Celina Janion

Celina Janion was born in Warsaw, Poland. She received her M.S. degree in biochemistry from the Mathematical-Biology Department, Lódz University; and her Ph.D. degree (under the supervision of professor David Shugar) and the Habilitation from the Institute of Biochemistry and Biophysics of the Polish Academy of Sciences, in 1969. She was nominated as an Extraordinary Professor of biological science in 1987 and 1889. She worked in various laboratories in the USA, with Ernest Borek (Denver, Colorado) and Michel Laskowski, Sr. (Buffalo, NY) and in Europe, with Soren Lovtrup (University of Goterborg, Sweden), Karl-Heinz Scheit, in Max Planck-Institute in Gettingen, Germany), Barry.W. Glickman (State University at Leiden, The Netherlands) and (for a short period) with Bryn A. Bridges (Sussex University, UK). Dr. Janion's main interest was in the nucleic acids. She worked on physical chemistry of nucleic acids; on the metabolism and reactivity of DNA and RNA with a variety of mutagens; as well as on enzymology and mechanisms of DNA mutagenesis. Recently, she has concentrated on genotoxicity, mutagenesis, and prevention of mutations by systems that are induced in E. coli; it is worth noting that similar repair proteins are present in all the species of the living Kingdoms (including human). Celina Janion has devoted special attention to the AlkB protein, which is synthesized in E. coli cells in response to treatment with alkilating agents. The direct mode of base repair in DNA is very rarely used in cells.

Biography Updated on 2 April 2007

Articles in Scholarly Journals [Incomplete List]

