Alexander J Szalai
Alexander J. Szalai holds a Ph.D. degree. He serves as Professor of Medicine at the Division of Clinical Immunology and Rheumatology, Department of Medicine, The University of Alabama at Birmingham, Birmingham, AL, USA.The overarching goal of his research is to understand the contribution of C-reactive protein (CRP) to maintenance of health and propagation of disease. To approach this goal, Szalai and the members of his laboratory use a multifaceted and translational approach that entails studies of CRP biology in transgenic and knockout mice, bolstered by studies with human cells and DNA, aimed at revealing CRP genetic and phenotypic associations. Among the diseases of research interest in his CRP-centric laboratory are autoimmune ones (systemic lupus erythematosus, multiple sclerosis, and rheumatoid arthritis) and cardiovascular ones (atherosclerosis, arteriovenous fistula failure, neointima generation, and thrombosis). Their latest work is geared towards development of CRP-lowering drugs for clinical use. Ligand-bound CRP activates the complement system and binds to Fc gamma receptors; therefore they also study these two effector pathways. They have a growing interest in CRP’s contribution to metabolic regulation and Alzheimer’s disease. Finally as CRP is an evolutionarily ancient/highly conserved molecule, much of his CRP work is comparative in nature – those efforts focus on investigation of CRP action in lower vertebrates such as fish.
Biography Updated on 18 April 2012