Vladimir Larionov

Vladimir Larionov obtained his Ph.D. degree from the Institute of Experimental Medicine, the USSR Academy of Medical Sciences, Leningrad, in 1977, for work on extrachromosomal elements in yeast. After the postdoctoral fellowship at the Leningrad State University and Enhelhardt Institute of Molecular Biology, Moscow, he came to the Institute of Cytology, Russian Academy of Sciences as a staff scientist. He received his D.S. degree from the Institute of Cytology for work on genetic control of chromosome transmission in 1983. One year later, he became the chief of the Laboratory of Genetics in the same Institute. He moved to the Laboratory of Molecular Genetics in the National Institute of Environmental Health Sciences, NIH, as a visiting scientist in 1991. In 2000, he became the leader of Genome Structure and Function Section in the Laboratory of Biosystems and Cancer in the National Cancer Institute, NIH. His recent studies have focused on studying the organization and function of human centromere and on characterization of recent genomic changes in the human genome causing disorders.

Biography Updated on 20 March 2007

Articles in Scholarly Journals [Incomplete List]

  1. Mutational analysis ofSPANX genes in families with X-Linked prostate cancer
    The Prostate, vol. 67, no. 8, pp. 820–828, 2007
  2. A minimal CENP-A core is required for nucleation and maintenance of a functional human centromere
    The EMBO Journal, vol. 26, no. 5, Article ID 7601584, 12 pages, 2007
  3. TAR cloning: insights into gene function, long-range haplotypes and genome structure and evolution
    Nature Reviews Genetics, vol. 7, no. 10, Article ID nrg1943, 7 pages, 2006
  4. A novel expression system for genomic DNA loci using a human artificial chromosome vector with transformation-associated recombination cloning
    Journal of Human Genetics, vol. 50, no. 11, pp. 592–599, 2005
  5. Differential cis-regulation of human versus mouse TERT gene expression in vivo: Identification of a human-specific repressive element
    Proceedings of the National Academy of Sciences, vol. 102, no. 51, pp. 18437–18442, 2005
  6. The microcephaly ASPM gene is expressed in proliferating tissues and encodes for a mitotic spindle protein
    Human Molecular Genetics, vol. 14, no. 15, pp. 2155–2165, 2005
  7. Rapid generation of long synthetic tandem repeats and its application for analysis in human artificial chromosome formation
    Nucleic Acids Research, vol. 33, no. 15, pp. e130–e130, 2005
  8. Dynamic structure of the SPANX gene cluster mapped to the prostate cancer susceptibility locus HPCX at Xq27
    Genome Research, vol. 15, no. 11, pp. 1477–1486, 2005
  9. Evolution of the tumor suppressor BRCA1 locus in primates: implications for cancer predisposition
    Human Molecular Genetics, vol. 13, no. 22, pp. 2737–2751, 2004
  10. Accelerated Evolution of the ASPM Gene Controlling Brain Size Begins Prior to Human Brain Expansion
    PLoS Biology, vol. 2, no. 5, p. e126, 2004
  11. Closing the Gaps on Human Chromosome 19 Revealed Genes With a High Density of Repetitive Tandemly Arrayed Elements
    Genome Research, vol. 14, no. 2, pp. 239–246, 2004
  12. The SPANX gene family of cancer/testis-specific antigens: Rapid evolution and amplification in African great apes and hominids
    Proceedings of the National Academy of Sciences, vol. 101, no. 9, pp. 3077–3082, 2004
  13. The DNA sequence and biology of human chromosome 19
    Nature, vol. 428, no. 6982, Article ID nature02399, 6 pages, 2004
  14. Exploiting the yeast Saccharomyces cerevisiae for the study of the organization and evolution of complex genomes
    FEMS Microbiology Reviews, vol. 27, no. 5, pp. 629–649, 2003
  15. Segments missing from the draft human genome sequence can be isolated by transformation-associated recombination cloning in yeast
    EMBO Reports, vol. 4, no. 3, Article ID embor766, 5 pages, 2003
  16. A Novel Strategy for Analysis of Gene Homologues and Segmental Genome Duplications
    Journal of Molecular Evolution, vol. 56, no. 6, pp. 702–710, 2003
