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and Proposals
Takehiko Uchiyama
Nevada Cancer Institute, Japan
Articles in Scholarly Journals [Incomplete List]
Molecular and supra-molecular structure related differences in toxicity and granulomatogenic activity of mycobacterial cord factor in mice
Microbial Pathogenesis, vol. 43, no. 1, pp. 10–21, 2007
Crystal Structure of Streptococcus dysgalactiae-Derived Mitogen Reveals a Zinc-Binding Site and Alterations in TcR Binding
Journal of Molecular Biology, vol. 373, no. 5, pp. 1089–1097, 2007
Long-term exposure to superantigen induces p27Kip1 and Bcl-2 expression in effector memory CD4+ T cells
Cellular Immunology, vol. 248, no. 2, pp. 77–85, 2007
Cloning, Expression, and Characterization of the Superantigen Streptococcal Pyrogenic Exotoxin G from Streptococcus dysgalactiae
Infection and Immunity, vol. 75, no. 4, pp. 1721–1729, 2007
Synthesis of Pyrophosphate-Containing Compounds that Stimulate VγVδ2 T Cells: Application to Cancer Immunotherapy
Medicinal Chemistry, vol. 3, no. 1, pp. 85–99, 2007
A SEVERE CASE OF NEONATAL TOXIC SHOCK SYNDROME-LIKE EXANTHEMATOUS DISEASE WITH SUPERANTIGEN-INDUCED HIGH T CELL RESPONSE
The Pediatric Infectious Disease Journal, vol. 25, no. 10, pp. 950–952, 2006
Safety profile and anti-tumor effects of adoptive immunotherapy using gamma-delta T cells against advanced renal cell carcinoma: a pilot study
Cancer Immunology, Immunotherapy, vol. 56, no. 4, pp. 469–476, 2006
Genetic background influences Th cell differentiation by controlling the capacity for IL-2-induced IL-4 production by naive CD4+ T cells
International Immunology, vol. 18, no. 12, pp. 1681–1690, 2006
Use of DNA Arrays to Identify a Mutation in the Negative Regulator, csrR, Responsible for the High Virulence of a Naturally Occurring Type M3 Group A Streptococcus Clinical Isolate
The Journal of Infectious Diseases, vol. 193, no. 12, pp. 1677–1684, 2006
Expression, purification and crystallization of Streptococcus dysgalactiae-derived mitogen
Acta Crystallographica Section F Structural Biology and Crystallization Communications, vol. 62, no. 3, pp. 242–244, 2006
Lipoteichoic acid may affect the pathogenesis of bile duct damage in primary biliary cirrhosis
Autoimmunity, vol. 39, no. 2, pp. 129–135, 2006
CD28 is required for induction and maintenance of immunological memory in toxin-reactive CD4+ T cells in vivo?
Cellular Immunology, vol. 238, no. 2, pp. 103–112, 2005
Inhibitory effect of antimicrobial agents and anisodamine on the staphylococcal superantigenic toxin-induced overproduction of proinflammatory cytokines by human peripheral blood mononuclear cells
Journal of Infection and Chemotherapy, vol. 11, no. 4, pp. 192–195, 2005
Cytocidal Effect of Streptococcus pyogenes on Mouse Neutrophils In Vivo and the Critical Role of Streptolysin S
The Journal of Infectious Diseases, vol. 192, no. 1, pp. 107–116, 2005
Specific Inhibitory Action of Anisodamine against a Staphylococcal Superantigenic Toxin, Toxic Shock Syndrome Toxin 1 (TSST-1), Leading to Down-Regulation of Cytokine Production and Blocking of TSST-1 Toxicity in Mice
Clinical and Diagnostic Laboratory Immunology, vol. 12, no. 3, pp. 399–408, 2005
Detection of heat shock proteins but not superantigen by isolated oral bacteria from patients with Behcet's disease
Oral Microbiology and Immunology, vol. 20, no. 3, pp. 167–171, 2005
Characterization of Novel Staphylococcal Enterotoxin-Like Toxin Type P
Infection and Immunity, vol. 73, no. 9, pp. 5540–5546, 2005
Biological Properties of Staphylococcal Enterotoxin-Like Toxin Type R
Infection and Immunity, vol. 72, no. 6, pp. 3664–3667, 2004
Immunologic immaturity, but high IL-4 productivity, of murine neonatal thymic CD4 single-positive T cells in the last stage of maturation
International Immunology, vol. 16, no. 2, pp. 315–326, 2004
Contrasting contributions of complementarity-determining region 2 and hypervariable region 4 of rat BV8S2+ (V 8.2) TCR to the recognition of myelin basic protein and different types of bacterial superantigens
International Immunology, vol. 16, no. 5, pp. 655–663, 2004
Akt Is a Neutral Amplifier for Th Cell Differentiation
Journal of Biological Chemistry, vol. 279, no. 12, pp. 11408–11416, 2004