  1. Variation in scorpion metabolic rate and rate?temperature relationships: implications for the fundamental equation of the metabolic theory of ecology
    Journal of Evolutionary Biology, vol. 20, no. 4, pp. 1602–1612, 2007
  2. AlkB dioxygenase in preventing MMS-induced mutagenesis in Escherichia coli: Effect of Pol V and AlkA proteins
    DNA Repair, vol. 5, no. 2, pp. 181–188, 2006
  3. Mutator activity and specificity of allele ? effect of products
    Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, vol. 572, no. 1-2, pp. 113–122, 2005
  4. Effect of deletion of SOS-induced polymerases, pol II, IV, and V, on spontaneous mutagenesis inEscherichia coli mutD5
    Environmental and Molecular Mutagenesis, vol. 43, no. 4, pp. 226–234, 2004
  5. E. coli BW535, a triple mutant for the DNA repair genesxth,nth, andnfo, chronically induces the SOS response
    Environmental and Molecular Mutagenesis, vol. 41, no. 4, pp. 237–242, 2003
  6. Lethality of visible light for Escherichia coli hemH1 mutants influence of defects in DNA repair
    DNA Repair, vol. 2, no. 1, pp. 61–71, 2003
  7. 32nd Annual Meeting of European Environmental Mutagen Society DNA Damage and Repair Fundamental Aspects and Contribution to Human Disorders
    DNA Repair, 2003
  8. Induction of the SOS response in starvedEscherichia coli
    Environmental and Molecular Mutagenesis, vol. 40, no. 2, pp. 129–133, 2002
  9. Some Provocative Thoughts on Damage and Repair of DNA
    Journal of Biomedicine and Biotechnology, vol. 1, no. 2, pp. 50–51, 2001
  10. Effect of Tn10/Tn5 transposons on the survival and mutation frequency of halogen light-irradiated AB1157 Escherichia coli K-12
    Mutagenesis, vol. 14, no. 1, pp. 129–134, 1999
  11. Mutation frequency decline in MMS-treated Escherichia coli K–12 mutS strains
    Mutagenesis, vol. 13, no. 2, pp. 127–132, 1998
  12. DNA mutagenesis and repair in UV-irradiated E. coli K-12 under condition of mutation frequency decline
    Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, vol. 402, no. 1-2, pp. 59–66, 1998
  13. Mutation induction and mutation frequency decline in halogen light-irradiated Escherichia coli K-12 AB1157 strains
    Mutation Research/Genetic Toxicology and Environmental Mutagenesis, vol. 390, no. 1-2, pp. 85–92, 1997
  14. MMS-induced mutagenesis and DNA repair in Escherichia coli dnaQ49: Contribution of UmuD' to DNA repair
    Mutation Research/DNA Repair, vol. 362, no. 2, pp. 147–154, 1996
  15. Conformation of plasmid DNA from Escherichia coli deficient in the repair systems protecting DNA from 8-oxyguanine lesions
    Biochimie, vol. 78, no. 2, pp. 85–89, 1996
  16. The frequency of MMS-induced, umuDC-dependent, mutations declines during starvation in Escherichia coli
    MGG Molecular & General Genetics, vol. 245, no. 4, pp. 486–492, 1994
  17. Some aspects of EMS-induced mutagenesis in Escherichia coli
    Mutation Research/Reviews in Genetic Toxicology, vol. 297, no. 3, pp. 313–321, 1993
  18. Effect of heat shock on expression of proteins not involved in the heat-shock regulon
    European Journal of Biochemistry, vol. 209, no. 2, pp. 549–553, 1992
  19. Base-pairing models to account for the mutagenicity and specificity of the purine analog 2-amino-N6-hydroxyadenine
    Mutation Research/Environmental Mutagenesis and Related Subjects, vol. 253, no. 1, pp. 17–20, 1991
  20. Alternative pathways of methyl methanesulfonate-induced mutagenesis in Escherichia coli
    MGG Molecular & General Genetics, vol. 216, no. 1, pp. 126–131, 1989
  21. Influence of dam and mismatch repair system on mutagenic and SOS-inducing activity of methyl methanesulfonate in Escherichia coli
    Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, vol. 210, no. 1, pp. 15–22, 1989
  22. Ability of base analogs to induce the SOS response: effect of a dam mutation and mismatch repair system
    MGG Molecular & General Genetics, vol. 201, no. 3, pp. 519–524, 1985
  23. Involvement of the mismatch repair system in base analogue-induced mutagenesis
    MGG Molecular & General Genetics, vol. 191, no. 2, pp. 276–281, 1983
  24. Effect of bacterial host repair systems on the viability of hydroxylamine and methyl methanesulfonate treated T4 and ? bacteriophages
    MGG Molecular & General Genetics, vol. 186, no. 3, pp. 419–426, 1982
  25. Effect of proofreading anddam-instructed mismatch repair systems on N4-hydroxycytidine-induced mutagenesis
    MGG Molecular & General Genetics, vol. 186, no. 3, pp. 411–418, 1982
  26. Influence of methionine on the mutation frequency in Salmonella typhimurium
    Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, vol. 94, no. 2, pp. 331–338, 1982
  27. Mutagenic and inhibitory properties of some new purine analogs on Salmonella typhimurium TA1530
    Mutation Research Letters, vol. 91, no. 3, pp. 193–197, 1981
  28. Mutagenic specificity of N4-hydroxycytidine
    Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, vol. 70, no. 1, pp. 11–16, 1980
  29. N4-hydroxycytidine: A mutagen specific for at to GC transitions
    Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, vol. 72, no. 1, pp. 43–47, 1980
  30. Mutagenesis induced in amber P22 phages by base analogues
    Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, vol. 62, no. 1, pp. 191–195, 1979
  31. The efficiency and extent of mutagenic activity of some new mutagens of base-analogue type
    Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, vol. 56, no. 3, pp. 225–234, 1978
  32. N6-Hydroxy-2-aminopurine, N4-hydroxycytidine and 5-methyl-N4-hydroxideoxycytidine: potent mutagens of the base analog type
    Mutation Research/Environmental Mutagenesis and Related Subjects, vol. 46, no. 3, pp. 222–223, 1977
  33. The effect of thioketo substitution on uracil-2-aminopurine and uracil-2,6-diaminopurine interactions in polynucleotides
    Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, vol. 432, no. 2, pp. 192–198, 1976
  34. N4-hydroxycytidine ? A new mutagen of a base analogue type
    Biochemical and Biophysical Research Communications, vol. 56, no. 2, pp. 459–466, 1974
  35. Interaction of polynucleotides: A hypothesis on reasons for the changes in the ultraviolet spectrum upon complex formation
    FEBS Letters, vol. 27, no. 2, pp. 198–202, 1972
  36. Effect of composition of the light satellite DNA on solubility in phenol
    Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, vol. 262, no. 1, pp. 11–17, 1972
  37. Poly 2?-O-methylcytidylic acid and the role of the 2?-hydroxyl in polynucleotide structure
    Biochemical and Biophysical Research Communications, vol. 37, no. 6, pp. 895–901, 1969