Pierre-Olivier Vidalain serves as a Research Scientist at CNRS (Centre National de la Recherche Scientifique), and a Project Manager at the Viral Genomics and Vaccination Unit (G2V) at Institut Pasteur (Paris, France). He received his Ph.D. degree on measles virus (MV), studying cellular mechanisms responsible for the lymphopenia and immunosuppression induced by this important human pathogen (Ecole Normale Supérieure de Lyon, France, 2002). After a post-doc in proteomics at Harvard Medical School (2002–2005), he joined the G2V Laboratory headed by Dr. Frederic Tangy in 2005. Since then, he has developed a yeast two-hybrid platform dedicated to the high-throughput mapping of virus-host protein-protein interactions. This led to the identification and characterization of several interactions between viral virulence factors and host signaling components that allow different viruses (MV, chikungunya virus, human parainfluenza virus type 3, coronavirus 229E, etc.) to control of the innate antiviral response. Since 2008, he has developed several screening strategies to identify immunostimulating molecules that aim at restauring the innate antiviral response in infected host cells. In 2009, he was appointed a coordinator of a research program from Institut Carnot Pasteur-MI to further develop this approach and isolate broad-spectrum antiviral chemical compounds.
Biography Updated on 24 June 2012