Streptococcus dysgalactiae-derived mitogen (SDM), a novel bacterial superantigen: characterization of its biological activity and predicted tertiary structure
Molecular Microbiology, vol. 47, no. 6, pp. 1589–1599, 2003
Preparation of a superantigen-adsorbing device and its superantigen removal efficacies in vitro and in vivo
International Journal of Infectious Diseases, vol. 7, no. 1, pp. 21–28, 2003
Quantitative and Qualitative Comparison of Virulence Traits, Including Murine Lethality, among Different M Types of Group A Streptococci
The Journal of Infectious Diseases, vol. 187, no. 12, pp. 1876–1887, 2003
Maturation of adult peripheral blood CD38+CD4+ T cells demonstrated by cytokine production in response to a superantigen, TSST-1
Cellular Immunology, vol. 222, no. 2, pp. 89–96, 2003
Molecular Epidemiology of Methicillin-Resistant Staphylococcus aureus Strains Causing Neonatal Toxic Shock Syndrome-Like Exanthematous Disease in Neonatal and Perinatal Wards
Journal of Clinical Microbiology, vol. 41, no. 7, pp. 3001–3006, 2003
Evaluation of a new serotyping kit for Streptococcus pneumoniae
Journal of Medical Microbiology, vol. 52, no. 11, pp. 975–980, 2003
A co-stimulatory molecule on activated T cells, H4/ICOS, delivers specific signals in Th cells and regulates their responses
International Immunology, vol. 14, no. 6, pp. 555–566, 2002
Gamma /delta T cells provide innate immunity against renal cell carcinoma
Cancer Immunology, Immunotherapy, vol. 50, no. 3, pp. 115–124, 2001
Functional Uncoupling of T-cell Receptor Engagement and Lck Activation in Anergic Human Thymic CD4+ T Cells
Journal of Biological Chemistry, vol. 276, no. 20, pp. 17455–17460, 2001
Recurrent Septicemia Caused by Streptococcus canis after a Dog Bite
Scandinavian Journal of Infectious Diseases, vol. 33, no. 12, pp. 927–928, 2001
Comparison of pathogenic factors expressed by group A Streptococci isolated from patients with streptococcal toxic shock syndrome and scarlet fever
Microbial Pathogenesis, vol. 27, no. 4, pp. 243–252, 1999
Exanthematous disease induced by toxic shock syndrome toxin 1 in the early neonatal period
The Lancet, vol. 351, no. 9116, pp. 1614–1619, 1998
Influence of Retinoic Acid on the Differentiation Pathway of T Cells in the Thymus
Cellular Immunology, vol. 181, no. 2, pp. 153–162, 1997
In vitro combined effects of fosfomycin and ß-lactam antibiotics against penicillin-resistantStreptococcus pneumoniae
Journal of Infection and Chemotherapy, vol. 3, no. 1, pp. 49–54, 1997
Tumor necrosis factor production by human T-cells stimulated with bacterial superantigens
International Journal of Immunopharmacology, vol. 17, no. 10, pp. 841–848, 1995
Inhibin .ALPHA., .BETA.A Subunit and Activin Type II Receptor mRNAs Are Expressed in Human Brain Tumors.
Endocrine Journal, vol. 42, no. 3, pp. 307–313, 1995
Expression of Inhibin .ALPHA., and .BETA.A Subunit and Activin Type II Receptor mRNAs in Various Human Pituitary Adenomas.
Endocrine Journal, vol. 42, no. 1, pp. 95–100, 1995
Toxicological and immunological evaluation of the immunosuppressant 15-deoxyspergualin in BALB/c mice: an in vivo and in vitro study
Immunopharmacology, vol. 21, no. 2, pp. 99–107, 1991
Activation of murine T cells by staphylococcal enterotoxin E: Requirement of MHC class II molecules expressed on accessory cells and identification of V? sequence of T cell receptors in T cells reactive to the toxin
Cellular Immunology, vol. 133, no. 2, pp. 446–455, 1991
Activation of human t cells by toxic shock syndrome toxin-1: the toxin-binding structures expressed on human lymphoid cells acting as accessory cells are hla class ii molecules
European Journal of Immunology, vol. 19, no. 10, pp. 1803–1809, 1989
Lupus nephropathy in New Zealand F1 hybrid mice treated by (-)15-deoxyspergualin
Kidney International, vol. 34, no. 4, Article ID ki1988204, 6 pages, 1988
A low level of macrophages enhances anti-TNP plaque-forming cell generation by human lymphocytes against TNP-Brucella abortus, a T-independent antigen
Cellular Immunology, vol. 98, no. 2, pp. 552–559, 1986
Effect of mizoribine on lupus nephropathy of New Zealand black/white F1 hybrid mice
Clinical Immunology and Immunopathology, vol. 33, no. 1, pp. 31–38, 1984