent antigen
    Cellular Immunology, vol. 98, no. 2, pp. 552–559, 1986
  44. Effect of mizoribine on lupus nephropathy of New Zealand black/white F1 hybrid mice
    Clinical Immunology and Immunopathology, vol. 33, no. 1, pp. 31–38, 1984