Jac A. Nickoloff0000-0001-8606-7545
Jac A. Nickoloff holds a Ph.D. degree. He has held faculty positions at Harvard University School of Public Health, the University of New Mexico School of Medicine, and Colorado State University, and he led departments at the latter two institutions. He also led the Cancer Biology Program within the University of New Mexico Cancer Center. He has been continuously funded by the NIH since 1990 for research focused on DNA repair mechanisms, DNA damage signaling pathways, and how these systems help maintain genome stability. Specific interests include DNA double-strand break repair by homologous recombination and nonhomologous end-joining; the genetic consequences of DNA damage caused by ionizing radiation, UV light, and cancer chemotherapeutics; chromatin regulation of DNA repair; regulation of topoisomerase-mediated chromosome decatenation; normal and cancer cell responses to replication stress; and regulation of programmed cell death and antiproliferative pathways including apoptosis, necrosis, autophagy, senescence, and mitotic catastrophe. These studies are aimed at defining differences between normal and tumor cells, to enhance cancer therapy efficacy and minimize risks of treatment-induced secondary cancers.
Biography Updated on 30 May 2012