  17. Cloning of human centromeres by transformation-associated recombination in yeast and generation of functional human artificial chromosomes
    Nucleic Acids Research, vol. 31, no. 3, pp. 922–934, 2003
  18. BMC Genomics, vol. 4, no. 1, p. 16, 2003
  19. Large-Insert BAC/YAC Libraries for Selective Re-isolation of Genomic Regions by Homologous Recombination in Yeast
    Genomics, vol. 77, no. 1-2, pp. 27–34, 2001
  20. Isolation of a functional copy of the human BRCA1 gene by transformation-associated recombination in yeast
    Gene, vol. 250, no. 1-2, pp. 201–208, 2000
  21. Integrity of Human YACs during Propagation in Recombination-Deficient Yeast Strains
    Genomics, vol. 56, no. 3, pp. 262–273, 1999
  22. Direct Cloning of Human 10q25 Neocentromere DNA Using Transformation-Associated Recombination (TAR) in Yeast
    Genomics, vol. 47, no. 3, pp. 399–404, 1998
  23. Construction of Human Chromosome 16- and 5-Specific Circular YAC/BAC Libraries byin VivoRecombination in Yeast (TAR Cloning)
    Genomics, vol. 53, no. 1, pp. 21–28, 1998
  24. Rapid cloning of mouse DNA as yeast artificial chromosomes by transformation-associated recombination (TAR)
    Mammalian Genome, vol. 9, no. 2, pp. 157–159, 1998
  25. Functional copies of a human gene can be directly isolated by transformation-associated recombination cloning with a small 3' end target sequence
    Proceedings of the National Academy of Sciences, vol. 95, no. 8, pp. 4469–4474, 1998
  26. Direct isolation of human BRCA2 gene by transformation-associated recombination in yeast
    Proceedings of the National Academy of Sciences, vol. 94, no. 14, pp. 7384–7387, 1997
  27. Specific isolation of human rDNA genes by TAR cloning
    Gene, vol. 197, no. 1-2, pp. 269–276, 1997
  28. Specific cloning of human DNA as yeast artificial chromosomes by transformation-associated recombination
    Proceedings of the National Academy of Sciences, vol. 93, no. 1, pp. 491–496, 1996
  29. Highly selective isolation of human DNAs from rodent-human hybrid cells as circular yeast artificial chromosomes by transformation-associated recombination cloning
    Proceedings of the National Academy of Sciences, vol. 93, no. 24, pp. 13925–13930, 1996
  30. Transformation-associated recombination between diverged and homologous DNA repeats is induced by strand breaks
    Yeast, vol. 10, no. 1, pp. 93–104, 1994
  31. A Model System to Assess the Integrity of Mammalian YACs during Transformation and Propagation in Yeast
    Genomics, vol. 21, no. 1, pp. 7–17, 1994
  32. Identification and genetic mapping ofCHL genes controlling mitotic chromosome transmission in yeast
    Yeast, vol. 9, no. 1, pp. 11–19, 1993
  33. SMC1: an essential yeast gene encoding a putative head-rod-tail protein is required for nuclear division and defines a new ubiquitous protein family
    The Journal of Cell Biology, vol. 123, no. 6, pp. 1635–1648, 1993
  34. A direct selection procedure for isolating yeast mutants with an impaired segregation of artificial minichromosomes
    Current Genetics, vol. 15, no. 1, pp. 17–25, 1989
  35. Genetic control of chromosone stability in the yeastSaccharomyces cerevisiae
    Yeast, vol. 4, no. 4, pp. 257–269, 1988
  36. The stability of chromosomes in yeast
    Current Genetics, vol. 11, no. 6-7, pp. 435–443, 1987
  37. A mutant of Saccharomyces cerevisiae with impaired maintenance of centromeric plasmids
    Current Genetics, vol. 10, no. 1, pp. 15–20, 1985
  38. Stability of recombinant plasmids containing the ars sequence of yeast extrachromosomal rDNA in several strains of Saccharomyces cerevisiae
    Gene, vol. 28, no. 2, pp. 229–235, 1984
  39. Appendix Determination of probability of plasmid loss per generation
    Gene, vol. 28, no. 2, pp. 237–239, 1984
  40. The study of a rDNA replicator in Saccharomyces
    Current Genetics, vol. 7, no. 6, pp. 433–438, 1983
  41. 3 µm DNA — an extrachromosomal ribosomal DNA in the yeast Saccharomyces cerevisiae
    Gene, vol. 12, no. 1-2, pp. 41–49, 1980
  42. Determinant for multiple drug resistance possessing features of a mitochondrial episome in saccharomyces cerevisiae
    Molecular and Cellular Biochemistry, vol. 14, no. 1-3, pp. 19–24, 1977